Nature Chemical Biology Contents: February 2018, Volume 14 No 2 pp 103 - 186

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Advertisement Discover the LOPAC®1280 small molecule library.  The power and performance of MilliporeSigma's Library of Pharmacologically Active Compounds is assured. 1,280 pharmacologically active compounds Ready-to-use DMSO stocks: less time-consuming sample preparation Highly pure compounds with full QC: re-supply as individual catalog items Learn More TABLE OF CONTENTS February 2018 Volume 14, Issue 2 Commentary Research Highlights News and Views Articles Erratum Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement Nature Catalysis is now live! Explore the first issue which is free to access online for a limited time.  READ NOW >>    Commentary Top Toward an orthogonal central dogma   pp103 - 106 Chang C Liu, Michael C Jewett, Jason W Chin and Chris A Voigt doi:10.1038/nchembio.2554 The central dogma processes of DNA replication, transcription, and translation are responsible for the maintenance and expression of every gene in an organism. An orthogonal central dogma may insulate genetic programs from host regulation and allow expansion of the roles of these processes within the cell. Research Highlights Top Synthetic biology: License to kill | Cancer therapy: A path of DSF destruction | Cell biology: Eaten up from the inside | RNA Splicing: Making the cut News and Views Top Natural products: Tapping into personalized chemistry   pp108 - 109 Jack R Davison and Carole A Bewley doi:10.1038/nchembio.2560 By integrating metagenomics, spectroscopy and synthetic biology, the individualized chemistry of small reef-dwelling organisms and their associated microbiota can be characterized in exquisite detail, unlocking a wealth of structural diversity for the development of new drugs. See also: Article by Smith et al. Plant hormones: Metabolic end run to jasmonate   pp109 - 110 Gregg A Howe doi:10.1038/nchembio.2553 The lipid-derived hormone jasmonate promotes durable resistance of plants to a myriad of herbivores and pathogens. New evidence reveals an alternative pathway for the terminal steps of jasmonate biosynthesis and further advances our understanding of bioactive oxylipins in the plant kingdom. See also: Article by Chini et al. Drug development: Allosteric inhibitors hit USP7 hard   pp110 - 111 Wei Zhang and Sachdev S Sidhu doi:10.1038/nchembio.2557 A potent and specific small-molecule inhibitor of a long-sought-after anticancer drug target, USP7, that acts allosterically to inhibit MDM2-stabilizing activity foretells of more allosteric inhibitors for deubiquitinases and E3 ligases. See also: Article by Gavory et al. Nature Chemical Biology JOBS of the week Chemical Biology / Medicinal Chemistry – Tenure track Position University of Nebraska Medical Center Junior Group Leader Positions Insitut Curie Postdoctoral Associate University of Pittsburgh ISTplus postdoctoral fellowship program Institute of Science and Technology Austria (IST Austria) Pioneer Award Postdoctoral Fellowships University of Miami More Science jobs from Nature Chemical Biology EVENT International Conference "Plant Physiology & Biochemistry" 9 - 10 July 2018 Vienna, Austria More science events from Advertisement Do you have a career question?  The Naturejobs podcast features one-on-one Q&As, panel discussions and other exclusive content to help scientists with their careers. Hosted on the Naturejobs blog, the podcast is also available on iTunes and Soundcloud.  Listen today!   Articles Top Human antibody-based chemically induced dimerizers for cell therapeutic applications   pp112 - 117 Zachary B Hill, Alexander J Martinko, Duy P Nguyen and James A Wells doi:10.1038/nchembio.2529 Selections with a phage-displayed antibody library against an existing protein-small-molecule complex enabled the generation of antibody-based chemically induced dimerizers (AbCIDs) with the properties necessary for use in regulating cell therapies. Chemical compounds Discovery and characterization of highly potent and selective allosteric USP7 inhibitors   pp118 - 125 Gerald Gavory, Colin R O'Dowd, Matthew D Helm, Jakub Flasz, Elias Arkoudis et al. doi:10.1038/nchembio.2528 A selective inhibitor of the deubiquitinase USP7 binds an allosteric site to inhibit its MDM2-stabilizing activity, resulting in stabilization of p53 and p21, which confers hypersensitivity to cancer cells for killing by the