| | Mechanism of tandem duplication formation in BRCA1-mutant cells
BRCA1, but not BRCA2, suppresses the formation of tandem duplications at stalled replication forks in primary mammalian cells.
Nicholas A. Willis, Richard L. Frock, Francesca Menghi et al. | Probing many-body dynamics on a 51-atom quantum simulator
Programmable quantum simulations of many-body systems are demonstrated using a reconfigurable array of 51 individually trapped cold atoms with strong, coherent interactions controlled via excitation to Rydberg states.
Hannes Bernien, Sylvain Schwartz, Alexander Keesling et al. | Salt-responsive gut commensal modulates TH17 axis and disease
High salt intake changed the gut microbiome and increased TH17 cell numbers in mice, and reduced intestinal survival of Lactobacillus species, increased the number of TH17 cells and increased blood pressure in humans.
Nicola Wilck, Mariana G. Matus, Sean M. Kearney et al. | | Mild oxidation of methane to methanol or acetic acid on supported isolated rhodium catalysts
Single-site isolated rhodium species anchored on zeolites or titanium dioxide are shown to catalyse the direct conversion of methane to methanol and acetic acid, using oxygen and carbon monoxide under mild conditions.
Junjun Shan, Mengwei Li, Lawrence F. Allard et al. | Greater post-Neolithic wealth disparities in Eurasia than in North America and Mesoamerica
Analyses of house-size distributions in the Old and New World showed that wealth disparities increased with the domestication of plants and animals and with increased sociopolitical scale.
Timothy A. Kohler, Michael E. Smith, Amy Bogaard et al. | Orthogonal muscle fibres have different instructive roles in planarian regeneration
Longitudinal and circular muscle fibres have distinct regulatory roles during planarian regeneration.
M. Lucila Scimone, Lauren E. Cote, Peter W. Reddien | Halogens in chondritic meteorites and terrestrial accretion
Halogen abundances in chondrites are 6 to 37 times lower than previously reported, which is consistent with the low abundances of these elements found in Earth.
Patricia L. Clay, Ray Burgess, Henner Busemann et al. | A gut bacterial pathway metabolizes aromatic amino acids into nine circulating metabolites
A pathway for the production of aromatic amino acid metabolites in Clostridium sporogenes is described; modulation of serum levels of these metabolites in gnotobiotic mice affects intestinal permeability and systemic immunity.
Dylan Dodd, Matthew H. Spitzer, William Van Treuren et al. | Structural basis for the initiation of eukaryotic transcription-coupled DNA repair
Cryo-electron microscopy analysis of yeast Rad26 bound to RNA polymerase II provides insight into the initiation of the transcription-coupled DNA repair mechanism in eukaryotes.
Jun Xu, Indrajit Lahiri, Wei Wang et al. | Measurement of the multi-TeV neutrino interaction cross-section with IceCube using Earth absorption
IceCube has measured the absorption of atmospheric and astrophysical neutrinos in the Earth, and found that the interaction cross-section of multi-TeV neutrinos is within 50 per cent of the predictions of the standard model.
The IceCube Collaboration | Observation of a many-body dynamical phase transition with a 53-qubit quantum simulator
Many-body dynamical phases in an Ising-like quantum spin model with long-range interactions are observed by measuring correlations in single shots, using a quantum simulator composed of 53 qubits.
J. Zhang, G. Pagano, P. W. Hess et al. | Site-selective and stereoselective functionalization of non-activated tertiary C–H bonds
The functionalization of specific inert C–H bonds avoids the need for functional groups in organic synthesis and here the challenges of this approach are overcome using a dirhodium catalyst that is capable of C–H bond site-selectivity.
Kuangbiao Liao, Thomas C. Pickel, Vyacheslav Boyarskikh et al. | A lysosomal switch triggers proteostasis renewal in the immortal C. elegans germ lineage
Sperm-activated lysosomes enhance proteostasis in nematode oocytes just before fertilization; this could prevent transmission of damaged proteins to the next generation and may explain the immortality of the germ-cell lineage.
K. Adam Bohnert, Cynthia Kenyon | A tethering complex drives the terminal stage of SNARE-dependent membrane fusion
Tethering proteins, known to mediate initial recognition and attachment during membrane fusion, are essential for driving the transition from the hemifused state to fusion pore formation.
Massimo D’Agostino, Herre Jelger Risselada, Anna Lürick et al. | NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis
Cancers growing in high-oxygen environments, such as lung adenocarcinomas, select for the iron–sulfur cluster synthesizing enzyme NFS1 to support malignant proliferation and to protect from oxidative damage.
Samantha W. Alvarez, Vladislav O. Sviderskiy, Erdem M. Terzi et al. | A semi-synthetic organism that stores and retrieves increased genetic information
A modified Escherichia coli is used to demonstrate that semi-synthetic organisms can use non-natural hydrophobic base pairs to genetically encode for the incorporation of non-canonical amino acids into proteins.
Yorke Zhang, Jerod L. Ptacin, Emil C. Fischer et al. | | | | |
No comments:
Post a Comment