Nature Reviews Genetics Contents January 2018 Volume 19 Number 1 pp 1-62

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TABLE OF CONTENTS
January 2018 Volume 19 Number 1
2016 2-year Impact Factor 40.282 Journal Metrics 2-year Median 28.5	In this issue Editorial Research Highlights Reviews Analysis   Also this month Article series: Applications of next-generation sequencing  Featured article: Towards a genomics-informed, real-time, global pathogen surveillance system Jennifer L. Gardy & Nicholas J. Loman
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Genomics of Rare Disease (26-28 March 2018)  This meeting will explore how cutting-edge genomic research translates into clinical care and informs our understanding of the biology of rare disease. Deadlines: Early Bird - 4 Jan/ Bursaries - 16 Jan/ Abstracts - 30 Jan/ Registration - 27 Feb
EDITORIAL		Top
Putting gene essentiality into context p1 | doi:10.1038/nrg.2017.141 Full Text | PDF
RESEARCH HIGHLIGHTS   Top Pathogen genomics: Genomics in the time of cholera p3 | doi:10.1038/nrg.2017.105 PDF Transcription: Shedding light on alternative promoter selection p4 | doi:10.1038/nrg.2017.100 PDF Stem cells: Regenerating the skin of a young patient p4 | doi:10.1038/nrg.2017.106 PDF Transcription: Putting R loops firmly on the map p5 | doi:10.1038/nrg.2017.98 PDF Synthetic biology: Multiplex genome engineering in eukaryotes p6 | doi:10.1038/nrg.2017.103 PDF Functional genomics: Shining a light on genetic screen strategies p6 | doi:10.1038/nrg.2017.99 PDF Gene expression: SPOTting single RNA molecules transcriptome-wide p7 | doi:10.1038/nrg.2017.107 PDF
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40 years of Sanger DNA sequencing  Research and Commentary reflecting on the evolution and future of Sanger DNA sequencing  Access the Collection online >>
REVIEWS		Top
Article series: Applications of next-generation sequencing Towards a genomics-informed, real-time, global pathogen surveillance system Jennifer L. Gardy & Nicholas J. Loman p9 | doi:10.1038/nrg.2017.88 Next-generation sequencing has the potential to support public health surveillance systems to improve the early detection of emerging infectious diseases. This Review delineates the role of genomics in rapid outbreak response and the challenges that need to be tackled for genomics-informed pathogen surveillance to become a global reality. Abstract | Full Text | PDF
Navigating complexity to breed disease-resistant crops Rebecca Nelson, Tyr Wiesner-Hanks, Randall Wisser & Peter Balint-Kurti p21 | doi:10.1038/nrg.2017.82 Disease-resistant crops have the potential to reduce crop losses. This Review discusses how advances in genetic and genomic technologies are contributing to efforts by plant breeders to generate durable, broad-spectrum disease resistance in crop plants. Abstract | Full Text | PDF | Supplementary information
Emerging and evolving concepts in gene essentiality Giulia Rancati, Jason Moffat, Athanasios Typas & Norman Pavelka p34 | doi:10.1038/nrg.2017.74 Identifying which genes in a genome are essential for survival has been a long-standing goal of geneticists. This Review discusses our evolving understanding of cellular gene essentiality across diverse organisms. It describes how essentiality is often non-absolute but is instead dependent on the environment or genetic background and how this knowledge can be exploited therapeutically. Abstract | Full Text | PDF | Supplementary information
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GTEx Collection  Nature Research is pleased to present this Collection of Commentary, News and Research from across the Nature journals for the second phase of the GTEx project.  Access the Collection online >>
ANALYSIS		Top
Human gene essentiality Istvan Bartha, Julia di Iulio, J. Craig Venter & Amalio Telenti p51 | doi:10.1038/nrg.2017.75 Characterizing the essentiality of human genes provides insights into gene function and genome evolution and facilitates the clinical interpretation of genetic variants. This article analyses essentiality metrics based on the statistical intolerance to loss-of-function mutations in human population sequencing studies and discusses commonalities and distinctions relative to data sets from knockout mice and functional genomics screens in human cell culture. Implications for disease genetics and extrapolation to non-coding regions are also discussed. Abstract | Full Text | PDF | Supplementary information
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