Nature Communications -20 December 2017

Weekly Content Alert Nature Communications is fully open access. Read more. 20 December 2017  Latest content: Articles Advertisement Nature Outlook: Fatty liver disease    The worldwide rise in obesity and diabetes has led to a spike in non-alcoholic fatty liver disease, which often progresses to the more severe non-alcoholic steatohepatitis. This Outlook discusses diagnostic techniques and therapies.   Access the Outlook free online >>    Produced with support from: Gilead Sciences  Journal homepage Recommend to library Web feed     Latest Articles View all Articles     Impact of grain boundaries on efficiency and stability of organic-inorganic trihalide perovskites OPEN Zhaodong Chu, Mengjin Yang, Philip Schulz, Di Wu, Xin Ma, Edward Seifert, Liuyang Sun, Xiaoqin Li, Kai Zhu & Keji Lai Probing the nanoscale photoconductivity of methylammonium lead triiodide is important for understanding the microstructures of the solar cell devices, but scanning probe methods suffer from sample degradation. Here Chu et al. solve the problem with noncontact microwave impedance microscopy. 20 December 2017 | doi: 10.1038/s41467-017-02331-4 Electronic properties and materials  Organic–inorganic nanostructures  Solar cells  Dynamic intramolecular regulation of the histone chaperone nucleoplasmin controls histone binding and release OPEN Christopher Warren, Tsutomu Matsui, Jerome M. Karp, Takashi Onikubo, Sean Cahill, Michael Brenowitz, David Cowburn, Mark Girvin & David Shechter The histone chaperone nucleoplasmin (Npm) stores histones H2A/H2B in the egg and embryo. Here, the authors use NMR to show that Npm’s intrinsically disordered tail domain controls histone binding at an acidic stretch, which is autoregulated through direct competition with its basic C-terminus. 20 December 2017 | doi: 10.1038/s41467-017-02308-3 Biochemistry  Chromatin  SAXS  Solution-state NMR  Broadband impedance match to two-dimensional materials in the terahertz domain OPEN Phi H. Q. Pham, Weidong Zhang, Nhi V. Quach, Jinfeng Li, Weiwei Zhou, Dominic Scarmardo, Elliott R. Brown & Peter J. Burke Efficient coupling of an electromagnetic wave to a thin conductor relies on the sheet conductance of the given material. Here, the authors demonstrate that engineering the monolayer graphene sheet resistance enables electrical or chemical tuning from the transmission to the absorption regime up to THz frequencies. 20 December 2017 | doi: 10.1038/s41467-017-02336-z Electronic properties and materials  Two-dimensional materials  Fundamental interplay between anionic/cationic redox governing the kinetics and thermodynamics of lithium-rich cathodes OPEN Gaurav Assat, Dominique Foix, Charles Delacourt, Antonella Iadecola, Rémi Dedryvère & Jean-Marie Tarascon Anionic redox chemistry has enabled the design of high-capacity battery cathodes for energy storage. Here, the authors demonstrate reversible anionic redox in an archetypical lithium-rich oxide via bulk-sensitive spectroscopies, further revealing its crucial role in practically important properties. 20 December 2017 | doi: 10.1038/s41467-017-02291-9 Batteries  Materials for energy and catalysis  Inter-annual and decadal changes in teleconnections drive continental-scale synchronization of tree reproduction OPEN Davide Ascoli, Giorgio Vacchiano, Marco Turco, Marco Conedera, Igor Drobyshev, Janet Maringer, Renzo Motta & Andrew Hacket-Pain Climate oscillations affect weather on different temporal-spatial scales, which poses difficulty in understanding how they influence tree reproduction. Here Ascoli et al. show relationships between low- and high-frequency components of the NAO and masting in two European tree species across multiple decades. 20 December 2017 | doi: 10.1038/s41467-017-02348-9 Atmospheric dynamics  Evolutionary ecology  Forest ecology  Phenology  Engineering cell sensing and responses using a GPCR-coupled CRISPR-Cas system OPEN Nathan H. Kipniss, P. C. Dave P. Dingal, Timothy R. Abbott, Yuchen Gao, Haifeng Wang, Antonia A. Dominguez, Louai Labanieh & Lei S. Qi G-protein-coupled receptors are a large and diverse group of eukaryotic membrane receptors. Here the authors couple GPCRs to dCas9 to link extracellular sensing to genome regulation. 20 December 2017 | doi: 10.1038/s41467-017-02075-1 CRISPR-Cas9 genome editing  Genetic engineering  Protein design  Synthetic biology  Supervised learning in spiking neural networks with FORCE training OPEN Wilten Nicola & Claudia Clopath FORCE training is a . Here the authors implement FORCE training in models of spiking neuronal networks and demonstrate that these networks can be trained to exhibit different dynamic behaviours. 20 December 2017 | doi: 10.1038/s41467-017-01827-3 Dynamical systems  Learning algorithms  Network models  Neural encoding  Morphology of travel routes and the organization of cities OPEN Minjin Lee, Hugo Barbosa, Hyejin Youn, Petter Holme & Gourab Ghoshal Complex networks are a useful tool to investigate the structure of cities and their street networks. Here the authors investigate the shape of travel routes in 92 cities and define a metric called inness which reveals connections between common urban features in cities with similar inness profiles. 20 December 2017 | doi: 10.1038/s41467-017-02374-7 Complex networks  Geography  NAIP/NLRC4 inflammasome activation in MRP8+ cells is sufficient to cause systemic inflammatory disease OPEN Randilea D. Nichols, Jakob von Moltke & Russell E. Vance Inflammasomes are protein complexes induced by pathogens for the secretion of pro-inflammatory cytokines IL-1β and IL-18 in immune cells. Here the authors show, using a new mouse model, that aberrant NLRC4 and ASC-dependent inflammasome activation in neutrophils contributes to systemic inflammation. 20 December 2017 | doi: 10.1038/s41467-017-02266-w Autoimmunity  Inflammasome  Neutrophils  Signal transduction  The sigma-1 receptor modulates methamphetamine dysregulation of dopamine neurotransmission OPEN Danielle O. Sambo, Min Lin, Anthony Owens, Joseph J. Lebowitz, Ben Richardson, Darin A. Jagnarine, Madhur Shetty, Meghan Rodriquez, Taiwo Alonge, Mishaal Ali, Jonathan Katz, Long Yan, Marcelo Febo, L. Keith Henry, Adriaan W. Bruijnzeel, Lynette Daws & Habibeh Khoshbouei The dopamine transporter (DAT), a regulator of dopamine homeostasis in the brain, and sigma-1 receptor (σ1R), an endoplasmic reticulum membrane protein, are both implicated in drug addiction. In this work, the authors investigate how σ1R modulates DAT response to methamphetamine. 20 December 2017 | doi: 10.1038/s41467-017-02087-x Addiction  Cell biology  Molecular biology  Transporters in the nervous system  A two-dimensional ON/OFF switching device based on anisotropic interactions of atomic quantum dots on Si(100):H OPEN Mayssa Yengui, Eric Duverger, Philippe Sonnet & Damien Riedel Using scanning tunnelling microscopes to manipulate atomic quantum dots at surfaces enables the creation of devices using inter-dot interactions. Here the authors demonstrate the design and operation of nanoscale ON/OFF switches by arranging four silicon dangling bonds. 20 December 2017 | doi: 10.1038/s41467-017-02377-4 Electronic devices  Quantum dots  Transient two-dimensional vibrational spectroscopy of an operating molecular machine OPEN Matthijs R. Panman, Chris N. van Dijk, Adriana Huerta-Viga, Hans J. Sanders, Bert H. Bakker, David A. Leigh, Albert M. Brouwer, Wybren Jan Buma & Sander Woutersen A deeper understanding of the mechanics of molecular machines is limited by the fast motions which are in the nanosecond or picosecond timescale. Here the authors present a real-time observation of structural changes in a rotaxane-based molecular shuttle by transient two-dimensional infrared spectroscopy. 20 December 2017 | doi: 10.1038/s41467-017-02278-6 Chemical physics  Infrared spectroscopy  Interlocked molecules  Contributions of changes in climatology and perturbation and the resulting nonlinearity to regional climate change OPEN Sachiho A. Adachi, Seiya Nishizawa, Ryuji Yoshida, Tsuyoshi Yamaura, Kazuto Ando, Hisashi Yashiro, Yoshiyuki Kajikawa & Hirofumi Tomita Changes in climatology and perturbation will lead to different impacts on regional climate change, but their effect remains a subject of debate. Here the authors develop a new downscaling procedure that reveals the importance of both changes on the regional climate and examines their nonlinear effect. 20 December 2017 | doi: 10.1038/s41467-017-02360-z Climate and Earth system modelling  Hydrology  Projection and prediction  Midbrain circuit regulation of individual alcohol drinking behaviors in mice OPEN Barbara Juarez, Carole Morel, Stacy M. Ku, Yutong Liu, Hongxing Zhang, Sarah Montgomery, Hilledna Gregoire, Efrain Ribeiro, Marshall Crumiller, Ciorana Roman-Ortiz, Jessica J. Walsh, Kelcy Jackson, Denise E. Croote, Yingbo Zhu, Song Zhang, Leandro F. Vendruscolo, Scott Edward, Amanda Roberts, Georgia E. Hodes, Yongke Lu et al. Mice exposed to a two-bottle alcohol choice paradigm can be divided into high and low drinking groups. Here, the authors show that stimulating VTA neurons to induce higher phasic activity patterns that are observed in low alcohol drinking mice, suppresses alcohol drinking in mice that are high alcohol drinking. 