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| | 03 January 2018 | | | | Advertisement | An open access, online-only journal providing researchers, policy makers and the public with the latest research on weather and climate, focusing on topics including climate dynamics, climate variability, weather and climate prediction, climate change, weather extremes, atmospheric composition including aerosols, the hydrological cycle and atmosphere-ocean interactions, npj Climate and Atmospheric Science has now published its first articles. | | | | | | | Advertisement | | | | | Advertisement | | | | | Advertisement | | npj Science of Food is a new open access journal that is now open for submissions. The journal aims to understand how processing influences biological functions of food in hope to support and nucleate maturation of these areas of research. | | | | | | | | Nature Communications - fully open access All new submissions, if accepted, will be published open access and an article processing charge (APC) will apply. For more information visit the website. Visit our open access funding page or contact openaccess@nature.com to learn more about APC funding. | | | | Latest Articles | View all Articles | | | Electrically reversible cracks in an intermetallic film controlled by an electric field OPEN | | Z. Q. Liu, J. H. Liu, M. D. Biegalski, J.-M. Hu, S. L. Shang, Y. Ji, J. M. Wang, S. L. Hsu, A. T. Wong, M. J. Cordill, B. Gludovatz, C. Marker, H. Yan, Z. X. Feng, L. You, M. W. Lin, T. Z. Ward, Z. K. Liu, C. B. Jiang, L. Q. Chen et al. | | | Electric-field-induced cracks are generally detrimental to functionality of ferroelectric ceramics. Liu et al. use an intermetallic alloy and ferroelectric oxide junction to mediate the reversible formation of cracks at nanoscales, resulting in colossal electroresistance modulation for memory applications. | | 03 January 2018 | doi: 10.1038/s41467-017-02454-8 | | Electronic devices Information storage | Transient rotation of photospheric vector magnetic fields associated with a solar flare OPEN | | Yan Xu, Wenda Cao, Kwangsu Ahn, Ju Jing, Chang Liu, Jongchul Chae, Nengyi Huang, Na Deng, Dale E. Gary & Haimin Wang | | | The violent solar eruptions known as flares are caused by magnetic reconnection. Here, the authors identify a sudden 12°–20° counter clockwise rotation of vector magnetic fields in photosphere, associated with the emissions of moving flare ribbons. | | 03 January 2018 | doi: 10.1038/s41467-017-02509-w | | Solar physics | Defects controlled hole doping and multivalley transport in SnSe single crystals OPEN | | Zhen Wang, Congcong Fan, Zhixuan Shen, Chenqiang Hua, Qifeng Hu, Feng Sheng, Yunhao Lu, Hanyan Fang, Zhizhan Qiu, Jiong Lu, Zhengtai Liu, Wanling Liu, Yaobo Huang, Zhu-An Xu, D. W. Shen & Yi Zheng | | | Knowledge of the electronic structure of group-IV monochalcogenides is essential for their application in high-performance thermoelectric energy harvesting. Here, using photoemission spectroscopy, the authors reveal the impact of doping, and the anisotropic nature of the band structure of SnSe. | | 03 January 2018 | doi: 10.1038/s41467-017-02566-1 | | Electronic properties and materials Thermoelectric devices and materials | Replication-dependent size reduction precedes differentiation in Chlamydia trachomatis OPEN | | Jennifer K. Lee, Germán A. Enciso, Daniela Boassa, Christopher N. Chander, Tracy H. Lou, Sean S. Pairawan, Melody C. Guo, Frederic Y. M. Wan, Mark H. Ellisman, Christine Sütterlin & Ming Tan | | | The vegetative forms of chlamydiae (RBs) replicate within infected cells and then convert into infectious forms (EBs). Here, the authors use quantitative 3D electron microscopy and computer modeling to show that RB size decreases with replication, and conversion into EBs correlates with an RB size threshold. | | 03 January 2018 | doi: 10.1038/s41467-017-02432-0 | | Bacteriology Cell biology Cellular microbiology Pathogens | A machine learning approach to integrate big data for precision medicine in acute myeloid leukemia OPEN | | Su-In Lee, Safiye Celik, Benjamin A. Logsdon, Scott M. Lundberg, Timothy J. Martins, Vivian