Nature Communications - 24 January 2018

	Weekly Content Alert Nature Communications is fully open access. Read more. 24 January 2018  Latest content: Review Articles Corrigenda Advertisement   Naturejobs Career Guide China 2018 China's scientific landscape is shifting fast. Where can you fit in? Read the latest issue of our career guide to see what opportunities await you.  Read more online >> Journal homepage Recommend to library Web feed   Advertisement Nature Collection: Mitochondria and the heart  Nature Reviews Cardiology brings together a collection of articles from Nature Research journals highlighting the importance of mitochondria in the heart and the new opportunities for mitochondria-targeted therapies in cardiac diseases.  Access here >> Produced with support from:  Stealth BioTherapeutics
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Latest Review       Understanding materials challenges for rechargeable ion batteries with in situ transmission electron microscopy OPEN Yifei Yuan, Khalil Amine, Jun Lu & Reza Shahbazian-Yassar In situ TEM is a powerful tool that helps to understand energy storage behaviors of various materials. This review summarizes the critical discoveries, enabled by in situ TEM, in rechargeable ion batteries, and foresees its bright future for extensive applications. 25 August 2017 | doi: 10.1038/ncomms15806 Batteries  Energy
Latest Articles View all Articles     Hydrologic resilience and Amazon productivity OPEN Anders Ahlström, Josep G. Canadell, Guy Schurgers, Minchao Wu, Joseph A. Berry, Kaiyu Guan & Robert B. Jackson Earth system model simulations of future climate in the Amazon show little agreement. Here, the authors show that biases in internally generated climate explain most of this uncertainty and that the balance between water-saturated and water-limited evapotranspiration controls the Amazon resilience to climate change. 30 August 2017 | doi: 10.1038/s41467-017-00306-z Carbon cycle  Climate and Earth system modelling  Ecological modelling  Hydrology  MHC matching improves engraftment of iPSC-derived neurons in non-human primates OPEN Asuka Morizane, Tetsuhiro Kikuchi, Takuya Hayashi, Hiroshi Mizuma, Sayuki Takara, Hisashi Doi, Aya Mawatari, Matthew F. Glasser, Takashi Shiina, Hirohito Ishigaki, Yasushi Itoh, Keisuke Okita, Emi Yamasaki, Daisuke Doi, Hirotaka Onoe, Kazumasa Ogasawara, Shinya Yamanaka & Jun Takahashi Major histocompatibility complex (MHC) matching improves graft survival rates after organ transplantation. Here the authors show that in macaques, MHC-matched iPSC-derived neurons provide better engraftment in the brain, with a lower immune response and higher survival of the transplanted neurons. 30 August 2017 | doi: 10.1038/s41467-017-00926-5 Allotransplantation  Induced pluripotent stem cells  Regeneration and repair in the nervous system  Stem-cell research  Transport and excitations in a negative-U quantum dot at the LaAlO3/SrTiO3 interface OPEN Guenevere E. D. K. Prawiroatmodjo, Martin Leijnse, Felix Trier, Yunzhong Chen, Dennis V. Christensen, Merlin von Soosten, Nini Pryds & Thomas S. Jespersen Complex oxide devices provide a platform for studying and making use of strongly correlated electronic behavior. Here the authors present a LaAlO3/SrTiO3 quantum dot and show that its transport behavior is consistent with the presence of attractive electron interactions and the charge Kondo effect. 30 August 2017 | doi: 10.1038/s41467-017-00495-7 Superconducting devices  Superconducting properties and materials  Surfaces, interfaces and thin films  The onset of widespread marine red beds and the evolution of ferruginous oceans OPEN Haijun Song, Ganqing Jiang, Simon W. Poulton, Paul B. Wignall, Jinnan Tong, Huyue Song, Zhihui An, Daoliang Chu, Li Tian, Zhenbing She & Chengshan Wang The evolution of oceanic redox state in the past is poorly known. Here, the authors present a temporal record of banded iron formations and marine red beds, which indicate deep-ocean oxygenation occurred in the middle Ediacaran, coinciding with the onset of widespread marine red beds. 30 August 2017 | doi: 10.1038/s41467-017-00502-x Element cycles  Marine chemistry  Palaeoceanography  High-quality monolayer superconductor NbSe2 grown by chemical vapour deposition OPEN Hong Wang, Xiangwei Huang, Junhao Lin, Jian Cui, Yu Chen, Chao Zhu, Fucai Liu, Qingsheng Zeng, Jiadong Zhou, Peng Yu, Xuewen Wang, Haiyong He, Siu Hon Tsang, Weibo Gao, Kazu Suenaga, Fengcai Ma, Changli Yang, Li Lu, Ting Yu, Edwin Hang Tong Teo et al. Two-dimensional superconductors will likely have applications not only in devices, but also in the study of fundamental physics. Here, Wang et al. demonstrate the CVD growth of superconducting NbSe2 on a variety of substrates, making these novel materials increasingly accessible. 30 August 2017 | doi: 10.1038/s41467-017-00427-5 Superconducting devices  Superconductors  Two-dimensional materials  Variable repeats in the eukaryotic polyubiquitin gene ubi4 modulate proteostasis and stress survival OPEN Rita Gemayel, Yudi Yang, Maria C. Dzialo, Jacek Kominek, Jakob Vowinckel, Veerle Saels, Leen Van Huffel, Elisa van der Zande, Markus Ralser, Jan Steensels, Karin Voordeckers & Kevin J. Verstrepen Eukaryotic cells rely on the ubiquitin-proteasome system for selective degradation of proteins, a process vital to organismal fitness. Here the authors show that the number of repeats in the polyubiquitin gene is evolutionarily unstable within and between yeast species, and that this variability may tune the cell’s capacity to respond to sudden environmental perturbations. 30 August 2017 | doi: 10.1038/s41467-017-00533-4 Evolvability  Fungi  Ubiquitylation  Small nucleoli are a cellular hallmark of longevity OPEN Varnesh Tiku, Chirag Jain, Yotam Raz, Shuhei Nakamura, Bree Heestand, Wei Liu, Martin Späth, H. Eka. D. Suchiman, Roman-Ulrich Müller, P. Eline Slagboom, Linda Partridge & Adam Antebi Animal lifespan is plastic and is regulated by conserved signalling pathways. Here, Tiku et al. show that longevity-enhancing mutations or interventions are associated with reduced nucleolar size in worms, flies, mice and humans, and that nucleolar size can predict life-expectancy in individual worms. 