20 December 2017 | doi: 10.1038/s41467-017-02365-8 Addiction  Intrinsic excitability  Neural circuits  Whole proteome analysis of human tankyrase knockout cells reveals targets of tankyrase-mediated degradation OPEN Amit Bhardwaj, Yanling Yang, Beatrix Ueberheide & Susan Smith Tankyrase 1 and 2 are poly(ADP-ribose) polymerases that mark proteins for degradation, but there is a current lack of knowledge about their distinct functions and substrates. Here, the authors elucidate the cellular roles and substrates of these polymerases using comparative functional and proteomics analyses of tankyrase knockout cell lines. 20 December 2017 | doi: 10.1038/s41467-017-02363-w PolyADP-ribosylation  Proteasome  Proteomics  The HIV co-receptor CCR5 regulates osteoclast function OPEN Ji-Won Lee, Akiyoshi Hoshino, Kazuki Inoue, Takashi Saitou, Shunsuke Uehara, Yasuhiro Kobayashi, Satoshi Ueha, Kouji Matsushima, Akira Yamaguchi, Yuuki Imai & Tadahiro Iimura CCR5 is a co-receptor for HIV, and loss of function is associated with lower incidence of HIV but also with bone-destructive diseases. Here the authors show that ablation of CCR5 impairs osteoclast function and improves resistance to osteoporosis in mouse models. 20 December 2017 | doi: 10.1038/s41467-017-02368-5 Actin  Osteoporosis  Brd4 binds to active enhancers to control cell identity gene induction in adipogenesis and myogenesis OPEN Ji-Eun Lee, Young-Kwon Park, Sarah Park, Younghoon Jang, Nicholas Waring, Anup Dey, Keiko Ozato, Binbin Lai, Weiqun Peng & Kai Ge Despite being an important cancer drug target, the role of epigenetic reader Brd4 in cell differentiation and development remains unclear. Here, the authors provide evidence that Brd4 plays an important role in adipogenesis and myogenesis by binding to active enhancers to regulate gene expression. 20 December 2017 | doi: 10.1038/s41467-017-02403-5 Differentiation  Epigenetics  Transcription  Bio-inspired reversible underwater adhesive OPEN Yanhua Zhao, Yang Wu, Liang Wang, Manman Zhang, Xuan Chen, Minjie Liu, Jun Fan, Junqiu Liu, Feng Zhou & Zuankai Wang Many industrial applications require switchable adhesive properties in wet conditions, but this still remains challenging to achieve. Here the authors synthesize an adhesive based on host-guest interactions that exhibits reversible, tunable and fast regulation of the wet adhesion on diverse surfaces. 20 December 2017 | doi: 10.1038/s41467-017-02387-2 Bioinspired materials  Mechanical engineering  Wetting  Snail determines the therapeutic response to mTOR kinase inhibitors by transcriptional repression of 4E-BP1 OPEN Jun Wang, Qing Ye, Yanan Cao, Yubin Guo, Xiuping Huang, Wenting Mi, Side Liu, Chi Wang, Hsin-Sheng Yang, Binhua P. Zhou, B. Mark Evers & Qing-Bai She 4E-BP1 is a translational repressor critical in mTOR signaling, whereas Snail is a critical promoter of epithelial to mesenchymal transition. Here the authors show that Snail induces resistance to mTOR inhibitors by repressing 4E-BP1 expression and promoting cell cycle progression via upregulating cycD. 20 December 2017 | doi: 10.1038/s41467-017-02243-3 Cancer therapeutic resistance  Oncogenes  Hydralazine induces stress resistance and extends C. elegans lifespan by activating the NRF2/SKN-1 signalling pathway OPEN Esmaeil Dehghan, Yiqiang Zhang, Bahar Saremi, Sivaramakrishna Yadavali, Amirmansoor Hakimi, Maryam Dehghani, Mohammad Goodarzi, Xiaoqin Tu, Scott Robertson, Rueyling Lin, Asish Chudhuri & Hamid Mirzaei Hydralazine is an FDA approved drug for the treatment of hypertension. Here, Dehghan et al. report that hydralazine triggers the cellular oxidative stress response by activating NRF2/SKN-1 signaling and extends C. elegans healthy lifespan, suggesting hydralazine may have potential to treat age-associated diseases more broadly. 20 December 2017 | doi: 10.1038/s41467-017-02394-3 Ageing  Pharmacodynamics  PCH1 and PCHL promote photomorphogenesis in plants by controlling phytochrome B dark reversion OPEN Beatrix Enderle, David J. Sheerin, Inyup Paik, Praveen Kumar Kathare, Philipp Schwenk, Cornelia Klose, Maximilian H. Ulbrich, Enamul Huq & Andreas Hiltbrunner Dark reversion of the red-light receptor phytochrome B (phyB) converts the receptor to the inactive state. Here, Enderle et al. show that PCH1 and PCHL bind phyB and suppress dark reversion, and that far-red and blue-light induced upregulation of PCH1 and PCHL increases red light sensitivity in Arabidopsis. 20 December 2017 | doi: 10.1038/s41467-017-02311-8 Light responses  Plant signalling  Forest productivity in southwestern Europe is controlled by coupled North Atlantic and Atlantic Multidecadal Oscillations OPEN Jaime Madrigal-González, Juan A. Ballesteros-Cánovas, Asier Herrero, Paloma Ruiz-Benito, Markus Stoffel, Manuel E. Lucas-Borja, Enrique Andivia, Cesar Sancho-García & Miguel A. Zavala The North Atlantic Oscillation (NAO) drives biological responses in terrestrial ecosystems through oscillatory modes of climatic variability. Here, the authors show how landscape scale productivity responses to NAO are contingent upon the Atlantic Multidecadal Oscillation in southwestern Europe. 20 December 2017 | doi: 10.1038/s41467-017-02319-0 Ecosystem ecology  Forest ecology  Transcriptional signatures of schizophrenia in hiPSC-derived NPCs and neurons are concordant with post-mortem adult brains OPEN Gabriel E. Hoffman, Brigham J. Hartley, Erin Flaherty, Ian Ladran, Peter Gochman, Douglas M. Ruderfer, Eli A. Stahl, Judith Rapoport, Pamela Sklar & Kristen J. Brennand Induced pluripotent stem cell (hiPSC)-based models have inherent variations in their cellular and molecular output and readouts. Here, Hoffman and colleagues devise a method to account for gene expression variations in hiPSC-derived neurons from patients with childhood-onset schizophrenia. 20 December 2017 | doi: 10.1038/s41467-017-02330-5 Gene expression  Induced pluripotent stem cells  Neural stem cells  Schizophrenia  Reduced biomass burning emissions reconcile conflicting estimates of the post-2006 atmospheric methane budget OPEN John R. Worden, A. Anthony Bloom, Sudhanshu Pandey, Zhe Jiang, Helen M. Worden, Thomas W. Walker, Sander Houweling & Thomas Röckmann The drivers of the increase in atmospheric methane since 2006 remain unclear. Here, the authors use satellite and in situ measurements of CO and CH4 to show that fossil fuels and biogenic sources contribute 12–19 Tg CH4per year and 12–16 Tg CH4per year respectively to the recent atmospheric methane increase. 20 December 2017 | doi: 10.1038/s41467-017-02246-0 Carbon cycle  Identifying the ubiquitination targets of E6AP by orthogonal ubiquitin transfer OPEN Yiyang Wang, Xianpeng Liu, Li Zhou, Duc Duong, Karan Bhuripanyo, Bo Zhao, Han Zhou, Ruochuan Liu, Yingtao Bi, Hiroaki Kiyokawa & Jun Yin E3 ubiquitin ligases regulate biological functions by ubiquitinating defined substrate proteins but overlapping specificities complicate the identification of E3-substrate relationships. Here, the authors construct an orthogonal UB transfer cascade and identify specific substrates of the E3 enzyme E6AP. 20 December 2017 | doi: 10.1038/s41467-017-01974-7 Protein design  Proteomics  Target identification  Ubiquitylation  Interdependent action of KH domain proteins Krr1 and Dim2 drive the 40S platform assembly OPEN Miriam Sturm, Jingdong Cheng, Jochen Baßler, Roland Beckmann & Ed Hurt The biogenesis of eukaryotic ribosomes involves the coordinated interplay of a large number of assembly factors. Here, the authors detail how the conserved KH domain-containing assembly factors Dim2 and Krr1 function in ordering key events during ribosome maturation. 20 December 2017 | doi: 10.1038/s41467-017-02199-4 Ribosomal proteins  RNA  Polarized actin and VE-cadherin dynamics regulate junctional remodelling and cell migration during sprouting angiogenesis OPEN Jiahui Cao, Manuel Ehling, Sigrid März, Jochen Seebach, Katsiaryna Tarbashevich, Tomas Sixta, Mara E. Pitulescu, Ann-Cathrin Werner, Boris Flach, Eloi Montanez, Erez Raz, Ralf H. Adams & Hans Schnittler The formation of new blood vessels requires both polarized cell migration and coordinated control of endothelial cell contacts. Here, Cao and colleagues describe at the sub-cellular level the cytoskeletal and cell junction dynamics regulating these processes upon VEGF-induced cell elongation. 20 December 2017 | doi: 10.1038/s41467-017-02373-8 Adherens junctions  Angiogenesis  Cell migration  Integrated nano-opto-electro-mechanical sensor for spectrometry and nanometrology OPEN Žarko Zobenica, Rob W. van der Heijden, Maurangelo Petruzzella, Francesco Pagliano, Rick Leijssen, Tian Xia, Leonardo Midolo, Michele Cotrufo, YongJin Cho, Frank W. M. van Otten, Ewold Verhagen & Andrea Fiore Fully integratable spectrometers have trade-offs between size and resolution. Here, the authors present a nano-opto-electro-mechanical system where the functionalities of transduction, actuation and detection are fully integrated, resulting in an ultra-compact high-resolution spectrometer with a micrometer-scale footprint. 