Nature Biotechnology Contents: Volume 36 pp 1 - 116

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Advertisement GTEx Collection Nature Research is pleased to present this Collection of Commentary, News and Research from across the Nature journals for the second phase of the GTEx project.  Access the Collection online >>  TABLE OF CONTENTS January 2018 Volume 36, Issue 1 Editorial News News Feature Opinion and Comment Feature News and Views Research Careers and Recruitment Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement BIOPHARMA DEALMAKERS Company Profiles and Partnering Opportunities     Advertisement Nature Collection: 2017 Nobel Prize in Physiology or Medicine The 2017 Nobel Prize in Physiology or Medicine was awarded to Jeffrey C. Hall, Michael Rosbash and Michael W. Young for their pioneering work in Drosophila that elucidated the molecular mechanisms controlling circadian rhythm.  Access this collection free online>> Produced with support from:  Vanda Pharmaceuticals     Editorial Aligning stars of all colors    p1 doi:10.1038/nbt.4050 News Drugmakers cling to dual IL-13/IL-4 blockbuster hopes    pp3 - 5 Cormac Sheridan doi:10.1038/nbt0118-3 AI for your heart, on your wrist    p5 doi:10.1038/nbt0118-5a First in vivo human genome editing trial    p5 doi:10.1038/nbt0118-5b FDA approves hereditary blindness gene therapy    p6 doi:10.1038/nbt0118-6a With a free pass, CRISPR-edited plants reach market in record time    pp6 - 7 Emily Waltz doi:10.1038/nbt0118-6b China's fledgling biotech sector fizzes into life    pp8 - 9 Shannon Ellis doi:10.1038/nbt0118-8 FDA to relax grip on at-home genetic tests, but concerns linger    pp10 - 11 Mark Ratner doi:10.1038/nbt0118-10 PODCAST: First rounders: Susan Windham-Bannister    p11 doi:10.1038/nbt.4053 Bluebird's BCMA CAR-T impresses at ASH    p11 doi:10.1038/nbt0118-11 Texas displays 'Silicon Valley' credentials to lure Brazilian biotechs    pp12 - 13 Melanie Senior doi:10.1038/nbt0118-12 Around the world in a month    p13 doi:10.1038/nbt0118-13 News Feature DNA makes an appearance    pp14 - 17 Laura DeFrancesco doi:10.1038/nbt.4057 An online-only, open access journal publishing high-quality original papers and review articles relevant to all aspects of digital medicine and health, npj Digital Medicine has now published its first articles. Part of the Nature Partner Journals series, npj Digital Medicine is published in partnership with the Scripps Translational Science Institute.   Explore all articles available >>>  Opinion and Comment Correspondence Why the European Union needs a national GMO opt-in mechanism    pp18 - 19 Dennis Eriksson, Eugénia de Andrade, Borut Bohanec, Sevasti Chatzopolou, Roberto Defez et al. doi:10.1038/nbt.4051 Feature Biotech's pale shadow    pp20 - 30 Brady Huggett doi:10.1038/nbt.4046 Patents Mapping the global influence of published research on industry and innovation    pp31 - 39 Osmat A Jefferson, Adam Jaffe, Doug Ashton, Ben Warren, Deniz Koellhofer et al. doi:10.1038/nbt.4049 Recent patents in proteomics    p40 doi:10.1038/nbt.4064 npj Vaccines is an online-only, open access, multidisciplinary journal dedicated to publishing cutting-edge research and development on human and veterinary vaccines.npj Vaccines is now open for submissions.   Explore the benefits of submitting your next manuscript to the journal   News and Views Strength in numbers from integrated single-cell neuroscience    pp41 - 42 Rahul Satija doi:10.1038/nbt.4055 Viruses leave their stamp on single cells    pp42 - 44 Ede A Rancz & Andreas T Schaefer doi:10.1038/nbt.4043 RNA-targeting CRISPR comes of age    pp44 - 45 V Narry Kim doi:10.1038/nbt.4054 Research Highlights    p45 doi:10.1038/nbt.4058 Biotechnology JOBS of the week Postdoctoral Fellow Icahn School of Medicine at Mount Sinai Recruitment for Academic Positions Regional Centre for Biotechnology (RCB) Experimental (wet-lab) postdoctoral position in proteomics at Cornell University Cornell University Southern Medical University Recruitment for High-level Talents Southern Medical University Shenzhen Second People's Hospital: Seeking Post-doctoral Fellows Shenzhen Second People's Hospital More Science jobs from Research Review Precision oncology in the age of integrative genomics    pp46 - 60 Chandan Kumar-Sinha & Arul M Chinnaiyan doi:10.1038/nbt.4017 Chandan Kumar-Sinha and Arul Chinnaiyan summarize the increasing use of sequencing panels to screen for cancer-associated genes in tumor and germline samples. The authors highlight the increasing appreciation of aberrations in regulatory genes or chromatin-related genes and argue that precision oncology must be considered in the context of adding value to the standard of care, not apart from it. Articles Metagenomic binning and association of plasmids with bacterial host genomes using DNA methylation    pp61 - 69 John Beaulaurier, Shijia Zhu, Gintaras Deikus, Ilaria Mogno, Xue-Song Zhang et al. doi:10.1038/nbt.4037 Similar bacterial species and strains in metagenomes are resolved and linked to the plasmids that they harbor using DNA methylation analysis. Integrative single-cell analysis of transcriptional and epigenetic states in the human adult brain    pp70 - 80 Blue B Lake, Song Chen, Brandon C Sos, Jean Fan, Gwendolyn E Kaeser et al. doi:10.1038/nbt.4038 Single-cell analysis of the adult human brain is facilitated by improved methods for RNA-seq and hypersensitive-site mapping. Virus stamping for targeted single-cell infection in vitro and in vivo    pp81 - 88 Rajib Schubert, Stuart Trenholm, Kamill Balint, Georg Kosche, Cameron S Cowan et al. doi:10.1038/nbt.4034 Viruses are transduced to single cells in tissues, organoids and in the mouse brain using mechanical carriers. Multiplexed droplet single-cell RNA-sequencing using natural genetic variation    pp89 - 94 Hyun Min Kang, Meena Subramaniam, Sasha Targ, Michelle Nguyen, Lenka Maliskova et al. doi:10.1038/nbt.4042 Droplet single-cell RNA-seq is applied to large numbers of pooled samples from unrelated individuals. Letter Inhibition of 53BP1 favors homology-dependent DNA repair and increases CRISPR–Cas9 genome-editing efficiency    pp95 - 102 Marella D Canny, Nathalie Moatti, Leo C K Wan, Amélie Fradet-Turcotte, Danielle Krasner et al. doi:10.1038/nbt.4021 Modulation of DNA repair pathway choice by a potent inhibitor of 53BP1 improves the efficiency of homology-dependent genome editing in human and mouse cells. Resources Global landscape of cell envelope protein complexes in Escherichia coli    pp103 - 112 Mohan Babu, Cedoljub Bundalovic-Torma, Charles Calmettes, Sadhna Phanse, Qingzhou Zhang et al. doi:10.1038/nbt.4024 A survey of cell envelope proteins and their interacting partners in E. coli by mass spectrometry reveals insights into essential bacterial processes. Careers and Recruitment Mentoring for diversity in technology    pp113 - 115 Maggie Werner-Washburne doi:10.1038/nbt.4025 People People    p116 doi:10.1038/nbt.4065 Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

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