| | Advertisement | | | | | | | | | Advertisement | | | | | Advertisement | | | | | | | Nature Communications - fully open access All new submissions, if accepted, will be published open access and an article processing charge (APC) will apply. For more information visit the website. Visit our open access funding page or contact openaccess@nature.com to learn more about APC funding. | | | | Latest Articles | View all Articles | | | Engineering yeast for the production of breviscapine by genomic analysis and synthetic biology approaches OPEN | | Xiaonan Liu, Jian Cheng, Guanghui Zhang, Wentao Ding, Lijin Duan, Jing Yang, Ling Kui, Xiaozhi Cheng, Jiangxing Ruan, Wei Fan, Junwen Chen, Guangqiang Long, Yan Zhao, Jing Cai, Wen Wang, Yanhe Ma, Yang Dong, Shengchao Yang & Huifeng Jiang | | | Breviscapine is the flavonoid extract from medical plant Erigeron breviscapus for the treatment of cardio- and cerebrovascular disease. Here, the authors identify the key enzymes of the biosynthetic pathway from the plant genome and engineer yeast to produce breviscapine from glucose. | | 31 January 2018 | doi: 10.1038/s41467-018-02883-z | | Metabolic engineering Metabolic pathways Synthetic biology | Integrated circuits based on conjugated polymer monolayer OPEN | | Mengmeng Li, Deepthi Kamath Mangalore, Jingbo Zhao, Joshua H. Carpenter, Hongping Yan, Harald Ade, He Yan, Klaus Müllen, Paul W. M. Blom, Wojciech Pisula, Dago M. de Leeuw & Kamal Asadi | | | Polymer monolayer field-effect transistors hold promise for faster circuits, but their performance is currently limited by the polymer packing disorder. Li et al. pre-aggregate polymers in a solution to achieve high carrier mobility of 3 cm2 V−1s−1 in monolayers and utilize them in integrated circuits. | | 31 January 2018 | doi: 10.1038/s41467-017-02805-5 | | Electronic and spintronic devices Electronic devices | A naturally occurring epiallele associates with leaf senescence and local climate adaptation in Arabidopsis accessions OPEN | | Li He, Wenwu Wu, Gaurav Zinta, Lan Yang, Dong Wang, Renyi Liu, Huiming Zhang, Zhimin Zheng, Huan Huang, Qingzhu Zhang & Jian-Kang Zhu | | | Epigenetic variation underlies various aspects of phenotypic diversity of plants. Here, He et al show a naturally occurring epiallele controls Arabidopsis leaf senescence by regulating the expression of PHEOPHYTIN PHEOPHORBIDE HYDROLASE (PPH), and is associated with local climate adaptation. | | 31 January 2018 | doi: 10.1038/s41467-018-02839-3 | | DNA methylation Natural variation in plants | Cellular stressors contribute to the expansion of hematopoietic clones of varying leukemic potential OPEN | | Terrence N. Wong, Christopher A. Miller, Matthew R. M. Jotte, Nusayba Bagegni, Jack D. Baty, Amy P. Schmidt, Amanda F. Cashen, Eric J. Duncavage, Nichole M. Helton, Mark Fiala, Robert S. Fulton, Sharon E. Heath, Megan Janke, Kierstin Luber, Peter Westervelt, Ravi Vij, John F. DiPersio, John S. Welch, Timothy A. Graubert, Matthew J. Walter et al. | | | Cellular stressors can impact clonal hematopoiesis. Here, the authors explore the impact of cytotoxic therapy and hematopoietic transplantation on clonal expansion, suggesting different stressors can promote expansion of distinct long-lived clones. | | 31 January 2018 | doi: 10.1038/s41467-018-02858-0 | | Acute myeloid leukaemia Cancer genomics Myelodysplastic syndrome Next-generation sequencing | Adenoviral vector with shield and adapter increases tumor specificity and escapes liver and immune control OPEN | | Markus Schmid, Patrick Ernst, Annemarie Honegger, Maarit Suomalainen, Martina Zimmermann, Lukas Braun, Sarah Stauffer, Cristian Thom, Birgit Dreier, Matthias Eibauer, Anja Kipar, Viola Vogel, Urs F. Greber, Ohad Medalia & Andreas Plückthun | | | Viral gene therapy can be limited by the efficacy of virion sequestration, immune responses and the silencing of genetic payloads. Here the authors engineer an advenovirus protein coat which shields the virion from the immune system while targeting cancer cells. | | 31 January 2018 | doi: 10.1038/s41467-017-02707-6 | | Cryoelectron microscopy Genetic vectors Targeted therapies Viral proteins | A-to-I miR-378a-3p editing can prevent melanoma progression via regulation of