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| | 30 November 2017 | | | | Advertisement | The 2017 Nobel Prize in Physiology or Medicine was awarded to Jeffrey C. Hall, Michael Rosbash and Michael W. Young for their pioneering work in Drosophila that elucidated the molecular mechanisms controlling circadian rhythm. | | | | | | Advertisement | | Stay up to date with the latest research published in Nature Catalysis by signing up to the e-alert. Register now to get content delivered directly to your inbox from January 2018. REGISTER FOR THE E-ALERT | | | | | | | Latest Articles | View all Articles | | | Directing intracellular supramolecular assembly with N-heteroaromatic quaterthiophene analogues OPEN | | David Y. W. Ng, Roman Vill, Yuzhou Wu, Kaloian Koynov, Yu Tokura, Weina Liu, Susanne Sihler, Andreas Kreyes, Sandra Ritz, Holger Barth, Ulrich Ziener & Tanja Weil | | | Self-assembly of synthetic molecules in living cells can influence cell function, but is extremely challenging due to the complex environment of cells. Here the authors report the self-assembly of small organic molecules that locate, target and self-report their supramolecular behavior in living cells. | | 29 November 2017 | doi: 10.1038/s41467-017-02020-2 | | Molecular self-assembly Self-assembly Structural properties | Giant barocaloric effects over a wide temperature range in superionic conductor AgI OPEN | | Araceli Aznar, Pol Lloveras, Michela Romanini, María Barrio, Josep-Lluís Tamarit, Claudio Cazorla, Daniel Errandonea, Neil D. Mathur, Antoni Planes, Xavier Moya & Lluís Mañosa | | | Barocaloric materials offer promise in solid-state cooling devices, but few materials have been show to display giant barocaloric effects near room temperature. Here, the authors demonstrate that solid electrolyte AgI displays giant inverse barocaloric effects near its superionic phase transition at ~420 K. | | 29 November 2017 | doi: 10.1038/s41467-017-01898-2 | | Materials chemistry Materials for energy and catalysis Phase transitions and critical phenomena | Low-threshold optically pumped lasing in highly strained germanium nanowires OPEN | | Shuyu Bao, Daeik Kim, Chibuzo Onwukaeme, Shashank Gupta, Krishna Saraswat, Kwang Hong Lee, Yeji Kim, Dabin Min, Yongduck Jung, Haodong Qiu, Hong Wang, Eugene A. Fitzgerald, Chuan Seng Tan & Donguk Nam | | | Integrating group IV lasing devices into technologically relevant CMOS architectures has proven challenging. Here, the authors demonstrate low-threshold lasing, which is important for potential electronic and photonic circuits, using strained germanium nanowires as the gain material. | | 29 November 2017 | doi: 10.1038/s41467-017-02026-w | | Semiconductor lasers Silicon photonics | Notch transactivates Rheb to maintain the multipotency of TSC-null cells OPEN | | Jun-Hung Cho, Bhaumik Patel, Santosh Bonala, Sasikanth Manne, Yan Zhou, Surya K. Vadrevu, Jalpa Patel, Marco Peronaci, Shanawaz Ghouse, Elizabeth P. Henske, Fabrice Roegiers, Krinio Giannikou, David J. Kwiatkowski, Hossein Mansouri, Maciej M. Markiewski, Brandon White & Magdalena Karbowniczek | | | Tuberous sclerosis complex (TSC) is a rare genetic condition causing tumours with differentiation abnormalities; however the molecular mechanisms causing these defects are unclear. Here the authors show that Notch cooperates with Rheb to block cell differentiation forming a regulatory loop that could underlie TSC tumorigenesis. | | 29 November 2017 | doi: 10.1038/s41467-017-01845-1 | | Cancer Tumour-suppressor proteins | Parkin targets HIF-1α for ubiquitination and degradation to inhibit breast tumor progression OPEN | | Juan Liu, Cen Zhang, Yuhan Zhao, Xuetian Yue, Hao Wu, Shan Huang, James Chen, Kyle Tomsky, Haiyang Xie, Christen A. Khella, Michael L. Gatza, Dajing