30 August 2017 | doi: 10.1038/ncomms16083 Ageing  Caenorhabditis elegans  Gene regulation  Nucleolus  On-chip single photon filtering and multiplexing in hybrid quantum photonic circuits OPEN Ali W. Elshaari, Iman Esmaeil Zadeh, Andreas Fognini, Michael E. Reimer, Dan Dalacu, Philip J. Poole, Val Zwiller & Klaus D. Jöns Combining different integration platforms on the same chip is currently one of the main challenges for quantum technologies. Here, Elshaari et al. show III-V Quantum Dots embedded in nanowires operating in a CMOS compatible circuit, with controlled on-chip filtering and tunable routing. 30 August 2017 | doi: 10.1038/s41467-017-00486-8 Integrated optics  Nanowires  Quantum dots  Single photons and quantum effects  ATRX is a regulator of therapy induced senescence in human cells OPEN Marta Kovatcheva, Will Liao, Mary E. Klein, Nicolas Robine, Heather Geiger, Aimee M. Crago, Mark A. Dickson, William D. Tap, Samuel Singer & Andrew Koff Therapy induced senescence (TIS) is a growth suppressive program activated by cytostatic agents in some cancer cells. Here the authors show that the chromatin remodeling enzyme ATRX is a regulator of TIS and drives cells into this state via multiple mechanisms. 30 August 2017 | doi: 10.1038/s41467-017-00540-5 Cell-cycle exit  Chromatin remodelling  Senescence  Blood monocyte transcriptome and epigenome analyses reveal loci associated with human atherosclerosis OPEN Yongmei Liu, Lindsay M. Reynolds, Jingzhong Ding, Li Hou, Kurt Lohman, Tracey Young, Wei Cui, Zhiqing Huang, Carole Grenier, Ma Wan, Hendrik G. Stunnenberg, David Siscovick, Lifang Hou, Bruce M. Psaty, Stephen S. Rich, Jerome I. Rotter, Joel D. Kaufman, Gregory L. Burke, Susan Murphy, David R. Jacobs Jr et al. The molecular mechanisms mediating the impact of environmental factors in atherosclerosis are unclear. Here, the authors examine CD14+ blood monocyte’s transcriptome and epigenome signatures to find differential methylation and expression of ARID5B to be associated with human atherosclerosis. 30 August 2017 | doi: 10.1038/s41467-017-00517-4 Atherosclerosis  DNA methylation  Gene expression profiling  Mechanisms of disease  Transcriptomics  Hit-and-run programming of therapeutic cytoreagents using mRNA nanocarriers OPEN H. F. Moffett, M. E. Coon, S. Radtke, S. B. Stephan, L. McKnight, A. Lambert, B. L. Stoddard, H. P. Kiem & M. T. Stephan Current widely used viral and electroporation methods for creating therapeutic cell-based products are complex and expensive. Here, the authors develop targeted mRNA nanocarriers that can transiently program gene expression by simply mixing them with cells, to improve their therapeutic potential. 30 August 2017 | doi: 10.1038/s41467-017-00505-8 Gene delivery  Immunotherapy  Nanoparticles  Photoelectrochemical oxidation of organic substrates in organic media OPEN Tengfei Li, Takahito Kasahara, Jingfu He, Kevan E. Dettelbach, Glenn M. Sammis & Curtis P. Berlinguette Photoelectrochemical water splitting is a promising method for H2 fuel production, but the O2 by-product generated has little economic value. Here, Berlinguette and colleagues demonstrate that BiVO4 photoanodes immersed in organic media can instead perform valuable alcohol oxidation and C–H functionalization reactions. 30 August 2017 | doi: 10.1038/s41467-017-00420-y Electrocatalysis  Materials chemistry  Synthetic chemistry methodology  Photocatalysis  Chaperones rescue the energetic landscape of mutant CFTR at single molecule and in cell OPEN Miklos Bagdany, Guido Veit, Ryosuke Fukuda, Radu G. Avramescu, Tsukasa Okiyoneda, Imad Baaklini, Jay Singh, Guy Sovak, Haijin Xu, Pirjo M. Apaja, Sara Sattin, Lenore K. Beitel, Ariel Roldan, Giorgio Colombo, William Balch, Jason C. Young & Gergely L. Lukacs The F508 deletion (F508del) in the cystic fibrosis transmembrane conductance regulator (CFTR) is the most common CF causing mutation. Here the authors show that cytosolic chaperones shift the F508del channel conformation to the native fold by kinetic and thermodynamic remodelling of the gating energetics towards that of wild-type CTFR. 30 August 2017 | doi: 10.1038/s41467-017-00444-4 Chaperones  Single-molecule biophysics  Artificial web of disclination lines in nematic liquid crystals OPEN Mengfei Wang, Yannian Li & Hiroshi Yokoyama Disclination lines are topological defects in molecular orientation widely found in liquid crystals. Here Wang et al. use a surface patterning technique to produce a very stable freestanding 3D array of ½ twist disclinations, which could be exploited in a variety of nanometre scale applications. 30 August 2017 | doi: 10.1038/s41467-017-00548-x Liquid crystals  Structure of solids and liquids  Retinol saturase coordinates liver metabolism by regulating ChREBP activity OPEN Steffi Heidenreich, Nicole Witte, Pamela Weber, Isabel Goehring, Alexander Tolkachov, Christian von Loeffelholz, Stephanie Döcke, Michael Bauer, Martin Stockmann, Andreas F. H. Pfeiffer, Andreas L. Birkenfeld, Matthias Pietzke, Stefan Kempa, Matthias Muenzner & Michael Schupp Fatty liver is one of the major features of metabolic syndrome and its development is associated with deregulation of systemic lipid and glucose homeostasis. Here Heidenreich et al. show that retinol saturase is implicated in hepatic lipid metabolism by regulating the activity of the transcription factor ChREBP. 30 August 2017 | doi: 10.1038/s41467-017-00430-w Dyslipidaemias  Non-alcoholic fatty liver disease  Type 2 diabetes  Asymmetric dynamics of DNA entering and exiting a strongly confining nanopore OPEN Nicholas A. W. Bell, Kaikai Chen, Sandip Ghosal, Maria Ricci & Ulrich F. Keyser Translocation of a charged polymer through confined nanoenvironments is highly dependent on their geometrical parameters. Here, the authors investigate experimentally the translocation dynamics of DNA through conical nanopores and provide a quantitative model for the translocation into and out of confinement. 