Leukemia - Table of Contents alert Volume 32 Issue 1

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TABLE OF CONTENTS Volume 32, Issue 1 (January 2018) In this issue Review Original Articles Letters to the Editor Also new AOP   Sign up for e-alerts Recommend to your library Web feed Follow on Twitter Subscribe Review Top Therapeutic targeting of CK2 in acute and chronic leukemias OPEN F Buontempo, J A McCubrey, E Orsini, M Ruzzene, A Cappellini, A Lonetti, C Evangelisti, F Chiarini, C Evangelisti, J T Barata and A M Martelli Leukemia 2018 32: 1-10; advance online publication, September 27, 2017; 10.1038/leu.2017.301 Abstract | Full Text Original Articles Top ACUTE MYELOID LEUKEMIA Vitamin C-induced epigenomic remodelling in IDH1 mutant acute myeloid leukaemia OPEN M Mingay, A Chaturvedi, M Bilenky, Q Cao, L Jackson, T Hui, M Moksa, A Heravi-Moussavi, R K Humphries, M Heuser and M Hirst Leukemia 2018 32: 11-20; advance online publication, June 2, 2017; 10.1038/leu.2017.171 Abstract | Full Text Long-term outcome of older patients with newly diagnosed de novo acute promyelocytic leukemia treated with ATRA plus anthracycline-based therapy D Martínez-Cuadrón, P Montesinos, E Vellenga, T Bernal, O Salamero, A Holowiecka, S Brunet, C Gil, C Benavente, J M Ribera, M Pérez-Encinas, J De la Serna, J Esteve, V Rubio, J González-Campos, L Escoda, M E Amutio, M Arnan, J Arias, S Negri, B Lowënberg and M A Sanz on behalf of the PETHEMA, HOVON, PALG and GATLA groups Leukemia 2018 32: 21-29; advance online publication, June 6, 2017; 10.1038/leu.2017.178 Abstract | Full Text DNMT3A mutant transcript levels persist in remission and do not predict outcome in patients with acute myeloid leukemia V I Gaidzik, D Weber, P Paschka, A Kaumanns, S Krieger, A Corbacioglu, J Krönke, S Kapp-Schwoerer, D Krämer, H-A Horst, I Schmidt-Wolf, G Held, A Kündgen, M Ringhoffer, K Götze, T Kindler, W Fiedler, M Wattad, R F Schlenk, L Bullinger, V Teleanu, B Schlegelberger, F Thol, M Heuser, A Ganser, H Döhner, K Döhner and for the German-Austrian Acute Myeloid Leukemia Study Group (AMLSG) Leukemia 2018 32: 30-37; advance online publication, June 23, 2017; 10.1038/leu.2017.200 Abstract | Full Text ACUTE LYMPHOBLASTIC LEUKEMIA Deregulation of kinase signaling and lymphoid development in EBF1-PDGFRB ALL leukemogenesis S J Welsh, M L Churchman, M Togni, C G Mullighan and J Hagman Leukemia 2018 32: 38-48; advance online publication, May 30, 2017; 10.1038/leu.2017.166 Abstract | Full Text HDAC1,2 inhibition and doxorubicin impair Mre11-dependent DNA repair and DISC to override BCR-ABL1-driven DSB repair in Philadelphia chromosome-positive B-cell precursor acute lymphoblastic leukemia OPEN S Tharkar-Promod, D P Johnson, S E Bennett, E M Dennis, B G Banowsky, S S Jones, J R Shearstone, S N Quayle, C Min, M Jarpe, T Mosbruger, A D Pomicter, R R Miles, W Y Chen, K N Bhalla, P A Zweidler-McKay, D C Shrieve, M W Deininger, M B Chandrasekharan and S Bhaskara Leukemia 2018 32: 49-60; advance online publication, June 5, 2017; 10.1038/leu.2017.174 Abstract | Full Text TCRα rearrangements identify a subgroup of NKL-deregulated adult T-ALLs associated with favorable outcome P Villarese, C Lours, A Trinquand, S Le Noir, M Belhocine, L Lhermitte, A Cieslak, M Tesio, A Petit, M LeLorch, S Spicuglia, N Ifrah, H Dombret, A W