PARVA expression OPEN | | Guermarie Velazquez-Torres, Einav Shoshan, Cristina Ivan, Li Huang, Enrique Fuentes-Mattei, Harrison Paret, Sun Jin Kim, Cristian Rodriguez-Aguayo, Victoria Xie, Denise Brooks, Steven J. M. Jones, A. Gordon Robertson, George Calin, Gabriel Lopez-Berenstein, Anil Sood & Menashe Bar-Eli | | | In melanoma, reduced ADAR1 impairs A-to-I microRNA editing. Here, the authors show that miR-378a-3p undergoes this editing in non-metastatic cells and the edited form of miR-378a-3p binds to the PARVA oncogene, inhibiting its expression and preventing melanoma progression and metastasis. | | 31 January 2018 | doi: 10.1038/s41467-018-02851-7 | | Cancer epigenetics Mechanisms of disease Melanoma Metastasis | A peculiar low-luminosity short gamma-ray burst from a double neutron star merger progenitor OPEN | | B.-B. Zhang, B. Zhang, H. Sun, W.-H. Lei, H. Gao, Y. Li, L. Shao, Y. Zhao, Y.-D. Hu, H.-J. Lü, X.-F. Wu, X.-L. Fan, G. Wang, A. J. Castro-Tirado, S. Zhang, B.-Y. Yu, Y.-Y. Cao & E.-W. Liang | | | A short-duration gamma-ray burst was detected along with a double neutron start merger gravitational wave by LIGO-Virgo on August 17th 2017. Here, the authors show that the fluence and spectral peak energy of this event fall into the lower portion of the distribution of known short-duration gamma-ray bursts. | | 31 January 2018 | doi: 10.1038/s41467-018-02847-3 | | High-energy astrophysics Stars | Anderson light localization in biological nanostructures of native silk OPEN | | Seung Ho Choi, Seong-Wan Kim, Zahyun Ku, Michelle A. Visbal-Onufrak, Seong-Ryul Kim, Kwang-Ho Choi, Hakseok Ko, Wonshik Choi, Augustine M. Urbas, Tae-Won Goo & Young L. Kim | | | Light in biological media is known as freely diffusing because interference is negligible. Here, the authors demonstrate Anderson localization of light from quasi-two-dimensional nanostructures in silk fibres. | | 31 January 2018 | doi: 10.1038/s41467-017-02500-5 | | Biomaterials Nanoscience and technology Photonic devices Renewable energy | Type IX secretion system PorM and gliding machinery GldM form arches spanning the periplasmic space OPEN | | Philippe Leone, Jennifer Roche, Maxence S. Vincent, Quang Hieu Tran, Aline Desmyter, Eric Cascales, Christine Kellenberger, Christian Cambillau & Alain Roussel | | | No structural data for the bacterial type IX secretion system (T9SS) are available so far. Here, the authors present the crystal structures of the periplasmic domains from two major T9SS components PorM and GldM, which span most of the periplasmic space, and propose a putative model of the T9SS core membrane complex. | | 30 January 2018 | doi: 10.1038/s41467-017-02784-7 | | Bacterial secretion X-ray crystallography | A carbon nanotube tape for serial-section electron microscopy of brain ultrastructure OPEN | | Yoshiyuki Kubota, Jaerin Sohn, Sayuri Hatada, Meike Schurr, Jakob Straehle, Anjali Gour, Ralph Neujahr, Takafumi Miki, Shawn Mikula & Yasuo Kawaguchi | | | Electron microscopy requires electrically conductive and grounded samples to provide high-resolution, high-contrast images. Here, Kubota et al. describe a suitable carbon nanotube based tape for automated serial section collection and imaging, as in ATUM-based electron microscopy. | | 30 January 2018 | doi: 10.1038/s41467-017-02768-7 | | Imaging techniques Neural circuits Scanning electron microscopy | The genetic prehistory of the Baltic Sea region OPEN | | Alissa Mittnik, Chuan-Chao Wang, Saskia Pfrengle, Mantas Daubaras, Gunita Zariņa, Fredrik Hallgren, Raili Allmäe, Valery Khartanovich, Vyacheslav Moiseyev, Mari Tõrv, Anja Furtwängler, Aida Andrades Valtueña, Michal Feldman, Christos Economou, Markku Oinonen, Andrejs Vasks, Elena Balanovska, David Reich, Rimantas Jankauskas, Wolfgang Haak et al. | | | The population history of Europe is complex and its very north has not yet been comprehensively studied at a genetic level. Here, Mittnik et al. report genome-wide data from 38 ancient individuals from the Eastern Baltic, Russia and Scandinavia to analyse gene flow throughout the Mesolithic and Bronze Age. | | 30 January 2018 | doi: 10.1038/s41467-018-02825-9 | | Evolutionary biology Evolutionary genetics Genomics Population genetics | Probability