G. Oehler, Elihu H. Estey, Chris P. Miller, Sylvia Chien, Jin Dai, Akanksha Saxena, C. Anthony Blau & Pamela S. Becker | | | Identification of markers of drug response is essential for precision therapy. Here the authors introduce an algorithm that uses prior information about each gene’s importance in AML to identify the most predictive gene-drug associations from transcriptome and drug response data from 30 AML samples. | | 03 January 2018 | doi: 10.1038/s41467-017-02465-5 | | Acute myeloid leukaemia Cancer genomics Machine learning Molecular medicine | Antiferromagnetic correlations in the metallic strongly correlated transition metal oxide LaNiO3 OPEN | | H. Guo, Z. W. Li, L. Zhao, Z. Hu, C. F. Chang, C.-Y. Kuo, W. Schmidt, A. Piovano, T. W. Pi, O. Sobolev, D. I. Khomskii, L. H. Tjeng & A. C. Komarek | | | The phase transitions of rare earth nickelates have attracted intensive study as they arise from the complex interplay of charge, spin and lattice degrees of freedom. Here Guo et al. present evidence that LaNiO3 has an unanticipated magnetically ordered metallic phase. | | 03 January 2018 | doi: 10.1038/s41467-017-02524-x | | Electronic properties and materials Magnetic properties and materials Solid-state chemistry | TNF blockade induces a dysregulated type I interferon response without autoimmunity in paradoxical psoriasis OPEN | | Curdin Conrad, Jeremy Di Domizio, Alessio Mylonas, Cyrine Belkhodja, Olivier Demaria, Alexander A. Navarini, Anne-Karine Lapointe, Lars E. French, Maxime Vernez & Michel Gilliet | | | The pathogenesis of paradoxical psoriasis in patients receiving anti-TNF treatments for classical psoriasis is unclear. Here, the authors show that anti-TNF drugs enhance the production of type I interferon by plasmacytoid dendritic cells, causing skin lesions that, unlike classical psoriasis, lack T- cell autoimmunity. | | 02 January 2018 | doi: 10.1038/s41467-017-02466-4 | | Inflammatory diseases Interferons Plasmacytoid dendritic cells Tumour-necrosis factors | Targeting immune checkpoints potentiates immunoediting and changes the dynamics of tumor evolution OPEN | | Mirjana Efremova, Dietmar Rieder, Victoria Klepsch, Pornpimol Charoentong, Francesca Finotello, Hubert Hackl, Natascha Hermann-Kleiter, Martin Löwer, Gottfried Baier, Anne Krogsdam & Zlatko Trajanoski | | | The cancer immunoediting hypothesis assumes the immune system sculpts the cancer genome. Here the authors show, in a mouse model, that neutral evolution outweighs the effects of immunoselection and that immune checkpoint blockade potentiates the immunoediting, switching the system to non-neutral evolution. | | 02 January 2018 | doi: 10.1038/s41467-017-02424-0 | | Cancer genomics Computational biology and bioinformatics Tumour immunology | LncRNA CAIF inhibits autophagy and attenuates myocardial infarction by blocking p53-mediated myocardin transcription OPEN | | Cui-Yun Liu, Yu-Hui Zhang, Rui-Bei Li, Lu-Yu Zhou, Tao An, Rong-Cheng Zhang, Mei Zhai, Yan Huang, Kao-Wen Yan, Yan-Han Dong, Murugavel Ponnusamy, Chan Shan, Sheng Xu, Qi Wang, Yan-Hui Zhang, Jian Zhang & Kun Wang | | | Little is known about the role of long lncRNAs in autophagy. The authors identify lncCAIF, and show that it suppresses cardiac autophagy and attenuates myocardial infarction by targeting p53 -mediated transcription of myocardin. | | 02 January 2018 | doi: 10.1038/s41467-017-02280-y | | Autophagy Cardiovascular diseases Non-coding RNAs | Staphylococcus aureus produces pain through pore-forming toxins and neuronal TRPV1 that is silenced by QX-314 OPEN | | Kimbria J. Blake, Pankaj Baral, Tiphaine Voisin, Ashira Lubkin, Felipe Almeida Pinho-Ribeiro, Kelsey L. Adams, David P. Roberson, Yuxin C. Ma, Michael Otto, Clifford J. Woolf, Victor J. Torres & Isaac M. Chiu | | | Bacterial infection can cause pain but the underlying mechanism is unclear. This study shows pain induced in mice by methicillin-resistant Staphylococcus aureus infection is mediated by bacterial pore-forming toxins, and a sodium channel blocker QX-314 can alleviate infection-associated pain. | | 02 January 2018 | doi: 10.1038/s41467-017-02448-6 | | Bacterial