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TABLE OF CONTENTS
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December 2017 Volume 20, Issue 12 |
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| News & Views Comment Review Articles Brief Communications Articles Resources Technical Reports | |
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News &Views | Top |
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Comment | Top |
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Whole genome sequencing in psychiatric disorders: the WGSPD consortium pp1661 - 1668 Stephan J. Sanders, Benjamin M. Neale, Hailiang Huang, Donna M. Werling, Joon-Yong An et al. doi:10.1038/s41593-017-0017-9 |
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Review Articles | Top |
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Thalamic functions in distributed cognitive control pp1669 - 1679 Michael M. Halassa & Sabine Kastner doi:10.1038/s41593-017-0020-1 The authors propose a new framework for the thalamus in cognition. They review findings from rodents and primates, emphasizing thalamic control of functional cortical connectivity, its putative mechanisms and role in flexible construction of task-relevant cortical networks. |
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Brief Communications | Top |
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The central amygdala controls learning in the lateral amygdala pp1680 - 1685 Kai Yu, Sandra Ahrens, Xian Zhang, Hillary Schiff, Charu Ramakrishnan et al. doi:10.1038/s41593-017-0009-9 The authors show that PKC-δ-expressing neurons in the central amygdala, are essential for synaptic plasticity underlying learning in the lateral amygdala, as they convey information about unconditioned stimulus to the lateral amygdala as a teaching signal. |
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Articles | Top |
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Activation of planarian TRPA1 by reactive oxygen species reveals a conserved mechanism for animal nociception pp1686 - 1693 Oscar M. Arenas, Emanuela E. Zaharieva, Alessia Para, Constanza Vásquez-Doorman, Christian P. Petersen et al. doi:10.1038/s41593-017-0005-0 Animals must detect noxious stimuli to initiate protective behavior, but the evolutionary origin of nociceptive systems is poorly understood. The authors reveal a core function for TRPA1 in noxious heat transduction based on sensing H2O2 and ROS and demonstrate its conservation from planarians to humans. |
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Arid1b haploinsufficiency disrupts cortical interneuron development and mouse behavior pp1694 - 1707 Eui-Man Jung, Jeffrey Jay Moffat, Jinxu Liu, Shashank Manohar Dravid, Channabasavaiah Basavaraju Gurumurthy et al. doi:10.1038/s41593-017-0013-0 Arid1b haploinsufficiency causes autism and intellectual disability, yet the neurobiological basis of this is unknown. The authors demonstrate that Arid1b-heterozygous mice have impaired cortical interneuron development and epigenetic signatures. These mice also have cognitive and social deficits, which are reversed by treatment with a GABAA-receptor-positive allosteric modulator. |
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Lateral geniculate neurons projecting to primary visual cortex show ocular dominance plasticity in adult mice pp1708 - 1714 Juliane Jaepel, Mark Hübener, Tobias Bonhoeffer & Tobias Rose doi:10.1038/s41593-017-0021-0 Experience-dependent plasticity in the visual system has widely been considered to be exclusively cortical. Using chronic two-photon Ca2+imaging of individual thalamic boutons, Jaepel et al. now report that dLGN cells projecting to mouse visual cortex show pronounced ocular dominance plasticity after monocular deprivation. |
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Thalamic inhibition regulates critical-period plasticity in visual cortex and thalamus pp1715 - 1721 Jean-Pierre Sommeijer, Mehran Ahmadlou, M. Hadi Saiepour, Koen Seignette, Rogier Min et al. doi:10.1038/s41593-017-0002-3 The critical period of ocular dominance (OD) plasticity in the visual cortex is initiated by maturation of inhibition. The authors show that thalamic relay neurons in mouse dorsolateral geniculate nucleus also undergo OD plasticity. This process depends on thalamic inhibition and is required for consolidating the OD shift in visual cortex. |
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Oxytocin-receptor-expressing neurons in the parabrachial nucleus regulate fluid intake pp1722 - 1733 Philip J. Ryan, Silvano I. Ross, Carlos A. Campos, Victor A. Derkach & Richard D. Palmiter doi:10.1038/s41593-017-0014-z The authors show that oxytocin-receptor-expressing neurons in the parabrachial nucleus are key regulators of fluid homeostasis that suppress fluid intake when activated, but do not decrease food intake after fasting or salt intake after salt depletion. |