of phenotypically detectable protein damage by ENU-induced mutations in the Mutagenetix database OPEN | | Tao Wang, Chun Hui Bu, Sara Hildebrand, Gaoxiang Jia, Owen M. Siggs, Stephen Lyon, David Pratt, Lindsay Scott, Jamie Russell, Sara Ludwig, Anne R. Murray, Eva Marie Y. Moresco & Bruce Beutler | | | Programs such as PolyPhen-2 predict the relative severity of damage by missense mutations. Here, Wang et al estimate probabilities that putative null or missense alleles would reduce protein function to cause detectable phenotype by analyzing data from ENU-induced mouse mutations. | | 30 January 2018 | doi: 10.1038/s41467-017-02806-4 | | Data processing Genetic linkage study | Targeting Tyro3 ameliorates a model of PGRN-mutant FTLD-TDP via tau-mediated synaptic pathology OPEN | | Kyota Fujita, Xigui Chen, Hidenori Homma, Kazuhiko Tagawa, Mutsuki Amano, Ayumu Saito, Seiya Imoto, Hiroyasu Akatsu, Yoshio Hashizume, Kozo Kaibuchi, Satoru Miyano & Hitoshi Okazawa | | | Progranulin (PGRN) mutations cause frontotemporal lobe dementia with TDP-43 pathology. Here the authors develop a mutant PGRN knock-in mouse model of the disease, and show that Tyro3, a tyrosine kinase membrane receptor that acts upstream of PKC and MAPK, is inhibited by PGRN which contributes to pathology in this model. | | 30 January 2018 | doi: 10.1038/s41467-018-02821-z | | Dementia Neurodegeneration Spine structure | Gimap5-dependent inactivation of GSK3β is required for CD4+ T cell homeostasis and prevention of immune pathology OPEN | | Andrew R. Patterson, Mehari Endale, Kristin Lampe, Halil I. Aksoylar, Aron Flagg, Jim R. Woodgett, David Hildeman, Michael B. Jordan, Harinder Singh, Zeynep Kucuk, Jack Bleesing & Kasper Hoebe | | | Loss of function GIMAP5 mutation is associated with lymphopenia, but how it mediates T cell homeostasis is unclear. Here the authors study Gimap5−/− mice and a patient with GIMAP5 deficiency to show how this GTPAse negatively regulates GSK3β activity to prevent DNA damage and cell death. | | 30 January 2018 | doi: 10.1038/s41467-018-02897-7 | | Autoimmunity Lymphocyte activation Primary immunodeficiency disorders | Structure-guided design of an Hsp90β N-terminal isoform-selective inhibitor OPEN | | Anuj Khandelwal, Caitlin N. Kent, Maurie Balch, Shuxia Peng, Sanket J. Mishra, Junpeng Deng, Victor W. Day, Weiya Liu, Chitra Subramanian, Mark Cohen, Jeffery M. Holzbeierlein, Robert Matts & Brian S. J. Blagg | | | The molecular chaperone Hsp90 oversees the folding of many proteins associated with cancer progression but existing small-molecule inhibitors of this pathway are not isoform-selective. Here, the authors rationally design an Hsp90 inhibitor that displays high selectivity for the Hsp90β isoform. | | 30 January 2018 | doi: 10.1038/s41467-017-02013-1 | | Drug delivery Molecular medicine Structure-based drug design | RASSF1A uncouples Wnt from Hippo signalling and promotes YAP mediated differentiation via p73 OPEN | | Angelos Papaspyropoulos, Leanne Bradley, Asmita Thapa, Chuen Yan Leung, Konstantinos Toskas, Delia Koennig, Dafni-Eleftheria Pefani, Cinzia Raso, Claudia Grou, Garth Hamilton, Nikola Vlahov, Anna Grawenda, Syed Haider, Jagat Chauhan, Ludovico Buti, Alexander Kanapin, Xin Lu, Francesca Buffa, Grigory Dianov, Alex von Kriegsheim et al. | | | In development, the switch from pluripotency to differentiation is important but it is often unclear how it is regulated. Here, the authors show that the tumour suppressor RASSF1A mediates this switch by promoting YAP-p73 transcription, which in turn enables differentiation. | | 30 January 2018 | doi: 10.1038/s41467-017-02786-5 | | Cell signalling Embryonic stem cells Pluripotency | Transcriptomic alterations during ageing reflect the shift from cancer to degenerative diseases in the elderly OPEN | | Peer Aramillo Irizar, Sascha Schäuble, Daniela Esser, Marco Groth, Christiane Frahm, Steffen Priebe, Mario Baumgart, Nils Hartmann, Shiva Marthandan, Uwe Menzel, Julia Müller, Silvio Schmidt, Volker Ast, Amke Caliebe, Rainer König, Michael Krawczak, Michael Ristow, Stefan Schuster, Alessandro Cellerino, Stephan Diekmann et al. | | | Ageing is associated with a pronounced shift in mortality from cancer to degenerative