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December 2017 Volume 17 Number 12 | Advertisement | |||||||||||||||||||||||||||||||||||||||||||||
| In this issue Research Highlights Reviews Analysis
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REVIEWS | Top | |||||||||||||||||||||||||||||||||||||||||||||
Targeting immunosuppressive adenosine in cancer Dipti Vijayan, Arabella Young, Michele W.L. Teng & Mark J. Smyth p709 | doi:10.1038/nrc.2017.86 The adenosinergic pathway is a major immunosuppressive mechanism in the tumour microenvironment. In this Review, Vijayan et al. discuss how targeting components involved in the generation and downstream signalling of extracellular adenosine represents an attractive novel cancer therapy. Abstract | Full Text | PDF | ||||||||||||||||||||||||||||||||||||||||||||||
Small-cell lung cancer: what we know, what we need to know and the path forward Adi F. Gazdar, Paul A. Bunn & John D. Minna p725 | doi:10.1038/nrc.2017.87 Small-cell lung cancer is an aggressive form of lung cancer and has been difficult to treat due to therapy resistance. This Review discusses challenges and recent advances in uncovering molecular changes that allow potentially efficient therapies. Abstract | Full Text | PDF | Supplementary information | ||||||||||||||||||||||||||||||||||||||||||||||
Transport of drugs from blood vessels to tumour tissue Mark W. Dewhirst & Timothy W. Secomb p738 | doi:10.1038/nrc.2017.93 This Review by Dewhirst and Secomb describes the current understanding of drug transport to tumour cells and the progress that has been made in developing methods to enhance drug delivery. Abstract | Full Text | PDF | ||||||||||||||||||||||||||||||||||||||||||||||
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ANALYSIS | Top | |||||||||||||||||||||||||||||||||||||||||||||
Preclinical mouse solid tumour models: status quo, challenges and perspectives Nicolas Gengenbacher, Mahak Singhal & Hellmut G. Augustin p751 | doi:10.1038/nrc.2017.92This Analysis examines preclinical mouse tumour studies published in eight scientific journals in 2016. It reviews current practices, identifies some important challenges and discusses ways in which the relevance, reproducibility and translatability of tumour models could be improved. Abstract | Full Text | PDF | Supplementary information | ||||||||||||||||||||||||||||||||||||||||||||||
Corrigendum: Small-cell lung cancer: what we know, what we need to know and the path forward Adi F. Gazdar, Paul A. Bunn & John D. Minna p765 | doi:10.1038/nrc.2017.106 Full Text | PDF | ||||||||||||||||||||||||||||||||||||||||||||||
Corrigendum: Targeting immunosuppressive adenosine in cancer Dipti Vijayan, Arabella Young, Michele W. L. Teng & Mark J. Smyth p765 | doi:10.1038/nrc.2017.110 Full Text | PDF | ||||||||||||||||||||||||||||||||||||||||||||||
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