Nature Reviews Immunology Contents January 2018 Volume 18 Number 1 pp 1-78

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TABLE OF CONTENTS
January 2018 Volume 18 Number 1		Advertisement
2016 2-year Impact Factor 39.932 Journal Metrics 2-year Median 29	In this issue Research Highlights Reviews Correspondence   Also this month  Featured article: Single-cell RNA sequencing to explore immune cell heterogeneity Efthymia Papalexi & Rahul Satija	npj Vaccines is an online-only, open access, multidisciplinary journal dedicated to publishing cutting-edge research and development on human and veterinary vaccines. npj Vaccines is now open for submissions.   Explore the benefits of submitting your next manuscript to the journal.
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RESEARCH HIGHLIGHTS   Top Chemokines: Moving on up p1 | doi:10.1038/nri.2017.137 Chemotaxis of myeloid cells in response to CCL19 and CXCL12 involves temporal sensing of an increasing source concentration of chemokine. PDF Plasmacytoid dendritic cells: Division of labour p2 | doi:10.1038/nri.2017.153 Plasmacytoid dendritic cells diversify in response to a single stimulus. PDF Innate immunity: Revealing the secrets of IL-1 secretion p2 | doi:10.1038/nri.2017.155 IL-1 is released from living macrophages by gasdermin D pore formation. PDF Innate immunity: Platelets on the prowl p3 | doi:10.1038/nri.2017.147 Platelets actively migrate at inflamed sites and can collect and bundle bacteria and promote neutrophil activation. PDF JOURNAL CLUB ITIMs: episode 1 of the inhibitory saga p4 | doi:10.1038/nri.2017.134 Eric Vivier recounts how the initial description of the ITIM motif in FcγRIIB helped to launch the field of inhibitory immune receptors. PDF Inflammasome: Looking death in the eye p4 | doi:10.1038/nri.2017.154 Death of the retinal epithelium in age-related macular degeneration involves cGAS-dependent noncanonical inflammasome activation. PDF   Nature Reviews Immunology JOBS of the week Assistant or Associate Professor of Medicine, Canada Research Chair Tier 2 McGill University - Department of Medicine Assistant Professor of Nutritional Sciences University of Florida Postdoctoral Postion - The University of Pittsburgh School of Medicine University of Pittsbugh, School of Medicine Institute of Metabolism and Diseases,Shanghai General Hospital Shanghai General Hospital More Science jobs from Nature Reviews Immunology EVENT Advanced Course in Basic & Clinical Immunology 18.02.18 Scottsdale, USA More science events from
REVIEWS		Top
Complement in cancer: untangling an intricate relationship Edimara S. Reis et al. p5 | doi:10.1038/nri.2017.97 This Review focuses on how the complement cascade can both promote and inhibit antitumour immune responses. The authors discuss the potential of targeting complement components for immunotherapeutic purposes in patients with cancer. Abstract | Full Text | PDF
The spectrum of T cell metabolism in health and disease Glenn R. Bantug, Lorenzo Galluzzi, Guido Kroemer & Christoph Hess p19 | doi:10.1038/nri.2017.99 Here, the authors introduce the idea that a spectrum of metabolic states of immune cells can provide a basis for categorizing human diseases. They explore the metabolic and interlinked signalling requirements of T cells responding to acute infection and how metabolic reprogramming of T cells is linked to disease. Abstract | Full Text | PDF
Single-cell RNA sequencing to explore immune cell heterogeneity Efthymia Papalexi & Rahul Satija p35 | doi:10.1038/nri.2017.76 New technologies that enable the profiling of single cells using next-generation sequencing offer an unbiased approach for studying immune cell diversity. Abstract | Full Text | PDF
Beyond binding: antibody effector functions in infectious diseases Lenette L. Lu, Todd J. Suscovich, Sarah M. Fortune & Galit Alter p46 | doi:10.1038/nri.2017.106 Antibodies play an essential role in host defence against pathogens by binding to microorganisms and infected cells and exerting various effector functions. In this Review, Lu and colleagues summarize antibody isotypes and subclasses, modifications, receptor binding and signalling and effector functions in the context of infectious diseases. Abstract | Full Text | PDF
Type 2 immunity in tissue repair and fibrosis Richard L. Gieseck, III, Mark S. Wilson & Thomas A. Wynn p62 | doi:10.1038/nri.2017.90 In this Review, the authors describe how type 2 immune responses drive tissue repair and fibrosis. They explain how these responses are crucial for repairing damaged tissue but can also lead to pathological outcomes if not properly regulated. Abstract | Full Text | PDF
CORRESPONDENCE		Top
Correspondence: Science not art: statistically sound methods for identifying subsets in multi-dimensional flow and mass cytometry data sets Darya Y. Orlova, Leonore A. Herzenberg & Guenther Walther p77 | doi:10.1038/nri.2017.150 Full Text | PDF
Reply: Response to Orlova et al. "Science not art: statistically sound methods for identifying subsets in multi-dimensional flow and mass cytometry data sets" Yvan Saeys, Sofie Van Gassen & Bart Lambrecht p78 | doi:10.1038/nri.2017.151 Full Text | PDF
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