diseases. Here, the authors show that in concordance with this shift, conserved transcriptional alterations during ageing across four vertebrates align with degenerative diseases but are opposite to those in cancer. | | 30 January 2018 | doi: 10.1038/s41467-017-02395-2 | | Ageing Cancer Computational biology and bioinformatics Genetic association study | Competition between electron pairing and phase coherence in superconducting interfaces OPEN | | G. Singh, A. Jouan, L. Benfatto, F. Couëdo, P. Kumar, A. Dogra, R. C. Budhani, S. Caprara, M. Grilli, E. Lesne, A. Barthélémy, M. Bibes, C. Feuillet-Palma, J. Lesueur & N. Bergeal | | | The nature of the doping dependent superconducting transition remains elusive for a two dimensional electron gas at the LaAlO3/SrTiO3 interface. Here, Singh et al. report superfluid stiffness and the superconducting gap energy at such interface as a function of carrier density. | | 29 January 2018 | doi: 10.1038/s41467-018-02907-8 | | Superconducting properties and materials Surfaces, interfaces and thin films | Hotspots of dendritic spine turnover facilitate clustered spine addition and learning and memory OPEN | | Adam C. Frank, Shan Huang, Miou Zhou, Amos Gdalyahu, George Kastellakis, Tawnie K. Silva, Elaine Lu, Ximiao Wen, Panayiota Poirazi, Joshua T. Trachtenberg & Alcino J. Silva | | | Structural remodeling of dendritic spines is thought to be a mechanism of memory storage. Here, the authors look at how spine turnover and clustering predict future learning and memory performance, and see that a genetically modified mouse with enhanced spine turnover has enhanced learning. | | 29 January 2018 | doi: 10.1038/s41467-017-02751-2 | | Fear conditioning Network models Spatial memory Spine plasticity Spine structure | Membrane bending occurs at all stages of clathrin-coat assembly and defines endocytic dynamics OPEN | | Brandon L. Scott, Kem A. Sochacki, Shalini T. Low-Nam, Elizabeth M. Bailey, QuocAhn Luu, Amy Hor, Andrea M. Dickey, Steve Smith, Jason G. Kerkvliet, Justin W. Taraska & Adam D. Hoppe | | | Two distinct and opposing models for clathrin-mediated endocytosis have been inferred from EM and structural biology data. Here the authors develop an optical method to directly visualize membrane-bending dynamics and show that coat assembly accommodates membrane bending during or after the assembly of the clathrin lattice, which is not predicted by either model. | | 29 January 2018 | doi: 10.1038/s41467-018-02818-8 | | Endocytosis Membrane biophysics | An evolutionary NS1 mutation enhances Zika virus evasion of host interferon induction OPEN | | Hongjie Xia, Huanle Luo, Chao Shan, Antonio E. Muruato, Bruno T. D. Nunes, Daniele B. A. Medeiros, Jing Zou, Xuping Xie, Maria Isabel Giraldo, Pedro F. C. Vasconcelos, Scott C. Weaver, Tian Wang, Ricardo Rajsbaum & Pei-Yong Shi | | | The Asian lineage of Zika virus (ZIKV) has acquired a mutation in NS1 that enhances mosquito infection. Here, Xia et al. show that the same mutation interferes with interferon production through interaction with TBK1 and affects ZIKV replication in mice. | | 29 January 2018 | doi: 10.1038/s41467-017-02816-2 | | Viral evolution Viral immune evasion | Active sites of copper-complex catalytic materials for electrochemical carbon dioxide reduction OPEN | | Zhe Weng, Yueshen Wu, Maoyu Wang, Jianbing Jiang, Ke Yang, Shengjuan Huo, Xiao-Feng Wang, Qing Ma, Gary W. Brudvig, Victor S. Batista, Yongye Liang, Zhenxing Feng & Hailiang Wang | | | The catalytic conversion of carbon dioxide into value-added products requires an understanding of the active species present under working conditions. Here, the authors discover copper-containing complexes to reversibly transform during electrocatalysis into methane-producing copper nanoclusters. | | 29 January 2018 | doi: 10.1038/s41467-018-02819-7 | | Electrocatalysis Materials chemistry | Large magneto-thermopower in MnGe with topological spin texture OPEN | | Y. Fujishiro, N. Kanazawa, T. Shimojima, A. Nakamura, K. Ishizaka, T. Koretsune, R. Arita, A. Miyake, H. Mitamura, K. Akiba, M. Tokunaga, J. Shiogai, S. Kimura, S. Awaji, A. Tsukazaki, A. Kikkawa, Y. Taguchi & Y. Tokura | | | Topological spin textures produce versatile electronic