20 December 2017 | doi: 10.1038/s41467-017-02392-5 Nanometrology  NEMS  Optical sensors  Optomechanics  Cross-boundary subsidy cascades from oil palm degrade distant tropical forests OPEN Matthew Scott Luskin, Justin S. Brashares, Kalan Ickes, I-Fang Sun, Christine Fletcher, S. Joseph Wright & Matthew D. Potts The expansion of agriculture and rangelands can cause ecological spillover effects across cultivated-natural ecosystem boundaries. Here, Luskin et al. show irruptions of oil palm-subsidized wild boar alter the abundance and diversity of understory trees >1 km into a primary forest reserve in Malaysia. 20 December 2017 | doi: 10.1038/s41467-017-01920-7 Conservation biology  Tropical ecology  Silica-grafted ionic liquids for revealing the respective charging behaviors of cations and anions in supercapacitors OPEN Qingyun Dou, Lingyang Liu, Bingjun Yang, Junwei Lang & Xingbin Yan Quantifying the individual capacitance contributions of in-pore ions during charging remains a challenge. Here the authors design silica-grafted ionic liquids to reveal the charging behaviors of cations and anions separately, providing fresh insight into the storage mechanism of supercapacitors. 19 December 2017 | doi: 10.1038/s41467-017-02152-5 Batteries  Nanoscale evolution of interface morphology during electrodeposition OPEN Nicholas M. Schneider, Jeung Hun Park, Joseph M. Grogan, Daniel A. Steingart, Haim H. Bau & Frances M. Ross Understanding structure evolution during electrochemical growth is crucial in materials processing and design of devices such as batteries. Here, the authors image copper during electrodeposition to provide strategies for controlling interface morphology. 19 December 2017 | doi: 10.1038/s41467-017-02364-9 Batteries  Design, synthesis and processing  Imaging techniques  Surfaces, interfaces and thin films  The interhemispheric CA1 circuit governs rapid generalisation but not fear memory OPEN Heng Zhou, Gui-Jing Xiong, Liang Jing, Ning-Ning Song, De-Lin Pu, Xun Tang, Xiao-Bing He, Fu-Qiang Xu, Jing-Fei Huang, Ling-Jiang Li, Gal Richter-Levin, Rong-Rong Mao, Qi-Xin Zhou, Yu-Qiang Ding & Lin Xu Previous work has documented a slow form of memory generalization although a rapid one is demanded. Here the authors elucidate the role of the interhemispheric CA1-CA1 projection in a form of rapid generalization of contextual fear memory via gradual potentiation of these synapses over 24 h. 19 December 2017 | doi: 10.1038/s41467-017-02315-4 Fear conditioning  Hippocampus  Neural circuits  Nanoscale geochemical and geomechanical characterization of organic matter in shale OPEN Jing Yang, Javin Hatcherian, Paul C. Hackley & Andrew E. Pomerantz Solid organic matter (OM) plays a key role in the production of hydrocarbons in shale formations, yet information on OM heterogeneity at a nanoscale is lacking. Here, the authors use atomic force microscopy-based infrared spectroscopy to document the evolution of individual organic macerals with maturation. 19 December 2017 | doi: 10.1038/s41467-017-02254-0 Characterization and analytical techniques  Geochemistry  Dual blockade of the lipid kinase PIP4Ks and mitotic pathways leads to cancer-selective lethality OPEN Mayumi Kitagawa, Pei-Ju Liao, Kyung Hee Lee, Jasmine Wong, See Cheng Shang, Noriaki Minami, Oltea Sampetrean, Hideyuki Saya, Dai Lingyun, Nayana Prabhu, Go Ka Diam, Radoslaw Sobota, Andreas Larsson, Pär Nordlund, Frank McCormick, Sujoy Ghosh, David M. Epstein, Brian W. Dymock & Sang Hyun Lee The Ras/Raf/MEK/ERK and PI3K/Akt/mTOR signaling pathways are essential for cancer cell survival. Here, the authors describes a molecule a131 with dual-inhibitory properties, which targets PI5P4K and mitosis, and it is involved in Ras/Raf/MEK/ERK and PI3K/Akt/mTOR crosstalk, thereby causing reversible growth arrest in normal cells and cell death of tumor cells. 19 December 2017 | doi: 10.1038/s41467-017-02287-5 Growth factor signalling  Targeted therapies  TOR signalling  Experimental evidence supporting a global melt layer at the base of the Earth’s upper mantle OPEN D. Freitas, G. Manthilake, F. Schiavi, J. Chantel, N. Bolfan-Casanova, M. A. Bouhifd & D. Andrault A 56–60 km thick low velocity layer exists at the base of the Earth’s upper mantle. Here, the authors experimentally reproduced the wadsleyite-to-olivine transition in the upwelling mantle and show that the low velocity anomaly can be explained by melting of hydrous peridotite. 19 December 2017 | doi: 10.1038/s41467-017-02275-9 Geodynamics  Geophysics  Long-term carbon sink in Borneo’s forests halted by drought and vulnerable to edge effects OPEN Lan Qie, Simon L. Lewis, Martin J. P. Sullivan, Gabriela Lopez-Gonzalez, Georgia C. Pickavance, Terry Sunderland, Peter Ashton, Wannes Hubau, Kamariah Abu Salim, Shin-Ichiro Aiba, Lindsay F. Banin, Nicholas Berry, Francis Q. Brearley, David F. R. P. Burslem, Martin Dančák, Stuart J. Davies, Gabriella Fredriksson, Keith C. Hamer, Radim Hédl, Lip Khoon Kho et al. The existence of a pan-tropical forest carbon sink remains uncertain due to the lack of data from Asia. Here, using direct on-the-ground observations, the authors confirm remaining intact forests in Borneo have provided a long-term carbon sink, but carbon net gains are vulnerable to drought and edge effects. 19 December 2017 | doi: 10.1038/s41467-017-01997-0 Climate-change ecology  Climate-change impacts  Forest ecology  Genomic regression analysis of coordinated expression OPEN Ling Cai, Qiwei Li, Yi Du, Jonghyun Yun, Yang Xie, Ralph J. DeBerardinis & Guanghua Xiao Somatic copy number alterations (SCNA) can confound gene co-expression analysis in cancers. Here the authors develop a method to remove the effects of SCNA in co-expression analysis, improving the analysis of network rewiring in cancer, and provide a database with adjusted data from TCGA. 19 December 2017 | doi: 10.1038/s41467-017-02181-0 Cancer genomics  Regulatory networks  Increased ionization supports growth of aerosols into cloud condensation nuclei OPEN H. Svensmark, M. B. Enghoff, N. J. Shaviv & J. Svensmark Ions produced by cosmic rays have been thought to influence aerosol and cloud processes by an unknown mechanism. Here the authors show that the mass flux of ions to aerosols enhances their growth significantly, with implications for the formation of cloud condensation nuclei. 19 December 2017 | doi: 10.1038/s41467-017-02082-2 Atmospheric chemistry  Climate sciences  Physical chemistry  Space physics  Scale-invariant large nonlocality in polycrystalline graphene OPEN Mário Ribeiro, Stephen R. Power, Stephan Roche, Luis E. Hueso & Fèlix Casanova Nonlocal resistances in graphene Hall bars attributed to neutral current Hall effects have been mainly measured at the microscale. Here, the authors observe consistently strong nonlocal signals in Hall bars with channel length ranging from the micrometer up to the millimeter scale, and explain them by field-induced spin-split edge states. 19 December 2017 | doi: 10.1038/s41467-017-02346-x Electronic and spintronic devices  Electronic properties and devices  Quantum Hall  Spintronics  Hippocampal-prefrontal theta-gamma coupling during performance of a spatial working memory task OPEN Makoto Tamura, Timothy J. Spellman, Andrew M. Rosen, Joseph A. Gogos & Joshua A. Gordon Theta- and gamma-frequency oscillatory synchrony correlates with spatial working memory performance. Here the authors report increases in theta-gamma cross-frequency coupling as a compensatory mechism associated with better working memory performance in models of cognitive dysfunction in mice. 19 December 2017 | doi: 10.1038/s41467-017-02108-9 Cognitive control  Neural circuits  Schizophrenia  Spatial memory  Lower plate serpentinite diapirism in the Calabrian Arc subduction complex OPEN A. Polonia, L. Torelli, L. Gasperini, L. Cocchi, F. Muccini, E. Bonatti, C. Hensen, M. Schmidt, S. Romano, A. Artoni & M. Carlini Understanding subduction zone mechanics and resulting volcanism remains challenging. Here, the authors present seismic reflection profiles from the Mediterranean Sea where serpentinite diapirs are present on the external subduction system of the Calabrian Arc and may be linked to recent volcanism at Etna. 19 December 2017 | doi: 10.1038/s41467-017-02273-x Geodynamics  Geophysics  Tectonics  Increased striatal activity in adolescence benefits learning OPEN S. Peters & E. A. Crone Adolescence is associated with negative behaviors that are related to enhanced reward-related striatal activity, but it is unclear whether this activity could also be beneficial. Here, authors report longitudinal data showing that enhanced striatal activity is related with increased learning ability. 19 December 2017 | doi: 10.1038/s41467-017-02174-z Cognitive neuroscience  Learning and memory  Reward  Revealing chiral cell motility by 3D Riesz transform-differential interference contrast microscopy and computational kinematic analysis OPEN Atsushi Tamada & Michihiro Igarashi The lack of an appropriate method has hampered quantitative measurements of cell chirality. Here, the authors combine Riesz transform-differential interference contrast microscopy and computational kinematic analysis to reveal chiral cell motility of neuronal growth cone filopodia and cellular slime mold. 19 December 2017 | doi: 10.1038/s41467-017-02193-w 3-D reconstruction  Amoeboid migration  Filopodia  Morphogenesis  Hyperstretching DNA OPEN Koen Schakenraad, Andreas S. Biebricher, Maarten Sebregts, Brian ten Bensel, Erwin J. G. Peterman, Gijs J. L. Wuite, Iddo Heller, Cornelis Storm & Paul van der Schoot The mechanics and structural transitions of DNA are important to many essential processes inside living cells. Here the authors combine theory and single-molecule experiments to show that intercalator binding stabilises a new structural state of DNA: hyperstretched DNA. 19 December 2017 | doi: 10.1038/s41467-017-02396-1 Computational biophysics  DNA and RNA  Single-molecule biophysics  Reservoir computing using dynamic memristors for temporal information processing OPEN Chao Du, Fuxi Cai, Mohammed A. Zidan, Wen Ma, Seung Hwan Lee & Wei D. Lu Reservoir computing facilitates the projection of temporal input signals onto a high-dimensional feature space via a dynamic system, known as the reservoir. Du et al. realise this concept using metal-oxide-based memristors with short-term memory to perform digit recognition tasks and solve non-linear problems. 19 December 2017 | doi: 10.1038/s41467-017-02337-y Electrical and electronic engineering  Electronic devices  Mutational patterns in chemotherapy resistant muscle-invasive bladder cancer OPEN David Liu, Philip Abbosh, Daniel Keliher, Brendan Reardon, Diana Miao, Kent Mouw, Amaro Weiner-Taylor, Stephanie Wankowicz, Garam Han, Min Yuen Teo, Catharine Cipolla, Jaegil Kim, Gopa Iyer, Hikmat Al-Ahmadie, Essel Dulaimi, David Y. T. Chen, R. Katherine Alpaugh, Jean Hoffman-Censits, Levi A. Garraway, Gad Getz et al. The impact of cisplatin-based chemotherapy on tumor genomes is complex. Here, the authors study matched pre- and post-chemotherapy primary samples in muscle-invasive bladder cancer, finding a cisplatin-based mutational signature, and highlighting the impact of intratumor heterogeneity on survival. 19 December 2017 | doi: 10.1038/s41467-017-02320-7 Bladder cancer  Cancer genomics  Tumour heterogeneity  RAS-pathway mutation patterns define epigenetic subclasses in juvenile myelomonocytic leukemia OPEN Daniel B. Lipka, Tania Witte, Reka Toth, Jing Yang, Manuel Wiesenfarth, Peter Nöllke, Alexandra Fischer, David Brocks, Zuguang Gu, Jeongbin Park, Brigitte Strahm, Marcin Wlodarski, Ayami Yoshimi, Rainer Claus, Michael Lübbert, Hauke Busch, Melanie Boerries, Mark Hartmann, Maximilian Schönung, Umut Kilik et al. Juvenile myelomonocytic leukemia (JMML) is an aggressive disease with limited options for treatment. Here, the authors analyse the DNA methylome and mutational profile of JMML to define three subgroups with unique molecular and clinical characteristics. 19 December 2017 | doi: 10.1038/s41467-017-02177-w Cancer genomics  DNA methylation  Epigenomics  Myeloproliferative disease  Extensive gene content variation in the Brachypodium distachyon pan-genome correlates with population structure OPEN Sean P. Gordon, Bruno Contreras-Moreira, Daniel P. Woods, David L. Des Marais, Diane Burgess, Shengqiang Shu, Christoph Stritt, Anne C. Roulin, Wendy Schackwitz, Ludmila Tyler, Joel Martin, Anna Lipzen, Niklas Dochy, Jeremy Phillips, Kerrie Barry, Koen Geuten, Hikmet Budak, Thomas E. Juenger, Richard Amasino, Ana L. Caicedo et al. The role of differential gene content in the evolution and function of eukaryotic genomes remains poorly explored. Here the authors assemble and annotate the Brachypodium distachyon pan-genome consisting of 54 diverse lines and reveal the differential present genes as a major driver of phenotypic variation. 19 December 2017 | doi: 10.1038/s41467-017-02292-8 Comparative genomics  Plant genetics  Structural variation  Sixteen isostructural phosphonate metal-organic frameworks with controlled Lewis acidity and chemical stability for asymmetric catalysis OPEN Xu Chen, Yongwu Peng, Xing Han, Yan Liu, Xiaochao Lin & Yong Cui Asymmetric synthesis predominantly falls within the realm of homogeneous catalysis. Here, the authors synthesized 16 chiral metal–organic frameworks differing in the nature of the transition metal and demonstrate their excellent stability, catalytic activity and recyclability in a number of enantioselective reactions. 19 December 2017 | doi: 10.1038/s41467-017-02335-0 Asymmetric catalysis  Heterogeneous catalysis  Metal–organic frameworks  Metas-Chip precisely identifies presence of micrometastasis in live biopsy samples by label free approach OPEN Mohammad Saeid Nikshoar, Mohammad Ali Khayamian, Saeid Ansaryan, Hassan Sanati, Milad Gharooni, Leila Farahmand, Farshad Rezakhanloo, Keivan Majidzadeh-A, Parisa Hoseinpour, Shahrzad Dadgari, Leila Kiani-M, Mohammad Saqafi, Masoumeh Gity & Mohammad Abdolahad Detecting metastatic cells in tumor/lymph node samples of breast cancer patients is extremely important for diagnosis. Here the authors develop a microelectronic biochip that detect the presence of invasive/metastatic cells in unprocessed biopsies and performs better than the current gold standards. 19 December 2017 | doi: 10.1038/s41467-017-02184-x Assay systems  Cancer screening  Lab-on-a-chip  Metastasis  Model-free inference of direct network interactions from nonlinear collective dynamics OPEN Jose Casadiego, Mor Nitzan, Sarah Hallerberg & Marc Timme Network dynamical systems can represent the interactions involved in the collective dynamics of gene regulatory networks or metabolic circuits. Here Casadiego et al. present a method for inferring these types of interactions directly from observed time series without relying on their model. 19 December 2017 | doi: 10.1038/s41467-017-02288-4 Complex networks  Machine learning  Network topology  Nonlinear phenomena  Generalized laws of thermodynamics in the presence of correlations OPEN Manabendra N. Bera, Arnau Riera, Maciej Lewenstein & Andreas Winter In presence of inter-system correlations, violations of the laws of thermodynamics become possible. Here, the authors develop a formalism redefining heat, work and thermodynamic laws in terms of quantum conditional entropy, which consistently generalize thermodynamics in correlated scenarios. 19 December 2017 | doi: 10.1038/s41467-017-02370-x Information theory and computation  Quantum information  Theoretical physics  Thermodynamics  A hydrophobic anchor mechanism defines a deacetylase family that suppresses host response against YopJ effectors OPEN Marco Bürger, Björn C. Willige & Joanne Chory A subset of α/β hydrolases is known to suppress the pathogen-triggered hypersensitive response (HR) in plants, but their mechanism of action remains unclear. The authors present two crystal structures and functional analyses of these enzymes, showing that HR is suppressed by a previously unknown family of deacetylases. 19 December 2017 | doi: 10.1038/s41467-017-02347-w Effectors in plant pathology  Enzyme mechanisms  Plant molecular biology  X-ray crystallography  Unravelling the specificity and mechanism of sialic acid recognition by the gut symbiont Ruminococcus gnavus  OPEN C. David Owen, Louise E. Tailford, Serena Monaco, Tanja Šuligoj, Laura Vaux, Romane Lallement, Zahra Khedri, Hai Yu, Karine Lecointe, John Walshaw, Sandra Tribolo, Marc Horrex, Andrew Bell, Xi Chen, Gary L. Taylor, Ajit Varki, Jesus Angulo & Nathalie Juge The mucus layer is an important physical niche within the gut which harbours a distinct microbial community. Here the authors show that specific carbohydrate-binding modules associated with bacterial carbohydrate-active enzymes are mucus adhesins that target regions of the distal colon rich in sialomucins. 19 December 2017 | doi: 10.1038/s41467-017-02109-8 Glycobiology  Lectins  Symbiosis  X-ray crystallography  Allosteric modulation of protein-protein interactions by individual lipid binding events OPEN Xiao Cong, Yang Liu, Wen Liu, Xiaowen Liang & Arthur Laganowsky Native mass spectrometry (MS) is a technique that preserves non-covalent interactions in the mass spectrometer. Here the authors use native MS to study integral membrane proteins, and find that lipids with different headgroups and tails can allosterically modulate protein-protein interactions in different fashions. 19 December 2017 | doi: 10.1038/s41467-017-02397-0 Biophysics  Mass spectrometry  Membrane proteins  Structural biology  Neural computations underpinning the strategic management of influence in advice giving OPEN Uri Hertz, Stefano Palminteri, Silvia Brunetti, Cecilie Olesen, Chris D Frith & Bahador Bahrami Though it's important to influence others' decisions, the neural correlates of persuasive strategies are not known. Here, authors show that people change their advice based on its accuracy and whether they are being listened to, and identify the distinct brain regions underpinning each strategy. 