Nature Reviews Molecular Cell Biology contents January 2018 Volume 19 Number 1 pp 1-70

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TABLE OF CONTENTS
January 2018 Volume 19 Number 1
2016 2-year Impact Factor 46.602 Journal Metrics 2-year Median 28.5	In this issue Research Highlights Reviews   Also this month Article series: Translation and protein quality control Metabolic signalling RNA processing and modifications Post-translational modifications  Featured article: Regulation of heat shock transcription factors and their roles in physiology and disease Rocio Gomez-Pastor, Eileen T. Burchfiel & Dennis J. Thiele
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Proteomics in Cell Biology and Disease Mechanisms (28 Feb-2 Mar 2018)  This cross-disciplinary conference will focus on novel proteomics approaches to study key questions in cell biology and disease, bringing together those interested in systems biology, cell signalling, structural biology, and disease and clinical proteomics. Deadlines: Abstracts - 2 Jan/ Registration 30 Feb
RESEARCH HIGHLIGHTS   Top Stem cells: Regenerating the skin of a young patient p1 | doi:10.1038/nrm.2017.124 The entire skin of a young patient with junctional epidermolysis bullosa was successfuly regenerated using a combination of ex vivo gene therapy and stem-cell replacement therapy, which is a major achievement in the translation of stem cell-based therapies to the clinic. PDF RNA metabolism: The short tail that wags the mRNA p2 | doi:10.1038/nrm.2017.120 In contrast to the prevailing view, abundant and efficiently translated mRNAs tend to have short, pruned poly(A) tails. PDF Chromosome biology: Spindle asymmetry drives selfish segregation p2 | doi:10.1038/nrm.2017.121 Tubulin in meiotic oocyte spindles is asymmetrically tyrosinated, and this spindle asymmetry can drive biased, non-Mendelian inheritance of chromosomes. PDF Splicing: Going in circles p3 | doi:10.1038/nrm.2017.128 The production of circular RNAs is enhanced when canonical splicing of parent genes or transcription termination at upstream genes is reduced. PDF   Molecular Cell Biology JOBS of the week NIDDK / NIH Post-Doctoral Fellowship position National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) Program Officer, Crohn's Disease The Leona M. and Harry B. Helmsley Charitable Trust Research Scientist in Epidemiology Alberta Health Services, Cancer Epidemiology Postdoctoral Fellowship in Metabolism or Tissue Fibrosis University of California - San Francisco Postdoctoral Postion - The University of Pittsburgh School of Medicine University of Pittsbugh, School of Medicine More Science jobs from Molecular Cell Biology EVENT Essential Molecular Biology - Hands-On Laboratory Course - 12th edition 22.01.18 Porto, Portugal More science events from
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40 years of Sanger DNA sequencing Research and Commentary reflecting on the evolution and future of Sanger DNA sequencing Access the Collection online
REVIEWS		Top
Regulation of heat shock transcription factors and their roles in physiology and disease Rocio Gomez-Pastor, Eileen T. Burchfiel & Dennis J. Thiele p4 | doi:10.1038/nrm.2017.73 Heat shock transcription factors (HSFs) regulate heat shock proteins in conditions of thermal stress, but they also control gene expression in other stress conditions, as well as in other contexts, including the regulation of cell proliferation and energy metabolism. HSFs are misregulated in various diseases, such as cancer and neurodegeneration, which underlines their important physiological roles. Abstract | Full Text | PDF | Supplementary information
Article series: Translation and protein quality control Codon optimality, bias and usage in translation and mRNA decay Gavin Hanson & Jeff Coller p20 | doi:10.1038/nrm.2017.91 The uneven use of the synonymous amino acid codons in the transcriptome coupled with the relative concentrations of different tRNA species gives rise to non-uniform codon decoding rates by ribosomes, known as codon optimality. Codon optimality influences translation efficiency and fidelity, protein folding and mRNA decay. Abstract | Full Text | PDF
Article series: Metabolic signalling Biochemical and cellular properties of insulin receptor signalling Rebecca A. Haeusler, Timothy E. McGraw & Domenico Accili p31 | doi:10.1038/nrm.2017.89 Research over the past few decades has elucidated the biochemical mechanisms underlying insulin receptor signalling. Recent insights into the complexity of its temporal and tissue-specific regulation, which involves various combinations of signalling modules in different cell types, are shedding light on the pleiotropic effects of insulin action and the pathogenesis of insulin resistance. Abstract | Full Text | PDF
Article series: RNA processing and modifications The emerging complexity of the tRNA world: mammalian tRNAs beyond protein synthesis Paul Schimmel p45 | doi:10.1038/nrm.2017.77 tRNAs exist as diverse species, including sequence isoforms and nuclease-generated fragments, which are further functionally diversified by base modifications and various protein interactions. Perhaps unsurprisingly, tRNAs are now being implicated in various cellular processes beyond protein synthesis per se, including in stress responses, proliferation, cell fate determination and tumorigenesis. Abstract | Full Text | PDF | Supplementary information
Article series: Post-translational modifications Ubiquitylation at the crossroads of development and disease Michael Rape p59 | doi:10.1038/nrm.2017.83 Ubiquitylation is a post-translational modification that modulates protein stability and regulates various cellular signalling pathways and cellular processes, including cell differentiation, proliferation and migration. Recent insights highlight its crucial role in development and how its deregulation is associated with several diseases. Abstract | Full Text | PDF
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