functionalities, but are scarcely exploited for achieving heat to electricity conversion. Here, Fujishiro et al. attribute an enhanced magneto-thermopower in MnGe with topological spin hedgehogs, to electron scattering via the dynamics of an emergent magnetic field. | | 29 January 2018 | doi: 10.1038/s41467-018-02857-1 | | Magnetic properties and materials Thermoelectrics | In-situ liquid cell transmission electron microscopy investigation on oriented attachment of gold nanoparticles OPEN | | Chao Zhu, Suxia Liang, Erhong Song, Yuanjun Zhou, Wen Wang, Feng Shan, Yantao Shi, Ce Hao, Kuibo Yin, Tong Zhang, Jianjun Liu, Haimei Zheng & Litao Sun | | | The non-classical oriented attachment crystallization pathway explains the growth of many nanocrystals. Here, the authors study citrate-stabilized gold nanoparticles by in-situ liquid transmission electron microscopy to reveal that surface ligands are a critical driving force in the oriented attachment process. | | 29 January 2018 | doi: 10.1038/s41467-018-02925-6 | | Nanoparticles Surface chemistry Transmission electron microscopy | Fused electron deficient semiconducting polymers for air stable electron transport OPEN | | Ada Onwubiko, Wan Yue, Cameron Jellett, Mingfei Xiao, Hung-Yang Chen, Mahesh Kumar Ravva, David A. Hanifi, Astrid-Caroline Knall, Balaji Purushothaman, Mark Nikolka, Jean-Charles Flores, Alberto Salleo, Jean-Luc Bredas, Henning Sirringhaus, Pascal Hayoz & Iain McCulloch | | | Semiconducting polymers are usually prepared by transition metal mediated coupling reactions that cause problems for sustainability and biological applications. Here the authors synthesise fused electron deficient polymers that are air stable and have high electron affinities, via metal free aldol polymerisation reactions. | | 29 January 2018 | doi: 10.1038/s41467-018-02852-6 | | Electronic materials Polymer synthesis | GWAS of epigenetic aging rates in blood reveals a critical role for TERT OPEN | | Ake T. Lu, Luting Xue, Elias L. Salfati, Brian H. Chen, Luigi Ferrucci, Daniel Levy, Roby Joehanes, Joanne M. Murabito, Douglas P. Kiel, Pei-Chien Tsai, Idil Yet, Jordana T. Bell, Massimo Mangino, Toshiko Tanaka, Allan F. McRae, Riccardo E. Marioni, Peter M. Visscher, Naomi R. Wray, Ian J. Deary, Morgan E. Levine et al. | | | Epigenetic clocks based on DNA methylation levels are estimators of chronological age. Here, the authors perform a GWAS of epigenetic aging rates in blood and find SNP variants in the TERT locus associated with increased intrinsic epigenetic age are also associated with longer telomeres. | | 26 January 2018 | doi: 10.1038/s41467-017-02697-5 | | Diseases Genome-wide association studies | A dual role for the N-terminal domain of the IL-3 receptor in cell signalling OPEN | | Sophie E. Broughton, Timothy R. Hercus, Tracy L. Nero, Winnie L. Kan, Emma F. Barry, Mara Dottore, Karen S. Cheung Tung Shing, Craig J. Morton, Urmi Dhagat, Matthew P. Hardy, Nicholas J. Wilson, Matthew T. Downton, Christine Schieber, Timothy P. Hughes, Angel F. Lopez & Michael W. Parker | | | The N-terminal domain (NTD) of interleukin-3 receptor α-subunit (IL3Rα) is involved in IL-3 recognition but the underlying mechanism is unknown. Here, the authors present crystal structures of the IL3Rα complex and provide biochemical evidence that the NTD regulates IL-3 binding and signalling complex assembly. | | 26 January 2018 | doi: 10.1038/s41467-017-02633-7 | | Interleukins Signal transduction X-ray crystallography | Caging tin oxide in three-dimensional graphene networks for superior volumetric lithium storage OPEN | | Junwei Han, Debin Kong, Wei Lv, Dai-Ming Tang, Daliang Han, Chao Zhang, Donghai Liu, Zhichang Xiao, Xinghao Zhang, Jing Xiao, Xinzi He, Feng-Chun Hsia, Chen Zhang, Ying Tao, Dmitri Golberg, Feiyu Kang, Linjie Zhi & Quan-Hong Yang | | | The excessive porous space in carbon anodes for lithium-ion batteries has to be utilized for high volumetric performance. Here the authors show an adaptable sulfur template strategy to yield graphene-caged noncarbon materials with a precisely controlled amount of void, enabling ultrahigh volumetric lithium storage. | | 26 January 2018 | doi: 10.1038/s41467-017-02808-2 | | Batteries | Identification of a Golgi