Thursday, November 16, 2017

Nature Immunology Contents: December 2017 Volume 18 pp 1273 - 1361

If you are unable to see the message below, click here to view.
Nature Immunology

Better visualize, analyze, and phenotype immune cells in situ in FFPE tissue sections and TMAs

Learn how Vectra Polaris™ quantitative pathology imaging system provides unparalleled speed and performance for extracting proteomic and morphometric information from tissue sections. 

Download Application Note

December 2017 Volume 18, Issue 12

News and Views
Research Highlights

A*STAR Research - Highlighting the latest breakthroughs at the Agency for Science, Technology and Research (A*STAR), Singapore's premier research organization 

Recent Highlights

Immunology: New strategy for fighting invaders |
Immune system: Unraveling the complexity | Immunology: New hope for eczema sufferers

Download the A*STAR Research app now!

Recommend to library

Poster on: The expanding CRISPR toolbox

The CRISPR-Cas9 system can do a lot more than gene editing. This Poster, from Nature Methods, explores the newest possibilities of CRISPR. 

Available to download free online 

Produced with support from: 
Naturejobs Career Expo Düsseldorf - limited space left! 

Register now for the free Naturejobs Career Expo Düsseldorf on Friday, 17 November 2017. Don't miss out on your chance to build connections with leading global employers, attend free talks, workshops and so much more.

Register FREE now!

Open for Submissions >>>
Online-only and open access, npj Primary Care Respiratory Medicine is the only fully-indexed scientific journal devoted to the management of respiratory diseases in primary care.

Explore the benefits of submitting your next research article.



Charles D. Surh 1960-2017   p1273
Janko Nikolich-Žugich



Adaptive Immune Receptor Repertoire Community recommendations for sharing immune-repertoire sequencing data   pp1274 - 1278
Florian Rubelt, Christian E Busse, Syed Ahmad Chan Bukhari, Jean-Philippe Bürckert, Encarnita Mariotti-Ferrandiz et al.
High-throughput sequencing of B and T cell receptors is routinely being applied in studies of adaptive immunity. The Adaptive Immune Receptor Repertoire (AIRR) Community was formed in 2015 to address issues in AIRR sequencing studies, including the development of reporting standards for the sharing of data sets.

News and Views


Trained macrophages support hygiene hypothesis   pp1279 - 1280
Bérengère de Laval and Michael H Sieweke
Replacement of resident alveolar macrophages by monocyte-derived macrophages after herpesvirus infection protects against asthma.

See also: Article by Machiels et al.

Feeling stressed? It might be your T cells   pp1281 - 1283
Laura Strauss, Nikolaos Patsoukis and Vassiliki A Boussiotis
Abolishing signals mediated by the inhibitory receptor PD-1 results in a systemic decrease in tryptophan and tyrosine, which leads to a striking deficiency in the neurotransmitters serotonin and dopamine in the brain and anxiety-like behavior and exacerbated fear.

See also: Article by Miyajima et al.

MAIT cells in type 1 diabetes: a good friend turned bad   pp1283 - 1285
Lina Petersone and Lucy S K Walker
Mucosal-associated invariant T cells (MAIT cells) normally preserve gut-barrier integrity but can switch their phenotype to have a pathogenic role in type 1 diabetes.

See also: Article by Rouxel et al.

Suppression from beyond the grave   pp1285 - 1286
Yosuke Togashi and Hiroyoshi Nishikawa
Adenosine produced by apoptotic regulatory T cells (Treg cells) has a more important immunosuppressive role in the tumor microenvironment than that of live Treg cells. This discovery raises the possibility of novel strategies for cancer immunotherapy.

See also: Article by Maj et al.

JOBS of the week
Assistant or Associate Professor of Medicine, Canada Research Chair Tier 2
McGill University - Department of Medicine
Assistant Professor of Nutritional Sciences
University of Florida
Research Assistant - FMI Group Liberali
Friedrich Miescher Institute for Biomedical Research (FMI)
Postdoctoral Postion - The University of Pittsburgh School of Medicine
University of Pittsbugh, School of Medicine
Institute of Metabolism and Diseases,Shanghai General Hospital
Shanghai General Hospital
More Science jobs from
Advanced Course in Basic & Clinical Immunology
Scottsdale, USA
More science events from

Research Highlights


Modulation of CD46 in T cells | Inflammatory lipids | Epithelial stem cell memory | Tumor control | Gut clues to MS | Interferons control fungus




Novel mechanisms and functions of complement   pp1288 - 1298
George Hajishengallis, Edimara S Reis, Dimitrios C Mastellos, Daniel Ricklin and John D Lambris
Lambris and colleagues discuss new and previously unanticipated functions of complement and how these affect immunity and disease pathogenesis.

Do you have a career question?

The Naturejobs podcast features one-on-one Q&As, panel discussions and other exclusive content to help scientists with their careers. Hosted on the Naturejobs blog, the podcast is also available on iTunes and Soundcloud. 

Listen today! 