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A craniofacial-specific monosynaptic circuit enables heightened affective pain pp1734 - 1743 Erica Rodriguez, Katsuyasu Sakurai, Jennie Xu, Yong Chen, Koji Toda et al. doi:10.1038/s41593-017-0012-1 The authors show that unlike body sensory neurons, craniofacial nociceptive neurons directly synapse with noxious-stimulus-activated lateral parabrachial neurons (PBL), which in turn project to multiple limbic centers processing emotions and affects. This monosynaptic pathway is both sufficient and necessary for craniofacial-pain-activated aversive behaviors. |
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Altered cerebellar connectivity in autism and cerebellar-mediated rescue of autism-related behaviors in mice pp1744 - 1751 Catherine J. Stoodley, Anila M. D'Mello, Jacob Ellegood, Vikram Jakkamsetti, Pei Liu et al. doi:10.1038/s41593-017-0004-1 Cerebellar right Crus I (RCrusI) has been implicated in autism spectrum disorder (ASD). RCrusI modulation altered RCrusI–inferior parietal lobule connectivity, and this connectivity was atypical in children with ASD and in a TscI mouse model of ASD. Inhibition of RCrusI in mice led to autism-related behaviors, and RCrusI activation rescued social impairments in TscI mice. |
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Social stress induces neurovascular pathology promoting depression pp1752 - 1760 Caroline Menard, Madeline L. Pfau, Georgia E. Hodes, Veronika Kana, Victoria X. Wang et al. doi:10.1038/s41593-017-0010-3 Chronic social defeat stress induces loss of protein claudin-5, leading to abnormalities in blood vessel morphology, increased blood brain barrier permeability, infiltration of immune signals and depression-like behaviors. |
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Weak correlations between hemodynamic signals and ongoing neural activity during the resting state pp1761 - 1769 Aaron T. Winder, Christina Echagarruga, Qingguang Zhang & Patrick J. Drew doi:10.1038/s41593-017-0007-y The relationship of resting-state hemodynamics signals to ongoing neural activity is poorly understood. Using optical imaging, electrophysiology, and local pharmacological infusions, Winder et al. found that resting hemodynamic signals were weakly correlated with neural activity and that these hemodynamic fluctuations persisted when neural activity was silenced. |
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Mixed selectivity morphs population codes in prefrontal cortex pp1770 - 1779 Aishwarya Parthasarathy, Roger Herikstad, Jit Hon Bong, Felipe Salvador Medina, Camilo Libedinsky et al. doi:10.1038/s41593-017-0003-2 Neurons in the lateral prefrontal cortex (but not the frontal eye fields) appear to maintain working memory information when disrupted by a transient distractor, not by using an immutable persistent code but by morphing from one persistent code to another. This code-morphing may provide the lateral prefrontal cortex with cognitive flexibility. |
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Elucidating the underlying components of food valuation in the human orbitofrontal cortex pp1780 - 1786 Shinsuke Suzuki, Logan Cross & John P. O'Doherty doi:10.1038/s41593-017-0008-x Suzuki et al. found that food valuation is related to beliefs about nutritive attributes. Functional MRI revealed these attribute codes in lateral orbitofrontal cortex, suggesting a mechanism by which value signals are constructed from constituent attributes. |
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Resources | Top |
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A multiregional proteomic survey of the postnatal human brain pp1787 - 1795 Becky C. Carlyle, Robert R. Kitchen, Jean E. Kanyo, Edward Z. Voss, Mihovil Pletikos et al. doi:10.1038/s41593-017-0011-2 Quantitative mass spectrometry was used to produce a proteomic survey of postnatal human brain regions. Compared to matched RNA-seq, protein levels showed more regional variation, especially for membrane-associated proteins in the neocortex. |
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Technical Reports | Top |
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Temporally precise single-cell-resolution optogenetics pp1796 - 1806 Or A. Shemesh, Dimitrii Tanese, Valeria Zampini, Changyang Linghu, Kiryl Piatkevich et al. doi:10.1038/s41593-017-0018-8 The authors develop a methods suite for millisecond-precise, single-cell-resolution control of neural activity through protein engineering of novel opsin/trafficking sequence combinations, as well as optimized holographic two-photon optics. |
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