19 December 2017 | doi: 10.1038/s41467-017-02314-5 Cognitive neuroscience  Decision  Motivation  Social neuroscience  Application of optimal band-limited control protocols to quantum noise sensing OPEN V. M. Frey, S. Mavadia, L. M. Norris, W. de Ferranti, D. Lucarelli, L. Viola & M. J. Biercuk Control of qubits’ frequency response by dynamical decoupling is usually vexed by control’s out-of-band harmonics, a problem known in metrology as “spectral leakage”. Here, the authors reduce this problem by orders of magnitude exploiting discrete prolate spheroidal sequences to control a trapped-ion qubit. 19 December 2017 | doi: 10.1038/s41467-017-02298-2 Quantum metrology  Qubits  Sensors  Systematic screening of generic drugs for progressive multiple sclerosis identifies clomipramine as a promising therapeutic OPEN Simon Faissner, Manoj Mishra, Deepak K. Kaushik, Jianxiong Wang, Yan Fan, Claudia Silva, Gail Rauw, Luanne Metz, Marcus Koch & V. Wee Yong Progressive multiple sclerosis is an inflammatory and degenerative disease of the central nervous system, for which effective treatment is lacking. The authors carry out a screen to identify orally available generic medications, and show that the antidepressant clomipramine reduces pathology in mouse models. 19 December 2017 | doi: 10.1038/s41467-017-02119-6 High-throughput screening  Multiple sclerosis  Neuroimmunology  Type I interferon-mediated autoinflammation due to DNase II deficiency OPEN Mathieu P. Rodero, Alessandra Tesser, Eva Bartok, Gillian I. Rice, Erika Della Mina, Marine Depp, Benoit Beitz, Vincent Bondet, Nicolas Cagnard, Darragh Duffy, Michael Dussiot, Marie-Louise Frémond, Marco Gattorno, Flavia Guillem, Naoki Kitabayashi, Fabrice Porcheray, Frederic Rieux-Laucat, Luis Seabra, Carolina Uggenti, Stefano Volpi et al. Nucleic acid sensing is important to ensure that an innate immune response is only mounted against microbial nucleic acid. Here, the authors identify loss-of-function mutations in the DNASE2 gene that cause type I interferon-mediated autoinflammation due to enhanced systemic interferon signaling. 19 December 2017 | doi: 10.1038/s41467-017-01932-3 Autoinflammatory syndrome  Disease genetics  Immunogenetics  A circular white-light flare with impulsive and gradual white-light kernels OPEN Q. Hao, K. Yang, X. Cheng, Y. Guo, C. Fang, M. D. Ding, P. F. Chen & Z. Li White-light flares are rare solar events entailing emission in the optical continuum. Here, the authors report a nearly circular white-light flare observed on March 10th 2015 that contains simultaneously both impulsive and gradual white-light kernels. 19 December 2017 | doi: 10.1038/s41467-017-02343-0 High-energy astrophysics  Solar physics  Stars  Catastrophic disassembly of actin filaments via Mical-mediated oxidation OPEN Elena E. Grintsevich, Peng Ge, Michael R. Sawaya, Hunkar Gizem Yesilyurt, Jonathan R. Terman, Z. Hong Zhou & Emil Reisler MICAL Redox enzymes post-translationally modify F-actin to promote its cellular destabilization. Here, the authors present a 3.9Å cryoEM structure of Mical-oxidized F-actin, showing its nucleotide-state dependent dynamic instability and susceptibility to cofilin-induced severing in the presence of inorganic phosphate. 19 December 2017 | doi: 10.1038/s41467-017-02357-8 Cryoelectron microscopy  Cytoskeletal proteins  Post-translational modifications  Genome-wide DNA methylation is predictive of outcome in juvenile myelomonocytic leukemia OPEN Elliot Stieglitz, Tali Mazor, Adam B. Olshen, Huimin Geng, Laura C. Gelston, Jon Akutagawa, Daniel B. Lipka, Christoph Plass, Christian Flotho, Farid F. Chehab, Benjamin S. Braun, Joseph F. Costello & Mignon L. Loh Juvenile myelomonocytic leukemia (JMML) is an aggressive disease with limited options for treatment. Here, the authors utilize DNA methylation based subgroups in JMML to predict clinical outcome. 19 December 2017 | doi: 10.1038/s41467-017-02178-9 Cancer genomics  Myeloproliferative disease  Paediatric cancer  Tumour biomarkers  The evolutionary landscape of chronic lymphocytic leukemia treated with ibrutinib targeted therapy OPEN Dan A. Landau, Clare Sun, Daniel Rosebrock, Sarah E. M. Herman, Joshua Fein, Mariela Sivina, Chingiz Underbayev, Delong Liu, Julia Hoellenriegel, Sarangan Ravichandran, Mohammed Z. H. Farooqui, Wandi Zhang, Carrie Cibulskis, Asaf Zviran, Donna S. Neuberg, Dimitri Livitz, Ivana Bozic, Ignaty Leshchiner, Gad Getz, Jan A. Burger et al. In a subset of patients with chronic lymphocytic leukemia (CLL) treated with targeted agents, such as ibrutinib, drug resistant subclones emerge. Here, the authors report on transcriptional changes in CLL patients treated with ibrutinib and identify early clonal shifts associated with evolution of resistant clones. 19 December 2017 | doi: 10.1038/s41467-017-02329-y Cancer genomics  Evolutionary biology  Dynamic patterns of information flow in complex networks OPEN Uzi Harush & Baruch Barzel Complex networks are a useful tool to investigate spreading processes but topology alone is insufficient to predict information flow. Here the authors propose a measure of information flow and predict its behavior from the interplay between structure and dynamics. 19 December 2017 | doi: 10.1038/s41467-017-01916-3 Complex networks  Statistical physics  In situ inward epitaxial growth of bulk macroporous single crystals OPEN Chenlong Chen, Shujing Sun, Mitch M. C. Chou & Kui Xie Porous single crystals are desirable for optoelectronic applications, but their fabrication remains challenging. Here the authors produce centimetre-sized macroporous GaN single crystals with electron mobility comparable to that of bulk crystals via in situ inward epitaxial growth on parent LiGaO2 crystals. 19 December 2017 | doi: 10.1038/s41467-017-02197-6 Electronic materials  Optical materials  Solid-state chemistry  Oxidative rearrangement of (+)-sesamin by CYP92B14 co-generates twin dietary lignans in sesame OPEN Jun Murata, Eiichiro Ono, Seigo Yoroizuka, Hiromi Toyonaga, Akira Shiraishi, Shoko Mori, Masayuki Tera, Toshiaki Azuma, Atsushi J. Nagano, Masaru Nakayasu, Masaharu Mizutani, Tatsuya Wakasugi, Masayuki P. Yamamoto & Manabu Horikawa Sesame seeds contain phenylpropanoid-derived lignans that are potentially beneficial to human health. Here, the authors clone a cytochrome P450 enzyme that is responsible for the last steps of sesame lignan biosynthesis and show that it acts through a novel oxidative rearrangement mechanism. 18 December 2017 | doi: 10.1038/s41467-017-02053-7 Enzyme mechanisms  Oxidoreductases  Secondary metabolism  Frustration-driven C 4 symmetric order in a naturally-heterostructured superconductor Sr2VO3FeAs OPEN Jong Mok Ok, S.-H. Baek, C. Hoch, R. K. Kremer, S. Y. Park, Sungdae Ji, B. Büchner, J.-H. Park, S. I. Hyun, J. H. Shim, Yunkyu Bang, E. G. Moon, I. I. Mazin & Jun Sung Kim Iron-based superconductors exhibit complex couplings between different electronic degrees of freedom, leading to unusual correlated phases. Ok et al. show that Sr2VO3FeAs develops a hidden order state due to frustrated interactions between the magnetic fluctuations of its SrVO3 and SrFeAs layers. 18 December 2017 | doi: 10.1038/s41467-017-02327-0 Phase transitions and critical phenomena  Superconducting properties and materials  ANGPTL8 negatively regulates NF-κB activation by facilitating selective autophagic degradation of IKKγ OPEN Yu Zhang, Xian Guo, Wanyao Yan, Yan Chen, Mengxiang Ke, Cheng Cheng, Xiuqin Zhu, Weili Xue, Qiaoqiao Zhou, Ling Zheng, Shun Wang, Bin Wu, Xinran Liu, Liang Ma, Lianqi Huang & Kun Huang NF-κB activation mediated by TNFα has a critical role in inflammation; however, the underlying mechanisms await further investigation. Here the authors show that selective autophagy regulates NF-κB activation via an ANGPTL8/p62-IKKγ signaling axis. 18 December 2017 | doi: 10.1038/s41467-017-02355-w Inflammation  Macroautophagy  Nanoparticle conjugates of a highly potent toxin enhance safety and circumvent platinum resistance in ovarian cancer OPEN Ruogu Qi, Yongheng Wang, Peter M. Bruno, Haihua Xiao, Yu Yingjie, Ting Li, Sam Lauffer, Wei Wei, Qixian Chen, Xiang Kang, Haiqin Song, Xi Yang, Xing Huang, Alexandre Detappe, Ursula Matulonis, David Pepin, Michael T. Hemann, Michael J. Birrer & P. Peter Ghoroghchian Improving the safety and efficacy of chemotherapeutics will help to enhance their effects. Here, the authors show that intraperitoneal delivery of nanoparticle conjugates of a potent toxin prolongs tumor inhibition and survival as compared to cisplatin in advanced-stage and platinum-resistant ovarian cancer mouse models. 18 December 2017 | doi: 10.1038/s41467-017-02390-7 Chemotherapy  Nanoparticles  Ovarian cancer  High-resolution adaptive optical imaging within thick scattering media using closed-loop accumulation of single scattering OPEN Sungsam Kang, Pilsung Kang, Seungwon Jeong, Yongwoo Kwon, Taeseok D. Yang, Jin Hee Hong, Moonseok Kim, Kyung–Deok Song, Jin Hyoung Park, Jun Ho Lee, Myoung Joon Kim, Ki Hean Kim & Wonshik Choi Optical imaging deep in biological tissue is difficult due to multiple scattering and specimen induced aberrations of both the incident and reflected light. Here, Kang et al. develop an adaptive closed-loop algorithm to correct tissue aberrations in the presence of multiple scattering for deep tissue imaging. 