Nature Reviews Genetics Contents December 2017 Volume 18 Number 12 pp 701-760

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TABLE OF CONTENTS
December 2017 Volume 18 Number 12		Advertisement
2016 2-year Impact Factor 40.282 Journal Metrics 2-year Median 28.5	In this issue Research Highlights Reviews Analysis Perspectives   Also this month Article series: Study designs Disease mechanisms  Featured article: Beyond editing to writing large genomes Raj Chari & George M. Church	A new open access journal dedicated to publishing the most important scientific advances in all aspects of genomics and its application in the practice of medicine. Part of the Nature Partner Journals series, the journal is published in partnership with the Center of Excellence in Genomic Medicine Research. Open for submissions >>>
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Animation on CRISPR: Gene editing and beyond The CRISPR-Cas9 system has revolutionised gene editing, but cutting DNA isn't all it can do. This Animation, from Nature Methods, explores where CRISPR might be headed next. Watch the Animation here>> Produced with support from:  Dharmacon
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Nature Outlook: Women’s health  From common diseases that affect the sexes differently to conditions that affect only women — and from birth, through the menopause, to old age — there are many challenges in women’s health. Access the Outlook free online to learn more >> Produced with support from: Symbiomix Therapeutics, LLC
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RESEARCH HIGHLIGHTS   Top Gene expression: Principles of gene regulation across tissues p701 | doi:10.1038/nrg.2017.94 PDF Genetic variation: Birds of a feather — genetic mapping of yellow pigmentation p702 | doi:10.1038/nrg.2017.87 PDF Transcription: Intragenic enhancers dampen gene expression p702 | doi:10.1038/nrg.2017.90 PDF Cancer genomics: The driving force of cancer evolution p703 | doi:10.1038/nrg.2017.95 PDF Genetic engineering: On the road to efficient gene drives p704 | doi:10.1038/nrg.2017.91 PDF Transcription: Promoters dictate termination mode p704 | doi:10.1038/nrg.2017.93 PDF   Genetics JOBS of the week Posdoctoral position CNRS & Bordeaux University Junior and Senior Faculty Positions at the Department of Biology, SUSTech Southern University of Science and Technology (SUSTech) Program Officer, Crohn's Disease The Leona M. and Harry B. Helmsley Charitable Trust Postdoctoral Research Fellow Boston Children's Hospital Postdoctoral Scholar University of California San Francisco - UCSF More Science jobs from Genetics EVENT Cancer Genetics Course 29.01.18 London, UK More science events from
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REVIEWS		Top
Demographic history, selection and functional diversity of the canine genome Elaine A. Ostrander, Robert K. Wayne, Adam H. Freedman & Brian W. Davis p705 | doi:10.1038/nrg.2017.67 Despite being a single species, dogs represent nearly 400 breeds with substantial genetic, morphological and behavioural diversity. In this Review, Ostrander et al. discuss how genomics studies of dogs have enhanced our understanding of dog and human population history, the desired and unintended consequences of trait-based selective breeding, and potentially human-applicable insights into cancer, ageing, behaviour and neurological diseases. Abstract | Full Text | PDF
Population genetics of sexual conflict in the genomic era Judith E. Mank p721 | doi:10.1038/nrg.2017.83 Sexual conflict is thought to increase population genetic diversity though balancing selection, which has important evolutionary implications. This Review discusses how population genomic approaches are contributing to a deeper understanding of sexual conflict and how it is resolved. Abstract | Full Text | PDF
ANALYSIS		Top
Article series: Disease mechanisms Convergence between biological, behavioural and genetic determinants of obesity Sujoy Ghosh & Claude Bouchard p731 | doi:10.1038/nrg.2017.72 Recent large-scale genome-wide association studies have identified numerous variants that are associated with obesity-relevant traits such as body mass index or body fat percentage. Here, the authors explore to what extent this genomic evidence matches the evidence from functional and mechanistic studies. Abstract | Full Text | PDF | Supplementary information
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Nature Reviews Collection — The obesity epidemic: molecular and clinical considerations  This collection of articles describes the latest efforts to understand the molecular mechanisms underlying obesity against a complex backdrop of factors that include socioeconomic status, environment and personal behaviour, as well as advances in treatment.  View the collection
PERSPECTIVES		Top
OPINION Article series: Study designs Beyond editing to writing large genomes Raj Chari & George M. Church p749 | doi:10.1038/nrg.2017.59 Advances in genome sequencing, editing and synthetic biology have enhanced the feasibility of large-scale genome engineering, termed genome writing. In this Opinion article, Chari and Church discuss the strengths and limitations of diverse strategies for genome writing, including extensively modifying existing genomes versus synthesizing genomes de novo, and they provide future visions for writing large genomes. Abstract | Full Text | PDF
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