toxins Bacteriology Infection Pain Pathogens | Macrophages orchestrate breast cancer early dissemination and metastasis OPEN | | Nina Linde, Maria Casanova-Acebes, Maria Soledad Sosa, Arthur Mortha, Adeeb Rahman, Eduardo Farias, Kathryn Harper, Ethan Tardio, Ivan Reyes Torres, Joan Jones, John Condeelis, Miriam Merad & Julio A. Aguirre-Ghiso | | | Early dissemination of cancer cells has been reported to occur in certain breast cancer models. Here the authors show that intra-epithelial macrophages in the early pre-cancer lesions drive early cancer cell dissemination through Wnt-1 secretion and that such events impact the later development of metastasis. | | 02 January 2018 | doi: 10.1038/s41467-017-02481-5 | | Breast cancer Cancer microenvironment Metastasis Tumour immunology | Amphiphilic nanocarrier-induced modulation of PLK1 and miR-34a leads to improved therapeutic response in pancreatic cancer OPEN | | Hadas Gibori, Shay Eliyahu, Adva Krivitsky, Dikla Ben-Shushan, Yana Epshtein, Galia Tiram, Rachel Blau, Paula Ofek, Joo Sang Lee, Eytan Ruppin, Limor Landsman, Iris Barshack, Talia Golan, Emmanuelle Merquiol, Galia Blum & Ronit Satchi-Fainaro | | | Treatment of pancreatic ductal adenocarcinoma is still challenging and patients survival has only marginally improved in the last decade. Here the authors produce a PGA-based polymeric nanocarrier for the dual delivery of miR-34a-mimic and PLK1-targeting siRNA resulting in killing of pancreatic cancer cells in vivo. | | 02 January 2018 | doi: 10.1038/s41467-017-02283-9 | | RNAi therapy Targeted therapies | Protein-inspired antibiotics active against vancomycin- and daptomycin-resistant bacteria OPEN | | Mark A. T. Blaskovich, Karl A. Hansford, Yujing Gong, Mark S. Butler, Craig Muldoon, Johnny X. Huang, Soumya Ramu, Alberto B. Silva, Mu Cheng, Angela M. Kavanagh, Zyta Ziora, Rajaratnam Premraj, Fredrik Lindahl, Tanya A. Bradford, June C. Lee, Tomislav Karoli, Ruby Pelingon, David J. Edwards, Maite Amado, Alysha G. Elliott et al. | | | The antibiotic vancomycin inhibits bacterial cell wall synthesis by binding to a membrane-associated precursor. Here, Blaskovich et al. synthesize vancomycin derivatives containing lipophilic peptide moieties that enhance membrane affinity and in vivo activities against glycopeptide-resistant strains. | | 02 January 2018 | doi: 10.1038/s41467-017-02123-w | | Antibiotics Bacterial infection Drug discovery and development Mechanism of action | ERK-mediated phosphorylation regulates SOX10 sumoylation and targets expression in mutant BRAF melanoma OPEN | | Shujun Han, Yibo Ren, Wangxiao He, Huadong Liu, Zhe Zhi, Xinliang Zhu, Tielin Yang, Yu Rong, Bohan Ma, Timothy J. Purwin, Zhenlin Ouyang, Caixia Li, Xun Wang, Xueqiang Wang, Huizi Yang, Yan Zheng, Andrew E. Aplin, Jiankang Liu & Yongping Shao | | | In BRAF mutant melanoma, inhibition of ERK1/2 induces FOXD3 and mediates RAF inhibitor resistance. Here, the authors show that ERK1/2 mediated phosphorylation regulates sumoylation of SOX10 which activates FOXD3, and depletion of SOX10 sensitises BRAF mutant melanoma cells to RAF inhibitors. | | 02 January 2018 | doi: 10.1038/s41467-017-02354-x | | Cancer Cell signalling | Homocysteine directly interacts and activates the angiotensin II type I receptor to aggravate vascular injury OPEN | | Tuoyi Li, Bing Yu, Zhixin Liu, Jingyuan Li, Mingliang Ma, Yingbao Wang, Mingjiang Zhu, Huiyong Yin, Xiaofeng Wang, Yi Fu, Fang Yu, Xian Wang, Xiaohong Fang, Jinpeng Sun & Wei Kong | | | High homocysteine plasma levels are associated with cardiovascular diseases. Here, Li and colleagues find that homocysteine aggravates vascular injury by direct binding to the angiotensin II type 1 receptor (AT1R), identifying AT1R inhibition as a potential strategy to counteract the deleterious vascular effects of hyperhomocysteinemia. | | 02 January 2018 | doi: 10.1038/s41467-017-02401-7 | | Aneurysm Extracellular signalling molecules Hormone receptors | Diabetes impairs wound healing by Dnmt1-dependent dysregulation of hematopoietic stem cells differentiation towards macrophages OPEN | | Jinglian Yan, Guodong Tie, Shouying Wang, Amanda