30 August 2017 | doi: 10.1038/s41467-017-00423-9 Biophysical chemistry  Biosensors  Nanopores  Biosynthesis of ilamycins featuring unusual building blocks and engineered production of enhanced anti-tuberculosis agents OPEN Junying Ma, Hongbo Huang, Yunchang Xie, Zhiyong Liu, Jin Zhao, Chunyan Zhang, Yanxi Jia, Yun Zhang, Hua Zhang, Tianyu Zhang & Jianhua Ju Tuberculosis (TB) remains one of the world’s deadliest communicable diseases, novel anti-TB agents are urgently needed due to severe drug resistance and the co-epidemic of TB/HIV. Here, the authors show that anti-mycobacterial ilamycin congeners bearing unusual structural units possess extremely potent anti-tuberculosis activities. 30 August 2017 | doi: 10.1038/s41467-017-00419-5 Antibiotics  Pharmaceutics  Correlated electronic states at domain walls of a Mott-charge-density-wave insulator 1T-TaS2  OPEN Doohee Cho, Gyeongcheol Gye, Jinwon Lee, Sung-Hoon Lee, Lihai Wang, Sang-Wook Cheong & Han Woong Yeom The electronic states within domain walls in an interacting electronic system remain elusive. Here, Cho et al. report that the domain wall state in a charge-density-wave insulator 1T-TaS2 decomposes into two localized but nonconducting states at the center or edges of domain walls. 30 August 2017 | doi: 10.1038/s41467-017-00438-2 Electronic properties and materials  Surfaces, interfaces and thin films  Developing a molecular picture of soil organic matter–mineral interactions by quantifying organo–mineral binding OPEN C. J. Newcomb, N. P. Qafoku, J. W. Grate, V. L. Bailey & J. J. De Yoreo Most molecular scale knowledge on soil organo–mineral interactions remains qualitative due to instrument limitations. Here, the authors use force spectroscopy to directly measure free binding energy between organic ligands and minerals and find that both chemistry and environmental conditions affect binding. 30 August 2017 | doi: 10.1038/s41467-017-00407-9 Carbon cycle  Geochemistry  Nucleolar expansion and elevated protein translation in premature aging OPEN Abigail Buchwalter & Martin W. Hetzer HGPS is a premature aging disease caused by mutations in the nuclear protein lamin A. Here, the authors show that cells from patients with HGPS have expanded nucleoli and increased protein synthesis, and report that nucleoli also expand as aging progresses in cells derived from healthy individuals. 30 August 2017 | doi: 10.1038/s41467-017-00322-z Ageing  Mechanisms of disease  Nucleolus  Proteomics  VEGF amplifies transcription through ETS1 acetylation to enable angiogenesis OPEN Jiahuan Chen, Yi Fu, Daniel S. Day, Ye Sun, Shiyan Wang, Xiaodong Liang, Fei Gu, Fang Zhang, Sean M. Stevens, Pingzhu Zhou, Kai Li, Yan Zhang, Ruei-zeng Lin, Lois E. H. Smith, Jin Zhang, Kun Sun, Juan M. Melero-Martin, Zeguang Han, Peter J. Park, Bing Zhang et al. Promoter proximal RNAPII pausing is a rate-limiting transcriptional mechanism. Chen et al. show that this process is essential in angiogenesis by demonstrating that the endothelial master transcription factor ETS1 promotes global RNAPII pause release, and that this process is governed by VEGF. 29 August 2017 | doi: 10.1038/s41467-017-00405-x Angiogenesis  Transcription  Agricultural pesticide use and adverse birth outcomes in the San Joaquin Valley of California OPEN Ashley E. Larsen, Steven D. Gaines & Olivier Deschênes The health consequences of exposure to pesticides are uncertain and subject to much debate. Here, the effect of exposure during pregnancy is investigated in an agriculturally dominated residential area, showing that an increase in adverse birth outcomes is observed with very high levels of pesticide exposure. 29 August 2017 | doi: 10.1038/s41467-017-00349-2 Environmental impact  Sustainability  Using ALoFT to determine the impact of putative loss-of-function variants in protein-coding genes OPEN Suganthi Balasubramanian, Yao Fu, Mayur Pawashe, Patrick McGillivray, Mike Jin, Jeremy Liu, Konrad J. Karczewski, Daniel G. MacArthur & Mark Gerstein Variants causing loss of function (LoF) of human genes have clinical implications. Here, the authors present a method to predict disease-causing potential of LoF variants, ALoFT (annotation of Loss-of-Function Transcripts) and show its application to interpreting LoF variants in different contexts. 29 August 2017 | doi: 10.1038/s41467-017-00443-5 Computational biology and bioinformatics  Genomic analysis  Arctic Ocean sea ice cover during the penultimate glacial and the last interglacial OPEN Ruediger Stein, Kirsten Fahl, Paul Gierz, Frank Niessen & Gerrit Lohmann Coinciding with global warming, Arctic sea ice has rapidly decreased during the last four decades. Here, using biomarker records, the authors show that permanent sea ice was still present in the central Arctic Ocean during the last interglacial, when high latitudes were warmer than present. 29 August 2017 | doi: 10.1038/s41467-017-00552-1 Palaeoceanography  Palaeoclimate  Poliovirus intrahost evolution is required to overcome tissue-specific innate immune responses OPEN Yinghong Xiao, Patrick Timothy Dolan, Elizabeth Faul Goldstein, Min Li, Mikhail Farkov, Leonid Brodsky & Raul Andino RNA viruses, such as polioviruses, have a great evolutionary capacity and can adapt quickly during infection. Here, the authors show that poliovirus infection in mice requires adaptation to innate immune microenvironments encountered in different tissues. 29 August 2017 | doi: 10.1038/s41467-017-00354-5 Viral evolution  Viral pathogenesis  Multifunctional quantum dot DNA hydrogels OPEN Libing Zhang, Sae Rin Jean, Sharif Ahmed, Peter M. Aldridge, Xiyan Li, Fengjia Fan, Edward H. Sargent & Shana O. Kelley The development of nanomaterials for imaging and drug delivery has been of great interest to the field. Here, the authors synthesized multifunctional enzyme-responsive hydrogels with self-assembling quantum dots for nucleic acid and drug delivery as well as having imaging capability. 29 August 2017 | doi: 10.1038/s41467-017-00298-w DNA and RNA  Nanoparticles  Matrix degradability controls multicellularity of 3D cell migration OPEN Britta Trappmann, Brendon M. Baker, William J. Polacheck, Colin K. Choi, Jason A. Burdick & Christopher S. Chen The fabrication of vascularized 3D tissues requires an understanding of how material properties govern endothelial cell invasion into the surrounding matrix. Here the authors integrate a non-swelling synthetic hydrogel with a microfluidic device to study chemokine gradient-driven angiogenic sprouting and find that matrix degradability modulates the collectivity of cell migration. 