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- Growing collection of sensors (e.g. Calcium and glutamate) CaMPARI, GCaMP3, GCaMP5, GCaMP6, jRCaMP1, jRGECO1 & iGLuSnFR
- Choice of promoter and the ability to include Cre inducible (FLEx-ON) expression
- Perfect for in vitro or in vivo models
Learn more | | | | | | | | | | Advertisement | | | | | Advertisement | | | | | | Latest Editorial | | | | | | | | | Latest Articles | View all Articles | | | Warhead biosynthesis and the origin of structural diversity in hydroxamate metalloproteinase inhibitors OPEN | | Franziska Leipoldt, Javier Santos-Aberturas, Dennis P. Stegmann, Felix Wolf, Andreas Kulik, Rodney Lacret, Désirée Popadić, Daniela Keinhörster, Norbert Kirchner, Paulina Bekiesch, Harald Gross, Andrew W. Truman & Leonard Kaysser | | | Metalloproteinase inhibitors are leads for drug development, but their biosynthetic pathways are often unknown. Here the authors show that the acyl branched warhead of actinonin and matlystatins derives from an ethylmalonyl-CoA-like pathway and the structural diversity of matlystatins is due to the activity of a decarboxylase-dehydrogenase enzyme. | | 06 December 2017 | doi: 10.1038/s41467-017-01975-6 | | Applied microbiology Metabolic engineering Multienzyme complexes | Developmental nonlinearity drives phenotypic robustness OPEN | | Rebecca M. Green, Jennifer L. Fish, Nathan M. Young, Francis J. Smith, Benjamin Roberts, Katie Dolan, Irene Choi, Courtney L. Leach, Paul Gordon, James M. Cheverud, Charles C. Roseman, Trevor J. Williams, Ralph S. Marcucio & Benedikt Hallgrímsson | | | Developmental processes often involve nonlinearities, but the consequences for translating genotype to phenotype are not well characterized. Here, Green et al. vary Fgf8 signaling across allelic series of mice and show that phenotypic robustness in craniofacial shape is explained by a nonlinear effect of Fgf8 expression. | | 06 December 2017 | doi: 10.1038/s41467-017-02037-7 | | Evolutionary developmental biology Evolutionary genetics Morphogenesis | Human CD26high T cells elicit tumor immunity against multiple malignancies via enhanced migration and persistence OPEN | | Stefanie R. Bailey, Michelle H. Nelson, Kinga Majchrzak, Jacob S. Bowers, Megan M. Wyatt, Aubrey S. Smith, Lillian R. Neal, Keisuke Shirai, Carmine Carpenito, Carl H. June, Michael J. Zilliox & Chrystal M. Paulos | | | The role of human CD4+ T cell subsets in cancer immunotherapy is still unclear. Here, the authors show that CD26 identifies three CD4+ T cell subsets with distinct immunological properties in both healthy individuals and cancer patients. | | 06 December 2017 | doi: 10.1038/s41467-017-01867-9 | | CD4-positive T cells Immunotherapy Melanoma Mesothelioma Pancreatic cancer | Galectin-3 impacts Cryptococcus neoformans infection through direct antifungal effects OPEN | | Fausto Almeida, Julie M. Wolf, Thiago Aparecido da Silva, Carlos M. DeLeon-Rodriguez, Caroline Patini Rezende, André Moreira Pessoni, Fabrício Freitas Fernandes, Rafael Silva-Rocha, Roberto Martinez, Marcio L. Rodrigues, Maria Cristina Roque-Barreira & Arturo Casadevall | | | The protein Galectin-3 modulates host immunity and plays roles during infections. Here, Almeida et al. show that this protein contributes to host defence against infection with the fungal pathogen Cryptococcus neoformans by inhibiting fungal growth and inducing lysis of fungal extracellular vesicles. | | 06 December 2017 | doi: 10.1038/s41467-017-02126-7 | | Antimicrobial responses Fungal host response Fungal infection Pathogens | Neuronal signals regulate obesity induced β-cell proliferation by FoxM1 dependent mechanism OPEN | | Junpei Yamamoto, Junta Imai, Tomohito Izumi, Hironori Takahashi, Yohei Kawana, Kei Takahashi, Shinjiro Kodama, Keizo