Tutto, Natale DeMarco, Lyne Khair, Thomas G. Fazzio & Louis M. Messina | | | Type 2 diabetes is associated with impaired wound healing, which can lead to limb loss. Here, the authors show that in Type 2 diabetic mouse models, Dnmt1 is upregulated in hematopoietic stem cells, leading to impaired differentiation towards macrophages, reduced macrophage infiltration in the wound and skewed M1/M2 polarization. | | 02 January 2018 | doi: 10.1038/s41467-017-02425-z | | Diabetes complications DNA methylation Haematopoietic stem cells Monocytes and macrophages | Network connectivity determines cortical thinning in early Parkinson’s disease progression OPEN | | Y. Yau, Y. Zeighami, T. E. Baker, K. Larcher, U. Vainik, M. Dadar, V. S. Fonov, P. Hagmann, A. Griffa, B. Mišić, D. L. Collins & A. Dagher | | | In Parkinson’s disease (PD), neurodegeneration spreads from the brainstem to the cerebral cortex. Here, in a longitudinal study of PD patients, the authors found that cortical thinning followed neural connectivity from a “disease reservoir”. | | 02 January 2018 | doi: 10.1038/s41467-017-02416-0 | | Neural circuits Parkinson's disease | Obligatory and facilitative allelic variation in the DNA methylome within common disease-associated loci OPEN | | Christopher G. Bell, Fei Gao, Wei Yuan, Leonie Roos, Richard J. Acton, Yudong Xia, Jordana Bell, Kirsten Ward, Massimo Mangino, Pirro G. Hysi, Jun Wang & Timothy D. Spector | | | Genomic polymorphisms affect the epigenome, which in turn influences how epigenome- and genome-wide analysis are interpreted. Here, the authors characterise allelic differences in DNA methylation driven by obligatory or facilitative genetic effects, which may affect disease-related loci. | | 02 January 2018 | doi: 10.1038/s41467-017-01586-1 | | Epigenomics Genetics research | Trapping IgE in a closed conformation by mimicking CD23 binding prevents and disrupts FcεRI interaction OPEN | | Frederic Jabs, Melanie Plum, Nick S. Laursen, Rasmus K. Jensen, Brian Mølgaard, Michaela Miehe, Marco Mandolesi, Michèle M. Rauber, Wolfgang Pfützner, Thilo Jakob, Christian Möbs, Gregers R. Andersen & Edzard Spillner | | | IgE is linked to allergic diseases and there is a great interest in developing anti-IgE therapeutics. Here the authors characterize the binding of human IgE Fc to a single domain antibody (sdab) and show that the sdab induces a closed conformation, which prevents and disrupts IgE binding to its receptor FcεRI and abrogates allergen mediated activation. | | 02 January 2018 | doi: 10.1038/s41467-017-02312-7 | | Allergy Antibody therapy | Cooperative interactions between seed-borne bacterial and air-borne fungal pathogens on rice OPEN | | Boknam Jung, Jungwook Park, Namgyu Kim, Taiying Li, Soyeon Kim, Laura E. Bartley, Jinnyun Kim, Inyoung Kim, Yoonhee Kang, Kihoon Yun, Younghae Choi, Hyun-Hee Lee, Sungyeon Ji, Kwang Sik Lee, Bo Yeon Kim, Jong Cheol Shon, Won Cheol Kim, Kwang-Hyeon Liu, Dahye Yoon, Suhkman Kim et al. | | | Interactions between bacteria and fungi are common and contribute to ecosystem processes. Here, Jung et al. show that the interaction between two plant pathogens (a seed-borne bacterium and an air-borne fungus) promotes their own survival and dispersal, as well as disease progression on rice plants. | | 02 January 2018 | doi: 10.1038/s41467-017-02430-2 | | Bacterial pathogenesis Fungal pathogenesis Microbial ecology Pathogens | The opposing forces of shear flow and sphingosine-1-phosphate control marginal zone B cell shuttling OPEN | | Kerry Tedford, Michael Steiner, Stanislav Koshutin, Karin Richter, Laura Tech, Yannik Eggers, Inga Jansing, Kerstin Schilling, Anja Erika Hauser, Mark Korthals & Klaus-Dieter Fischer | | | Marginal zone B (MZB) cells shuttle between the marginal zone and lymphoid follicle to capture and present peripheral blood antigens. Here the authors show that shear force, such as blood flow from the sinus around the follicle, is a directional cue that induces MZB migration on ICAM-1, and that S1P signaling inhibits this directional migration. | | 22 December 2017 | doi: 10.1038/s41467-017-02482-4 | | Cell migration Cellular motility Integrins