Xia, Jimin Gao, Eileen White, Bruce G. Haffty, Wenwei Hu & Zhaohui Feng | | | Parkin is an E3 ubiquitin ligase involved in Parkinson’s disease. Parkin has also been linked to cancer suppression but the mechanisms are unclear. Here the authors show that Parkin regulates HIF-1α through ubiquitin-dependent degradation, thus inhibiting metastasis of breast cancer cells. | | 28 November 2017 | doi: 10.1038/s41467-017-01947-w | | Tumour-suppressor proteins Ubiquitylation | Centromere evolution and CpG methylation during vertebrate speciation OPEN | | Kazuki Ichikawa, Shingo Tomioka, Yuta Suzuki, Ryohei Nakamura, Koichiro Doi, Jun Yoshimura, Masahiko Kumagai, Yusuke Inoue, Yui Uchida, Naoki Irie, Hiroyuki Takeda & Shinich Morishita | | | Centromeres and large-scale structural variants evolve and contribute to genome diversity during vertebrate speciation. Here Ichikawa et al perform de novo long-read genome assembly of three inbred medaka strains, and report long-range structure of centromeres and their methylation as well as correlation of structural variants with differential gene expression. | | 28 November 2017 | doi: 10.1038/s41467-017-01982-7 | | Genome Genome informatics Speciation Transcriptomics | Counter-intuitive influence of Himalayan river morphodynamics on Indus Civilisation urban settlements OPEN | | Ajit Singh, Kristina J. Thomsen, Rajiv Sinha, Jan-Pieter Buylaert, Andrew Carter, Darren F. Mark, Philippa J. Mason, Alexander L. Densmore, Andrew S. Murray, Mayank Jain, Debajyoti Paul & Sanjeev Gupta | | | The Bronze-age Indus civilisation (4.6–3.9 ka) was thought to have been linked to the development of water resources in the Himalayas. Here, the authors show that along the former course of the Sutlej River the Indus settlements developed along the abandoned river valley rather than an active Himalayan river. | | 28 November 2017 | doi: 10.1038/s41467-017-01643-9 | | Archaeology Geomorphology Sedimentology | Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma OPEN | | Jose Mario Gonzalez-Meljem, Scott Haston, Gabriela Carreno, John R. Apps, Sara Pozzi, Christina Stache, Grace Kaushal, Alex Virasami, Leonidas Panousopoulos, Seyedeh Neda Mousavy-Gharavy, Ana Guerrero, Mamunur Rashid, Nital Jani, Colin R. Goding, Thomas S. Jacques, David J. Adams, Jesus Gil, Cynthia L. Andoniadou & Juan Pedro Martinez-Barbera | | | Senescent cells can promote tumour progression through the activation of a senescenceassociated secretory phenotype (SASP). Here, the authors show that SASP activation is associated with non-cell autonomous cell transformation and tumour initiation in an in vivo model of adamantinomatous craniopharyngioma. | | 28 November 2017 | doi: 10.1038/s41467-017-01992-5 | | Cancer stem cells Paediatric cancer | A Co3O4-CDots-C3N4 three component electrocatalyst design concept for efficient and tunable CO2 reduction to syngas OPEN | | Sijie Guo, Siqi Zhao, Xiuqin Wu, Hao Li, Yunjie Zhou, Cheng Zhu, Nianjun Yang, Xin Jiang, Jin Gao, Liang Bai, Yang Liu, Yeshayahu Lifshitz, Shuit-Tong Lee & Zhenhui Kang | | | Simultaneous electrochemical reduction of CO2 and H+/H2O is an attractive renewable route to produce syngas mixtures. Here, the authors introduce a ternary Co3O4-CDots-C3N4 electrocatalyst that couples hydrogen evolution and CO2 reduction catalysts and achieves cheap, stable and tunable production of syngas. | | 28 November 2017 | doi: 10.1038/s41467-017-01893-7 | | Carbon capture and storage Electrocatalysis Environmental, health and safety issues Renewable energy | Quantum-disordered state of magnetic and electric dipoles in an organic Mott system OPEN | | M. Shimozawa, K. Hashimoto, A. Ueda, Y. Suzuki, K. Sugii, S. Yamada, Y. Imai, R. Kobayashi, K. Itoh, S. Iguchi, M. Naka, S. Ishihara, H. Mori, T. Sasaki & M. Yamashita | | | The organic material κ-H3(Cat-EDT-TTF)2 has been suggested to exhibit a quantum spin liquid phase in which quantum fluctuations prevent the formation of magnetic order. Here, the authors show that this may be a result of fluctuations of hydrogen atoms, rather than more conventional geometric frustration. | | 28 November 2017 | doi: 10.1038/s41467-017-01849-x | | Ferroelectrics and multiferroics Magnetic properties and materials | Methane- and dissolved organic carbon-fueled microbial loop supports a tropical subterranean estuary ecosystem OPEN | | D. Brankovits, J. W. Pohlman, H. Niemann, M. B. Leigh, M. C. Leewis, K. W. Becker, T. M. Iliffe, F. Alvarez, M. F. Lehmann & B. Phillips | | | It remains unclear how oligotrophic habitats in subterranean estuaries sustain complex ecosystems. Here, using stable isotopic evidence from organic matter and pelagic shrimp, the authors show that a microbial loop fuelled by methane and dissolved organic carbon sustains the anchialine food web. | | 28 November 2017 | doi: 10.1038/s41467-017-01776-x | | Carbon cycle Ecosystem ecology Marine chemistry | Label-free nanoscale optical metrology on myelinated axons in vivo OPEN | | Junhwan Kwon, Moonseok Kim, Hyejin Park, Bok-Man Kang, Yongjae Jo, Jae-Hwan Kim, Oliver James, Seok-Hyun Yun, Seong-Gi Kim, Minah Suh & Myunghwan Choi | | | Spectral reflectance has been used to achieve label-free, in vivo imaging of myelin, a membranous sheath that allows faster electrical conduction along neuronal axons. Here the authors extend this technique to measure nanoscale features, including changes following traumatic brain injury. | | 28 November 2017 | doi: 10.1038/s41467-017-01979-2 | | Imaging and sensing Myelin biology and repair | Hepatic protein tyrosine phosphatase receptor gamma links obesity-induced inflammation to insulin resistance OPEN | | Xavier Brenachot, Giorgio Ramadori, Rafael M. Ioris, Christelle Veyrat-Durebex, Jordi Altirriba, Ebru Aras, Sanda Ljubicic, Daisuke Kohno, Salvatore Fabbiano, Sophie Clement, Nicolas Goossens, Mirko Trajkovski, Sheila Harroch, Francesco Negro & Roberto Coppari | | | During obesity, chronic inflammation leads to insulin resistance and diabetes. Here, Brenachot et al. show that Protein Tyrosine Phosphatase Receptor Gamma is upregulated in obesity by inflammatory signals and correlates with insulin resistance in humans. Its deletion in mouse models of obesity and inflammation ameliorates insulin resistance by suppressing glucose production. | | 28 November 2017 | doi: 10.1038/s41467-017-02074-2 | | Chronic inflammation Type 2 diabetes | Zero-field edge plasmons in a magnetic topological insulator OPEN | | Alice C. Mahoney, James I. Colless, Lucas Peeters, Sebastian J. Pauka, Eli J. Fox, Xufeng Kou, Lei Pan, Kang L. Wang, David Goldhaber-Gordon & David J. Reilly | | | Direct measurement of edge transport in the quantum anomalous Hall effect can be made difficult due to the presence of parallel conductive paths. Here, Mahoney et al. report features associated with chiral edge plasmons, a signature of robust edge states, by probing the zero-field microwave response of a magnetised disk of Cr-(Bi,Sb)2Te3. | | 28 November 2017 | doi: 10.1038/s41467-017-01984-5 | | Quantum Hall Topological insulators | Genetic and pharmacological inhibition of microRNA-92a maintains podocyte cell cycle quiescence and limits crescentic glomerulonephritis OPEN | | Carole Henique, Guillaume Bollée, Xavier Loyer, Florian Grahammer, Neeraj Dhaun, Marine Camus, Julien Vernerey, Léa Guyonnet, François Gaillard, Hélène Lazareth, Charlotte Meyer, Imane Bensaada, Luc Legrès, Takashi Satoh, Shizuo Akira, Patrick Bruneval, Stefanie Dimmeler, Alain Tedgui, Alexandre Karras, Eric Thervet et al. | | | Crescentic rapidly