Kaneko, Junhong Gao, Kenji Uno, Shojiro Sawada, Tomoichiro Asano, Vladimir V. Kalinichenko, Etsuo A. Susaki, Makoto Kanzaki, Hiroki R. Ueda, Yasushi Ishigaki, Tetsuya Yamada & Hideki Katagiri | | | Neuronal signals, in particular those transmitted via the vagal nerve, regulate both β-cell function and proliferation. Here, Yamamoto et al. show that the forkhead box M1 pathway is required for vagal signal-mediated induction of β-cell proliferation during obesity. | | 05 December 2017 | doi: 10.1038/s41467-017-01869-7 | | Obesity Type 2 diabetes | Pandemic H1N1 influenza A viruses suppress immunogenic RIPK3-driven dendritic cell death OPEN | | Boris M. Hartmann, Randy A. Albrecht, Elena Zaslavsky, German Nudelman, Hanna Pincas, Nada Marjanovic, Michael Schotsaert, Carles Martínez-Romero, Rafael Fenutria, Justin P. Ingram, Irene Ramos, Ana Fernandez-Sesma, Siddharth Balachandran, Adolfo García-Sastre & Stuart C. Sealfon | | | The differences in virus-host interactions resulting in distinct pathogenicity of seasonal and pandemic influenza A viruses (IAV) are not well understood. Here, the authors show that the hemagglutinin segment from pandemic, but not seasonal, IAV suppresses RIPK3-mediated dendritic cell death, thereby reducing T cell activation. | | 05 December 2017 | doi: 10.1038/s41467-017-02035-9 | | Immune cell death Influenza virus Necroptosis Viral immune evasion | Inhibition of D-Ala:D-Ala ligase through a phosphorylated form of the antibiotic D-cycloserine OPEN | | Sarah Batson, Cesira de Chiara, Vita Majce, Adrian J. Lloyd, Stanislav Gobec, Dean Rea, Vilmos Fülöp, Christopher W. Thoroughgood, Katie J. Simmons, Christopher G. Dowson, Colin W. G. Fishwick, Luiz Pedro S. de Carvalho & David I. Roper | | | The antibiotic D-cycloserine (DCS) targets the peptidoglycan biosynthesis enzyme D-Ala-D-Ala ligase (Ddl). Here the authors reveal the DCS inhibitory mechanism by determining the structure of E. coli DdlB with a phosphorylated DCS molecule in the active site that formed in crystallo and mimics the D-alanyl phosphate intermediate. | | 05 December 2017 | doi: 10.1038/s41467-017-02118-7 | | Antibiotics X-ray crystallography | Albumin/vaccine nanocomplexes that assemble in vivo for combination cancer immunotherapy OPEN | | Guizhi Zhu, Geoffrey M. Lynn, Orit Jacobson, Kai Chen, Yi Liu, Huimin Zhang, Ying Ma, Fuwu Zhang, Rui Tian, Qianqian Ni, Siyuan Cheng, Zhantong Wang, Nan Lu, Bryant C. Yung, Zhe Wang, Lixin Lang, Xiao Fu, Albert Jin, Ido D. Weiss, Harshad Vishwasrao et al. | | | Albumin conjugates can enhance drug delivery. Here, the authors repurpose albumin-binding Evans blue to develop nanovaccines that co-deliver adjuvants and tumor neoantigens to antigen-presenting cells in lymph nodes, resulting in potent and durable antitumour immunity in combination immunotherapy. | | 05 December 2017 | doi: 10.1038/s41467-017-02191-y | | Cancer immunotherapy Nanoparticles Tumour vaccines | Exploration of pyrazine-embedded antiaromatic polycyclic hydrocarbons generated by solution and on-surface azomethine ylide homocoupling OPEN | | Xiao-Ye Wang, Marcus Richter, Yuanqin He, Jonas Björk, Alexander Riss, Raju Rajesh, Manuela Garnica, Felix Hennersdorf, Jan J. Weigand, Akimitsu Narita, Reinhard Berger, Xinliang Feng, Willi Auwärter, Johannes V. Barth, Carlos-Andres Palma & Klaus Müllen | | | Polyaromatic hydrocarbons can be precisely manipulated to yield ever more complex and discrete graphene analogs, such as nanographenes. Here, the authors use azomethine ylide homocoupling to insert an antiaromatic pyrazine ring into the core of a nanographene, and characterize the molecule’s unique electronic character. | | 05 December 2017 | doi: 10.1038/s41467-017-01934-1 | | Nanoscale materials Organic chemistry Surface chemistry | Cooperation and the evolution of hunter-gatherer storytelling OPEN | | Daniel Smith, Philip Schlaepfer, Katie Major, Mark Dyble, Abigail E. Page, James Thompson, Nikhil Chaudhary, Gul Deniz Salali, Ruth Mace, Leonora Astete, Marilyn Ngales, Lucio Vinicius & Andrea Bamberg Migliano | | | Storytelling entails costs in terms of time and effort, yet it is a ubiquitous feature of human society. Here, Smith et al. show benefits of storytelling in Agta hunter-gatherer communities, as storytellers have higher reproductive success and storytelling is associated with higher cooperation in the group. | | 05 December 2017 | doi: 10.1038/s41467-017-02036-8 | | Behavioural ecology Biological anthropology Cultural evolution Social anthropology | 3D genome of multiple myeloma reveals spatial genome disorganization associated with copy number variations OPEN | | Pengze Wu, Tingting Li, Ruifeng Li, Lumeng Jia, Ping Zhu, Yifang Liu, Qing Chen, Daiwei Tang, Yuezhou Yu & Cheng Li | | | Chromosome conformation capture techniques enable the study of genome organization in cancer cells. Here, the authors use Hi-C, WGS, and RNA-seq to study the 3D genome of multiple myeloma and find that genome disorganization is associated with copy number variations and changes in gene expression. | | 05 December 2017 | doi: 10.1038/s41467-017-01793-w | | Cancer genomics Structural variation | The interdomain flexible linker of the polypeptide GalNAc transferases dictates their long-range glycosylation preferences OPEN | | Matilde de las Rivas, Erandi Lira-Navarrete, Earnest James Paul Daniel, Ismael Compañón, Helena Coelho, Ana Diniz, Jesús Jiménez-Barbero, Jesús M. Peregrina, Henrik Clausen, Francisco Corzana, Filipa Marcelo, Gonzalo Jiménez-Osés, Thomas A. Gerken & Ramon Hurtado-Guerrero | | | GalNAc transferases’ (GalNAc-Ts) catalytic domains are connected to a lectin domain through a flexible linker. Here the authors present a structural analysis of GalNAc-T4 that implicates the linker region as modulator of the orientations of the lectin domain, which in turn imparts substrate specificity. | | 05 December 2017 | doi: 10.1038/s41467-017-02006-0 | | Enzyme mechanisms Glycobiology Kinetics | Polη O-GlcNAcylation governs genome integrity during translesion DNA synthesis OPEN | | Xiaolu Ma, Hongmei Liu, Jing Li, Yihao Wang, Yue-He Ding, Hongyan Shen, Yeran Yang, Chenyi Sun, Min Huang, Yingfeng Tu, Yang Liu, Yongliang Zhao, Meng-Qiu Dong, Ping Xu, Tie-Shan Tang & Caixia Guo | | | Polη is a key player in translesion DNA synthesis. Here, the authors uncover that, in response to DNA damage, Polη undergoes O-GlcNAcylation at threonine 457 by O-GlcNAc transferase to facilitate the timely disassembly of Polη after DNA lesion bypass. | | 05 December 2017 | doi: 10.1038/s41467-017-02164-1 | | Glycosylation Translesion synthesis Ubiquitylation | The anthelmintic praziquantel is a human serotoninergic G-protein-coupled receptor ligand OPEN | | John D. Chan, Pauline M. Cupit, Gihan S. Gunaratne, John D. McCorvy, Yang Yang, Kristen Stoltz, Thomas R. Webb, Peter I. Dosa, Bryan L. Roth, Ruben Abagyan, Charles Cunningham & Jonathan S. Marchant | | | Schistosomiasis is caused by infection with the flatworm Schistosoma, and praziquantel is the drug of choice for its treatment. Here, Chan and colleagues identify praziquantel as a ligand for the human serotoninergic 5-HT2B G-protein-coupled receptor, and reveal a function for praziquantel as a regulator of vascular tone in treated hosts. | | 05 December 2017 | doi: 10.1038/s41467-017-02084-0 | | Parasite host response Parasitic infection Receptor pharmacology | Alu-dependent RNA editing of GLI1 promotes malignant regeneration in multiple myeloma OPEN | | Elisa Lazzari, Phoebe K. Mondala, Nathaniel Delos Santos, Amber C. Miller, Gabriel