Marginal zone B cells | Excitotoxic inactivation of constitutive oxidative stress detoxification pathway in neurons can be rescued by PKD1 OPEN | | Julia Pose-Utrilla, Lucía García-Guerra, Ana Del Puerto, Abraham Martín, Jerónimo Jurado-Arjona, Noelia S. De León-Reyes, Andrea Gamir-Morralla, Álvaro Sebastián Serrano, Mónica García-Gallo, Leonor Kremer, Jens Fielitz, Christofer Ireson, Mª José Pérez-Álvarez, Isidro Ferrer, Félix Hernández, Jesús Ávila, Marina Lasa, Miguel R. Campanero & Teresa Iglesias | | | Excitotoxicity due to excessive glutamate release causes oxidative stress and neuronal death, and is a feature of many brain diseases. Here the authors show that protein kinase D1 is inactivated by excitotoxicity in a model of stroke and that its activation can be neuroprotective. | | 22 December 2017 | doi: 10.1038/s41467-017-02322-5 | | Cell death in the nervous system Neurodegeneration Stroke | Methylation-regulated decommissioning of multimeric PP2A complexes OPEN | | Cheng-Guo Wu, Aiping Zheng, Li Jiang, Michael Rowse, Vitali Stanevich, Hui Chen, Yitong Li, Kenneth A. Satyshur, Benjamin Johnson, Ting-Jia Gu, Zuojia Liu & Yongna Xing | | | Protein phosphatase 2A (PP2A) forms different holoenzymes but little is known about the disassembly of these important signalling complexes. Here the authors present the crystal structure of PP2A bound to TOR signaling pathway regulator (TIPRL) and give insights into the methylation-dependent disassembly of PP2A holenzymes. | | 22 December 2017 | doi: 10.1038/s41467-017-02405-3 | | Chaperones Enzyme mechanisms Tumour-suppressor proteins X-ray crystallography | TNFα blockade overcomes resistance to anti-PD-1 in experimental melanoma OPEN | | Florie Bertrand, Anne Montfort, Elie Marcheteau, Caroline Imbert, Julia Gilhodes, Thomas Filleron, Philippe Rochaix, Nathalie Andrieu-Abadie, Thierry Levade, Nicolas Meyer, Céline Colacios & Bruno Ségui | | | Most melanoma patients do not respond to anti-PD1 therapy. Here, the authors show that TNFα blockade synergizes with anti-PD-1 by preventing anti-PD-1-induced CD8+ T cell death and TIM-3 expression on such cells. | | 22 December 2017 | doi: 10.1038/s41467-017-02358-7 | | Melanoma Tumour immunology | The F-box protein FKF1 inhibits dimerization of COP1 in the control of photoperiodic flowering OPEN | | Byoung-Doo Lee, Mi Ri Kim, Min-Young Kang, Joon-Yung Cha, Su-Hyun Han, Ganesh M. Nawkar, Yasuhito Sakuraba, Sang Yeol Lee, Takato Imaizumi, C. Robertson McClung, Woe-Yeon Kim & Nam-Chon Paek | | | CONSTANS promotes flowering under long-day conditions in Arabidopsis but is rapidly degraded in short-day conditions. Here the authors show that the blue-light photoreceptor FKF1 can interact with the E3 ligase COP1 in a light-dependent manner and prevent degradation of CO in long-day conditions. | | 22 December 2017 | doi: 10.1038/s41467-017-02476-2 | | Flowering Light responses | RNA sequencing provides insights into the evolution of lettuce and the regulation of flavonoid biosynthesis OPEN | | Lei Zhang, Wenqing Su, Rong Tao, Weiyi Zhang, Jiongjiong Chen, Peiyao Wu, Chenghuan Yan, Yue Jia, Robert M. Larkin, Dean Lavelle, Maria-Jose Truco, Sebastian Reyes Chin-Wo, Richard W. Michelmore & Hanhui Kuang | | | Horticultural lettuce varieties vary considerably in phenotype. Here, via RNA-seq of 240 different lettuce accessions, the authors identify loci and expression patterns associated with flavonoid and anthocyanin content and show that cultivated lettuce likely arose via a single domestication event. | | 22 December 2017 | doi: 10.1038/s41467-017-02445-9 | | Agricultural genetics Comparative genomics Genetic variation Plant domestication | Reading and editing the Pleurodeles waltl genome reveals novel features of tetrapod regeneration OPEN | | Ahmed Elewa, Heng Wang, Carlos Talavera-López, Alberto Joven, Gonçalo Brito, Anoop Kumar, L. Shahul Hameed, May Penrad-Mobayed, Zeyu Yao, Neda Zamani, Yamen Abbas, Ilgar Abdullayev, Rickard Sandberg, Manfred Grabherr, Björn Andersson & András Simon | | | The Iberian ribbed newt Pleurodeles waltl has a wide spectrum of regeneration abilities. Here, Elewa et