29 August 2017 | doi: 10.1038/s41467-017-00418-6 Biomaterials  Extracellular matrix  Lab-on-a-chip  Tissue engineering  Dispersion engineering and frequency comb generation in thin silicon nitride concentric microresonators OPEN Sangsik Kim, Kyunghun Han, Cong Wang, Jose A. Jaramillo-Villegas, Xiaoxiao Xue, Chengying Bao, Yi Xuan, Daniel E. Leaird, Andrew M. Weiner & Minghao Qi Kerr frequency comb generation from microresonators requires anomalous dispersion, imposing restrictions on materials and resonator design. Here, Kim et al. propose a concentric racetrack-resonator design where the dispersion can be engineered to be anomalous via resonant mode coupling. 29 August 2017 | doi: 10.1038/s41467-017-00491-x Frequency combs  Microresonators  Nonlinear optics  Solitons  Probing the crystallographic orientation of two-dimensional atomic crystals with supramolecular self-assembly OPEN Jinghui Wang, Hongde Yu, Xu Zhou, Xiaozhi Liu, Renjie Zhang, Zhixing Lu, Jingying Zheng, Lin Gu, Kaihui Liu, Dong Wang & Liying Jiao Identifying the crystallographic orientations of 2D materials is important, but methods to do so are typically destructive. Here, the authors show that the orientational dependency of self-assembled nanoribbons of oleamide molecules can be used to non-invasively probe the lattice orientations of various 2D substrates. 29 August 2017 | doi: 10.1038/s41467-017-00329-6 Molecular self-assembly  Self-assembly  Two-dimensional materials  An allosteric ligand-binding site in the extracellular cap of K2P channels OPEN Qichao Luo, Liping Chen, Xi Cheng, Yuqin Ma, Xiaona Li, Bing Zhang, Li Li, Shilei Zhang, Fei Guo, Yang Li & Huaiyu Yang TREKs are members of the two-pore domain potassium (K2P) channels, being important clinical targets. Here the authors identify inhibitors of K2P that bind to an allosteric site located in their extracellular cap, suggesting that it might be a promising drug target for these channels. 29 August 2017 | doi: 10.1038/s41467-017-00499-3 Membrane proteins  Potassium channels  Target identification  Improved split fluorescent proteins for endogenous protein labeling OPEN Siyu Feng, Sayaka Sekine, Veronica Pessino, Han Li, Manuel D. Leonetti & Bo Huang Split fluorescent proteins (FPs) have been widely used to visualise proteins in cells. Here the authors develop a screen for engineering new split FPs, and report a yellow-green split-mNeonGreen2 with reduced background, a red split-sfCherry2 for multicolour labeling, and its photoactivatable variant for super-resolution use. 29 August 2017 | doi: 10.1038/s41467-017-00494-8 Cellular imaging  Fluorescent proteins  Protein design  Ultrafast carrier thermalization in lead iodide perovskite probed with two-dimensional electronic spectroscopy OPEN Johannes M. Richter, Federico Branchi, Franco Valduga de Almeida Camargo, Baodan Zhao, Richard H. Friend, Giulio Cerullo & Felix Deschler Carrier-carrier scattering rates determine the fundamental limits of carrier transport and electronic coherence. Using two-dimensional electronic spectroscopy with sub-10 fs resolution, Richter and Branchi et al. extract carrier thermalization times of 10 to 85 fs in hybrid perovskites. 29 August 2017 | doi: 10.1038/s41467-017-00546-z Semiconductors  Solar cells  Solar energy and photovoltaic technology  Ultrafast lasers  Synthetic lethality between androgen receptor signalling and the PARP pathway in prostate cancer OPEN Mohammad Asim, Firas Tarish, Heather I. Zecchini, Kumar Sanjiv, Eleni Gelali, Charles E. Massie, Ajoeb Baridi, Anne Y. Warren, Wanfeng Zhao, Christoph Ogris, Leigh-Anne McDuffus, Patrice Mascalchi, Greg Shaw, Harveer Dev, Karan Wadhwa, Paul Wijnhoven, Josep V. Forment, Scott R. Lyons, Andy G. Lynch, Cormac O’Neill et al. Tumours with homologous recombination (HR) defects become sensitive to PARPi. Here, the authors show that androgen receptor (AR) regulates HR and AR inhibition activates the PARP pathway in vivo, thus inhibition of both AR and PARP is required for effective treatment of high risk prostate cancer. 29 August 2017 | doi: 10.1038/s41467-017-00393-y Prostate cancer  Redox reactions and weak buffering capacity lead to acidification in the Chesapeake Bay OPEN Wei-Jun Cai, Wei-Jen Huang, George W. Luther III, Denis Pierrot, Ming Li, Jeremy Testa, Ming Xue, Andrew Joesoef, Roger Mann, Jean Brodeur, Yuan-Yuan Xu, Baoshan Chen, Najid Hussain, George G. Waldbusser, Jeffrey Cornwell & W. Michael Kemp The potential contribution of redox reactions to acidification in coastal waters is unclear. Here, using measurements from the Chesapeake Bay, the authors show that pH minimum occurs at mid-depths where acids are produced via hydrogen sulfide oxidation in waters mixed upward from anoxic depths. 28 August 2017 | doi: 10.1038/s41467-017-00417-7 Carbon cycle  Marine chemistry  Thermally-drawn fibers with spatially-selective porous domains OPEN Benjamin Grena, Jean-Baptiste Alayrac, Etgar Levy, Alexander M. Stolyarov, John D. Joannopoulos & Yoel Fink Porous polymer fibers show great potential for a range of applications, but their simple structures typically limit their functionality. Here, the authors combine a thermal drawing process with polymer solution phase separation to fabricate porous multimaterial fibers with complex internal architectures. 28 August 2017 | doi: 10.1038/s41467-017-00375-0 Design, synthesis and processing  Polymers  Porous materials  Interactions between fibroblastic reticular cells and B cells promote mesenteric lymph node lymphangiogenesis OPEN Lalit Kumar Dubey, Praneeth Karempudi, Sanjiv A. Luther, Burkhard Ludewig & Nicola L. Harris The growth of lymph nodes in response to infection requires lymphangiogenesis. Dubey et al. show that the mesenteric lymph node lymphangiogenesis upon helminth infection depends on the signaling loop between the B and fibroblastic reticular cells (FRCs), whereby the FRCs respond to lymphotoxin secreted by B cells by releasing B cell activating factor. 