Pineda, Qingfei Jiang, Heather Leu, Shawn A. Ali, Anusha-Preethi Ganesan, Christina N. Wu, Caitlin Costello, Mark Minden, Raffaella Chiaramonte, A. Keith Stewart, Leslie A. Crews & Catriona H. M. Jamieson | | | The treatment of multiple myeloma is challenging due to high relapse rates. Here the authors show that expression of ADAR1 correlates with poor patient outcomes, and that ADAR1-mediated editing of GLI1 is a mechanism relevant in the context of multiple myeloma progression and drug resistance. | | 04 December 2017 | doi: 10.1038/s41467-017-01890-w | | Cancer stem cells Myeloma Transcriptomics | Lysosomal integral membrane protein-2 as a phospholipid receptor revealed by biophysical and cellular studies OPEN | | Karen S. Conrad, Ting-Wen Cheng, Daniel Ysselstein, Saskia Heybrock, Lise R. Hoth, Boris A. Chrunyk, Christopher W. am Ende, Dimitri Krainc, Michael Schwake, Paul Saftig, Shenping Liu, Xiayang Qiu & Michael D. Ehlers | | | Lysosomal integral membrane protein-2 (LIMP-2) is a glucocerebrosidase receptor, which is linked to kidney failure and other diseases. Here the authors show that LIMP-2 is also a phospholipid receptor and present the lipid-bound structure of the LIMP-2 luminal domain dimer and discuss its lipid trafficking mechanism. | | 04 December 2017 | doi: 10.1038/s41467-017-02044-8 | | Membrane trafficking X-ray crystallography | ORAI channels are critical for receptor-mediated endocytosis of albumin OPEN | | Bo Zeng, Gui-Lan Chen, Eliana Garcia-Vaz, Sunil Bhandari, Nikoleta Daskoulidou, Lisa M. Berglund, Hongni Jiang, Thomas Hallett, Lu-Ping Zhou, Li Huang, Zi-Hao Xu, Viji Nair, Robert G. Nelson, Wenjun Ju, Matthias Kretzler, Stephen L. Atkin, Maria F. Gomez & Shang-Zhong Xu | | | Patients with diabetic nephropathy suffer from impaired albumin reabsorption by proximal tubular epithelial cells. Here authors use diabetic and transgenic mouse models and in vitro models to show the cause for this lies in the down regulation and internalization of the ion channels, ORAI1-3. | | 04 December 2017 | doi: 10.1038/s41467-017-02094-y | | Kidney Nephrons Physiology | Multiyne chains chelating osmium via three metal-carbon σ bonds OPEN | | Qingde Zhuo, Jianfeng Lin, Yuhui Hua, Xiaoxi Zhou, Yifan Shao, Shiyan Chen, Zhixin Chen, Jun Zhu, Hong Zhang & Haiping Xia | | | Metal-carbon σ bonds mark the basis of organometallic chemistry, but the formation of multiple such bonds between single organic and metal entities remains a challenge. Here, the authors report a one-pot aromaticity-driven method to construct osmium-based multidentate complexes containing three metal-carbon σ bonds from multiyn chains. | | 04 December 2017 | doi: 10.1038/s41467-017-02120-z | | Organic chemistry Organometallic chemistry Reaction mechanisms | Dendrogenin A drives LXR to trigger lethal autophagy in cancers OPEN | | Gregory Segala, Marion David, Philippe de Medina, Mathias C. Poirot, Nizar Serhan, François Vergez, Aurelie Mougel, Estelle Saland, Kevin Carayon, Julie Leignadier, Nicolas Caron, Maud Voisin, Julia Cherier, Laetitia Ligat, Frederic Lopez, Emmanuel Noguer, Arnaud Rives, Bruno Payré, Talal al Saati, Antonin Lamaziere et al. | | | Dendrogenin A, cholesterol metabolite, has tumor suppressive properties but the mechanisms are unknown. Here the authors show that Dendrogenin A can induce autophagy-mediated cell death in both melanoma and acute myeloid leukaemia. | | 04 December 2017 | doi: 10.1038/s41467-017-01948-9 | | Acute myeloid leukaemia Drug development Macroautophagy Melanoma Receptor pharmacology | Interleukin-13 receptor alpha 2 cooperates with EGFRvIII signaling to promote glioblastoma multiforme OPEN | | Jennifer P. Newman, Grace Y. Wang, Kazuhiko Arima, Shou P. Guan, Michael R. Waters, Webster K. Cavenee, Edward