al. sequence its ~20 Gb genome and transcriptome to investigate the molecular features underlying its regenerative capacities. | | 22 December 2017 | doi: 10.1038/s41467-017-01964-9 | | Genome Next-generation sequencing Regeneration Reprogramming | Molecular understanding of polyelectrolyte binders that actively regulate ion transport in sulfur cathodes OPEN | | Longjun Li, Tod A. Pascal, Justin G. Connell, Frank Y. Fan, Stephen M. Meckler, Lin Ma, Yet-Ming Chiang, David Prendergast & Brett A. Helms | | | Polymer binders in battery electrodes can affect their performance, however design rules are still lacking. Here, the authors reveal why polyelectrolyte binders outperform charge-neutral alternatives in lithium–sulfur batteries, showing how cationic polyelectrolytes can regulate ion transport selectively. | | 22 December 2017 | doi: 10.1038/s41467-017-02410-6 | | Batteries Polymer characterization | Near-field spectroscopic investigation of dual-band heavy fermion metamaterials OPEN | | Stephanie N. Gilbert Corder, Xinzhong Chen, Shaoqing Zhang, Fengrui Hu, Jiawei Zhang, Yilong Luan, Jack A. Logan, Thomas Ciavatti, Hans A. Bechtel, Michael C. Martin, Meigan Aronson, Hiroyuki S. Suzuki, Shin-ichi Kimura, Takuya Iizuka, Zhe Fei, Keiichiro Imura, Noriaki K. Sato, Tiger H. Tao & Mengkun Liu | | | Understanding the electromagnetic responses at subwavelength scales is important for achieving tunability. Using a combination of the near-field and far-field spectroscopy, the authors demonstrate a heavy fermion metamaterial with tunable dual-band optical responses by selectively and separately modifying the 4f and 5d band electrons. | | 22 December 2017 | doi: 10.1038/s41467-017-02378-3 | | Applied optics Metamaterials Phase transitions and critical phenomena | Generic wound signals initiate regeneration in missing-tissue contexts OPEN | | Suthira Owlarn, Felix Klenner, David Schmidt, Franziska Rabert, Antonio Tomasso, Hanna Reuter, Medhanie A. Mulaw, Sören Moritz, Luca Gentile, Gilbert Weidinger & Kerstin Bartscherer | | | Some wounds trigger regeneration, while others simply heal but how this is regulated is unclear. Here, by manipulating ERK and Wnt signalling pathways, the authors create headless planarians and finless zebrafish and show that wounds that normally only trigger wound healing can activate regeneration of heads and bones. | | 22 December 2017 | doi: 10.1038/s41467-017-02338-x | | Experimental organisms Morphogenesis | Double mimicry evades tRNA synthetase editing by toxic vegetable-sourced non-proteinogenic amino acid OPEN | | Youngzee Song, Huihao Zhou, My-Nuong Vo, Yi Shi, Mir Hussain Nawaz, Oscar Vargas-Rodriguez, Jolene K. Diedrich, John R. Yates, Shuji Kishi, Karin Musier-Forsyth & Paul Schimmel | | | Non-proteinogenic (np) amino acids in the food chain present challenges for the human translation machinery. Here the authors show that, while AlaRS and ProRS activate toxic np azetidine-2-carboxylic acid (Aze) present in sugar beets and lilies, only the AlaRS editing system rejects Aze. | | 22 December 2017 | doi: 10.1038/s41467-017-02201-z | | Enzyme mechanisms Proteins tRNAs X-ray crystallography | Quantum Hall states observed in thin films of Dirac semimetal Cd3As2 OPEN | | Masaki Uchida, Yusuke Nakazawa, Shinichi Nishihaya, Kazuto Akiba, Markus Kriener, Yusuke Kozuka, Atsushi Miyake, Yasujiro Taguchi, Masashi Tokunaga, Naoto Nagaosa, Yoshinori Tokura & Masashi Kawasaki | | | Despite many achievements in the topological semimetal Cd3As2, the high-quality Cd3As2 films are still rare. Here, Uchida et al. grow high-crystallinity and high-mobility Cd3As2 thin films and observe quantum Hall states dependent on the confinement thickness. | | 22 December 2017 | doi: 10.1038/s41467-017-02423-1 | | Electronic properties and materials Surfaces, interfaces and thin films Topological insulators | Imaging the square of the correlated two-electron wave function of a hydrogen molecule OPEN | | M. Waitz, R. Y. Bello, D. Metz, J. Lower, F. Trinter, C. Schober, M. Keiling, U. Lenz, M. Pitzer, K. Mertens, M. Martins, J. Viefhaus, S. Klumpp, T. Weber, L. Ph. H. Schmidt, J. B. Williams, M. S. Schöffler, V. V. Serov, A. S. Kheifets, L. Argenti