| | Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity
Amyloid-β peptide proteopathies disrupt mitochondria, and restoring mitochondrial proteostasis reduces protein aggregation in animal models of amyloid-β disease.
Vincenzo Sorrentino, Mario Romani, Laurent Mouchiroud et al. | Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4
Disulfiram is metabolized into copper–diethyldithiocarbamate, which binds to NPL4 and induces its aggregation in cells, leading to blockade of the p97–NPL4–UFD1 pathway and induction of a complex cellular phenotype that results in cell death.
Zdenek Skrott, Martin Mistrik, Klaus Kaae Andersen et al. | Electron cryo-microscopy structure of a human TRPM4 channel
The structure of the Ca2+-activated, non-selective ion channel TRPM4 bound to the agonist Ca2+ and a modulator decavanadate, solved using electron cryo-microscopy.
Paige A. Winkler, Yihe Huang, Weinan Sun et al. | Structures of the calcium-activated, non-selective cation channel TRPM4
Electron cryo-microscopy structures of mouse TRPM4, a calcium-activated, non-selective cation channel, in the apo and ATP-bound states.
Jiangtao Guo, Ji She, Weizhong Zeng et al. | | Magnetically gated accretion in an accreting ‘non-magnetic’ white dwarf
A weak magnetic field regulates magnetically gated accretion of gas from a companion star onto the white dwarf in the binary system MV Lyrae, previously labelled as a ‘non-magnetic’ system.
S. Scaringi, T. J. Maccarone, C. D’Angelo et al. | An electric-eel-inspired soft power source from stacked hydrogels
Miniature hydrogel compartments in scalable stacked and folded geometries were used to prepare a contact-activated artificial electric organ.
Thomas B. H. Schroeder, Anirvan Guha, Aaron Lamoureux et al. | Force loading explains spatial sensing of ligands by cells
The formation of cellular adhesion complexes is important in normal and pathological cell activity, and is determined by the force imposed by the combined effect of the distribution of extracellular matrix molecules and substrate rigidity.
Roger Oria, Tina Wiegand, Jorge Escribano et al. | Initiation and long-term instability of the East Antarctic Ice Sheet
Geophysical and geological data reveal increased ice-sheet variability and surface meltwater—possibly analogous to future conditions—offshore of the Aurora subglacial basin of East Antarctica during warm climate intervals of the past 50 million years.
Sean P. S. Gulick, Amelia E. Shevenell, Aleksandr Montelli et al. | Large emissions from floodplain trees close the Amazon methane budget
Methane fluxes from the stems of Amazonian floodplain trees indicate that the escape of soil gas through wetland trees is the dominant source of methane emissions in the Amazon basin.
Sunitha R. Pangala, Alex Enrich-Prast, Luana S. Basso et al. | A compositional tipping point governing the mobilization and eruption style of rhyolitic magma
Measurements of the composition-dependent viscosity of rhyolitic magma reveal a tipping point that changes the physical properties of the melt and controls the transition between effusive and explosive eruptions.
D. Di Genova, S. Kolzenburg, S. Wiesmaier et al. | Pluripotent state transitions coordinate morphogenesis in mouse and human embryos
Exit of epiblasts from an unrestricted naive pluripotent state is required for epithelialization and generation of the pro-amniotic cavity in mouse embryos and for amniotic cavity formation in human embryos and human embryonic stem cells.
Marta N. Shahbazi, Antonio Scialdone, Natalia Skorupska et al. | Moving beyond microbiome-wide associations to causal microbe identification
Triangulation of microbe–phenotype relationships is an effective method for reducing the noise inherent in microbiota studies and enabling identification of causal microbes of disease, which may be applicable to human microbiome studies.
Neeraj K. Surana, Dennis L. Kasper | Inhibition of soluble epoxide hydrolase prevents diabetic retinopathy
A product of the soluble epoxide hydrolase enzyme, 19,20-dihydroxydocosapentaenoic acid (19,20-DHDP), is implicated in the pathogenesis of diabetic retinopathy; levels of 19,20-DHDP increase in the retinas of mice and humans with diabetes, and inhibition of its production can rescue vascular abnormalities in a mouse model of the disease.
Jiong Hu, Sarah Dziumbla, Jihong Lin et al. | Runx3 programs CD8+ T cell residency in non-lymphoid tissues and tumours
The transcription factor Runx3 is identified as a central regulator of the development of tissue-resident memory CD8+ T cells, providing insights into the signals that promote T cell residency in non-lymphoid tissues and tumours.
J. Justin Milner, Clara Toma, Bingfei Yu et al. | A non-canonical Notch complex regulates adherens junctions and vascular barrier function
The transmembrane domain of NOTCH1 plays a key role in the assembly of adherens junctions and the non-transcriptional regulation of vascular permeability that links transcriptional programs with adhesive and cytoskeletal remodelling.
William J. Polacheck, Matthew L. Kutys, Jinling Yang et al. | RNA polymerase III limits longevity downstream of TORC1
RNA polymerase III is a key evolutionarily conserved regulator of longevity that may have potential as a therapeutic target for age-related conditions.
Danny Filer, Maximillian A. Thompson, Vakil Takhaveev et al. | piRNA-mediated regulation of transposon alternative splicing in the soma and germ line
A new mechanism of pre-mRNA splicing regulation is revealed that is mediated by piRNA pathway components and is dependent on heterochromatin histone modifications.
Felipe Karam Teixeira, Martyna Okuniewska, Colin D. Malone et al. | KAT2A coupled with the α-KGDH complex acts as a histone H3 succinyltransferase
The histone acetyl transferase KAT2A (also known as GCN5) can also catalyse histone succinylation, with the α-KGDH complex providing a local source of succinyl-CoA.
Yugang Wang, Yusong R. Guo, Ke Liu et al. | | | | |
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