GPI-N-acetylgalactosamine transferase with tandem transmembrane regions in the catalytic domain OPEN | | Tetsuya Hirata, Sushil K. Mishra, Shota Nakamura, Kazunobu Saito, Daisuke Motooka, Yoko Takada, Noriyuki Kanzawa, Yoshiko Murakami, Yusuke Maeda, Morihisa Fujita, Yoshiki Yamaguchi & Taroh Kinoshita | | | Mammalian GPI membrane anchors are modified by GalNAc to confer structural diversity but the biosynthetic pathway is poorly understood. Here, the authors identify and characterize the Golgi-resident GPI-GalNAc transferase PGAP4, providing insights into the initial step of GPI-GalNAc biosynthesis. | | 26 January 2018 | doi: 10.1038/s41467-017-02799-0 | | Glycobiology Glycolipids Transferases | Beyond a phenomenological description of magnetostriction OPEN | | A. H. Reid, X. Shen, P. Maldonado, T. Chase, E. Jal, P. W. Granitzka, K. Carva, R. K. Li, J. Li, L. Wu, T. Vecchione, T. Liu, Z. Chen, D. J. Higley, N. Hartmann, R. Coffee, J. Wu, G. L. Dakovski, W. F. Schlotter, H. Ohldag et al. | | | Although magnetostriction is universal in magnetic materials, understanding its microscopic origin remains challenging. Here the authors use X-ray and ultrafast electron diffraction to separate the material’s sub-picosecond spin and lattice responses and reveal the magnetoelastic stress generated by demagnetization. | | 26 January 2018 | doi: 10.1038/s41467-017-02730-7 | | Magnetic properties and materials Nanoparticles Structure of solids and liquids | Dendritic core-shell nickel-iron-copper metal/metal oxide electrode for efficient electrocatalytic water oxidation OPEN | | Peili Zhang, Lin Li, Dennis Nordlund, Hong Chen, Lizhou Fan, Biaobiao Zhang, Xia Sheng, Quentin Daniel & Licheng Sun | | | Splitting water into high-energy fuel represents a renewable way to generate energy, yet the sluggish oxidation kinetics drives up technological costs. Here, the authors prepare tri-metallic core-shell electrodes using nickel, iron, and copper metals to accelerate electricity-driven water splitting. | | 26 January 2018 | doi: 10.1038/s41467-017-02429-9 | | Electrocatalysis Electronic devices Energy Heterogeneous catalysis | Configurable topological textures in strain graded ferroelectric nanoplates OPEN | | Kwang-Eun Kim, Seuri Jeong, Kanghyun Chu, Jin Hong Lee, Gi-Yeop Kim, Fei Xue, Tae Yeong Koo, Long-Qing Chen, Si-Young Choi, Ramamoorthy Ramesh & Chan-Ho Yang | | | Exploring topological textures in ferroelectrics facilitates the understanding and application of topological features in matter. Here the authors demonstrate the strain field induced evolution of topological vortices in nanoplatelets of rhombohedral phase BiFeO3 using the angle-resolved piezoresponse force microscopy. | | 26 January 2018 | doi: 10.1038/s41467-017-02813-5 | | Ferroelectrics and multiferroics Surfaces, interfaces and thin films | Female sexual behavior in mice is controlled by kisspeptin neurons OPEN | | Vincent Hellier, Olivier Brock, Michael Candlish, Elodie Desroziers, Mari Aoki, Christian Mayer, Richard Piet, Allan Herbison, William Henry Colledge, Vincent Prévot, Ulrich Boehm & Julie Bakker | | | Mate preference and copulatory behavior in female rodents are coordinated with the ovulation cycles of the animal. This study shows that hypothalamic kisspeptin neurons control both mate choice and copulation, and therefore, that sexual behavior and ovulation may be synchronized by the same neuropeptide. | | 26 January 2018 | doi: 10.1038/s41467-017-02797-2 | | Pheromone Sexual dimorphism | High-resolution patterning of solution-processable materials via externally engineered pinning of capillary bridges OPEN | | Shunpu Li, Young Tea Chun, Shuo Zhao, Hyungju Ahn, Docheon Ahn, Jung Inn Sohn, Yongbing Xu, Pawan Shrestha, Mike Pivnenko & Daping Chu | | | Solution-processed electronics is desirable for large-scale electronics, but it is challenging to fabricate nanometre patterns via liquid processes. Li et al. address this problem using soft molds with groove and ridge structures, which control thin-film morphology upon dying via the pinning effect. | | 26 January 2018 | doi: 10.1038/s41467-018-02835-7 | | Electronic devices Synthesis and processing | Lipopolysaccharide O-antigen delays plant innate immune recognition