18 December 2017 | doi: 10.1038/s41467-017-02117-8 Imaging and sensing  Interference microscopy  Optical imaging  A 1-phytase type III effector interferes with plant hormone signaling OPEN Doreen Blüher, Debabrata Laha, Sabine Thieme, Alexandre Hofer, Lennart Eschen-Lippold, Antonia Masch, Gerd Balcke, Igor Pavlovic, Oliver Nagel, Antje Schonsky, Rahel Hinkelmann, Jakob Wörner, Nargis Parvin, Ralf Greiner, Stefan Weber, Alain Tissier, Mike Schutkowski, Justin Lee, Henning Jessen, Gabriel Schaaf et al. Plant pathogens translocate type III effector (T3E) proteins that may be recognized by plants to trigger immunity. Here, the authors show that the Xanthomonas T3E XopH possesses a novel 1-phytase activity that is required for XopH-mediated immunity of plants carrying the Bs7 resistance gene. 18 December 2017 | doi: 10.1038/s41467-017-02195-8 Effectors in plant pathology  Hydrolases  NMR spectroscopy  Small molecules  Telluriding monolayer MoS2 and WS2 via alkali metal scooter OPEN Seok Joon Yun, Gang Hee Han, Hyun Kim, Dinh Loc Duong, Bong Gyu Shin, Jiong Zhao, Quoc An Vu, Jubok Lee, Seung Mi Lee & Young Hee Lee Two dimensional monolayer transition metal ditellurides and their alloys are interesting but their growth has been difficult. Herein, Yun et al. demonstrate the use of sodium salts to convert transition metal disulfide to ditelluride and alloys in tellurium vapor at low temperature. 18 December 2017 | doi: 10.1038/s41467-017-02238-0 Nanophotonics and plasmonics  Two-dimensional materials  Evolution of sequence-specific anti-silencing systems in Arabidopsis  OPEN Aoi Hosaka, Raku Saito, Kazuya Takashima, Taku Sasaki, Yu Fu, Akira Kawabe, Tasuku Ito, Atsushi Toyoda, Asao Fujiyama, Yoshiaki Tarutani & Tetsuji Kakutani Eukaryotes often silence transposable elements (TEs) via DNA methylation. Here, the authors show that evolution of VANC, an Arabidopsis anti-silencing factor, and its target motifs allows sequence-specific demethylation, suggesting a way TEs can proliferate while minimizing damage to the host genome. 18 December 2017 | doi: 10.1038/s41467-017-02150-7 Epigenomics  Molecular evolution  Plant evolution  PAX7 target genes are globally repressed in facioscapulohumeral muscular dystrophy skeletal muscle OPEN Christopher R. S. Banerji, Maryna Panamarova, Husam Hebaishi, Robert B. White, Frédéric Relaix, Simone Severini & Peter S. Zammit Facioscapulohumeral muscular dystrophy is a myopathy linked to ectopic expression of the DUX4 transcription factor. The authors show that the suppression of targets genes of the myogenesis regulator PAX7 is a signature of FSHD, and might explain oxidative stress sensitivity and epigenetic changes. 18 December 2017 | doi: 10.1038/s41467-017-01200-4 Data mining  Mechanisms of disease  Neuromuscular disease  Skeletal muscle  Designing flows to resolve human and environmental water needs in a dam-regulated river OPEN William Chen & Julian D. Olden Human and environmental water needs can come into conflict in dam-regulated river systems. Here, Chen and Olden investigate the potential for the use of fish–flow modeling to make recommendations for the management of native and nonnative fish species whilst providing water for society. 18 December 2017 | doi: 10.1038/s41467-017-02226-4 Freshwater ecology  Hydrology  Invasive species  RNA degradation by the plant RNA exosome involves both phosphorolytic and hydrolytic activities OPEN Natalia Sikorska, Hélène Zuber, Anthony Gobert, Heike Lange & Dominique Gagliardi The yeast and human RNA exosome is structurally related to prokaryotic phosphorylases but degrades RNA only via associated hydrolytic activities. Here the authors show that the RNA exosome of plants, and likely those of a few basal eukaryotes, combines phosphorolytic and hydrolytic activities to degrade RNA. 18 December 2017 | doi: 10.1038/s41467-017-02066-2 Plant molecular biology  RNA decay  Tyrosine phosphatase SHP2 negatively regulates NLRP3 inflammasome activation via ANT1-dependent mitochondrial homeostasis OPEN Wenjie Guo, Wen Liu, Zhen Chen, Yanhong Gu, Shuang Peng, Lihong Shen, Yan Shen, Xingqi Wang, Gen-Sheng Feng, Yang Sun & Qiang Xu The NLRP3 inflammasome is central to a variety of inflammatory diseases, but how it is regulated to prevent excessive inflammation is not clear. Here the authors show that NLRP3 activation causes SHP2 translocation to the mitochondria to interact with and dephosphorylate ANT1, thus stabilizing the mitochondria and preventing release of proinflammatory mitochondrial DNA and ROS. 18 December 2017 | doi: 10.1038/s41467-017-02351-0 Inflammasome  Inflammatory diseases  Evolutionary action and structural basis of the allosteric switch controlling β2AR functional selectivity OPEN Anne-Marie Schönegge, Jonathan Gallion, Louis-Philippe Picard, Angela D. Wilkins, Christian Le Gouill, Martin Audet, Wayne Stallaert, Martin J. Lohse, Marek Kimmel, Olivier Lichtarge & Michel Bouvier Ligand-induced biased signaling is thought to result in part from ligand-specific receptor conformations that cause the engagement of distinct effectors. Here the authors trace and evaluate the impact of mutations of the β2–adrenergic receptor on multiple signaling outputs to provide structural-level insight into the determinants of GPCR functional selectivity. 18 December 2017 | doi: 10.1038/s41467-017-02257-x Functional clustering  Molecular modelling  Protein design  Receptor pharmacology  Survey of solution dynamics in Src kinase reveals allosteric cross talk between the ligand binding and regulatory sites OPEN Michael Tong, Jeff G. Pelton, Michelle L. Gill, Weibing Zhang, Francis Picart & Markus A. Seeliger Src is a prototypical signaling non-receptor protein tyrosine kinase that interconverts between distinct conformations. Here the authors use variants of the kinase-inhibitor dasatinib to define three specific conformational states of the Src kinase and shed insight on the effect of conformation-specific inhibitors on Src dynamics. 18 December 2017 | doi: 10.1038/s41467-017-02240-6 Kinases  Molecular conformation  Solution-state NMR  Longitudinal intravital imaging of the femoral bone marrow reveals plasticity within marrow vasculature OPEN David Reismann, Jonathan Stefanowski, Robert Günther, Asylkhan Rakhymzhan, Romano Matthys, Reto Nützi, Sandra Zehentmeier, Katharina Schmidt-Bleek, Georg Petkau, Hyun-Dong Chang, Sandra Naundorf, York Winter, Fritz Melchers, Georg Duda, Anja E. Hauser & Raluca A. Niesner Longitudinal imaging of bone marrow would shed insight into long-term cellular dynamics within this compartment. Here, the authors develop a multi-photon imaging approach for the mouse femur and reveal extensive vascular plasticity within the bone marrow during bone healing and steady-state homeostasis. 18 December 2017 | doi: 10.1038/s41467-017-01538-9 Applied optics  Bone marrow  Microendoscopy  Imaging the immune system  Electric-field control of ferromagnetism through oxygen ion gating OPEN Hao-Bo Li, Nianpeng Lu, Qinghua Zhang, Yujia Wang, Deqiang Feng, Tianzhe Chen, Shuzhen Yang, Zheng Duan, Zhuolu Li, Yujun Shi, Weichao Wang, Wei-Hua Wang, Kui Jin, Hui Liu, Jing Ma, Lin Gu, Cewen Nan & Pu Yu It has been suggested that the magnetic properties of metal layers using reversible redox reactions could form the basis of memory devices but this requires fast electric control to be practical. Here the authors demonstrate this on sub-millisecond timescales in a metal–oxide heterostructure. 18 December 2017 | doi: 10.1038/s41467-017-02359-6 Ferroelectrics and multiferroics  Magnetic properties and materials  Surfaces, interfaces and thin films  Single-molecule imaging reveals multiple pathways for the recruitment of translesion polymerases after DNA damage OPEN Elizabeth S. Thrall, James E. Kath, Seungwoo Chang & Joseph J. Loparo Translesion synthesis (TLS) enables cells to tolerate damaged DNA encountered during replication. Here the authors use super-resolution photoactivation localization microscopy to reveal a lesion type dependent mechanism of recruitment of the TLS polymerase Pol IV following DNA damage. 18 December 2017 | doi: 10.1038/s41467-017-02333-2 Single-molecule biophysics  Translesion synthesis  Evidence for causal top-down frontal contributions to predictive processes in speech perception OPEN Thomas E. Cope, E. Sohoglu, W. Sedley, K. Patterson, P. S. Jones, J. Wiggins, C. Dawson, M. Grube, R. P. Carlyon, T. D. Griffiths, Matthew H. Davis & James B. Rowe The role of frontal lobes in speech perception is controversial. Here, the authors show that neurodegeneration of frontal speech regions delays prediction reconciliation in temporal cortex and results in inflexible prior expectations, indicating that fronto-temporal interactions determine predictive processes in speech. 