Langerak, N Boissel, E Macintyre and V Asnafi Leukemia 2018 32: 61-71; advance online publication, June 8, 2017; 10.1038/leu.2017.176 Abstract | Full Text CHRONIC LYMPHOCYTIC LEUKEMIA Aberrant splicing of the tumor suppressor CYLD promotes the development of chronic lymphocytic leukemia via sustained NF-κB signaling M Hahn, J-P Bürckert, C A Luttenberger, S Klebow, M Hess, M Al-Maarri, M Vogt, S Reißig, M Hallek, A Wienecke-Baldacchino, T Buch, C P Muller, C P Pallasch, F T Wunderlich, A Waisman and N Hövelmeyer Leukemia 2018 32: 72-82; advance online publication, June 1, 2017; 10.1038/leu.2017.168 Abstract | Full Text Extended follow-up and impact of high-risk prognostic factors from the phase 3 RESONATE study in patients with previously treated CLL/SLL OPEN J R Brown, P Hillmen, S O’Brien, J C Barrientos, N M Reddy, S E Coutre, C S Tam, S P Mulligan, U Jaeger, P M Barr, R R Furman, T J Kipps, F Cymbalista, P Thornton, F Caligaris-Cappio, J Delgado, M Montillo, S DeVos, C Moreno, J M Pagel, T Munir, J A Burger, D Chung, J Lin, L Gau, B Chang, G Cole, E Hsu, D F James and J C Byrd Leukemia 2018 32: 83-91; advance online publication, June 8, 2017; 10.1038/leu.2017.175 Abstract | Full Text LYMPHOMA An oncogenic axis of STAT-mediated BATF3 upregulation causing MYC activity in classical Hodgkin lymphoma and anaplastic large cell lymphoma A Lollies, S Hartmann, M Schneider, T Bracht, A L Weiß, J Arnolds, L Klein-Hitpass, B Sitek, M-L Hansmann, R Küppers and M A Weniger Leukemia 2018 32: 92-101; advance online publication, June 29, 2017; 10.1038/leu.2017.203 Abstract | Full Text MULTIPLE MYELOMA, GAMMOPATHIES Prediction of outcome in newly diagnosed myeloma: a meta-analysis of the molecular profiles of 1905 trial patients OPEN V Shah, A L Sherborne, B A Walker, D C Johnson, E M Boyle, S Ellis, D B Begum, P Z Proszek, J R Jones, C Pawlyn, S Savola, M W Jenner, M T Drayson, R G Owen, R S Houlston, D A Cairns, W M Gregory, G Cook, F E Davies, G H Jackson, G J Morgan and M F Kaiser on behalf of the NCRI Haemato-oncology CSG Leukemia 2018 32: 102-110; advance online publication, June 6, 2017; 10.1038/leu.2017.179 Abstract | Full Text Nucleotide excision repair is a potential therapeutic target in multiple myeloma OPEN R Szalat, M K Samur, M Fulciniti, M Lopez, P Nanjappa, A Cleynen, K Wen, S Kumar, T Perini, A S Calkins, E Reznichenko, D Chauhan, Y-T Tai, M A Shammas, K C Anderson, J-P Fermand, B Arnulf, H Avet-Loiseau, J-B Lazaro and N C Munshi Leukemia 2018 32: 111-119; advance online publication, June 7, 2017; 10.1038/leu.2017.182 Abstract | Full Text Integrative network analysis identifies novel drivers of pathogenesis and progression in newly diagnosed multiple myeloma A Laganà, D Perumal, D Melnekoff, B Readhead, B A Kidd, V Leshchenko, P-Y Kuo, J Keats, M DeRome, J Yesil, D Auclair, S Lonial, A Chari, H J Cho, B Barlogie, S Jagannath, J T Dudley and S Parekh Leukemia 2018 32: 120-130; advance online publication, June 23, 2017; 10.1038/leu.2017.197 Abstract | Full Text Natural history of t(11;14) multiple myeloma A Lakshman, M Alhaj Moustafa, S V Rajkumar, A Dispenzieri, M A Gertz, F K Buadi, M Q Lacy, D Dingli, A L Fonder, S R Hayman, M A Hobbs, W I Gonsalves, Y L Hwa, P Kapoor, N Leung, R S Go, Y Lin, T V Kourelis, J A Lust, S J Russell, S R Zeldenrust, R A Kyle and S K Kumar Leukemia 