Nature Reviews Immunology Contents December 2017 Volume 17 Number 12 pp 729-785

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TABLE OF CONTENTS
December 2017 Volume 17 Number 12		Advertisement
2016 2-year Impact Factor 39.932 Journal Metrics 2-year Median 29	In this issue Research Highlights Reviews   Also this month  Featured article: γδ T cells in homeostasis and host defence of epithelial barrier tissues Morten M. Nielsen, Deborah A. Witherden & Wendy L. Havran	Better visualize, analyze, and phenotype immune cells in situ in FFPE tissue sections and TMAs Learn how Vectra Polaris™ quantitative pathology imaging system provides unparalleled speed and performance for extracting proteomic and morphometric information from tissue sections.  Download Application Note
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RESEARCH HIGHLIGHTS   Top MHC molecules: Immune editing shapes the cancer landscape p729 | doi:10.1038/nri.2017.129 HLA variation or loss is associated with immune editing in human tumours. PDF Immunometabolism: T cells activate the fear p730 | doi:10.1038/nri.2017.126 T cell activation is associated with a depletion of amino acids and neurotransmitters and may result in behavioural changes PDF Dendritic cells: Managing migration p730 | doi:10.1038/nri.2017.128 Lysosomal calcium signalling links antigen uptake by tissue dendritic cells to migration to the lymph nodes. PDF Inflammation: Inflammatory memory is skin deep p731 | doi:10.1038/nri.2017.127 Skin epithelial stem cells show inflammatory memory, which enhances their response to tissue damage. PDF Cytokines: The inflamed heart p732 | doi:10.1038/nri.2017.135 Type I interferons, induced by DNA released from ischaemic cardiomyocytes, drive inflammation after myocardial infarction. PDF JOURNAL CLUB New beginnings p732 | doi:10.1038/nri.2017.91 Florent Ginhoux reflects on a 2002 paper by Merad and colleagues that challenged the dogma that adult Langerhans cells arise from blood-circulating precursors. PDF   Nature Reviews Immunology JOBS of the week Assistant or Associate Professor of Medicine, Canada Research Chair Tier 2 McGill University - Department of Medicine Assistant Professor of Nutritional Sciences University of Florida Research Assistant - FMI Group Liberali Friedrich Miescher Institute for Biomedical Research (FMI) Postdoctoral Postion - The University of Pittsburgh School of Medicine University of Pittsbugh, School of Medicine Institute of Metabolism and Diseases,Shanghai General Hospital Shanghai General Hospital More Science jobs from Nature Reviews Immunology EVENT Advanced Course in Basic & Clinical Immunology 18.02.18 Scottsdale, USA More science events from
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REVIEWS		Top
γδ T cells in homeostasis and host defence of epithelial barrier tissues Morten M. Nielsen, Deborah A. Witherden & Wendy L. Havran p733 | doi:10.1038/nri.2017.101 γδ T cells are found mainly in epithelial tissues, where they have crucial roles in tissue homeostasis and repair. Here, the authors describe how γδ T cells are activated and regulated in epithelial tissues, such as the skin and intestine, to mediate host microbial tolerance and provide protection against infection. Abstract | Full Text | PDF
Functions of tissue-resident eosinophils Peter F. Weller & Lisa A. Spencer p746 | doi:10.1038/nri.2017.95 Tissue-resident eosinophils selectively secrete cytokines and other mediators that have diverse functions in health and disease. Abstract | Full Text | PDF
Organ-specific protection mediated by cooperation between vascular and epithelial barriers Ilaria Spadoni, Giulia Fornasa & Maria Rescigno p761 | doi:10.1038/nri.2017.100 Here, the authors discuss the role of cellular barriers in establishing immune privilege, both in the intestine and in other organs, such as the brain and the eyes. They compare protective epithelial and vascular barriers in different organs and examine how several pathologies are linked to the disruption of these barriers. Abstract | Full Text | PDF
Regulation of immunity and inflammation by hypoxia in immunological niches Cormac T. Taylor & Sean P. Colgan p774 | doi:10.1038/nri.2017.103 Hypoxia is a microenvironmental feature that is associated with physiological and pathological immunological niches. In this Review, Taylor and Colgan summarize the effects of physiological and pathological hypoxia on immune cells and processes and discuss the possibility of therapeutically targeting hypoxia-sensitive pathways. Abstract | Full Text | PDF
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