28 August 2017 | doi: 10.1038/s41467-017-00504-9 Imaging the immune system  Lymph node  Lymphangiogenesis  Parasitic infection  Observation of ultrahigh mobility surface states in a topological crystalline insulator by infrared spectroscopy OPEN Ying Wang, Guoyu Luo, Junwei Liu, R. Sankar, Nan-Lin Wang, Fangcheng Chou, Liang Fu & Zhiqiang Li Probing optical and transport properties of the surface states in topological crystalline insulators remains a challenge. Here, Wang et al. demonstrate that the far-infrared conductivity of Pb1−x Sn x Se (x = 0.23−0.25) single crystals is dominated by the surface states where carriers show a high surface mobility of 40,000 cm2 V−1 s−1. 28 August 2017 | doi: 10.1038/s41467-017-00446-2 Electronic properties and materials  Surfaces, interfaces and thin films  Topological insulators  A reporter system coupled with high-throughput sequencing unveils key bacterial transcription and translation determinants OPEN Eva Yus, Jae-Seong Yang, Adrià Sogues & Luis Serrano Quantitative analysis of how DNA sequence determines transcription and translation regulation is of interest to systems and synthetic biologists. Here the authors present ELM-seq, which uses Dam activity as reporter for high-throughput analysis of promoter and 5’-UTR regions. 28 August 2017 | doi: 10.1038/s41467-017-00239-7 Bacterial transcription  Systems analysis  Transcription  Translation  Systems analysis of apoptotic priming in ovarian cancer identifies vulnerabilities and predictors of drug response OPEN Ioannis K. Zervantonakis, Claudia Iavarone, Hsing-Yu Chen, Laura M. Selfors, Sangeetha Palakurthi, Joyce F. Liu, Ronny Drapkin, Ursula Matulonis, Joel D. Leverson, Deepak Sampath, Gordon B. Mills & Joan S. Brugge High-grade serous ovarian cancers (HGS-OvCa) frequently develop chemotherapy resistance. Here, the authors through a systematic analysis of proteomic and drug response data of 14 HGS-OvCa PDXs demonstrate that targeting apoptosis regulators can improve response of these tumors to inhibitors of the PI3K/mTOR pathway. 28 August 2017 | doi: 10.1038/s41467-017-00263-7 Apoptosis  Cancer therapeutic resistance  Ovarian cancer  Systems analysis  Tumour biomarkers  Conformal metasurface-coated dielectric waveguides for highly confined broadband optical activity with simultaneous low-visibility and reduced crosstalk OPEN Zhi Hao Jiang, Lei Kang & Douglas H. Werner Controlling all the optical properties of dielectric waveguides is a challenging task and often requires complicated core- and cladding designs. Here, Jiang et al. demonstrate that a thin metasurface coating can control several optical properties simultaneously over a broad frequency range. 25 August 2017 | doi: 10.1038/s41467-017-00391-0 Electrical and electronic engineering  Metamaterials  Microwave photonics  A probabilistic assessment of the rapidity of PETM onset OPEN Sandra Kirtland Turner, Pincelli M. Hull, Lee R. Kump & Andy Ridgwell Single-foraminifera measurements of the PETM carbon isotope excursion from Maud Rise have been interpreted as indicating geologically instantaneous carbon release. Here, the authors explain these records using an Earth system model and a sediment-mixing model and extract the likely PETM onset duration. 25 August 2017 | doi: 10.1038/s41467-017-00292-2 Palaeoceanography  Palaeoclimate  HSP70-Hrd1 axis precludes the oncorepressor potential of N-terminal misfolded Blimp-1s in lymphoma cells OPEN Wen-Fang Wang, Li Yan, Zhao Liu, Lan-Xuan Liu, Jian Lin, Zhi-Yin Liu, Xiong-Ping Chen, Wu Zhang, Zi-Zhen Xu, Ting Shi, Jun-Min Li, Yi-Lei Zhao, Guoyu Meng, Yi Xia, Jian-Yong Li & Jiang Zhu The transcriptional repressor Blimp-1 has an important role in B-cell differentiation. Here the authors show that lymphoma-associated Blimp-1 mutants are selectively recognized by HSP70-Hrd1, which leads to their accelerated degradation and propose HSP70 inhibition as a therapeutic approach for certain lymphomas. 25 August 2017 | doi: 10.1038/s41467-017-00476-w B-cell lymphoma  Chaperones  Sumoylation  Targeted therapies  Ubiquitylation  Tumor-selective catalytic nanomedicine by nanocatalyst delivery OPEN Minfeng Huo, Liying Wang, Yu Chen & Jianlin Shi The specific metabolism of cancer cells may allow for selective tumor therapeutics. Here, the authors show that a suitable combination of an enzyme and iron nanoparticles loaded on dendritic silica induces apoptosis of cancer cells in response to the glucose-reliant and mild acidic microenvironment. 25 August 2017 | doi: 10.1038/s41467-017-00424-8 Biocatalysis  Cancer therapy  Drug delivery  Chemical synthesis  Nanodiamonds suppress the growth of lithium dendrites OPEN Xin-Bing Cheng, Meng-Qiang Zhao, Chi Chen, Amanda Pentecost, Kathleen Maleski, Tyler Mathis, Xue-Qiang Zhang, Qiang Zhang, Jianjun Jiang & Yury Gogotsi Lithium metal is an ideal anode material for rechargeable batteries but suffer from the growth of lithium dendrites and low Coulombic efficiency. Here the authors show that nanodiamonds serve as an electrolyte additive to co-deposit with lithium metal and suppress the formation of dendrites. 25 August 2017 | doi: 10.1038/s41467-017-00519-2 Batteries  Nanoparticles  CDYL suppresses epileptogenesis in mice through repression of axonal Nav1.6 sodium channel expression OPEN Yongqing Liu, Shirong Lai, Weining Ma, Wei Ke, Chan Zhang, Shumeng Liu, Yu Zhang, Fei Pei, Shaoyi Li, Ming Yi, Yousheng Shu, Yongfeng Shang, Jing Liang & Zhuo Huang Alterations in intrinsic plasticity are important in epilepsy. Here the authors show that the epigenetic factor CDYL regulates the gene expression of the voltage gated sodium channel, Nav1.6, which contributes to seizures in a rat model of epilepsy. 25 August 2017 | doi: 10.1038/s41467-017-00368-z Epigenetics and plasticity  Epilepsy  Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis OPEN Jiefei Geng, Yasushi Ito, Linyu Shi, Palak Amin, Jiachen Chu, Amanda Tomie Ouchida, Adnan Kasim Mookhtiar, Heng Zhao, Daichao Xu, Bing Shan, Ayaz Najafov, Guangping Gao, Shizuo Akira & Junying Yuan TNFα can promote three distinct mechanisms of cell death: necroptosis, RIPK1-independent and dependent apoptosis. Here the authors show that TNFα-induced phosphorylation of RIPK1 in the intermediate domain by TAK1 plays a key role in regulating this decision. 