et al. | | | Electron-electron correlation is a complex and interesting phenomenon that occurs in multi-electron systems. Here, the authors demonstrate the imaging of the correlated two-electron wave function in hydrogen molecule using the coincident detection of the electron and proton after the photoionization. | | 22 December 2017 | doi: 10.1038/s41467-017-02437-9 | | Atomic and molecular interactions with photons Chemical physics Electronic structure of atoms and molecules Techniques and instrumentation | Antimicrobial peptide capsids of de novo design OPEN | | Emiliana De Santis, Hasan Alkassem, Baptiste Lamarre, Nilofar Faruqui, Angelo Bella, James E. Noble, Nicola Micale, Santanu Ray, Jonathan R. Burns, Alexander R. Yon, Bart W. Hoogenboom & Maxim G. Ryadnov | | | With the growing threat of antibiotic resistance, unconventional approaches to antimicrobial discovery are needed. Here, the authors present a peptide topology that mimics virus architecture and assembles into antimicrobial capsids that disrupt bacterial membranes upon contact. | | 22 December 2017 | doi: 10.1038/s41467-017-02475-3 | | Antimicrobials Protein design Self-assembly | Transmission of heat modes across a potential barrier OPEN | | Amir Rosenblatt, Fabien Lafont, Ivan Levkivskyi, Ron Sabo, Itamar Gurman, Daniel Banitt, Moty Heiblum & Vladimir Umansky | | | Understanding the transfer of heat currents, specifically, neutral heat modes which do not carry net charge, is of great interest. Here, the authors study the transmission of upstream neutral modes through a quantum point contact in order to render the relative spatial distribution of these chargeless modes. | | 21 December 2017 | doi: 10.1038/s41467-017-02433-z | | Electronic devices Quantum Hall | Circadian clock regulates hepatic polyploidy by modulating Mkp1-Erk1/2 signaling pathway OPEN | | Hsu-Wen Chao, Masao Doi, Jean-Michel Fustin, Huatao Chen, Kimihiko Murase, Yuki Maeda, Hida Hayashi, Rina Tanaka, Maho Sugawa, Naoki Mizukuchi, Yoshiaki Yamaguchi, Jun-ichirou Yasunaga, Masao Matsuoka, Mashito Sakai, Michihiro Matsumoto, Shinshichi Hamada & Hitoshi Okamura | | | Circadian clock regulates hepatic gene expression and functions. Here Chao et al. show that alteration of circadian clock genes by Period deletion induces polyploidy in hepatocytes due to impaired regulation of Erk signaling by mitogen-activated protein kinase phosphatase 1. | | 21 December 2017 | doi: 10.1038/s41467-017-02207-7 | | Circadian rhythms Cytokinesis | Systems analysis identifies melanoma-enriched pro-oncogenic networks controlled by the RNA binding protein CELF1 OPEN | | Metehan Cifdaloz, Lisa Osterloh, Osvaldo Graña, Erica Riveiro-Falkenbach, Pilar Ximénez-Embún, Javier Muñoz, Cristina Tejedo, Tonantzin G. Calvo, Panagiotis Karras, David Olmeda, Belén Miñana, Gonzalo Gómez-López, Estela Cañon, Eduardo Eyras, Haihong Guo, Ferdinand Kappes, Pablo L. Ortiz-Romero, Jose L. Rodríguez-Peralto, Diego Megías, Juan Valcárcel et al. | | | Hundreds of mRNA binding proteins (mRBPs) have been described in mammalian cells. Here, the authors identify RBPs differentially regulated in melanoma, and show the RBP CELF1 controlling a distinct set of protumorigenic factors. | | 21 December 2017 | doi: 10.1038/s41467-017-02353-y | | Cancer Oncogenes | Glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells OPEN | | Emmanuel Dornier, Nicolas Rabas, Louise Mitchell, David Novo, Sandeep Dhayade, Sergi Marco, Gillian Mackay, David Sumpton, Maria Pallares, Colin Nixon, Karen Blyth, Iain R. Macpherson, Elena Rainero & Jim C. Norman | | | Glutamine metabolism is well known to support tumour growth. Here the authors show that cancer cells also utilize glutamine to promote invasiveness by converting it to glutamate, which upon secretion activates metabotropic glutamate receptors to stimulate matrix metalloproteases recycling to the cell surface. | | 21 December 2017 | doi: 10.1038/s41467-017-02101-2 | | Cancer metabolism Cell invasion Membrane trafficking | A molecular basis for water motion detection by the mechanosensory lateral line of zebrafish