| | Chromosomal instability drives metastasis through a cytosolic DNA response
In chromosomally unstable tumour cells, rupture of micronuclei exposes genomic DNA and activates the cGAS–STING cytosolic DNA-sensing pathway, thereby promoting metastasis. | Midbrain circuits that set locomotor speed and gait selection
Speed and gait selection in mice are controlled by glutamatergic excitatory neurons in the cuneiform nucleus and the pedunculopontine nucleus, which act in conjunction to select context-dependent locomotor behaviours. | α-Klotho is a non-enzymatic molecular scaffold for FGF23 hormone signalling
The crystal structure of shed ectodomain of α-klotho bound to the FGFR1c ligand-binding domain and FGF23 unveils the mechanism by which klotho co-receptors promote hormonal FGF signalling. | Structures of β-klotho reveal a ‘zip code’-like mechanism for endocrine FGF signalling
Crystal structures of free and ligand-bound β-klotho reveal that it acts as a primary receptor for FGF21, and demonstrate how a sugar-cutting enzyme has evolved to become a receptor for hormones that regulate metabolic processes. | Centimetre-scale electron diffusion in photoactive organic heterostructures
For a suitably designed organic multilayer structure, optically or electrically generated electrons confined to a thin fullerene channel can diffuse over surprisingly long distances of several centimetres. | Observation of a phononic quadrupole topological insulator
A two-dimensional phononic quadrupole topological insulator is demonstrated experimentally using mechanical metamaterials, which has both the one-dimensional edge states and the zero-dimensional corner states predicted by theory. | Clonal evolution mechanisms in NT5C2 mutant-relapsed acute lymphoblastic leukaemia
Mutations in the nucleotidase-encoding gene NT5C2 drive chemotherapy resistance in relapsed acute lymphoid leukaemia but the mutations also lead to a loss-of-fitness phenotype and to collateral drug sensitivity, which could be exploited for therapy. | A Myc enhancer cluster regulates normal and leukaemic haematopoietic stem cell hierarchies
A blood enhancer cluster forms a highly combinatorial system that allows precise control of Myc expression across normal and leukaemic haematopoietic stem cell hierarchies. | Regulation of embryonic haematopoietic multipotency by EZH1
The production of haematopoietic stem cells is repressed during early mammalian embryogenesis by an epigenetic mechanism that involves the action of the Polycomb protein EZH1. | Structure and mutagenesis reveal essential capsid protein interactions for KSHV replication
Cryo-electron microscopy reveals the structure of the Kaposi’s sarcoma-associated herpesvirus capsid, and experiments with polypeptides that mimic the smallest capsid protein demonstrate the potential for structure-derived insights to help to develop antiviral agents. | Atomic structure of the eukaryotic intramembrane RAS methyltransferase ICMT
The X-ray structure of the integral membrane protein isoprenylcysteine carboxyl methyltransferase suggests mechanisms by which it recognizes both water-soluble and membrane-bound reactants to catalyse the methylation of RAS and other CAAX proteins at the membrane-cytosol interface. | Monitoring T cell–dendritic cell interactions in vivo by intercellular enzymatic labelling
Interactions between receptors and ligands on immune cells are visualized in vivo and in vitro using an enzyme-tagged ligand that, when cells interact, leaves behind a detectable label on the receptor-expressing cell. | | Erratum: Moving beyond microbiome-wide associations to causal microbe identification | | Corrigendum: mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer | | Dietary trehalose enhances virulence of epidemic Clostridium difficile
Two hypervirulent ribotypes of the enteric pathogen Clostridium difficile, RT027 and RT078, have independently acquired unique mechanisms to metabolize low concentrations of the disaccharide trehalose, suggesting a correlation between the emergence of these ribotypes and the widespread adoption of trehalose in the human diet.
J. Collins, C. Robinson, H. Danhof et al. | Molecular mechanism of promoter opening by RNA polymerase III
Cryo-EM structures of Pol III preinitiation complexes are presented, comprising Pol III and the transcription factor TFIIIB bound to a natural promoter in different functional states.
Matthias K. Vorländer, Heena Khatter, Rene Wetzel et al. | Structural basis of RNA polymerase III transcription initiation
Detailed structures of yeast RNA polymerase III and its initiation complex shed light on how the transcription of essential non-coding RNAs begins and allow comparisons with other RNA polymerases.
Guillermo Abascal-Palacios, Ewan Phillip Ramsay, Fabienne Beuron et al. | | Black-hole-regulated star formation in massive galaxies
The star formation histories of galaxies, as encapsulated in their integrated optical spectra, depend on the mass of the black holes present at their centres.
Ignacio Martín-Navarro, Jean P. Brodie, Aaron J. Romanowsky et al. | Large granulation cells on the surface of the giant star π1 Gruis
Interferometric images of the surface of the giant star π1 Gruis reveal few but large convective cells, consistent with existing models of stellar surface convection.
C. Paladini, F. Baron, A. Jorissen et al. | A record of deep-ocean dissolved O2 from the oxidation state of iron in submarine basalts
Deep-ocean O2 concentrations over the past 3.5 billion years are estimated using the oxidation state of iron in submarine basalts and indicate that deep-ocean oxygenation occurred in the Phanerozoic eon.
Daniel A. Stolper, C. Brenhin Keller | Paternal chromosome loss and metabolic crisis contribute to hybrid inviability in Xenopus
In hybrid inviability between Xenopus laevis and Xenopus tropicalis, genomic regions on two X. laevis chromosomes are incompatible with the X. tropicalis cytoplasm and are mis-segregated during mitosis, leading to unbalanced gene expression at the maternal to zygotic transition, followed by cell-autonomous catastrophic embryo death.
Romain Gibeaux, Rachael Acker, Maiko Kitaoka et al. | Pharmacological activation of REV-ERBs is lethal in cancer and oncogene-induced senescence
REV-ERBs, nuclear hormone receptors that regulate transcription as part of the circadian clock cell machinery, inhibit autophagy and lipogenesis in premalignant and malignant cells and impair tumour growth in vivo.
Gabriele Sulli, Amy Rommel, Xiaojie Wang et al. | AMD1 mRNA employs ribosome stalling as a mechanism for molecular memory formation
A regulatory mechanism that limits the number of complete protein molecules that can be synthesized from a single mRNA molecule of the human AMD1 gene encoding adenosylmethionine decarboxylase 1.
Martina M. Yordanova, Gary Loughran, Alexander V. Zhdanov et al. | Systems of mechanized and reactive droplets powered by multi-responsive surfactants
Droplets covered with surfactants that respond to multiple stimuli can assemble into hierarchical assemblies or non-spherical, patchy structures, mimic systems of mechanical gears, and even harbour sequences of chemical reactions.
Zhijie Yang, Jingjing Wei, Yaroslav I. Sobolev et al. | Emergent constraint on equilibrium climate sensitivity from global temperature variability
Equilibrium climate sensitivity—which remains the largest uncertainty in climate projections—is constrained to a ‘likely’ range of 2.2–3.4 K by taking into account the variability of global temperature about long-term historical warming.
Peter M. Cox, Chris Huntingford, Mark S. Williamson | Warfare and wildlife declines in Africa’s protected areas
Assessment of the impact of armed conflict on large herbivores in Africa between 1946 and 2010 reveals that high conflict frequency is an important predictor of wildlife population declines.
Joshua H. Daskin, Robert M. Pringle | A global map of travel time to cities to assess inequalities in accessibility in 2015
Travel time to cities in 2015 is quantified in a high-resolution global map that will be useful for socio-economic policy design and conservation research.
D. J. Weiss, A. Nelson, H. S. Gibson et al. | An extracellular network of Arabidopsis leucine-rich repeat receptor kinases
A high-throughput assay is used to analyse 40,000 potential extracellular domain interactions of a large family of plant cell surface receptors (LRR-RKs) and provide a cell surface interaction network for these receptors.
Elwira Smakowska-Luzan, G. Adam Mott, Katarzyna Parys et al. | High response rate to PD-1 blockade in desmoplastic melanomas
Immune checkpoint blockade with anti-PD-1 or anti-PD-L1 agents produces a high response rate in patients with desmoplastic melanoma.
Zeynep Eroglu, Jesse M. Zaretsky, Siwen Hu-Lieskovan et al. | Architecture of a channel-forming O-antigen polysaccharide ABC transporter
The crystal structure of a channel-forming O-antigen polysaccharide ABC transporter suggests a novel biopolymer translocation mechanism.
Yunchen Bi, Evan Mann, Chris Whitfield et al. | | | | | 
Benchtop Linear MALDI-TOF Mass Spec
Providing a dependable, robust, and easy-to-maintain platform, Shimadzu's new benchtop MALDI-8020 delivers sensitive detection and accurate mass determination by MALDI-TOF MS for a variety of analytes. Intuitive software simplifies operation and enables 21 CFR Part 11 compliance.
Learn more. | | | | | | | | | | | |
No comments:
Post a Comment