25 August 2017 | doi: 10.1038/s41467-017-00406-w Apoptosis  Necroptosis  Ultra-large single crystals by abnormal grain growth OPEN Tomoe Kusama, Toshihiro Omori, Takashi Saito, Sumio Kise, Toyonobu Tanaka, Yoshikazu Araki & Ryosuke Kainuma Growing large single crystals cheaply and reliably for structural applications remains challenging. Here, the authors combine accelerated abnormal grain growth and cyclic heat treatments to grow a superelastic shape memory alloy single crystal to 70 cm. 25 August 2017 | doi: 10.1038/s41467-017-00383-0 Mechanical engineering  Mechanical properties  Metals and alloys  Hierarchically self-assembled hexagonal honeycomb and kagome superlattices of binary 1D colloids OPEN Sung-Hwan Lim, Taehoon Lee, Younghoon Oh, Theyencheri Narayanan, Bong June Sung & Sung-Min Choi Binary mixtures of 1D particles are rarely observed to cooperatively self-assemble into binary superlattices, as the particle types separate into phases. Here, the authors design a system that avoids phase separation, obtaining binary superlattices with different symmetries by simply tuning the particle diameter and mixture composition. 25 August 2017 | doi: 10.1038/s41467-017-00512-9 Nanoparticles  Self-assembly  Release of free-volume bubbles by cooperative-rearrangement regions during the deposition growth of a colloidal glass OPEN Xin Cao, Huijun Zhang & Yilong Han Vapor deposition can produce ultrastable glasses similar to conventional glasses aged over thousands of years. Here authors study deposition growth kinetics of a two-dimensional colloidal glass and report relatively frequent occurrence of large and anisotropic regions of cooperative rearrangements at intermediate depths from the surface. 25 August 2017 | doi: 10.1038/s41467-017-00428-4 Colloids  Glasses  Two-dimensional materials  Multi-orbital charge transfer at highly oriented organic/metal interfaces OPEN Giovanni Zamborlini, Daniel Lüftner, Zhijing Feng, Bernd Kollmann, Peter Puschnig, Carlo Dri, Mirko Panighel, Giovanni Di Santo, Andrea Goldoni, Giovanni Comelli, Matteo Jugovac, Vitaliy Feyer & Claus Michael Schneider Charge transfer at molecule-metal interfaces affects the overall physical and magnetic properties of organic-based devices, and ultimately their performance. Here, the authors report evidence of a pronounced charge transfer involving nickel tetraphenyl porphyrin molecules adsorbed on copper. 25 August 2017 | doi: 10.1038/s41467-017-00402-0 Chemical physics  Surface spectroscopy  Modifying electron transfer between photoredox and organocatalytic units via framework interpenetration for β-carbonyl functionalization OPEN Zhengqiang Xia, Cheng He, Xiaoge Wang & Chunying Duan Metal organic frameworks are promising catalysts due to their porous structure and the possible incorporation of multiple active sites. Here, the authors show that interpenetrated metal-organic frameworks containing both a photocatalyst and an organocatalyst catalyse the β-alkylation of carbonyl compounds. 25 August 2017 | doi: 10.1038/s41467-017-00416-8 Coordination chemistry  Heterogeneous catalysis  Photocatalysis  Construction and in vivo assembly of a catalytically proficient and hyperthermostable de novo enzyme OPEN Daniel W. Watkins, Jonathan M. X. Jenkins, Katie J. Grayson, Nicola Wood, Jack W. Steventon, Kristian K. Le Vay, Matthew I. Goodwin, Anna S. Mullen, Henry J. Bailey, Matthew P. Crump, Fraser MacMillan, Adrian J. Mulholland, Gus Cameron, Richard B. Sessions, Stephen Mann & J. L. Ross Anderson Catalytic mechanisms of enzymes are well understood, but achieving diverse reaction chemistries in re-engineered proteins can be difficult. Here the authors show a highly efficient and thermostable artificial enzyme that catalyzes a diverse array of substrate oxidations coupled to the reduction of H2O2. 25 August 2017 | doi: 10.1038/s41467-017-00541-4 Oxidoreductases  Protein design  USP26 functions as a negative regulator of cellular reprogramming by stabilising PRC1 complex components OPEN Bo Ning, Wei Zhao, Chen Qian, Pinghua Liu, Qingtian Li, Wenyuan Li & Rong-Fu Wang The ubiquitin-proteasome system regulates cellular reprogramming by degradation of key pluripotency factors. Here the authors report that the post-translational regulation of PRC1 components CBX4 and CBX6 by ubiquitination influences reprogramming. 24 August 2017 | doi: 10.1038/s41467-017-00301-4 Epigenetics  Reprogramming  Ubiquitylation  An integrated bioinformatics platform for investigating the human E3 ubiquitin ligase-substrate interaction network OPEN Yang Li, Ping Xie, Liang Lu, Jian Wang, Lihong Diao, Zhongyang Liu, Feifei Guo, Yangzhige He, Yuan Liu, Qin Huang, Han Liang, Dong Li & Fuchu He Protein stability modulation by E3 ubiquitin ligases is an important layer of functional regulation, but screening for E3 ligase-substrate interactions is time-consuming and costly. Here, the authors take an in silico naïve Bayesian classifier approach to integrate multiple lines of evidence for E3-substrate prediction, enabling prediction of the proteome-wide human E3 ligase interaction network. 24 August 2017 | doi: 10.1038/s41467-017-00299-9 Protein function predictions  Ubiquitin ligases  Piezo1 channels sense whole body physical activity to reset cardiovascular homeostasis and enhance performance OPEN Baptiste Rode, Jian Shi, Naima Endesh, Mark J. Drinkhill, Peter J. Webster, Sabine J. Lotteau, Marc A. Bailey, Nadira Y. Yuldasheva, Melanie J. Ludlow, Richard M. Cubbon, Jing Li, T. Simon Futers, Lara Morley, Hannah J. Gaunt, Katarzyna Marszalek, Hema Viswambharan, Kevin Cuthbertson, Paul D. Baxter, Richard Foster, Piruthivi Sukumar et al. The mechanisms that regulate the body’s response to exercise are poorly understood. Here, Rode et al. show that the mechanically activated cation channel Piezo1 is a molecular sensor of physical exercise in the endothelium that triggers endothelial communication to mesenteric vessel muscle cells, leading to vasoconstriction. 24 August 2017 | doi: 10.1038/s41467-017-00429-3 Cardiovascular biology  Membrane biophysics  In vivo cation exchange in quantum dots for tumor-specific imaging OPEN Xiangyou Liu, Gary B. Braun, Mingde Qin, Erkki Ruoslahti & Kazuki N. Sugahara The imaging of tumors in vivo using nanoprobes has been challenging due to the lack of sufficient tumor specificity. Here, the authors develop a tumor-specific quantum dot system that permits in vivo cation exchange to achieve selective background quenching and high tumor-specific imaging. 