The EMBO Journal Table of Contents for 15 November 2017; Vol. 36, No. 22

15 November 2017 | Volume 36, Number 22 Submit Table of Contents News & Views Articles Erratum Volume 36, Number 22 News & Views A genetically distinct microglial subset promotes myelination A unique microglia subpopulation regulates CNS myelination via Igf1 expression. Mariko L Bennett and Ben A Barres Published online 03.11.2017 Channel surfing uncovers a dual‐use transporter Identifying prostaglandin transporter SLCO2A1 as a core component of the Maxi‐Cl anion channel shows that a transporter protein can moonlight as an ion channel. Daniel L Minor, Jr Published online 19.10.2017 Articles Membrane scission driven by the PROPPIN Atg18 Atg18, a member of the PI3P‐binding PROPPIN family of proteins, carries membrane fission activity, which is necessary to divide the lysosome‐like yeast vacuoles into smaller vesicles. Navin Gopaldass, Bruno Fauvet, Hilal Lashuel, Aurélien Roux and Andreas Mayer Published online 13.10.2017 A novel microglial subset plays a key role in myelinogenesis in developing brain In contrast to the homeostatic and neuroinflammatory roles of adult microglia, a unique neonatal CD11c‐expressing subpopulation acts to deliver IGF1 and other signals needed for myelination and neurogenesis. Agnieszka Wlodarczyk, Inge R Holtman, Martin Krueger, Nir Yogev, Julia Bruttger, Reza Khorooshi, Anouk Benmamar‐Badel, Jelkje J de Boer‐Bergsma, Nellie A Martin, Khalad Karram, Isabella Kramer, Erik WGM Boddeke, Ari Waisman, Bart JL Eggen and Trevor Owens Published online 28.09.2017 The organic anion transporter SLCO2A1 constitutes the core component of the Maxi‐Cl channel A combination of proteomics, RNAi screening, and reconstitution approaches reveals the molecular identity of the long‐sought maxi‐anion channel activity in cells. Ravshan Z Sabirov, Petr G Merzlyak, Toshiaki Okada, Md Rafiqul Islam, Hiromi Uramoto, Tomoko Mori, Yumiko Makino, Hiroshi Matsuura, Yu Xie and Yasunobu Okada Published online 18.10.2017 LncRNA wires up Hippo and Hedgehog signaling to reprogramme glucose metabolism Yes‐associated protein activation triggers transcription of long noncoding RNA BCAR4, leading to GLI2‐mediated expression of key glycolytic enzymes. Xin Zheng, Han Han, Guang‐Ping Liu, Yan‐Xiu Ma, Ruo‐Lang Pan, Ling‐Jie Sang, Rui‐Hua Li, Luo‐Jia Yang, Jeffrey R Marks, Wenqi Wang and Aifu Lin Published online 28.09.2017 Tumor‐associated macrophages (TAMs) depend on ZEB1 for their cancer‐promoting roles Tumor‐associated macrophages express the EMT‐associated transcription factor ZEB1, which drives their tumor‐promoting and chemotherapy‐resistance functions in mouse ovarian cancer models. Marlies Cortés, Lidia Sanchez‐Moral, Oriol de Barrios, María J Fernández‐Aceñero, MC Martínez‐Campanario, Anna Esteve‐Codina, Douglas S Darling, Balázs Győrffy, Toby Lawrence, Douglas C Dean and Antonio Postigo Published online 16.10.2017 Increased localization of APP‐C99 in mitochondria‐associated ER membranes causes mitochondrial dysfunction in Alzheimer disease In animal and cellular models of Alzheimer disease (AD) and in fibroblasts from AD patients, APP‐C99 levels are increased in mitochondria‐associated endoplasmic reticulum membrane (ER‐MAM) regions, resulting in perturbed lipid homeostasis and mitochondrial dysfunction. Marta Pera, Delfina Larrea, Cristina Guardia‐Laguarta, Jorge Montesinos, Kevin R Velasco, Rishi R Agrawal, Yimeng Xu, Robin B Chan, Gilbert Di Paolo, Mark F Mehler, Geoffrey S Perumal, Frank P Macaluso, Zachary Z Freyberg, Rebeca Acin‐Perez, Jose Antonio Enriquez, Eric A Schon and Estela Area‐Gomez Published online 10.10.2017 Chromatin remodeler CHD1 promotes XPC‐to‐TFIIH handover of nucleosomal UV lesions in nucleotide excision repair Processing of UV‐induced cyclobutane pyrimidine dimers within the context of nucleosomes involves chromatin recruitment of the CHD1 remodeler via the primary lesion sensor XPC. Peter Rüthemann, Chiara Balbo Pogliano, Tamara Codilupi, Zuzana Garajovà and Hanspeter Naegeli Published online 10.10.2017 Combinatorial regulation of the balance between dynein microtubule end accumulation and initiation of directed motility In vitro reconstitution of the human dynein complex reveals the differential control of dynein activity on dynamic microtubules by a combination of its key regulators. Rupam Jha, Johanna Roostalu, Nicholas I Cade, Martina Trokter and Thomas Surrey Published online 16.10.2017 Erratum Rab35 GTPase recruits NDP52 to autophagy targets Atsuko Minowa‐Nozawa, Takashi Nozawa, Keiko Okamoto‐Furuta, Haruyasu Kohda and Ichiro Nakagawa Published online 15.11.2017   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 973 University Avenue * Los Gatos, CA 95032 * U.S.A. Copyright © 2017 by the European Molecular Biology Organisation.