Nature Immunology Contents: December 2017 Volume 18 pp 1273 - 1361

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Advertisement Better visualize, analyze, and phenotype immune cells in situ in FFPE tissue sections and TMAs Learn how Vectra Polaris™ quantitative pathology imaging system provides unparalleled speed and performance for extracting proteomic and morphometric information from tissue sections.  Download Application Note TABLE OF CONTENTS December 2017 Volume 18, Issue 12 Obituary Comment News and Views Research Highlights Review Articles Corrigenda   Advertisement   A*STAR Research - Highlighting the latest breakthroughs at the Agency for Science, Technology and Research (A*STAR), Singapore's premier research organization  Recent Highlights Immunology: New strategy for fighting invaders | Immune system: Unraveling the complexity | Immunology: New hope for eczema sufferers Download the A*STAR Research app now!   Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement Poster on: The expanding CRISPR toolbox The CRISPR-Cas9 system can do a lot more than gene editing. This Poster, from Nature Methods, explores the newest possibilities of CRISPR.  Available to download free online  Produced with support from:  Dharmacon     Advertisement Naturejobs Career Expo Düsseldorf - limited space left!  Register now for the free Naturejobs Career Expo Düsseldorf on Friday, 17 November 2017. Don't miss out on your chance to build connections with leading global employers, attend free talks, workshops and so much more. Register FREE now!   Advertisement Open for Submissions >>>   Online-only and open access, npj Primary Care Respiratory Medicine is the only fully-indexed scientific journal devoted to the management of respiratory diseases in primary care. Explore the benefits of submitting your next research article.   Obituary Top Charles D. Surh 1960-2017   p1273 Janko Nikolich-Žugich doi:10.1038/ni.3871   Comment Top Adaptive Immune Receptor Repertoire Community recommendations for sharing immune-repertoire sequencing data   pp1274 - 1278 Florian Rubelt, Christian E Busse, Syed Ahmad Chan Bukhari, Jean-Philippe Bürckert, Encarnita Mariotti-Ferrandiz et al. doi:10.1038/ni.3873 High-throughput sequencing of B and T cell receptors is routinely being applied in studies of adaptive immunity. The Adaptive Immune Receptor Repertoire (AIRR) Community was formed in 2015 to address issues in AIRR sequencing studies, including the development of reporting standards for the sharing of data sets.   News and Views Top Trained macrophages support hygiene hypothesis   pp1279 - 1280 Bérengère de Laval and Michael H Sieweke doi:10.1038/ni.3874 Replacement of resident alveolar macrophages by monocyte-derived macrophages after herpesvirus infection protects against asthma. See also: Article by Machiels et al. Feeling stressed? It might be your T cells   pp1281 - 1283 Laura Strauss, Nikolaos Patsoukis and Vassiliki A Boussiotis doi:10.1038/ni.3872 Abolishing signals mediated by the inhibitory receptor PD-1 results in a systemic decrease in tryptophan and tyrosine, which leads to a striking deficiency in the neurotransmitters serotonin and dopamine in the brain and anxiety-like behavior and exacerbated fear. See also: Article by Miyajima et al. MAIT cells in type 1 diabetes: a good friend turned bad   pp1283 - 1285 Lina Petersone and Lucy S K Walker doi:10.1038/ni.3869 Mucosal-associated invariant T cells (MAIT cells) normally preserve gut-barrier integrity but can switch their phenotype to have a pathogenic role in type 1 diabetes. See also: Article by Rouxel et al. Suppression from beyond the grave   pp1285 - 1286 Yosuke Togashi and Hiroyoshi Nishikawa doi:10.1038/ni.3870 Adenosine produced by apoptotic regulatory T cells (Treg cells) has a more important immunosuppressive role in the tumor microenvironment than that of live Treg cells. This discovery raises the possibility of novel strategies for cancer immunotherapy. See also: Article by Maj et al. Immunology JOBS of the week Assistant or Associate Professor of Medicine, Canada Research Chair Tier 2 McGill University - Department of Medicine Assistant Professor of Nutritional Sciences University of Florida Research Assistant - FMI Group Liberali Friedrich Miescher Institute for Biomedical Research (FMI) Postdoctoral Postion - The University of Pittsburgh School of Medicine University of Pittsbugh, School of Medicine Institute of Metabolism and Diseases,Shanghai General Hospital Shanghai General Hospital More Science jobs from Immunology EVENT Advanced Course in Basic & Clinical Immunology 18.02.18 Scottsdale, USA More science events from Research Highlights Top Modulation of CD46 in T cells | Inflammatory lipids | Epithelial stem cell memory | Tumor control | Gut clues to MS | Interferons control fungus   Review Top Novel mechanisms and functions of complement   pp1288 - 1298 George Hajishengallis, Edimara S Reis, Dimitrios C Mastellos, Daniel Ricklin and John D Lambris doi:10.1038/ni.3858 Lambris and colleagues discuss new and previously unanticipated functions of complement and how these affect immunity and disease pathogenesis.   