24 August 2017 | doi: 10.1038/s41467-017-00153-y Biomedical materials  Cancer imaging  Nanobiotechnology  Quantum dots  Glycoprotein 2 is a specific cell surface marker of human pancreatic progenitors OPEN Kathryn F. Cogger, Ankit Sinha, Farida Sarangi, Emily C. McGaugh, Diane Saunders, Craig Dorrell, Salvador Mejia-Guerrero, Yasaman Aghazadeh, Jillian L. Rourke, Robert A. Screaton, Markus Grompe, Philip R. Streeter, Alvin C. Powers, Marcela Brissova, Thomas Kislinger & M. Cristina Nostro Pancreatic progenitors (PPs) can be derived from human pluripotent stem cells in vitro but efficiency of differentiation varies, making it hard to sort for insulin-producing cells. Here, the authors use a proteomic approach to identify the secretory granule membrane glycoprotein 2 as a marker for PDX1+/NKX6-1+ PPs. 24 August 2017 | doi: 10.1038/s41467-017-00561-0 Stem-cell differentiation  Type 1 diabetes  Nickel-catalyzed synthesis of 1,1-diborylalkanes from terminal alkenes OPEN Lei Li, Tianjun Gong, Xi Lu, Bin Xiao & Yao Fu 1,1-diborylalkanes are useful building blocks in synthetic chemistry. Here, the authors present a highly chemo- and regioselective Ni-catalyzed reaction for the synthesis of 1,1-diborylalkanes from a wide variety of readily available terminal alkenes. 24 August 2017 | doi: 10.1038/s41467-017-00363-4 Homogeneous catalysis  Synthetic chemistry methodology  Energetics of Baird aromaticity supported by inversion of photoexcited chiral [4n]annulene derivatives OPEN Michihisa Ueda, Kjell Jorner, Young Mo Sung, Tadashi Mori, Qi Xiao, Dongho Kim, Henrik Ottosson, Takuzo Aida & Yoshimitsu Itoh Baird’s rule applies to cyclic π-conjugated molecules in their excited state, yet a quantification of the involved energetics is elusive. Here, the authors show the ring inversion kinetics of two nonplanar and chiral [4n]annulenes to support Baird’s rule from an energetic point of view. 24 August 2017 | doi: 10.1038/s41467-017-00382-1 Computational chemistry  Organic chemistry  Photochemistry  Fast kinetics of magnesium monochloride cations in interlayer-expanded titanium disulfide for magnesium rechargeable batteries OPEN Hyun Deog Yoo, Yanliang Liang, Hui Dong, Junhao Lin, Hua Wang, Yisheng Liu, Lu Ma, Tianpin Wu, Yifei Li, Qiang Ru, Yan Jing, Qinyou An, Wu Zhou, Jinghua Guo, Jun Lu, Sokrates T. Pantelides, Xiaofeng Qian & Yan Yao Magnesium rechargeable batteries potentially offer high-energy density, safety, and low cost. Here the authors show a battery that reversibly intercalates magnesium monochloride cations with excellent rate and cycle performances in addition to the large capacity. 24 August 2017 | doi: 10.1038/s41467-017-00431-9 Batteries  Two-dimensional materials  On the performance of pre-microRNA detection algorithms OPEN Müşerref Duygu Saçar Demirci, Jan Baumbach & Jens Allmer As the experimental discovery of microRNAs (miRNAs) is cumbersome, computational tools have been developed for the prediction of pre-miRNAs. Here the authors develop a framework to assess the performance of existing and novel pre-miRNA prediction tools and provide guidelines for selecting an appropriate approach for a given data set. 24 August 2017 | doi: 10.1038/s41467-017-00403-z Data mining  Software  Reinforcement determines the timing dependence of corticostriatal synaptic plasticity in vivo OPEN Simon D. Fisher, Paul B. Robertson, Melony J. Black, Peter Redgrave, Mark A. Sagar, Wickliffe C. Abraham & John N.J. Reynolds Spike timing dependent plasticity (STDP) has been studied extensively in slices but whether such pairings can induce plasticity in vivo is not known. Here the authors report an experimental paradigm that achieves bidirectional corticostriatal STDP in vivo through modulation by behaviourally relevant reinforcement signals, mediated by dopamine and adenosine signaling. 24 August 2017 | doi: 10.1038/s41467-017-00394-x Operant learning  Reward  Spike-timing-dependent plasticity  Identification of an insect-produced olfactory cue that primes plant defenses OPEN Anjel M. Helms, Consuelo M. De Moraes, Armin Tröger, Hans T. Alborn, Wittko Francke, John F. Tooker & Mark C. Mescher Plants are able to prime anti-herbivore defenses in response to olfactory cues of insect pests. Here, Helms et al. identify the insect pheromone E,S-conophthorin produced by the goldenrod gall fly as the specific chemical component that elicits this priming response in goldenrod plants. 24 August 2017 | doi: 10.1038/s41467-017-00335-8 Chemical ecology  Plant sciences  Biochemical phosphates observed using hyperpolarized 31P in physiological aqueous solutions OPEN Atara Nardi-Schreiber, Ayelet Gamliel, Talia Harris, Gal Sapir, Jacob Sosna, J. Moshe Gomori & Rachel Katz-Brull Real-time monitoring of phosphate metabolism and distribution in the live body without ionizing radiation is highly desirable. Here, the authors show dissolution-dynamic nuclear polarization technology can enable nuclear magnetic resonance detection of hyperpolarized 31P of important biological phosphates in aqueous solutions. 24 August 2017 | doi: 10.1038/s41467-017-00364-3 Biophysics  Diagnostic markers  Anomalous Dirac point transport due to extended defects in bilayer graphene OPEN Sam Shallcross, Sangeeta Sharma & Heiko B. Weber In seemingly indistinguishable bilayer graphene samples, two distinct transport regimes, insulating and metallic, have been identified experimentally. Here, the authors demonstrate that these two states originate from the interplay between extended defects and evanescent modes at the Dirac point. 24 August 2017 | doi: 10.1038/s41467-017-00397-8 Electronic properties and devices  Quantum simulation  Glutamine metabolism regulates autophagy-dependent mTORC1 reactivation during amino acid starvation OPEN Hayden Weng Siong Tan, Arthur Yi Loong Sim & Yun Chau Long mTORC1 is a critical kinase that regulates cell growth and proliferation. Here the authors show that glutamine metabolism is sufficient to restore mTORC1 activity during prolonged amino acid starvation in an autophagy-dependent manner. 