Nature Reviews Neuroscience contents December 2017 Volume 18 Number 12 pp 707-769

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TABLE OF CONTENTS
December 2017 Volume 18 Number 12		Advertisement
2016 2-year Impact Factor 28.880 Journal Metrics 2-year Median 23	In this issue Comment Research Highlights Reviews Correspondence   Also this month Article series: Food intake, metabolism and the brain  Featured article: The dopamine motive system: implications for drug and food addiction Nora D. Volkow, Roy A. Wise & Ruben Baler	From mice to men Touchscreen-based testing better translates cognitive assessment from animal models to humans and has reduced physically and mentally stress. The method is amenable to automation and increasing task complexity to generate detailed data to identify mild and severe cognitive dysfunction.
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Comment: Incorporating sex as a biological variable in neuroscience: what do we gain? Margaret M. McCarthy, Catherine S. Woolley & Arthur P. Arnold p707 | doi:10.1038/nrn.2017.137 In recent years, several funding agencies have introduced requirements for researchers to consider sex as a biological variable in preclinical research. In this Comment article, McCarthy and colleagues discuss the potential impact of these policies for neuroscience research. Full Text | PDF
RESEARCH HIGHLIGHTS   Top Neural coding: Flexible in the face of distraction p709 | doi:10.1038/nrn.2017.142 In a working memory task, the neural code for the target stimulus in the lateral prefrontal cortex transforms when a distractor is presented, without loss of target-related information. PDF Epigenetics: Leaving a lasting mark p710 | doi:10.1038/nrn.2017.144 Methylation of neuronal genes at CA sequences is modulated by neuronal activity during early postnatal periods and fine tunes gene expression in adult neurons. PDF Neural circuits: Shock signals p710 | doi:10.1038/nrn.2017.145 In fear conditioning in mice, neurons in the lateral central amygdala that express protein kinase Cδ convey the unconditioned stimulus to the lateral amygdala to enable the encoding of aversive memory. PDF Learning and memory: Holding the space p711 | doi:10.1038/nrn.2017.143 Spatial position is spontaneously stored as part of working memory, even in tasks where spatial location is not relevant to the task. PDF   Nature Reviews Neuroscience JOBS of the week Junior and Senior Faculty Positions at the Department of Biology, SUSTech Southern University of Science and Technology (SUSTech) Postdoctoral fellow / Research Associate in Developmental Neurobiology SUNY Upstate Medical College Multiple Faculty Positions at ShanghaiTech University ShanghaiTech University Instructor / Assistant / Associate Professor of Neurology Massachuesetts General Hospital / Harvard Medical School Group leader position open at the ICM ICM Foundation � Brain and spinal cord research Institute More Science jobs from Nature Reviews Neuroscience EVENT Summer Program in Neuroscience, Excellence and Success 14.06.18 USA More science events from
REVIEWS		Top
The nano-architecture of the axonal cytoskeleton Christophe Leterrier, Pankaj Dubey & Subhojit Roy p713 | doi:10.1038/nrn.2017.129 An axon's function is dictated by its morphology and, thus, by the properties and organization of the axonal cytoskeleton. Leterrier et al. describe how advances in super-resolution and live-cell imaging are transforming our understanding of the molecular architecture of the axonal shaft. Abstract | Full Text | PDF
Genetic insights into the neurodevelopmental origins of schizophrenia Rebecca Birnbaum & Daniel R. Weinberger p727 | doi:10.1038/nrn.2017.125 A causal explanation for the pathogenesis of schizophrenia is lacking. In this Review, Birnbaum and Weinberger explore recent genetic studies of schizophrenia and discuss how genetic and epigenetic risk of the disorder may converge to perturb key neurodevelopmental trajectories. Abstract | Full Text | PDF
Article series: Food intake, metabolism and the brain The dopamine motive system: implications for drug and food addiction Nora D. Volkow, Roy A. Wise & Ruben Baler p741 | doi:10.1038/nrn.2017.130 The dopamine motive system, which integrates reinforcement and motivation, is influenced by obesogenic foods and addictive drugs. In this Review, Volkow and colleagues highlight how these stimuli sensitize the subject's motivation towards them while desensitizing the subject's motivation towards alternative reinforcers. Abstract | Full Text | PDF | Supplementary information
Regenerating CNS myelin — from mechanisms to experimental medicines Robin J. M. Franklin & Charles ffrench-Constant p753 | doi:10.1038/nrn.2017.136 Promoting remyelination may be an effective therapeutic strategy for various disorders that are characterized by a loss of myelin, including multiple sclerosis. In this Review, Franklin and ffrench-Constant discuss recent developments in our understanding of remyelination and the efforts that are underway to enhance this process. Abstract | Full Text | PDF
CORRESPONDENCE		Top
Some considerations on de Waal and Preston review Giacomo Rizzolatti & Fausto Caruana p769 | doi:10.1038/nrn.2017.139 Full Text | PDF
REPLY		Top
Only the PAM explains the personalized nature of empathy Stephanie D. Preston & Frans B. M. de Waal p769 | doi:10.1038/nrn.2017.140 Full Text | PDF
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