Wednesday, November 22, 2017

Nature Reviews Cancer contents December 2017 Volume 17 Number 12 pp 705-765

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Nature Reviews Cancer

TCR pathway in action 

Explore ZAP70 signalling and immune checkpoint regulation in relevant primary models (PBMC and isolated T cells).
December 2017 Volume 17 Number 12 Advertisement
Nature Reviews Cancer cover
2016 2-year Impact Factor 37.147 Journal Metrics 2-year Median 28
In this issue
Research Highlights
Also this month
 Featured article:
Preclinical mouse solid tumour models: status quo, challenges and perspectives
Nicolas Gengenbacher, Mahak Singhal &aMP; Hellmut G. Augustin

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Poster on: The expanding CRISPR toolbox 

The CRISPR-Cas9 system can do a lot more than gene editing. This Poster, from Nature Methods, explores the newest possibilities of CRISPR.

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npj Molecular Phenomics is an online-only, open access journal that provides a forum for cutting-edge scientific advances in the emerging field of phenomics, the study of the physical and chemical characteristics of an individual in quantitative terms.

Part of the Nature Partner Journals series, npj Molecular Phenomics is published in partnership with Fudan University. The journal is now open for submissions.

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Cancer models: Escaping those primitive origins
p705 | doi:10.1038/nrc.2017.100
An embryonic avian model recapitulates the early stages of tumorigenesis and metastases seen in patients with neuroblastoma.

Tumour suppressors: Digging deeper into p53's functions
p706 | doi:10.1038/nrc.2017.108
Mello et al. analysed the effects of various p53 transactivation domain mutants in pancreatic ductal adenocarcinoma and uncovered a crucial tumour-suppressive pathway in which p53 mediates inhibition of the transcriptional co-activator YAP.

Immunotherapy: Rewiring cancer cells
p706 | doi:10.1038/nrc.2017.112
A modular synthetic RNA-based gene circuit has been developed to program tumour cells to express a combination of immunomodulators to improve the specificity and efficacy of cancer immunotherapy.

Metabolism: More lactate, please
p707 | doi:10.1038/nrc.2017.101
The importance of 'Warburgian' metabolism in cancer is an increasingly disputed topic. By studying cancer metabolism in patients and mouse models, Faubert et al. now show that lactate is used as a respiratory fuel in non-small-cell lung cancer in vivo.

Tumour angiogenesis: Controlling nerves
p708 | doi:10.1038/nrc.2017.107
Sympathetic nerves associate with tumours and regulate the tumour microenvironment. How this innervation promotes tumorigenesis is unclear. A new study in Science shows that β-adrenergic signalling controls tumour growth by promoting tumour angiogenesis, through the regulation of vascular metabolism.



Metabolism: Conscious decoupling | Leukaemia: Crowd control | Tumour biomarkers: A mark is a marker

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Targeting immunosuppressive adenosine in cancer
Dipti Vijayan, Arabella Young, Michele W.L. Teng & Mark J. Smyth

p709 | doi:10.1038/nrc.2017.86
The adenosinergic pathway is a major immunosuppressive mechanism in the tumour microenvironment. In this Review, Vijayan et al. discuss how targeting components involved in the generation and downstream signalling of extracellular adenosine represents an attractive novel cancer therapy.
Abstract | Full Text | PDF

Small-cell lung cancer: what we know, what we need to know and the path forward
Adi F. Gazdar, Paul A. Bunn & John D. Minna

p725 | doi:10.1038/nrc.2017.87
Small-cell lung cancer is an aggressive form of lung cancer and has been difficult to treat due to therapy resistance. This Review discusses challenges and recent advances in uncovering molecular changes that allow potentially efficient therapies.
Abstract | Full Text | PDF | Supplementary information

Transport of drugs from blood vessels to tumour tissue
Mark W. Dewhirst & Timothy W. Secomb

p738 | doi:10.1038/nrc.2017.93
This Review by Dewhirst and Secomb describes the current understanding of drug transport to tumour cells and the progress that has been made in developing methods to enhance drug delivery.
Abstract | Full Text | PDF

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Preclinical mouse solid tumour models: status quo, challenges and perspectives
Nicolas Gengenbacher, Mahak Singhal & Hellmut G. Augustin

p751 | doi:10.1038/nrc.2017.92This Analysis examines preclinical mouse tumour studies published in eight scientific journals in 2016. It reviews current practices, identifies some important challenges and discusses ways in which the relevance, reproducibility and translatability of tumour models could be improved.
Abstract | Full Text | PDF | Supplementary information
Corrigendum: Small-cell lung cancer: what we know, what we need to know and the path forward
Adi F. Gazdar, Paul A. Bunn & John D. Minna

p765 | doi:10.1038/nrc.2017.106
Full Text | PDF
Corrigendum: Targeting immunosuppressive adenosine in cancer
Dipti Vijayan, Arabella Young, Michele W. L. Teng & Mark J. Smyth

p765 | doi:10.1038/nrc.2017.110
Full Text | PDF
An online-only, open access, multidisciplinary journal dedicated to publishing high-quality original research articles, reviews, editorials, commentaries, and hypothesis generating observations on all areas of breast cancer research.
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