24 August 2017 | doi: 10.1038/s41467-017-00369-y Macroautophagy  Nutrient signalling  Phytochrome-interacting factors directly suppress MIR156 expression to enhance shade-avoidance syndrome in Arabidopsis  OPEN Yurong Xie, Yang Liu, Hai Wang, Xiaojing Ma, Baobao Wang, Guangxia Wu & Haiyang Wang Plants employ developmental strategies to avoid shade and compete with neighbors for light. Here, Xie et al. show that phytochrome-interacting factors, which are regulated in a light-dependent manner, directly repress MIR156 genes and promote the expression of SPL genes to enhance shade-avoidance responses. 24 August 2017 | doi: 10.1038/s41467-017-00404-y Leaf development  Light responses  Smac mimetics and oncolytic viruses synergize in driving anticancer T-cell responses through complementary mechanisms OPEN Dae-Sun Kim, Himika Dastidar, Chunfen Zhang, Franz J. Zemp, Keith Lau, Matthias Ernst, Andrea Rakic, Saif Sikdar, Jahanara Rajwani, Victor Naumenko, Dale R. Balce, Ben W. Ewanchuk, Pankaj Taylor, Robin M. Yates, Craig Jenne, Chris Gafuik & Douglas J. Mahoney Oncolytic viruses (OV) and second mitochondrial activator of caspase (Smac)-mimetic compounds (SMC) synergistically kill cancer cells directly. Here, the authors show that SMC and OV therapies combination also synergize in vivo by promoting anticancer immunity through an increase in CD8+ T-cell response. 24 August 2017 | doi: 10.1038/s41467-017-00324-x Cancer immunotherapy  Tumour immunology  Whi7 is an unstable cell-cycle repressor of the Start transcriptional program OPEN Mercè Gomar-Alba, Ester Méndez, Inma Quilis, M. Carmen Bañó & J. Carlos Igual The commitment of cells to a new cycle of division involves inactivation of the Start transcriptional repressor Whi5. Here the authors show that the sequence related protein Whi7 associates to G1/S gene promoters in late G1 and collaborates with Whi5 in Start repression. 24 August 2017 | doi: 10.1038/s41467-017-00374-1 Cell division  Exploiting a novel conformational switch to control innate immunity mediated by complement protein C3a OPEN Rink-Jan Lohman, Johan K. Hamidon, Robert C. Reid, Jessica A. Rowley, Mei-Kwan Yau, Maria A. Halili, Daniel S. Nielsen, Junxian Lim, Kai-Chen Wu, Zhixuan Loh, Anh Do, Jacky Y. Suen, Abishek Iyer & David P. Fairlie Complement C3a is an important protein in innate and adaptive immunity, but its roles in vivo are unclear. Here the authors develop novel chemical agonists and antagonists for the C3a receptor, and show that they modulate mast cell degranulation and inflammation in a rat paw edema model 24 August 2017 | doi: 10.1038/s41467-017-00414-w Complement  Granulocytes  Small molecules  Interfacial charge distributions in carbon-supported palladium catalysts OPEN Radhika G. Rao, Raoul Blume, Thomas W. Hansen, Erika Fuentes, Kathleen Dreyer, Simona Moldovan, Ovidiu Ersen, David D. Hibbitts, Yves J. Chabal, Robert Schlögl & Jean-Philippe Tessonnier Control over charge transfer in carbon-supported metal nanoparticles is essential for designing new catalysts. Here, the authors show that thermal treatments effectively tune the interfacial charge distribution in carbon-supported palladium catalysts with consequential changes in hydrogenation performance. 24 August 2017 | doi: 10.1038/s41467-017-00421-x Catalytic mechanisms  Heterogeneous catalysis  Nanoscale materials  A versatile platform for precise synthesis of asymmetric molecular brush in one shot OPEN Binbin Xu, Chun Feng & Xiaoyu Huang Producing well-defined polymer compositions and structures facilitates their use in many different applications. Here the authors show the synthesis of well-defined asymmetric double-brushes by a one-pot concurrent atom transfer radical polymerization and Cu-catalyzed Click reaction. 24 August 2017 | doi: 10.1038/s41467-017-00365-2 Polymer synthesis  Polymerization mechanisms    Nature Communications JOBS of the week Research Associate Imperial College London Research Associate University of Glasgow Post Doctoral Researcher The Ohio State University Comprehensive Cancer Center and Colleage of Medicine postdoctoral researcher The University of Iowa Research Scientist Mississippi State University Staff Scientist Carnegie Institution for Science, Dept. Geophysical Laboratory Postdoctoral Fellow Icahn School of Medicine at Mount Sinai Postdoctoral Associate Duke University Postdoctoral fellow Karolinska Institutet (KI) Apply for Faculty Positions Indian Institute of Science (IISc) More Science jobs from Nature Communications EVENT Global Smart Energy Summit 06.03.18 Dubai, UAE More science events from
Latest Corrigenda       Corrigendum: Snf1-related kinase improves cardiac mitochondrial efficiency and decreases mitochondrial uncoupling OPEN Amy K. Rines, Hsiang-Chun Chang, Rongxue Wu, Tatsuya Sato, Arineh Khechaduri, Hidemichi Kouzu, Jason Shapiro, Meng Shang, Michael A. Burke, Eltyeb Abdelwahid, Xinghang Jiang, Chunlei Chen, Tenley A. Rawlings, Gary D. Lopaschuk, Paul T. Schumacker, E. Dale Abel & Hossein Ardehali 30 August 2017 | doi: 10.1038/ncomms16155 Mechanisms of disease  Nutrient signalling  Corrigendum: 14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function OPEN Simone M. Schoenwaelder , Roxane Darbousset, Susan L. Cranmer, Hayley S. Ramshaw, Stephanie L. Orive, Sharelle Sturgeon, Yuping Yuan, Yu Yao, James R. Krycer, Joanna Woodcock, Jessica Maclean, Stuart Pitson, Zhaohua Zheng, Darren C. Henstridge, Dianne van der Wal, Elizabeth E. Gardiner, Michael C. Berndt, Robert K. Andrews, David E. James, Angel F. Lopez et al. 30 August 2017 | doi: 10.1038/ncomms16125 Mechanisms of disease  Platelets  Corrigendum: Isotope analysis in the transmission electron microscope OPEN Toma Susi, Christoph Hofer, Giacomo Argentero, Gregor T. Leuthner, Timothy J. Pennycook, Clemens Mangler, Jannik C. Meyer & Jani Kotakoski 30 August 2017 | doi: 10.1038/ncomms15780 Atomistic models  Graphene  Mass spectrometry  Transmission electron microscopy  Corrigendum: In situ targeted MRI detection of Helicobacter pylori with stable magnetic graphitic nanocapsules OPEN Yunjie Li, Xiaoxiao Hu, Ding Ding, Yuxiu Zou, Yiting Xu, Xuewei Wang, Yin Zhang, Long Chen, Zhuo Chen & Weihong Tan 30 August 2017 | doi: 10.1038/ncomms16154 Biomedical materials  Imaging techniques and agents  Magnetic properties and materials  Nanobiotechnology
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