NLRX1 promotes immediate IRF1-directed antiviral responses by limiting dsRNA-activated translational inhibition mediated by PKR   pp1299 - 1309
Hui Feng, Erik M Lenarcic, Daisuke Yamane, Eliane Wauthier, Jinyao Mo et al.
NLR proteins contribute to antiviral immune responses. Lemon and colleagues show that NLRX1 promotes antiviral responses in hepatocytes by competing with the kinase PKR for viral double-stranded RNA, which allows accumulation of the transcription factor IRF1 for early control of viral replication.

A gammaherpesvirus provides protection against allergic asthma by inducing the replacement of resident alveolar macrophages with regulatory monocytes   pp1310 - 1320
Bénèdicte Machiels, Mickael Dourcy, Xue Xiao, Justine Javaux, Claire Mesnil et al.
Gillet and colleagues find that infection with a gammaherpesvirus confers strong and lasting protection against airway allergy through the replacement of lung-resident alveolar macrophages with recruited regulatory monocytes of bone marrow origin.

See also: News and Views by de Laval & Sieweke

Cytotoxic and regulatory roles of mucosal-associated invariant T cells in type 1 diabetes   pp1321 - 1331
Ophélie Rouxel, Jennifer Da silva, Lucie Beaudoin, Isabelle Nel, Céline Tard et al.
Type 1 diabetes has a multifactorial etiology. Lehuen and colleagues demonstrate that MAIT cells serve both positive roles and negative roles in type 1 diabetes by maintaining gut integrity and limiting pancreatic inflammation but also directly destroying [beta]-cells.

See also: News and Views by Petersone & Walker

Oxidative stress controls regulatory T cell apoptosis and suppressor activity and PD-L1-blockade resistance in tumor   pp1332 - 1341
Tomasz Maj, Wei Wang, Joel Crespo, Hongjuan Zhang, Weimin Wang et al.
The tumor microenvironment represents a stressful cellular environment. Zou and colleagues show that Treg cells in tumors have heightened sensitivity to apoptosis, but unexpectedly this increases their suppressive potency.

See also: News and Views by Togashi & Nishikawa

Metabolic shift induced by systemic activation of T cells in PD-1-deficient mice perturbs brain monoamines and emotional behavior   pp1342 - 1352
Michio Miyajima, Baihao Zhang, Yuki Sugiura, Kazuhiro Sonomura, Matteo M Guerrini et al.
Fagarasan and colleagues show that excessive activation of T cells in mice deficient in the inhibitory receptor PD-1 causes a systemic decrease in tryptophan and tyrosine, which leads to deficiency in serotonin and dopamine in the brain and behavioral changes.

See also: News and Views by Strauss et al.

Direction of leukocyte polarization and migration by the phosphoinositide-transfer protein TIPE2   pp1353 - 1360
Svetlana A Fayngerts, Zhaojun Wang, Ali Zamani, Honghong Sun, Amanda E Boggs et al.
The polarization of leukocytes toward chemoattractants is essential for their directed migration. Chen and colleagues show that the phosphoinositide-transfer protein TIPE2 functions as a coordinator of leukocyte polarity.

Is your organization planning a scientific event or conference for 2018?

Looking for a way to increase the number of attendees?

Advertise in the Natureevents Directory 2018.

Available online and in print. Ad close deadline: 4 December, 2017.



Corrigendum: The RNA helicase DDX46 inhibits innate immunity by entrapping m6A-demethylated antiviral transcripts in the nucleus   p1361
Qingliang Zheng, Jin Hou, Ye Zhou, Zhenyang Li and Xuetao Cao

Corrigendum: Genome-wide DNA-methylation landscape defines specialization of regulatory T cells in tissues   p1361
Michael Delacher, Charles D Imbusch, Dieter Weichenhan, Achim Breiling, Agnes Hotz-Wagenblatt et al.

npj Precision Oncology is a new open access, online-only, peer-reviewed journal committed to publishing cutting-edge scientific research in all aspects of precision oncology from basic science to translational applications, to clinical medicine. The journal is part of the Nature Partner Journals series and published in partnership with The Hormel Institute, University of Minnesota.
Explore the benefits of submitting your manuscript
nature events
Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here.
Find the latest scientific conferences, courses, meetings and symposia on For event advertising opportunities across the Nature Publishing Group portfolio please contact
More Nature Events

You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your account at:
(You will need to log in to be recognised as a registrant)

For further technical assistance, please contact our registration department

For print subscription enquiries, please contact our subscription department

For other enquiries, please contact our customer feedback department

Springer Nature | One New York Plaza, Suite 4500 | New York | NY 10004-1562 | USA

Springer Nature's worldwide offices:
London - Paris - Munich - New Delhi - Tokyo - Melbourne
San Diego - San Francisco - Washington - New York - Boston

Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at The Campus, 4 Crinan Street, London, N1 9XW.

© 2017 Macmillan Publishers Limited, part of Springer Nature. All Rights Reserved.

Springer Nature

No comments: