Nature Immunology Contents: January 2018 Volume 19 Issue 1

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The journal is part of the Nature Partner Journals series and published in partnership with The Hormel Institute, University of Minnesota.    Explore the benefits of submitting your manuscript TABLE OF CONTENTS January 2018 Volume 19, Issue 1 Research Highlights News & Views Review Articles Articles Advertisement Open for Submissions  Online-only and open access, npj Primary Care Respiratory Medicine is the only fully-indexed scientific journal devoted to the management of respiratory diseases in primary care.   Explore the benefits of submitting your next research article.   Research Highlights Scoring presentation    p1 Ioana Visan doi:10.1038/s41590-017-0015-9 Silent clearance    p1 Ioana Visan doi:10.1038/s41590-017-0016-8 Microbiota & cancer response    p1 Laurie A Dempsey doi:10.1038/s41590-017-0017-7 STAT5B in RICD    p1 Laurie A Dempsey doi:10.1038/s41590-017-0018-6 Assaulting the microbiota    p1 Zoltan Fehervari doi:10.1038/s41590-017-0020-z News & Views Hyperactivated mitophagy in hematopoietic stem cells    pp2 - 3 Chong Yang & Toshio Suda doi:10.1038/s41590-017-0008-8 Self-RNA sentinels signal viral invasion    pp4 - 5 Andrew G. Bowie doi:10.1038/s41590-017-0010-1 Another way to not get eaten    pp6 - 7 Cheng Cheng Zhang & Yang-Xin Fu doi:10.1038/s41590-017-0009-7 Decoding the intestinal epithelium cell by cell    pp7 - 9 Yujung Michelle Lee & Janelle S. Ayres doi:10.1038/s41590-017-0011-0 Immunology JOBS of the week Assistant or Associate Professor of Medicine, Canada Research Chair Tier 2 McGill University - Department of Medicine Assistant Professor of Nutritional Sciences University of Florida Postdoctoral Postion - The University of Pittsburgh School of Medicine University of Pittsbugh, School of Medicine Institute of Metabolism and Diseases,Shanghai General Hospital Shanghai General Hospital More Science jobs from Immunology EVENT Advanced Course in Basic & Clinical Immunology 18.02.18 Scottsdale, USA More science events from Review Articles The twilight of immunity: emerging concepts in aging of the immune system    pp10 - 19 Janko Nikolich-ŽŽugich doi:10.1038/s41590-017-0006-x Nikolich-ŽŽugich reviews recent developments in our understanding of age-related changes affecting key components of immunity Emerging viral diseases from a vaccinology perspective: preparing for the next pandemic    pp20 - 28 Barney S. Graham & Nancy J. Sullivan doi:10.1038/s41590-017-0007-9 Emerging viral diseases present a huge and increasingly important global threat to public health systems. Graham and Sullivan discuss the challenges presented by emerging viral diseases and discuss how innovations in technology and policy can address this threat. Advertisement NEW! Michelson Prizes for Human Immunology and Vaccine Research for Young Investigators Two Prizes of $150,000 Pre-Application Deadline: February 12, 2018  APPLY NOW   Articles Atad3a suppresses Pink1-dependent mitophagy to maintain homeostasis of hematopoietic progenitor cells    pp29 - 40 Guoxiang Jin, Chuan Xu, Xian Zhang, Jie Long, Abdol Hossein Rezaeian et al. doi:10.1038/s41590-017-0002-1 The survival of hematopoietic stem cells requires tight regulation of mitophagy. Lin and colleagues show that Atad3a regulates mitophagy in these cells by sequestering the mitophagy initiator Pink1 and directing its import via the mitochondrial Tom40-–Tim23 complex. Nuclear RNF2 inhibits interferon function by promoting K33-linked STAT1 disassociation from DNA    pp41 - 52 Shuo Liu, Minghong Jiang, Wendie Wang, Wei Liu, Xiaoqi Song et al. doi:10.1038/s41590-017-0003-0 Cao and colleagues identify the E3 ubiquitin ligase RNF2 as an inhibitor of interferon-dependent antiviral responses that acts by promoting the K33-linked polyubiquitination of STAT1 and its disassociation from DNA. Viral unmasking of cellular 5S rRNA pseudogene transcripts induces RIG-I-mediated immunity    pp53 - 62 Jessica J. Chiang, Konstantin M. J. Sparrer, Michiel van Gent, Charlotte Lässig, Teng Huang et al. doi:10.1038/s41590-017-0005-y RIG-I is a cytosolic RNA sensor. Gack and colleagues show that herpesviruses, duplex DNA viruses, also activate RIG-I by inducing cytoplasmic translocation and unmasking of an endogenous host 5S ribosomal pseudogene RNA, RNA5SP141. Diversification of human plasmacytoid predendritic cells in response to a single stimulus    pp63 - 75 Solana G. Alculumbre, Violaine Saint-André, Jeremy Di Domizio, Pablo Vargas, Philemon Sirven et al. doi:10.1038/s41590-017-0012-z Plasmacytoid dendritic cells (pDCs) are known for their copious IFN-I production. Soumelis and colleagues show that functionally and transcriptomically distinct human pDC populations can be generated from a single microbial or cytokine stimulus. Engagement of MHC class I by the inhibitory receptor LILRB1 suppresses macrophages and is a target of cancer immunotherapy    pp76 - 84 Amira A. Barkal, Kipp Weiskopf, Kevin S. Kao, Sydney R. Gordon, Benyamin Rosental et al. doi:10.1038/s41590-017-0004-z Host cells display 'don't eat me' signals to protect themselves from phagocytosis. Maute and colleagues identify a novel 'don't eat me' system based on recognition of MHC class I by the phagocyte-expressed inhibitory molecule LILRB1. Single-cell analysis reveals the continuum of human lympho-myeloid progenitor cells    pp85 - 97 Dimitris Karamitros, Bilyana Stoilova, Zahra Aboukhalil, Fiona Hamey, Andreas Reinisch et al. doi:10.1038/s41590-017-0001-2 Vyas and colleagues show that a continuum of hemopoietic progenitor cells from human cord blood execute lymphoid and myeloid differentiation. Advertisement Nature Reviews Disease Primers — Stay updated  Nature Reviews Disease Primers covers all medical specialties, already having published on more than 120 diseases and disorders since launching in 2015. With such a comprehensive article collection, our e-alerts are the perfect solution to stay updated on the latest content published by the journal.  Register for the e-alert   Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. 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