Nature Immunology Contents: February 2018 Volume 19 Issue 2

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TABLE OF CONTENTS February 2018 Volume 19, Issue 2 Research Highlights News & Views Review Articles Articles   Advertisement npj Microgravity is a new open access journal specifically dedicated to publishing research which enables space exploration and research that is enabled by spaceflight and ground-based spaceflight analogues. npj Microgravity is published in cooperation the Biodesign Institute at Arizona State University, and is part of the Nature Partner Journals series.     Find out more >>>   Advertisement Nature Outlook: Cancer immunotherapy  Drugs that mobilize our immune systems against cancer are dramatically improving care for many people, and research is rapidly moving ahead in the lab and the clinic.  Access this Outlook free >> Produced with support from  F. Hoffmann-La Roche Ltd   Medimmune  Produced with support of a grant from Merck & Co., Inc.   Advertisement Spotlight on Kanagawa  A smart place to work Lower house prices, proximity to Tokyo, and a burgeoning R&D ecosystem are thrusting Kanagawa into the modern world from its ancient history. Access Free Online   Research Highlights   Adipose tissue TM cells    p99 Ioana Visan doi:10.1038/s41590-017-0036-4 Myocardial infarct inflammation    p99 Ioana Visan doi:10.1038/s41590-017-0037-3 Stress-induced depression    p99 Laurie A. Dempsey doi:10.1038/s41590-017-0038-2 NKT cells aid antiviral responses    p99 Laurie A. Dempsey doi:10.1038/s41590-017-0039-1 Macrophages: damage control    p99 Zoltan Fehervari doi:10.1038/s41590-017-0040-8 Antibiotics–immune system interactions    p99 Zoltan Fehervari doi:10.1038/s41590-017-0041-7 News & Views   mTECs Aire on the side of caution    pp100 - 101 Alexandra Bortnick & Cornelis Murre doi:10.1038/s41590-017-0033-7 Trials and Tribble-ations of tissue TRM cells    pp102 - 103 Jun Siong Low & Susan M. Kaech doi:10.1038/s41590-017-0031-9 Stressed-out ROS take a silent death route    pp103 - 105 Sannula Kesavardhana & Thirumala-Devi Kanneganti doi:10.1038/s41590-017-0034-6 ERAdP standing in the shadow of STING innate immune signaling    pp105 - 107 Martin Roelsgaard Jakobsen doi:10.1038/s41590-017-0026-6 Immunology JOBS of the week Junior Group Leader Positions Insitut Curie Postdoctoral Fellow German Cancer Research Center (DKFZ). Postdoctoral Fellowship The University of Texas MD Anderson Cancer Center Postdoctoral Fellow University Health Network (Toronto) Research Scientist in Cellular and Translational Immunology University of Virginia More Science jobs from Immunology EVENT 14th International Congress of Immunology and Allergy, Tehran, Iran (ICIA2018) 26.04.18 Tehran, Iran More science events from Review Articles   Myeloid-derived suppressor cells coming of age    pp108 - 119 Filippo Veglia, Michela Perego & Dmitry Gabrilovich doi:10.1038/s41590-017-0022-x Gabrilovich and colleagues review the origin and nature of myeloid-derived suppressor cells, as well as their distinctive features and biological roles in cancer, infectious diseases, autoimmunity, obesity and pregnancy.   RNA-binding proteins control gene expression and cell fate in the immune system    pp120 - 129 Martin Turner & Manuel D. Díaz-Muñoz doi:10.1038/s41590-017-0028-4 Turner and Díaz-Muñoz discuss the molecular mechanisms by which RNA-binding proteins modulate the diversity of the transcriptome and proteome in immune cells.   Advertisement Do you have a career question?  The Naturejobs podcast features one-on-one Q&As, panel discussions and other exclusive content to help scientists with their careers. Hosted on the Naturejobs blog, the podcast is also available on iTunes and Soundcloud.  Listen today!    Articles   Oxeiptosis, a ROS-induced caspase-independent apoptosis-like cell-death pathway    pp130 - 140 Cathleen Holze, Chloé Michaudel, Claire Mackowiak, Darya A. Haas, Christian Benda et al. doi:10.1038/s41590-017-0013-y Reactive oxygen species (ROS) are generated by cells during viral infection. Pichlmair and colleagues demonstrate a ROS-dependent form of cell death, ‘oxeiptosis’, that resembles apoptosis but uses a pathway distinct from all previously described death pathways.   The ER membrane adaptor ERAdP senses the bacterial second messenger c-di-AMP and initiates anti-bacterial immunity    pp141 - 150 Pengyan Xia, Shuo Wang, Zhen Xiong, Xiaoxiao Zhu, Buqing Ye et al. doi:10.1038/s41590-017-0014-x The bacterial secondary messenger c-di-AMP can be sensed by cytosolic receptors to activate innate immunity. Fan and colleagues show the ER-associated protein ERAdP to be a high-affinity receptor for c-di-AMP, linking it to downstream inflammatory responses.   Astrocytes decrease adult neurogenesis during virus-induced memory dysfunction via IL-1    pp151 - 161 Charise Garber, Michael J. Vasek, Lauren L. Vollmer, Tony Sun, Xiaoping Jiang et al. doi:10.1038/s41590-017-0021-y Klein and colleagues show, in a mouse model of West Nile virus–induced cognitive dysfunction, that neurogenesis is impaired by production of IL-1 from pro-inflammatory astrocytes.   Rapid chromatin repression by Aire provides precise control of immune tolerance    pp162 - 172 Andrew S. Koh, Erik L. Miller, Jason D. Buenrostro, David M. Moskowitz, Jing Wang et al. doi:10.1038/s41590-017-0032-8 Crabtree and colleagues show that Aire has an intrinsic repressive function that restricts chromatin accessibility and restrains the amplitude of active transcription.   Intravital mucosal imaging of CD8+ resident memory T cells shows tissue-autonomous recall responses that amplify secondary memory    pp173 - 182 Lalit K. Beura, Jason S. Mitchell, Emily A. Thompson, Jason M. Schenkel, Javed Mohammed et al. doi:10.1038/s41590-017-0029-3 Masopust and colleagues show that mucosal tissue-resident memory T cells proliferate in situ in response to local antigen and dominate the local recall response.   Local proliferation maintains a stable pool of tissue-resident memory T cells after antiviral recall responses    pp183 - 191 Simone L. Park, Ali Zaid, Jyh Liang Hor, Susan N. Christo, Julia E. Prier et al. doi:10.1038/s41590-017-0027-5 Mackay, Mueller and colleagues show that tissue-resident memory T cells proliferate in situ in response to local antigen and persist during subsequent antigen encounters.   Aged polymorphonuclear leukocytes cause fibrotic interstitial lung disease in the absence of regulation by B cells    pp192 - 201 Jung Hwan Kim, John Podstawka, Yuefei Lou, Lu Li, Esther K. S. Lee et al. doi:10.1038/s41590-017-0030-x Yipp and colleagues report that depletion of B cells leads to the accumulation of aged polymorphonuclear cells in the lungs, which causes fibrotic interstitial lung disease.   Advertisement Online-only and open access, npj Primary Care Respiratory Medicine is the only fully-indexed scientific journal devoted to the management of respiratory diseases in primary care.   Explore the benefits of submitting your next research article.   Advertisement Nature Mentoring Collection  Offering advice and support to scientist mentors and their mentees  Access the Collection >>   Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. 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