Advertisement Do you have a career question? The Naturejobs podcast features one-on-one Q&As, panel discussions and other exclusive content to help scientists with their careers. Hosted on the Naturejobs blog, the podcast is also available on iTunes and Soundcloud.  Listen today!    Articles Top NLRX1 promotes immediate IRF1-directed antiviral responses by limiting dsRNA-activated translational inhibition mediated by PKR   pp1299 - 1309 Hui Feng, Erik M Lenarcic, Daisuke Yamane, Eliane Wauthier, Jinyao Mo et al. doi:10.1038/ni.3853 NLR proteins contribute to antiviral immune responses. Lemon and colleagues show that NLRX1 promotes antiviral responses in hepatocytes by competing with the kinase PKR for viral double-stranded RNA, which allows accumulation of the transcription factor IRF1 for early control of viral replication.   A gammaherpesvirus provides protection against allergic asthma by inducing the replacement of resident alveolar macrophages with regulatory monocytes   pp1310 - 1320 Bénèdicte Machiels, Mickael Dourcy, Xue Xiao, Justine Javaux, Claire Mesnil et al. doi:10.1038/ni.3857 Gillet and colleagues find that infection with a gammaherpesvirus confers strong and lasting protection against airway allergy through the replacement of lung-resident alveolar macrophages with recruited regulatory monocytes of bone marrow origin. See also: News and Views by de Laval & Sieweke Cytotoxic and regulatory roles of mucosal-associated invariant T cells in type 1 diabetes   pp1321 - 1331 Ophélie Rouxel, Jennifer Da silva, Lucie Beaudoin, Isabelle Nel, Céline Tard et al. doi:10.1038/ni.3854 Type 1 diabetes has a multifactorial etiology. Lehuen and colleagues demonstrate that MAIT cells serve both positive roles and negative roles in type 1 diabetes by maintaining gut integrity and limiting pancreatic inflammation but also directly destroying [beta]-cells. See also: News and Views by Petersone & Walker Oxidative stress controls regulatory T cell apoptosis and suppressor activity and PD-L1-blockade resistance in tumor   pp1332 - 1341 Tomasz Maj, Wei Wang, Joel Crespo, Hongjuan Zhang, Weimin Wang et al. doi:10.1038/ni.3868 The tumor microenvironment represents a stressful cellular environment. Zou and colleagues show that Treg cells in tumors have heightened sensitivity to apoptosis, but unexpectedly this increases their suppressive potency. See also: News and Views by Togashi & Nishikawa Metabolic shift induced by systemic activation of T cells in PD-1-deficient mice perturbs brain monoamines and emotional behavior   pp1342 - 1352 Michio Miyajima, Baihao Zhang, Yuki Sugiura, Kazuhiro Sonomura, Matteo M Guerrini et al. doi:10.1038/ni.3867 Fagarasan and colleagues show that excessive activation of T cells in mice deficient in the inhibitory receptor PD-1 causes a systemic decrease in tryptophan and tyrosine, which leads to deficiency in serotonin and dopamine in the brain and behavioral changes. See also: News and Views by Strauss et al. Direction of leukocyte polarization and migration by the phosphoinositide-transfer protein TIPE2   pp1353 - 1360 Svetlana A Fayngerts, Zhaojun Wang, Ali Zamani, Honghong Sun, Amanda E Boggs et al. doi:10.1038/ni.3866 The polarization of leukocytes toward chemoattractants is essential for their directed migration. Chen and colleagues show that the phosphoinositide-transfer protein TIPE2 functions as a coordinator of leukocyte polarity.   Advertisement Is your organization planning a scientific event or conference for 2018? Looking for a way to increase the number of attendees? Advertise in the Natureevents Directory 2018. Available online and in print. Ad close deadline: 4 December, 2017.   Corrigenda Top Corrigendum: The RNA helicase DDX46 inhibits innate immunity by entrapping m6A-demethylated antiviral transcripts in the nucleus   p1361 Qingliang Zheng, Jin Hou, Ye Zhou, Zhenyang Li and Xuetao Cao doi:10.1038/ni1217-1361a   Corrigendum: Genome-wide DNA-methylation landscape defines specialization of regulatory T cells in tissues   p1361 Michael Delacher, Charles D Imbusch, Dieter Weichenhan, Achim Breiling, Agnes Hotz-Wagenblatt et al. doi:10.1038/ni1217-1361b   Top Advertisement npj Precision Oncology is a new open access, online-only, peer-reviewed journal committed to publishing cutting-edge scientific research in all aspects of precision oncology from basic science to translational applications, to clinical medicine. The journal is part of the Nature Partner Journals series and published in partnership with The Hormel Institute, University of Minnesota.   Explore the benefits of submitting your manuscript   Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

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