Pan, Edita Aliwarga, Siao T. Chong, Catherine Y. L. Kok, Berwini B. Endaya, Amyn A. Habib, Tomohisa Horibe, Wai H. Ng, Ivy A. W. Ho, Kam M. Hui, Tomasz Kordula & Paula Y. P. Lam | | | Interleukin-13 receptor alpha 2 is highly expressed in glioblastoma multiforme but its role in this malignancy is unclear. Here the authors show that this receptor interacts with mutant EGFR, stimulating its kinase activity, thus inducing proliferation. | | 04 December 2017 | doi: 10.1038/s41467-017-01392-9 | | CNS cancer Growth factor signalling | TRPM7 kinase activity is essential for T cell colonization and alloreactivity in the gut OPEN | | Andrea Romagnani, Valentina Vettore, Tanja Rezzonico-Jost, Sarah Hampe, Elsa Rottoli, Wiebke Nadolni, Michela Perotti, Melanie A. Meier, Constanze Hermanns, Sheila Geiger, Gunther Wennemuth, Camilla Recordati, Masayuki Matsushita, Susanne Muehlich, Michele Proietti, Vladimir Chubanov, Thomas Gudermann, Fabio Grassi & Susanna Zierler | | | Gut-homing and colonization of T cells are important for maintaining local immune homoeostasis and protective immunity. Here the authors show that the kinase activity of TRPM7 regulates Th17 differentiation and T cell alloreactivity in the gut by modulating SMAD2 activation and CD103 expression in T cells | | 04 December 2017 | doi: 10.1038/s41467-017-01960-z | | Allotransplantation Mucosal immunology Signal transduction T-helper 17 cells | Direct evidence of hidden local spin polarization in a centrosymmetric superconductor LaO0.55 F0.45BiS2 OPEN | | Shi-Long Wu, Kazuki Sumida, Koji Miyamoto, Kazuaki Taguchi, Tomoki Yoshikawa, Akio Kimura, Yoshifumi Ueda, Masashi Arita, Masanori Nagao, Satoshi Watauchi, Isao Tanaka & Taichi Okuda | | | The local broken symmetry induced spin-splitting in centrosymmetric materials has been predicted previously. Here the authors provide spectroscopic evidence for the coexistence of Rashba-like and Dresselhaus-like spin textures in centrosymmetric electron doped superconductor La(O,F)BiS2. | | 04 December 2017 | doi: 10.1038/s41467-017-02058-2 | | Electronic properties and materials Spintronics Superconducting properties and materials Topological insulators | Van der Waals epitaxial growth and optoelectronics of large-scale WSe2/SnS2 vertical bilayer p–n junctions OPEN | | Tiefeng Yang, Biyuan Zheng, Zhen Wang, Tao Xu, Chen Pan, Juan Zou, Xuehong Zhang, Zhaoyang Qi, Hongjun Liu, Yexin Feng, Weida Hu, Feng Miao, Litao Sun, Xiangfeng Duan & Anlian Pan | | | Growth of large area and defect-free two-dimensional semiconductor layers for high-performance p–n junction applications has been a great challenge. Yang et al. prepare millimeter-scaled WSe2/SnS2 vertical heterojunctions by two-step van der Waals epitaxy, which show excellent optoelectronic properties. | | 04 December 2017 | doi: 10.1038/s41467-017-02093-z | | Materials science Nanoscale materials Two-dimensional materials | Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility OPEN | | Amit Sud, Hauke Thomsen, Philip J. Law, Asta Försti, Miguel Inacio da Silva Filho, Amy Holroyd, Peter Broderick, Giulia Orlando, Oleg Lenive, Lauren Wright, Rosie Cooke, Douglas Easton, Paul Pharoah, Alison Dunning, Julian Peto, Federico Canzian, Rosalind Eeles, ZSofia Kote-Jarai, Kenneth Muir, Nora Pashayan et al. | | | Classical Hodgkin lymphoma is a cancer that originates in lymph nodes. Little is known about its genetic susceptibility. Here, the authors combined existing and new genome-wide association studies to identify risk loci for classical Hodgkin lymphoma at 6q22.33, and nodular sclerosis Hodgkin lymphoma at 3q28, 6q23.3, 10p14, 13q34, 16p13.13. | | 01 December 2017 | doi: 10.1038/s41467-017-00320-1 | | Cancer genetics Genome-wide association studies Hodgkin lymphoma Immunogenetics | Nematic superconducting state in iron pnictide superconductors OPEN | | Jun Li, Paulo J. Pereira, Jie Yuan, Yang-Yang Lv, Mei-Ping Jiang, Dachuan Lu, Zi-Quan Lin, Yong-Jie Liu, Jun-Feng Wang, Liang Li, Xiaoxing Ke, Gustaaf Van Tendeloo, Meng-Yue Li, Hai-Luke Feng, Takeshi Hatano, Hua-Bing Wang, Pei-Heng Wu, Kazunari Yamaura, Eiji Takayama-Muromachi, Johan Vanacken et al. | | | Nematic electronic order is rare and its onset often indicates a phase transition. Here, Li et al. report a nematic superconducting state in Ba0.5K0.5Fe2As2 by measuring the angular dependence of the in-plane and out-of-plane magnetoresistivity. | | 01 December 2017 | doi: 10.1038/s41467-017-02016-y | | Superconducting devices Superconducting properties and materials | Remodelling of the gut microbiota by hyperactive NLRP3 induces regulatory T cells to maintain homeostasis OPEN | | Xiaomin Yao, Chenhong Zhang, Yue Xing, Guang Xue, Qianpeng Zhang, Fengwei Pan, Guojun Wu, Yingxin Hu, Qiuhong Guo, Ailing Lu, Xiaoming Zhang, Rongbin Zhou, Zhigang Tian, Benhua Zeng, Hong Wei, Warren Strober, Liping Zhao & Guangxun Meng | | | Inflammasomes are involved in gut homeostasis and inflammatory pathologies. The authors show that a hyperactive NLRP3 inflammasome maintains gut homeostasis through remodelling of the gut microbiota and induction of regulatory T cells. | | 01 December 2017 | doi: 10.1038/s41467-017-01917-2 | | Inflammasome Microbiome T cells | Multiplex single-cell visualization of nucleic acids and protein during HIV infection OPEN | | Maritza Puray-Chavez, Philip R. Tedbury, Andrew D. Huber, Obiaara B. Ukah, Vincent Yapo, Dandan Liu, Juan Ji, Jennifer J. Wolf, Alan N. Engelman & Stefan G. Sarafianos | | | Technical limitations in simultaneous microscopic visualization of HIV transcription from individual integration sites have curtailed progress in the field. Here the authors report a branched DNA in situ hybridization method for direct single-cell visualization of HIV DNA, RNA, and protein. | | 01 December 2017 | doi: 10.1038/s41467-017-01693-z | | Fluorescence imaging Retrovirus | Schwann cell TRPA1 mediates neuroinflammation that sustains macrophage-dependent neuropathic pain in mice OPEN | | Francesco De Logu, Romina Nassini, Serena Materazzi, Muryel Carvalho Gonçalves, Daniele Nosi, Duccio Rossi Degl’Innocenti, Ilaria M. Marone, Juliano Ferreira, Simone Li Puma, Silvia Benemei, Gabriela Trevisan, Daniel Souza Monteiro de Araújo, Riccardo Patacchini, Nigel W. Bunnett & Pierangelo Geppetti | | | Following peripheral nerve injury, influx of immune cells to the site may contribute to the development of chronic pain. Here the authors show that TRPA1 is expressed on Schwann cells and contributes to immune cell influx in a mouse model of neuropathic pain. | | 01 December 2017 | doi: 10.1038/s41467-017-01739-2 | | Chronic pain Schwann cell | The Kalanchoë genome provides insights into convergent evolution and building blocks of crassulacean acid metabolism OPEN | | Xiaohan Yang, Rongbin Hu, Hengfu Yin, Jerry Jenkins, Shengqiang Shu, Haibao Tang, Degao Liu, Deborah A. Weighill, Won Cheol Yim, Jungmin Ha, Karolina Heyduk, David M. Goodstein, Hao-Bo Guo, Robert C. Moseley, Elisabeth Fitzek, Sara Jawdy, Zhihao Zhang, Meng Xie, James Hartwell, Jane Grimwood et al. | | | Crassulacean acid metabolism (CAM) is a metabolic adaptation of photosynthesis that enhances water use efficiency. Here, via genomic analysis of Kalanchoë, the authors provide evidence for convergent evolution of protein sequence and temporal gene expression underpinning the multiple independent emergences of CAM. | | 01 December 2017 | doi: 10.1038/s41467-017-01491-7 | | Photosynthesis Plant evolution Sequencing | Expressed fusion gene landscape and its impact in multiple myeloma OPEN | | A. Cleynen, R. Szalat, M. Kemal Samur, S. Robiou du Pont, L. Buisson, E. Boyle, M. L. Chretien, K. Anderson, S. Minvielle, P. Moreau, M. Attal, G. Parmigiani, J. Corre, N. Munshi & H. Avet-Loiseau | | | Multiple myeloma is a malignancy of plasma cells in the blood. Here, the authors establish the landscape of fusion genes within this disease, identifying novel recurrent fusion genes that impact survival and may drive disease progression. | | 01 December 2017 | doi: 10.1038/s41467-017-00638-w | | Cancer genomics Myeloma | Thin single crystal perovskite solar cells to harvest below-bandgap light absorption OPEN | | Zhaolai Chen, Qingfeng Dong, Ye Liu, Chunxiong Bao, Yanjun Fang, Yun Lin, Shi Tang, Qi Wang, Xun Xiao, Yang Bai, Yehao Deng & Jinsong Huang | | | Thin films of halide perovskites are promising for solar cell technology but they do not perform well at the band edge due to the low optical absorption. Herein, Chen et al. fabricate a high efficiency single crystal perovskite solar cell with thicker single crystals to harvest the below-bandgap photons. | | 01 December 2017 | doi: 10.1038/s41467-017-02039-5 | | Solar cells | Discovery of naturally occurring ESR1 mutations in breast cancer cell lines modelling endocrine resistance OPEN | | Lesley-Ann Martin, Ricardo Ribas, Nikiana Simigdala, Eugene Schuster, Sunil Pancholi, Tencho Tenev, Pascal Gellert, Laki Buluwela, Alison Harrod, Allan Thornhill, Joanna Nikitorowicz-Buniak, Amandeep Bhamra, Marc-Olivier Turgeon, George Poulogiannis, Qiong Gao, Vera Martins, Margaret Hills, Isaac Garcia-Murillas, Charlotte Fribbens, Neill Patani et al. | | | ESR1 mutations occur in endocrine-resistant patients but have not yet been reported in in vitro models of breast cancer. Here, the authors report the discovery of naturally occurring ESR1 Y537Cand ESR1 Y537S mutations in two breast cancer cell lines after acquisition of resistance to long-term-estrogen-deprivation. | | 30 November 2017 | doi: 10.1038/s41467-017-01864-y | | Breast cancer Hormone receptors | Contributions of Zea mays subspecies mexicana haplotypes to modern maize OPEN | | Ning Yang, Xi-Wen Xu, Rui-Ru Wang, Wen-Lei Peng, Lichun Cai, Jia-Ming Song, Wenqiang Li, Xin Luo, Luyao Niu, Yuebin Wang, Min Jin, Lu Chen, Jingyun Luo, Min Deng, Long Wang, Qingchun Pan, Feng Liu, David Jackson, Xiaohong Yang, Ling-Ling Chen et al. | | | Maize was domesticated from wild lowland progenitors that co-existed with upland subspecies in Southwestern Mexico. Here Yang et al. use a meta-assembly approach to assemble an upland mexicana genome and find evidence of introgression suggesting it contributed to modern maize adaptation | | 30 November 2017 | doi: 10.1038/s41467-017-02063-5 | | Genome Plant domestication Plant genetics | Structural basis of respiratory syncytial virus subtype-dependent neutralization by an antibody targeting the fusion glycoprotein OPEN | | Daiyin Tian, Michael B. Battles, Syed M. Moin, Man Chen, Kayvon Modjarrad, Azad Kumar, Masaru Kanekiyo, Kevin W. Graepel, Noor M. Taher, Anne L. Hotard, Martin L. Moore, Min Zhao, Zi-Zheng Zheng, Ning-Shao Xia, Jason S. McLellan & Barney S. Graham | | | Monoclonal antibodies to prevent respiratory syncytial virus (RSV) disease are under development, but the molecular requirements for cross-subtype neutralization are unclear. Here, the authors show that residue 201 in RSV fusion protein determines subtype specific neutralization for the clinically-relevant monoclonal antibody, 5C4. | | 30 November 2017 | doi: 10.1038/s41467-017-01858-w | | Antibody therapy Vaccines Viral immune evasion Virus structures | Inference of differentiation time for single cell transcriptomes using cell population reference data OPEN | | Na Sun, Xiaoming Yu, Fang Li, Denghui Liu, Shengbao Suo, Weiyang Chen, Shirui