2018 32: 131-138; advance online publication, June 27, 2017; 10.1038/leu.2017.204 Abstract | Full Text CHRONIC MYELOPROLIFERATIVE NEOPLASMS SETD2 and histone H3 lysine 36 methylation deficiency in advanced systemic mastocytosis OPEN G Martinelli, M Mancini, C De Benedittis, M Rondoni, C Papayannidis, M Manfrini, M Meggendorfer, R Calogero, V Guadagnuolo, M C Fontana, L Bavaro, A Padella, E Zago, L Pagano, R Zanotti, L Scaffidi, G Specchia, F Albano, S Merante, C Elena, P Savini, D Gangemi, P Tosi, F Ciceri, G Poletti, L Riccioni, F Morigi, M Delledonne, T Haferlach, M Cavo, P Valent and S Soverini Leukemia 2018 32: 139-148; advance online publication, June 16, 2017; 10.1038/leu.2017.183 Abstract | Full Text Irf8 regulates the progression of myeloproliferative neoplasm-like syndrome via Mertk signaling in zebrafish F Zhao, Y Shi, Y Huang, Y Zhan, L Zhou, Y Li, Y Wan, H Li, H Huang, H Ruan, L Luo and L Li Leukemia 2018 32: 149-158; advance online publication, June 19, 2017; 10.1038/leu.2017.189 Abstract | Full Text STEM CELL BIOLOGY Base excision repair proteins couple activation-induced cytidine deaminase and endonuclease G during replication stress-induced MLL destabilization B Gole, E Mian, M Rall and L Wiesmüller Leukemia 2018 32: 159-167; advance online publication, June 19, 2017; 10.1038/leu.2017.191 Abstract | Full Text STEM CELL TRANSPLANTATION HLA-DPB1 mismatch induces a graft-versus-leukemia effect without severe acute GVHD after single-unit umbilical cord blood transplantation T Yabe, F Azuma, K Kashiwase, K Matsumoto, T Orihara, H Yabe, S Kato, K Kato, S Kai, T Mori, S Morishima, M Satake, M Takanashi, K Nakajima, Y Morishima and on behalf of Japanese Cord Blood Transplantation Histocompatibility Research Group Leukemia 2018 32: 168-175; advance online publication, June 27, 2017; 10.1038/leu.2017.202 Abstract | Full Text MOLECULAR TARGETS FOR THERAPY Therapeutic effects of CSF1R-blocking antibodies in multiple myeloma Q Wang, Y Lu, R Li, Y Jiang, Y Zheng, J Qian, E Bi, C Zheng, J Hou, S Wang and Q Yi Leukemia 2018 32: 176-183; advance online publication, June 19, 2017; 10.1038/leu.2017.193 Abstract | Full Text TRANSCRIPTIONAL CONTROL AND SIGNAL TRANSDUCTION, CELL CYCLE PPAR-delta modulates membrane cholesterol and cytokine signaling in malignant B cells L Sun, Y Shi, G Wang, X Wang, S Zeng, S E Dunn, G D Fairn, Y-J Li and D E Spaner Leukemia 2018 32: 184-193; advance online publication, May 30, 2017; 10.1038/leu.2017.162 Abstract | Full Text Differential effects on gene transcription and hematopoietic differentiation correlate with GATA2 mutant disease phenotypes OPEN C-E Chong, P Venugopal, P H Stokes, Y K Lee, P J Brautigan, D T O Yeung, M Babic, G A Engler, S W Lane, M Klingler-Hoffmann, J M Matthews, R J D'Andrea, A L Brown, C N Hahn and H S Scott Leukemia 2018 32: 194-202; advance online publication, June 23, 2017; 10.1038/leu.2017.196 Abstract | Full Text SHP2 is required for BCR-ABL1-induced hematologic neoplasia S Gu, A Sayad, G Chan, W Yang, Z Lu, C Virtanen, R A Van Etten and B G Neel Leukemia 2018 32: 203-213; advance online publication, August 14, 2017; 10.1038/leu.2017.250 Abstract | Full Text S1PR1 drives a feedforward signalling loop to regulate BATF3 and the transcriptional programme of Hodgkin lymphoma cells OPEN K Vrzalikova, M Ibrahim, M Vockerodt, T Perry, S Margielewska, L Lupino, E Nagy, E Soilleux, D Liebelt, R Hollows, A Last, G Reynolds, M Abdullah, H Curley, M Care, D Krappmann, R Tooze, J Allegood, S Spiegel, W Wei, C B J Woodman and P G Murray Leukemia 2018 32: 214-223; advance online publication, September 7, 2017; 10.1038/leu.2017.275 Abstract | Full Text Letters to the Editor Top RNA interference efficiently targets human leukemia driven by a fusion oncogene in vivo N Jyotsana, A Sharma, A Chaturvedi, M Scherr, F Kuchenbauer, L Sajti, A Barchanski, R Lindner, F Noyan, K-W Sühs, D Grote-Koska, K Brand, H-P Vornlocher, M Stanulla, B Bornhauser, J-P Bourquin, M Eder, F Thol, A Ganser, R K Humphries, E Ramsay, P Cullis and M Heuser Leukemia 2018 32: 224-226; advance online publication, August 22, 2017; 10.1038/leu.2017.269 Full Text Prevalence of somatic mutations in patients with aplastic anemia using peripheral blood cfDNA as compared with BM OPEN A Albitar, D Townsley, W Ma, I De Dios, V Funari, N S Young and M Albitar Leukemia 2018 32: 227-229; advance online publication, August 23, 2017; 10.1038/leu.2017.271 Full Text Oncolytic reovirus sensitizes multiple myeloma cells to anti-PD-L1 therapy K R Kelly, C M Espitia, W Zhao, K Wu, V Visconte, F Anwer, C M Calton, J S Carew and S T Nawrocki Leukemia 2018 32: 230-233; advance online publication, August 23, 2017; 10.1038/leu.2017.272 Full Text Multiple productive IGH rearrangements denote oligoclonality even in immunophenotypically monoclonal CLL OPEN K Brazdilova, K Plevova, H Skuhrova Francova, H Kockova, M Borsky, V Bikos, J Malcikova, A Oltova, J Kotaskova, B Tichy, Y Brychtova, J Mayer, M Doubek and S Pospisilova Leukemia 2018 32: 234-236; advance online publication, August 29, 2017; 10.1038/leu.2017.274 Full Text Epigenetic targeting of Notch1-driven transcription using the HDACi panobinostat is a potential therapy against T-cell acute lymphoblastic leukemia M Waibel, S J Vervoort, I Y Kong, S Heinzel, K M Ramsbottom, B P Martin, E D Hawkins and R W Johnstone Leukemia 2018 32: 237-241; advance online publication, September 15, 2017; 10.1038/leu.2017.282 Full Text Achievement of a negative minimal residual disease state after hypomethylating agent therapy in older patients with AML reduces the risk of relapse P Boddu, J Jorgensen, H Kantarjian, G Borthakur, T Kadia, N Daver, Y Alvarado, N Pemmaraju, P Bose, K Naqvi, M Yilmaz, S Pierce, M Brandt, C D DiNardo, E J Jabbour, M Konopleva, G Garcia-Manero, J Cortes and F Ravandi Leukemia 2018 32: 241-244; advance online publication, September 18, 2017; 10.1038/leu.2017.285 Full Text Differential impact of drugs on the outcome of ETV6-RUNX1 positive childhood B-cell precursor acute lymphoblastic leukaemia: results of the EORTC CLG 58881 and 58951 trials C Piette, S Suciu, E Clappier, Y Bertrand, S Drunat, S Girard, K Yakouben, G Plat, N Dastugue, F Mazingue, N Grardel, N van Roy, A Uyttebroeck, V Costa, O Minckes, N Sirvent, P Simon, P Lutz, A Ferster, C Pluchart, M Poirée, C Freycon, M-F Dresse, F Millot, C Chantrain, J van der Werff ten Bosch, K Norga, C Gilotay, P-S Rohrlich, Y Benoit and H Cavé Leukemia 2018 32: 244-248; advance online publication, September 19, 2017; 10.1038/leu.2017.289 Full Text Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. 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