of Xylella fastidiosa OPEN | | Jeannette N. Rapicavoli, Barbara Blanco-Ulate, Artur Muszyński, Rosa Figueroa-Balderas, Abraham Morales-Cruz, Parastoo Azadi, Justyna M. Dobruchowska, Claudia Castro, Dario Cantu & M. Caroline Roper | | | Many pathogenic bacteria have evolved to subvert host immune responses triggered by lipopolysaccharides (LPS). Here the authors show that a long terminal polysaccharide chain, known as the O-antigen, present in LPS from the plant pathogen Xylella fastidiosa can delay recognition by grapevine hosts. | | 26 January 2018 | doi: 10.1038/s41467-018-02861-5 | | Microbe Pathogens | Distinct epigenetic programs regulate cardiac myocyte development and disease in the human heart in vivo OPEN | | Ralf Gilsbach, Martin Schwaderer, Sebastian Preissl, Björn A. Grüning, David Kranzhöfer, Pedro Schneider, Thomas G. Nührenberg, Sonia Mulero-Navarro, Dieter Weichenhan, Christian Braun, Martina Dreßen, Adam R. Jacobs, Harald Lahm, Torsten Doenst, Rolf Backofen, Markus Krane, Bruce D. Gelb & Lutz Hein | | | How the cardiac myocyte epigenome is rearranged during development, postnatal maturation and disease is not well understood. Here, the authors investigate the human cardiac myocyte epigenome during development and chronic heart failure and identify distinct epigenetic programs regulating these processes. | | 26 January 2018 | doi: 10.1038/s41467-017-02762-z | | DNA methylation Epigenetics Epigenomics Heart development | Generalized Fano lineshapes reveal exceptional points in photonic molecules OPEN | | Niccolò Caselli, Francesca Intonti, Federico La China, Francesco Biccari, Francesco Riboli, Annamaria Gerardino, Lianhe Li, Edmund H. Linfield, Francesco Pagliano, Andrea Fiore & Massimo Gurioli | | | Fano lineshapes are found in many photonic systems where discrete and extended spectra interfere. Here, the authors extend this description and introduce generalized Fano lineshapes to describe the results from hyperspectral mapping around an exceptional point in a coupled-cavity system. | | 26 January 2018 | doi: 10.1038/s41467-018-02855-3 | | Nanophotonics and plasmonics Near-infrared spectroscopy | SWELL1 is a glucose sensor regulating β-cell excitability and systemic glycaemia OPEN | | Chen Kang, Litao Xie, Susheel K. Gunasekar, Anil Mishra, Yanhui Zhang, Saachi Pai, Yiwen Gao, Ashutosh Kumar, Andrew W. Norris, Samuel B. Stephens & Rajan Sah | | | Insulin secretion by β-cells is stimulated by glucose and is dependent on the induction of β-cell membrane depolarization, mainly driven by the closure of KATP channels, which in turn promotes voltage-gated Ca2+ channel opening. Here Kang et al. show that the volume-regulated anion channel, SWELL1, is involved in glucose-stimulated calcium increase and insulin secretion. | | 25 January 2018 | doi: 10.1038/s41467-017-02664-0 | | Calcium signalling Insulin signalling Ion channel signalling | Endothelial deletion of Ino80 disrupts coronary angiogenesis and causes congenital heart disease OPEN | | Siyeon Rhee, Jae I. Chung, Devin A. King, Gaetano D’amato, David T. Paik, Anna Duan, Andrew Chang, Danielle Nagelberg, Bikram Sharma, Youngtae Jeong, Maximilian Diehn, Joseph C. Wu, Ashby J. Morrison & Kristy Red-Horse | | | Heart development requires compaction of the ventricular wall into a dense myocardium at mid-gestation. Here, Rhee and colleagues show that the chromatin remodeller Ino80 is critical for the formation of the coronary vasculature, and show that coronary vessels are needed for successful cardiac compaction during embryonic development. | | 25 January 2018 | doi: 10.1038/s41467-017-02796-3 | | Angiogenesis Congenital heart defects | Astrocytes modulate brainstem respiratory rhythm-generating circuits and determine exercise capacity OPEN | | Shahriar Sheikhbahaei, Egor A. Turovsky, Patrick S. Hosford, Anna Hadjihambi, Shefeeq M. Theparambil, Beihui Liu, Nephtali Marina, Anja G. Teschemacher, Sergey Kasparov, Jeffrey C. Smith & Alexander V. Gourine | | | Circuits of the preBötzinger complex generate rhythms needed for breathing. Here, the authors provide evidence, using a combination of chemogenetic approaches and approaches to inhibit vesicular release, that astrocytes play a role in regulating