| | Mean global ocean temperatures during the last glacial transition
Noble gases trapped in ice cores are used to show that the mean global ocean temperature increased by 2.6 degrees Celsius over the last glacial transition and is closely correlated with Antarctic temperature.
Bernhard Bereiter, Sarah Shackleton, Daniel Baggenstos et al. | Convergent evolution of bilaterian nerve cords
In bilaterian animals, the final configurations of central nervous systems seem unrelated to neuroectodermal patterning systems, so it is likely that the various architectures of the ventral nerve cords evolved convergently, many times.
José M. Martín-Durán, Kevin Pang, Aina Børve et al. | | Galaxy growth in a massive halo in the first billion years of cosmic history
Two extremely massive galaxies are seen 800 million years after the Big Bang, showing the rapid growth of early structure and marking the most massive halo known in that era.
D. P. Marrone, J. S. Spilker, C. C. Hayward et al. | Exploring 4D quantum Hall physics with a 2D topological charge pump
By implementing a 2D topological charge pump using ultracold bosonic atoms, the theoretically predicted 4D integer quantum Hall effect is confirmed experimentally.
Michael Lohse, Christian Schweizer, Hannah M. Price et al. | Photonic topological boundary pumping as a probe of 4D quantum Hall physics
A 2D topological charge pump in a photonic waveguide array is used to observe boundary physics associated with the 4D quantum Hall effect experimentally.
Oded Zilberberg, Sheng Huang, Jonathan Guglielmon et al. | One-pot growth of two-dimensional lateral heterostructures via sequential edge-epitaxy
An approach is developed for the continuous fabrication of lateral multi-junction heterostructures of transition-metal dichalcogenides, in which the sequential formation of heterojunctions is achieved solely by changing the composition of the reactive gas environment in the presence of water vapour.
Prasana K. Sahoo, Shahriar Memaran, Yan Xin et al. | Perovskite nickelates as electric-field sensors in salt water
Application of an electric field changes the transport and optical properties of samarium nickelate submerged in water, making it a suitable passive sensor of weak electric fields in salt water.
Zhen Zhang, Derek Schwanz, Badri Narayanan et al. | Unexpectedly large impact of forest management and grazing on global vegetation biomass
Analyses of potential and actual biomass stocks indicate that trade-offs exist between conserving carbon stocks on managed land and raising the contribution of biomass to raw material and energy supply for the mitigation of climate change.
Karl-Heinz Erb, Thomas Kastner, Christoph Plutzar et al. | Sooty mangabey genome sequence provides insight into AIDS resistance in a natural SIV host OPEN
Whole-genome sequencing and comparative genomic analysis of immune-related genes of Cercocebus atys and Macaca mulatta identify candidate genes, such as ICAM2 and TLR4, that may explain the AIDS resistance of C. atys.
David Palesch, Steven E. Bosinger, Gregory K. Tharp et al. | MicroRNAs from the parasitic plant Cuscuta campestris target host messenger RNAs
A parasitic plant produces microRNAs that target host messenger RNAs, causing them to be processed into small interfering RNAs.
Saima Shahid, Gunjune Kim, Nathan R. Johnson et al. | Acoustic reporter genes for noninvasive imaging of microorganisms in mammalian hosts
Heterologous expression of engineered gas vesicles allows noninvasive, deep-tissue ultrasound visualization of engineered bacteria in vivo in mouse tumour models and in the gastrointestinal tract.
Raymond W. Bourdeau, Audrey Lee-Gosselin, Anupama Lakshmanan et al. | Cyclin D–CDK4 kinase destabilizes PD-L1 via cullin 3–SPOP to control cancer immune surveillance
Abundance of PD-L1, the ligand of the anti-cancer immunotherapy target PD-1, is negatively regulated by poly-ubiquitination via the cyclin D–CDK4/cullin 3–SPOP axis and PD-1 blockade treatment in mice improved survival when combined with CDK4/6 inhibitors.
Jinfang Zhang, Xia Bu, Haizhen Wang et al. | Senescence-associated reprogramming promotes cancer stemness
Cellular senescence induced by chemotherapy leads to the acquisition of stemness in cancer cells, which results in enhanced tumour-promoting capacity after forced release or spontaneous escape from the senescent cell-cycle arrest.
Maja Milanovic, Dorothy N. Y. Fan, Dimitri Belenki et al. | Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling
Super enhancers regulate oncogenes and other molecular targets in ependymomas, and identification of these genes provides potential therapeutic targets.
Stephen C. Mack, Kristian W. Pajtler, Lukas Chavez et al. | Structure of the glucagon receptor in complex with a glucagon analogue
The crystal structure of the full-length glucagon receptor in complex with the glucagon analogue NNC1702 reveals how the peptide ligand interacts with its target and shows the conformational changes required for receptor activation.
Haonan Zhang, Anna Qiao, Linlin Yang et al. | Structure of the complement C5a receptor bound to the extra-helical antagonist NDT9513727
The crystal structure of the complement receptor C5aR1 bound to a small-molecule antagonist provides insights into this receptor class and how they could be better targeted therapeutically.
Nathan Robertson, Mathieu Rappas, Andrew S. Doré et al. | | | | |
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