OPEN | | Shih-Wei Chou, Zongwei Chen, Shaoyuan Zhu, Robin W. Davis, Jiaqi Hu, Li Liu, Carol A. Fernando, Kayla Kindig, William C. Brown, Ruben Stepanyan & Brian M. McDermott Jr. | | | In fish, water motion is detected by mechanosensitive hair cells located in the lateral line. Here the authors show that the molecular machinery for mechanotransduction, including transmembrane channel-like 2b (Tmc2b), varies depending on both hair cell location and hair bundle orientation. | | 21 December 2017 | doi: 10.1038/s41467-017-01604-2 | | Hair cell Molecular neuroscience Sensory processing | Factoring economic costs into conservation planning may not improve agreement over priorities for protection OPEN | | Paul R. Armsworth, Heather B. Jackson, Seong-Hoon Cho, Melissa Clark, Joseph E. Fargione, Gwenllian D. Iacona, Taeyoung Kim, Eric R. Larson, Thomas Minney & Nathan A. Sutton | | | Prioritising areas for conservation is hindered by disagreements over ecological targets. Here, Armsworth et al. combine a simulation approach and case study to test if considering economic return on investment aids in prioritisation, and find that its impact on reaching agreements varies greatly. | | 21 December 2017 | doi: 10.1038/s41467-017-02399-y | | Biodiversity Conservation biology Environmental economics Forestry Sustainability | Lipid moieties on lipoproteins of commensal and non-commensal staphylococci induce differential immune responses OPEN | | Minh-Thu Nguyen, Julia Uebele, Nimerta Kumari, Hiroshi Nakayama, Lena Peter, Olga Ticha, Anne-Kathrin Woischnig, Mathias Schmaler, Nina Khanna, Naoshi Dohmae, Bok Luel Lee, Isabelle Bekeredjian-Ding & Friedrich Götz | | | The Lpp lipoproteins of staphylococci trigger a TLR2-dependent immune response. Here, the authors show that commensal species (S. aureus, S. epidermidis) induce a less-intense TLR2 response than non-commensal species (S. carnosus) due to differential modification of the Lpp lipid moieties. | | 21 December 2017 | doi: 10.1038/s41467-017-02234-4 | | Bacterial immune evasion Cellular microbiology Immune evasion Toll-like receptors | Spontaneous and specific chemical cross-linking in live cells to capture and identify protein interactions OPEN | | Bing Yang, Shibing Tang, Cheng Ma, Shang-Tong Li, Guang-Can Shao, Bobo Dang, William F. DeGrado, Meng-Qiu Dong, Peng George Wang, Sheng Ding & Lei Wang | | | Proteins associate via weak and transient interactions that are challenging to identify in vivo. Here, the authors use a genetically encoded chemical cross-linker to covalently lock interacting proteins in live cells, allowing them to identify the captured proteins by mass spectrometry. | | 21 December 2017 | doi: 10.1038/s41467-017-02409-z | | Chemical tools Proteins | Mammalian display screening of diverse cystine-dense peptides for difficult to drug targets OPEN | | Zachary R. Crook, Gregory P. Sevilla, Della Friend, Mi-Youn Brusniak, Ashok D. Bandaranayake, Midori Clarke, Mesfin Gewe, Andrew J. Mhyre, David Baker, Roland K. Strong, Philip Bradley & James M. Olson | | | Pathologies related to protein:protein interaction are hard to treat but cystine-dense peptides have the potential to disrupt such interactions. Here the authors develop a high-diversity mammalian cell screen for cystine-dense peptides with drug potential and use it to identify a YAP:TEAD inhibitor. | | 21 December 2017 | doi: 10.1038/s41467-017-02098-8 | | Drug development High-throughput screening Protein design Recombinant peptide therapy | | | | | | | | Latest Erratum | | | | | | | | Advertisement | | Communications Biology: Open for Submissions Communications Biology is a new open access journal that publishes high-quality primary research articles, reviews and commentary representing significant advances and new insights to the field of biology. The journal is now open for submissions. Find out more >> | | | | | | Advertisement | | | | | Advertisement | | A new open access journal dedicated to publishing the most important scientific advances in all aspects of genomics and its application in the practice of medicine. 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