compound. Chemical compounds See also: News and Views by Zhang & Sidhu Structure-inspired design of β-arrestin-biased ligands for aminergic GPCRs   pp126 - 134 John D McCorvy, Kyle V Butler, Brendan Kelly, Katie Rechsteiner, Joel Karpiak et al. doi:10.1038/nchembio.2527 Development of D2 dopamine receptor ligands biased for β-arrestin recruitment based on a receptor homology model that identified conserved ligand contacts within the TM5 and EL2 regions as important for biased signaling. Chemical compounds Inhibiting mitochondrial phosphate transport as an unexploited antifungal strategy   pp135 - 141 Catherine A McLellan, Benjamin M Vincent, Norma V Solis, Alex K Lancaster, Lucas B Sullivan et al. doi:10.1038/nchembio.2534 A potent inhibitor of the conditionally essential mitochondrial phosphate carrier protein Mir1 in the fungi Candida albicans diminishes mitochondrial oxygen consumption and causes dramatic changes in concentrations of citrate and succinate. Chemical compounds Engineered synthetic scaffolds for organizing proteins within the bacterial cytoplasm   pp142 - 147 Matthew J Lee, Judith Mantell, Lorna Hodgson, Dominic Alibhai, Jordan M Fletcher et al. doi:10.1038/nchembio.2535 Two complementary coiled-coil peptides and a bacterial microcompartment shell protein are combined to construct cytoscaffolds within Escherichia coli cells. Targeting enzymes to the cytoplasmic scaffold results in colocalization and improved metabolic flux. A role for 2-Cys peroxiredoxins in facilitating cytosolic protein thiol oxidation   pp148 - 155 Sarah Stocker, Michael Maurer, Thomas Ruppert and Tobias P Dick doi:10.1038/nchembio.2536 Cytosolic 2-Cys peroxiredoxins can enable, rather than compete with, rapid thiol oxidation by relaying H2O2-derived oxidizing equivalents to other proteins, suggesting a broadened role for peroxiredoxins as sensors and transmitters of H2O2 signals. Expression system for structural and functional studies of human glycosylation enzymes   pp156 - 162 Kelley W Moremen, Annapoorani Ramiah, Melissa Stuart, Jason Steel, Lu Meng et al. doi:10.1038/nchembio.2539 A modular protein expression system enables the structural and functional characterization of human glycosyltransferases, glycoside hydrolases and other carbohydrate-modifying enzymes. Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation   pp163 - 170 Calla M Olson, Baishan Jiang, Michael A Erb, Yanke Liang, Zainab M Doctor et al. doi:10.1038/nchembio.2538 A selective small-molecule degrader of CDK9 was generated by conjugating an imide to SNS-032, a promiscuous ATP-site-directed CDK binder. The pharmacological consequences of CDK9 degradation versus inhibition were compared. Chemical compounds An OPR3-independent pathway uses 4,5-didehydrojasmonate for jasmonate synthesis   pp171 - 178 Andrea Chini, Isabel Monte, Angel M Zamarreno, Mats Hamberg, Steve Lassueur et al. doi:10.1038/nchembio.2540 OPR3 is required to reduce the JA-Ile precursor OPDA. Analyses of JA levels in a loss-of-function opr3-3 mutant identified an OPR3-independent pathway for JA-Ile biosynthesis, based on OPDA conversion to 4,5-ddh-JA and reduction to JA by OPR2. Chemical compounds See also: News and Views by Howe Accessing chemical diversity from the uncultivated symbionts of small marine animals   pp179 - 185 Thomas E Smith, Christopher D Pond, Elizabeth Pierce, Zachary P Harmer, Jason Kwan et al. doi:10.1038/nchembio.2537 A combination of spectroscopy, metagenomics, and synthetic biology enables the characterization of the antiviral divamides, a class of lanthipeptide natural products in which even minor changes in structure lead to different biological activities. Chemical compounds See also: News and Views by Davison & Bewley Advertisement Poster on: The expanding CRISPR toolbox  The CRISPR-Cas9 system can do a lot more than gene editing. This Poster, from Nature Methods, explores the newest possibilities of CRISPR.  Available to download free online >>  Produced with support from:  Dharmacon    Erratum Top Errata: Continuous directed evolution of aminoacyl-tRNA synthetases   p186 David I Bryson, Chenguang Fan, Li-Tao Guo, Corwin Miller, Dieter Soll et al. doi:10.1038/nchembio0218-186 Top Advertisement Nature Mentoring Collection  Offering advice and support to scientist mentors and their mentees  Access the Collection >>    Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

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