18 December 2017 | doi: 10.1038/s41467-017-01958-7 Language  Neurodegenerative diseases  Neurophysiology  Giant coercivity and high magnetic blocking temperatures for N2 3− radical-bridged dilanthanide complexes upon ligand dissociation OPEN Selvan Demir, Miguel I. Gonzalez, Lucy E. Darago, William J. Evans & Jeffrey R. Long Single-molecule magnets typically only retain information in the presence of an applied magnetic field and at very low temperatures. Here, Demir, Long and co-workers design N2 3– radical-bridged dilanthanide complexes that exhibit giant coercivities and 100-s magnetic blocking temperatures of up to 20 K. 15 December 2017 | doi: 10.1038/s41467-017-01553-w Coordination chemistry  Magnetic materials  Organometallic chemistry  She1 affects dynein through direct interactions with the microtubule and the dynein microtubule-binding domain OPEN Kari H. Ecklund, Tatsuya Morisaki, Lindsay G. Lammers, Matthew G. Marzo, Timothy J. Stasevich & Steven M. Markus Dynein is a microtubule motor the motility of which is affected by the microtubule-associated protein She1. Here, the authors show that She1 alters dynein stepping behavior and increases its microtubule affinity through simultaneous interactions with the microtubule and dynein microtubule binding domain. 15 December 2017 | doi: 10.1038/s41467-017-02004-2 Dynein  Microtubules  New twinning route in face-centered cubic nanocrystalline metals OPEN Lihua Wang, Pengfei Guan, Jiao Teng, Pan Liu, Dengke Chen, Weiyu Xie, Deli Kong, Shengbai Zhang, Ting Zhu, Ze Zhang, Evan Ma, Mingwei Chen & Xiaodong Han Twin nucleation in face-centered cubic metals with high twin-fault energies should theoretically be unfavourable, but instead twinning is very often observed. Here, the authors report a new twinning route in nanocrystalline platinum that bypasses the high twin-fault energy barrier using closely spaced partial dislocations. 15 December 2017 | doi: 10.1038/s41467-017-02393-4 Mechanical properties  Metals and alloys  Structural properties  Iron-based nanocatalyst for the acceptorless dehydrogenation reactions OPEN Garima Jaiswal, Vinod G. Landge, Dinesh Jagadeesan & Ekambaram Balaraman Catalytic acceptorless dehydrogenation reactions provide a sustainable route to valuable products and hydrogen fuel. Here, the authors show a recyclable iron catalyst that is highly active in the acceptorless dehydrogenation of a wide range of N-heterocycles and alcohols. 15 December 2017 | doi: 10.1038/s41467-017-01603-3 Catalyst synthesis  Green chemistry  Heterogeneous catalysis  Shear-induced Notch-Cx37-p27 axis arrests endothelial cell cycle to enable arterial specification OPEN Jennifer S. Fang, Brian G. Coon, Noelle Gillis, Zehua Chen, Jingyao Qiu, Thomas W. Chittenden, Janis M. Burt, Martin A. Schwartz & Karen K. Hirschi New vessel formation relies on a tightly controlled switch in endothelial biology from proliferating to  specializing phenotypes. Here, Fang et al. elucidate the molecular mechanisms of this switch and show that the arterial shear activates a Notch-Cx37-p27 axis promoting endothelial cell cycle arrest and enabling arterial gene expression. 15 December 2017 | doi: 10.1038/s41467-017-01742-7 Angiogenesis  Differentiation  Silicon CMOS architecture for a spin-based quantum computer OPEN M. Veldhorst, H. G. J. Eenink, C. H. Yang & A. S. Dzurak Realisation of large-scale quantum computation requires both error correction capability and a large number of qubits. Here, the authors propose to use a CMOS-compatible architecture featuring a spin qubit surface code and individual qubit control via floating memory gate electrodes. 15 December 2017 | doi: 10.1038/s41467-017-01905-6 Quantum information  Qubits  Spin-momentum locked interaction between guided photons and surface electrons in topological insulators OPEN Siyuan Luo, Li He & Mo Li Whether topologically protected electron moving and photon moving can couple each other remains an interesting question. Here, Luo et al. report reversion of photon spin and the direction of the photocurrent in a topological insulator by changing light propagation direction. 15 December 2017 | doi: 10.1038/s41467-017-02264-y Electronic and spintronic devices  Photonic devices  Topological insulators  Neurons along the auditory pathway exhibit a hierarchical organization of prediction error OPEN Gloria G. Parras, Javier Nieto-Diego, Guillermo V. Carbajal, Catalina Valdés-Baizabal, Carles Escera & Manuel S. Malmierca Perception can be explained by predictive coding, but it is unclear how this theory applies at the single-neuron level. Here, authors describe how auditory patterns are encoded and detected by single neurons along the auditory pathway, demonstrating that prediction error exists in single auditory neurons. 15 December 2017 | doi: 10.1038/s41467-017-02038-6 Cognitive neuroscience  Cortex  Midbrain  Sensory processing  Thalamus  Hydrologically-driven crustal stresses and seismicity in the New Madrid Seismic Zone OPEN Timothy J. Craig, Kristel Chanard & Eric Calais Large-scale changes in continental water storage have been shown to have an impact on seismicity. Here, the authors show that variation in the rate of microearthquakes in the New Madrid Seismic Zone coincides with hydrological loading in the Mississippi embayment at both annual and multi-annual timescales. 15 December 2017 | doi: 10.1038/s41467-017-01696-w Geodynamics  Tectonics  Estrogen-related receptor γ causes osteoarthritis by upregulating extracellular matrix-degrading enzymes OPEN Young-Ok Son, Seulki Park, Ji-Sun Kwak, Yoonkyung Won, Wan-Su Choi, Jinseol Rhee, Churl-Hong Chun, Je-Hwang Ryu, Don-Kyu Kim, Hueng-Sik Choi & Jang-Soo Chun The pathogenesis of osteoarthritis is unclear. The authors show that estrogen-related receptor gamma is upregulated in cartilage from patients and mouse models, where it drives production of matrix-degrading MMPs in chondrocytes, and that its downregulation ameliorates pathology in mice. 15 December 2017 | doi: 10.1038/s41467-017-01868-8 Gene delivery  Osteoarthritis  Proteolysis  Electrical semiconduction modulated by light in a cobalt and naphthalene diimide metal-organic framework OPEN Evandro Castaldelli, K. D. G. Imalka Jayawardena, David C. Cox, Guy J. Clarkson, Richard I. Walton, Long Le-Quang, Jerôme Chauvin, S. Ravi P. Silva & Grégoire Jean-François Demets Photoactive and semiconducting metal-organic frameworks are desirable for electrical and photoelectrical devices, but remain rare. Here Demets and co-workers design a naphthalene diimide and cobalt based MOF with anisotropic electrical semiconductivity and a high responsivity of 2.5 × 105 A W−1. 15 December 2017 | doi: 10.1038/s41467-017-02215-7 Coordination chemistry  Electronic devices  Metal–organic frameworks  Wavevector multiplexed atomic quantum memory via spatially-resolved single-photon detection OPEN Michał Parniak, Michał Dąbrowski, Mateusz Mazelanik, Adam Leszczyński, Michał Lipka & Wojciech Wasilewski Multiplexing of quantum memories could boost the efficiency of photon state preparation. Here, the authors use a cold atomic ensemble and a single-photon resolving camera to exploit emission multiplexing of Raman photons from 665 different angular modes, confirming nonclassical photon-number correlations. 15 December 2017 | doi: 10.1038/s41467-017-02366-7 Quantum optics  Single photons and quantum effects  Hepatocytic expression of human sodium-taurocholate cotransporting polypeptide enables hepatitis B virus infection of macaques OPEN Benjamin J. Burwitz, Jochen M. Wettengel, Martin A. Mück-Häusl, Marc Ringelhan, Chunkyu Ko, Marvin M. Festag, Katherine B. Hammond, Mina Northrup, Benjamin N. Bimber, Thomas Jacob, Jason S. Reed, Reed Norris, Byung Park, Sven Moller-Tank, Knud Esser, Justin M. Greene, Helen L. Wu, Shaheed Abdulhaqq, Gabriela Webb, William F. Sutton et al. Hepatitis B virus (HBV) has a limited host range and current animal models can only recapitulate certain aspects of HBV replication. Here, the authors show that expression of the HBV receptor NTCP in macaques supports HBV replication in vivo, suggesting this as animal model for future HBV studies. 15 December 2017 | doi: 10.1038/s41467-017-01953-y Hepatitis B virus  Viral pathogenesis  Virus–host interactions  Cell shape information is transduced through tension-independent mechanisms OPEN Amit Ron, Evren U. Azeloglu, Rhodora C. Calizo, Mufeng Hu, Smiti Bhattacharya, Yibang Chen, Gomathi Jayaraman, Sunwoo Lee, Susana R. Neves-Zaph, Hong Li, Ronald E. Gordon, John C. He, James C. Hone & Ravi Iyengar It is not known whether the shape of a cell can regulate cellular phenotype independently. Here, the authors show that culturing kidney podocytes or smooth muscle cells on 3-D biomimetic surfaces results in phenotypic changes and that cell shape is sensed by integrin β3 in a tension-independent manner. 15 December 2017 | doi: 10.1038/s41467-017-02218-4 Computational biophysics  Computational models  Nanofabrication and nanopatterning  RHO signalling  Evidence for topological type-II Weyl semimetal WTe2  OPEN Peng Li, Yan Wen, Xin He, Qiang Zhang, Chuan Xia, Zhi-Ming Yu, Shengyuan A. Yang, Zhiyong Zhu, Husam N. Alshareef & Xi-Xiang Zhang Exotic transport properties of type-II Weyl semimetals have been predicted but are yet to be experimentally evidenced. Here, Li et al. report evidences of an anisotropy of negative magnetoresistance and a quantum oscillation arising from the predicted Weyl orbit in the type-II Weyl semimetal WTe2. 