Chen, Lu Song, Christopher D. Green, Joseph McDermott, Qin Shen, Naihe Jing & Jing-Dong J. Han | | | Single cell transcriptome data can be used to determine developmental lineage trajectories. Here the authors map single cell transcriptomes onto a differentiation trajectory defined by cell population transcriptomes and show that cell cycle regulators have a role in differentiation timing. | | 30 November 2017 | doi: 10.1038/s41467-017-01860-2 | | Data integration Differentiation Embryonic stem cells Stem-cell differentiation | Downregulation of myostatin pathway in neuromuscular diseases may explain challenges of anti-myostatin therapeutic approaches OPEN | | Virginie Mariot, Romain Joubert, Christophe Hourdé, Léonard Féasson, Michael Hanna, Francesco Muntoni, Thierry Maisonobe, Laurent Servais, Caroline Bogni, Rozen Le Panse, Olivier Benvensite, Tanya Stojkovic, Pedro M. Machado, Thomas Voit, Ana Buj-Bello & Julie Dumonceaux | | | Drugs targeting myostatin reverse muscle wasting in animal models, but have limited efficacy in patients. The authors show that the myostatin pathway is downregulated in patients, possibly explaining the poor outcome of anti-myostatin approaches, and that it can be reactivated by correcting disease-causing mutations in mice. | | 30 November 2017 | doi: 10.1038/s41467-017-01486-4 | | Neuromuscular disease Skeletal muscle | Restoration of patterned vision with an engineered photoactivatable G protein-coupled receptor OPEN | | Michael H. Berry, Amy Holt, Joshua Levitz, Johannes Broichhagen, Benjamin M. Gaub, Meike Visel, Cherise Stanley, Krishan Aghi, Yang Joon Kim, Dirk Trauner, John Flannery & Ehud Y. Isacoff | | | To restore sight after retinal degeneration, one approach is to express light-sensitive proteins in remaining cells. Here the authors combine a light-sensitive engineered G protein-coupled receptor and ion channels to restore ON and OFF responses as well as superior visual pattern discrimination. | | 30 November 2017 | doi: 10.1038/s41467-017-01990-7 | | Molecular neuroscience Protein design Retina | Developmental YAPdeltaC determines adult pathology in a model of spinocerebellar ataxia type 1 OPEN | | Kyota Fujita, Ying Mao, Shigenori Uchida, Xigui Chen, Hiroki Shiwaku, Takuya Tamura, Hikaru Ito, Kei Watase, Hidenori Homma, Kazuhiko Tagawa, Marius Sudol & Hitoshi Okazawa | | | Ataxin-1, linked to spinocerebellar ataxia type 1, is known to interact with the orphan nuclear receptor RORα. Here, Fujita and colleagues show that genetic supplementation of RORα-interacting protein YAPdeltaC during early development can rescue the adult pathologies of SCA1 mouse model. | | 30 November 2017 | doi: 10.1038/s41467-017-01790-z | | Spinocerebellar ataxia Transcriptional regulatory elements | Demonstration of chemistry at a point through restructuring and catalytic activation at anchored nanoparticles OPEN | | Dragos Neagu, Evangelos I. Papaioannou, Wan K. W. Ramli, David N. Miller, Billy J. Murdoch, Hervé Ménard, Ahmed Umar, Anders J. Barlow, Peter J. Cumpson, John T. S. Irvine & Ian S. Metcalfe | | | Metal nanoparticles prepared by exsolution at the surface of perovskite oxides are key species in catalysis and energy fields. Here, the authors develop a chemistry at a point concept by tracking individual nanoparticles with excellent activity and stability throughout various chemical transformations. | | 30 November 2017 | doi: 10.1038/s41467-017-01880-y | | Catalyst synthesis Heterogeneous catalysis Nanoparticles | | | | | | | | Advertisement | | | | | Advertisement | | | | | | | | | | | Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com | | | | | | | | You have been sent this Table of Contents Alert because you have opted in to receive it. 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