respiratory rate. | | 25 January 2018 | doi: 10.1038/s41467-017-02723-6 | | Neural circuits Respiration | High-resolution spatiotemporal transcriptome mapping of tomato fruit development and ripening OPEN | | Yoshihito Shinozaki, Philippe Nicolas, Noe Fernandez-Pozo, Qiyue Ma, Daniel J. Evanich, Yanna Shi, Yimin Xu, Yi Zheng, Stephen I. Snyder, Laetitia B. B. Martin, Eliel Ruiz-May, Theodore W. Thannhauser, Kunsong Chen, David S. Domozych, Carmen Catalá, Zhangjun Fei, Lukas A. Mueller, James J. Giovannoni & Jocelyn K. C. Rose | | | Cell-type transcriptome profiling greatly elucidate organismal development. Here, the authors report a spatiotemporally resolved comprehensive transcriptome analysis of tomato fruit ontogeny and suggest a new model of fruit maturation which initiates in internal tissues then radiates outwards. | | 25 January 2018 | doi: 10.1038/s41467-017-02782-9 | | Cell proliferation Plant molecular biology Transcriptomics | A global ocean atlas of eukaryotic genes OPEN | | Quentin Carradec, Eric Pelletier, Corinne Da Silva, Adriana Alberti, Yoann Seeleuthner, Romain Blanc-Mathieu, Gipsi Lima-Mendez, Fabio Rocha, Leila Tirichine, Karine Labadie, Amos Kirilovsky, Alexis Bertrand, Stefan Engelen, Mohammed-Amin Madoui, Raphaël Méheust, Julie Poulain, Sarah Romac, Daniel J. Richter, Genki Yoshikawa, Céline Dimier et al. | | | Marine microbial eukaryotes and zooplankton display enormous diversity and largely unexplored physiologies. Here, the authors use metatranscriptomics to analyze four organismal size fractions from open-ocean stations, providing the largest reference collection of eukaryotic transcripts from any single biome. | | 25 January 2018 | doi: 10.1038/s41467-017-02342-1 | | Genomics Marine biology Microbial ecology Water microbiology | AMPK activation counteracts cardiac hypertrophy by reducing O-GlcNAcylation OPEN | | Roselle Gélinas, Florence Mailleux, Justine Dontaine, Laurent Bultot, Bénédicte Demeulder, Audrey Ginion, Evangelos P. Daskalopoulos, Hrag Esfahani, Emilie Dubois-Deruy, Benjamin Lauzier, Chantal Gauthier, Aaron K. Olson, Bertrand Bouchard, Christine Des Rosiers, Benoit Viollet, Kei Sakamoto, Jean-Luc Balligand, Jean-Louis Vanoverschelde, Christophe Beauloye, Sandrine Horman et al. | | | AMPK activation inhibits cardiac hypertrophy. Here the authors show that this occurs independently of previously proposed mechanisms and that AMPK controls the phosphorylation of the aminotransferase GFAT, thereby preventing cardiac hypertrophy through the reduction of protein O-GlcNAcylation. | | 25 January 2018 | doi: 10.1038/s41467-017-02795-4 | | Cardiac hypertrophy Glycosylation Kinases | Laser-accelerated particle beams for stress testing of materials OPEN | | M. Barberio, M. Scisciò, S. Vallières, F. Cardelli, S. N. Chen, G. Famulari, T. Gangolf, G. Revet, A. Schiavi, M. Senzacqua & P. Antici | | | Recently, there has been significant progress on the application of laser-generated proton beams in material science. Here the authors demonstrate the benefit of employing such beams in stress testing different materials by examining their mechanical, optical, electrical, and morphological properties. | | 25 January 2018 | doi: 10.1038/s41467-017-02675-x | | Characterization and analytical techniques Mechanical properties Plasma-based accelerators | | | | | | | | Advertisement | | | | | Advertisement | | | | | Advertisement | | | | | | | | | | | Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com | | | | | | | | You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at:www.nature.com/myaccount (You will need to log in to be recognised as a nature.com registrant) For further technical assistance, please contact our registration department For other enquiries, please contact our customer feedback department Springer Nature | One New York Plaza, Suite 4500 | New York | NY 10004-1562 | USA Springer Nature's worldwide offices: London - Paris - Munich - New Delhi - Tokyo - Melbourne San Diego - San Francisco - Washington - New York - Boston Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at Brunel Road, Houndmills, Basingstoke, Hampshire RG21 6XS. © 2018 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. | | | | |
No comments:
Post a Comment