15 December 2017 | doi: 10.1038/s41467-017-02237-1 Electronic properties and materials  Topological insulators  DNA damage causes rapid accumulation of phosphoinositides for ATR signaling OPEN Yu-Hsiu Wang, Anushya Hariharan, Giulia Bastianello, Yusuke Toyama, G. V. Shivashankar, Marco Foiani & Michael P. Sheetz Phosphoinositides are enriched in the nucleus and accumulate upon DNA damage but their role in responding to DNA damage is poorly defined. Here, the authors show that phosphoinositides rapidly accumulate at DNA damage sites and are required for ATR recruitment and subsequent Chk1 activation. 14 December 2017 | doi: 10.1038/s41467-017-01805-9 DNA damage response  Phosphoinositol signalling  Nuclear speckles  Stable transgenerational epigenetic inheritance requires a DNA methylation-sensing circuit OPEN Ben P. Williams & Mary Gehring DNA methylation patterns are inherited over many generations in plants. Here, Williams and Gehring show that the 5-methylcytosine DNA glycosylase ROS1 functions as part of a methylation-sensitive circuit that ensures long-term epigenetic fidelity in Arabidopsis. 14 December 2017 | doi: 10.1038/s41467-017-02219-3 DNA methylation  Plant sciences  Probing defect dynamics in monolayer MoS2 via noise nanospectroscopy OPEN Seung Hyun Song, Min-Kyu Joo, Michael Neumann, Hyun Kim & Young Hee Lee The intrinsic properties of atomically thin MoS2 are believed to be strongly affected by the presence of structural defects; however, the underlying physical mechanism of such link is not fully understood. Here, the authors combine noise-current analysis with atomic force microscopy to explore the relationship between point defects and the anomalous physical properties of MoS2 monolayers. 14 December 2017 | doi: 10.1038/s41467-017-02297-3 Characterization and analytical techniques  Electronic properties and materials  Two-dimensional materials  Efficient transgenesis and annotated genome sequence of the regenerative flatworm model Macrostomum lignano  OPEN Regeneration capable flatworms have emerged as powerful models for studying stem cell biology and patterning, however their study has been hindered by the lack of transgenesis methods. Here, the authors describe a transgenesis method for Macrostomum lignano, as well as a new annotated genome sequence. 14 December 2017 | doi: 10.1038/s41467-017-02214-8 Genetic techniques  Next-generation sequencing  Regeneration  Reporter genes  Stochastic gene expression in Arabidopsis thaliana  OPEN Ilka Schultheiß Araújo, Jessica Magdalena Pietsch, Emma Mathilde Keizer, Bettina Greese, Rachappa Balkunde, Christian Fleck & Martin Hülskamp Noisy gene expression can cause stochasticity in the expression of plant traits. Here, Araújo et al. use a dual reporter system of protein expression in Arabidopsis to show that expression noise is lowest in stomata relative to other tissues and that leaf cells are coupled with respect to noise. 14 December 2017 | doi: 10.1038/s41467-017-02285-7 Cell biology  Plant development  Stochastic modelling  Lipid bodies containing oxidatively truncated lipids block antigen cross-presentation by dendritic cells in cancer OPEN Filippo Veglia, Vladimir A. Tyurin, Dariush Mohammadyani, Maria Blasi, Elizabeth K. Duperret, Laxminarasimha Donthireddy, Ayumi Hashimoto, Alexandr Kapralov, Andrew Amoscato, Roberto Angelini, Sima Patel, Kevin Alicea-Torres, David Weiner, Maureen E. Murphy, Judith Klein-Seetharaman, Esteban Celis, Valerian E. Kagan & Dmitry I. Gabrilovich Tumor-associated dendritic cells are defective in their ability to cross-present antigens, and they accumulate lipid bodies. Here the authors show that this defect is due to an impaired trafficking of peptide-MHC class I caused by the interaction of electrophilic lipids with chaperone heat shock protein 70. 14 December 2017 | doi: 10.1038/s41467-017-02186-9 Antigen-presenting cells  Immunosurveillance  Tumour immunology  A general pharmacodynamic interaction model identifies perpetrators and victims in drug interactions OPEN Sebastian G. Wicha, Chunli Chen, Oskar Clewe & Ulrika S. H. Simonsson Assessment of pharmacodynamic interactions is at the heart of combination therapy development. Here the authors introduce a general drug interaction scoring model that enables quantification of synergistic and antagonistic interactions and determination of the directionality of the interactions. 14 December 2017 | doi: 10.1038/s41467-017-01929-y Computational models  Drug development  Fungal systems biology  Nuclear lamin A/C harnesses the perinuclear apical actin cables to protect nuclear morphology OPEN Jeong-Ki Kim, Arghavan Louhghalam, Geonhui Lee, Benjamin W. Schafer, Denis Wirtz & Dong-Hwee Kim An actin cap protects the morphology of the nucleus during cellular mechanical stress. Here, the authors show that the nuclear lamina protein lamin A/C mediates the formation of the actin cap in response to stress, and model the distribution of forces in the presence and absence of the actin cap. 14 December 2017 | doi: 10.1038/s41467-017-02217-5 Nuclear envelope  Nucleoskeleton  Stress fibres  Hepatitis B virus persistence in mice reveals IL-21 and IL-33 as regulators of viral clearance OPEN Zhongliang Shen, Huijuan Yang, Sisi Yang, Wei Wang, Xiaoxian Cui, Xian Zhou, Wei Liu, Shaokun Pan, Yanfeng Liu, Junqi Zhang, Jiming Zhang, Youhua Xie & Jing Liu Hepatitis B virus (HBV) establishes chronic infection in only some patients, but the mechanisms underlying clearance failure in these patients are not fully understood. Here, the authors identify and characterize an HBV strain that can persist in mice and show that IL-21 and IL-33 responses contribute to clearance. 14 December 2017 | doi: 10.1038/s41467-017-02304-7 Antimicrobial responses  Hepatitis B virus  Viral immune evasion  Virus–host interactions  Diversity of trion states and substrate effects in the optical properties of an MoS2 monolayer OPEN Matthias Drüppel, Thorsten Deilmann, Peter Krüger & Michael Rohlfing The optical and electrical properties of atomically thin transition metal dichalcogenides critically depend on the underlying substrate. Here, the authors develop an abinitio many-body formalism to investigate the full spectrum of negative and positive trions in these layered semicondutors. 14 December 2017 | doi: 10.1038/s41467-017-02286-6 Electronic properties and materials  Surfaces, interfaces and thin films  Two-dimensional materials  Ezh2 phosphorylation state determines its capacity to maintain CD8+ T memory precursors for antitumor immunity OPEN Shan He, Yongnian Liu, Lijun Meng, Hongxing Sun, Ying Wang, Yun Ji, Janaki Purushe, Pan Chen, Changhong Li, Jozef Madzo, Jean-Pierre Issa, Jonathan Soboloff, Ran Reshef, Bethany Moore, Luca Gattinoni & Yi Zhang During an immune response naive CD8+ T cells can differentiate into either effector or memory T cells. Here the authors show that Akt-mediated phosphorylation of the epigenetic regulator Ezh2 is critical for the generation of an anti-tumor CD8 T cell response and promotes the expansion of memory-precursors. 14 December 2017 | doi: 10.1038/s41467-017-02187-8 Cancer immunotherapy  Epigenetics in immune cells  Tumour immunology  Chiral expression from molecular to macroscopic level via pH modulation in terbium coordination polymers OPEN Jian Huang, Hong-ming Ding, Yan Xu, Dai Zeng, Hui Zhu, Dong-Mian Zang, Song-Song Bao, Yu-qiang Ma & Li-Min Zheng In biological systems it is common for molecular chirality to be expressed at the macroscopic level, but such translation is difficult to achieve in synthetic systems. Here, the authors synthesise homochiral terbium-based coordination polymers with both helical and crystalline morphologies. 14 December 2017 | doi: 10.1038/s41467-017-02260-2 Coordination chemistry  Inorganic chemistry  Molecular self-assembly  RNAs coordinate nuclear envelope assembly and DNA replication through ELYS recruitment to chromatin OPEN Antoine Aze, Michalis Fragkos, Stéphane Bocquet, Julien Cau & Marcel Méchali The factors that link chromatin remodelling to nuclear envelope formation in the sperm pronucleus are not fully characterised. Here, the authors show that in RNA-depleted Xenopus laevis egg extracts, ELYS recruitment and nuclear pore complex formation are impaired, resulting in defective nuclear processes. 14 December 2017 | doi: 10.1038/s41467-017-02180-1 Cell proliferation  DNA replication    Nature Communications JOBS of the week Postdoctoral Researcher John Innes Centre (JIC) Postdoctoral Fellows Albert Einstein College of Medicine in New York Two Professors and Academic Staff Members Hasso Plattner Institute Principle Investigators Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences CEO SPIE Post-Doctoral Research Fellow Aurora Health Care Postdoctoral Associate University of Rochester Department of Pharmacology & Physiology Assistant Professor Position UCLA Postdoctoral Scientist University of New Mexico, Health Sciences Center Open Rank, Term Tenure Track The University of Texas MD Anderson Cancer Center More Science jobs from Nature Communications EVENT World Cancer Congress 18.03.18 New Delhi, India More science events from     Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. 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