progressive glomerulonephritis is a severe form of glomerula disease characterized by podocyte proliferation and migration. Here Henique et al. demonstrate that inhibition of miRNA-92a prevents kidney failure by promoting the expression of CDK inhibitor p57Kip2 that regulates podocyte cell cycle. | | 28 November 2017 | doi: 10.1038/s41467-017-01885-7 | | Glomerular diseases Mechanisms of disease Molecular medicine | Break-induced replication promotes formation of lethal joint molecules dissolved by Srs2 OPEN | | Rajula Elango, Ziwei Sheng, Jessica Jackson, Jenna DeCata, Younis Ibrahim, Nhung T. Pham, Diana H. Liang, Cynthia J. Sakofsky, Alessandro Vindigni, Kirill S. Lobachev, Grzegorz Ira & Anna Malkova | | | Break-induced replication (BIR) is a double-strand break repair pathway that can lead to genomic instability. Here the authors show that the absence of Srs2 helicase during BIR leads to uncontrolled binding of Rad51 to single-stranded DNA, which promotes the formation of toxic intermediates that need to be resolved by Mus81 or Yen1. | | 27 November 2017 | doi: 10.1038/s41467-017-01987-2 | | DNA damage and repair DNA replication Genomic instability | Mitochondrial dynamics controls anti-tumour innate immunity by regulating CHIP-IRF1 axis stability OPEN | | Zhengjun Gao, Yiyuan Li, Fei Wang, Tao Huang, Keqi Fan, Yu Zhang, Jiangyan Zhong, Qian Cao, Tong Chao, Junling Jia, Shuo Yang, Long Zhang, Yichuan Xiao, Ji-Yong Zhou, Xin-Hua Feng & Jin Jin | | | Macrophage metabolism controls differentiation and subsequent adaptive immune responses. Here the authors show that mitochondrial membrane protein Fam73b regulates TLR-mediated mitochondrial switching of fusion to fission to induce IL-12 production via accumulation of Parkin and stabilization of IRF1 in macrophages, resulting in control of anti-tumor immunity in mice. | | 27 November 2017 | doi: 10.1038/s41467-017-01919-0 | | Acute inflammation Innate immunity Mitochondria Tumour immunology | Critical role of the HDAC6–cortactin axis in human megakaryocyte maturation leading to a proplatelet-formation defect OPEN | | Kahia Messaoudi, Ashfaq Ali, Rameez Ishaq, Alberta Palazzo, Dominika Sliwa, Olivier Bluteau, Sylvie Souquère, Delphine Muller, Khadija M. Diop, Philippe Rameau, Valérie Lapierre, Jean-Pierre Marolleau, Patrick Matthias, Isabelle Godin, Gérard Pierron, Steven G. Thomas, Stephen P. Watson, Nathalie Droin, William Vainchenker, Isabelle Plo et al. | | | Histone deacetylase (HDAC) inhibitors, a class of cancer therapeutics, cause thrombocytopenia via an unknown mechanism. Here, the authors show that HDAC6 inhibition impairs proplatelet formation in human megakaryocytes, and show that this is linked to hyperacetylation of the actin-binding protein cortactin. | | 27 November 2017 | doi: 10.1038/s41467-017-01690-2 | | Acetylation Cytoskeleton Platelets | Cellular microRNA networks regulate host dependency of hepatitis C virus infection OPEN | | Qisheng Li, Brianna Lowey, Catherine Sodroski, Siddharth Krishnamurthy, Hawwa Alao, Helen Cha, Stephan Chiu, Ramy El-Diwany, Marc G. Ghany & T. Jake Liang | | | Using genome-wide miRNA mimic and hairpin inhibitor screens, Li et al. identify 31 miRNAs that either inhibit or promote hepatitis C virus (HCV) replication at different steps of the viral life cycle. Furthermore, human liver biopsies show that HCV down-regulates identified miRNAs with antiviral function. | | 27 November 2017 | doi: 10.1038/s41467-017-01954-x | | Hepatitis C virus High-throughput screening miRNAs Virus–host interactions | Evolutionary recruitment of flexible Esrp-dependent splicing programs into diverse embryonic morphogenetic processes OPEN | | Demian Burguera, Yamile Marquez, Claudia Racioppi, Jon Permanyer, Antonio Torres-Méndez, Rosaria Esposito, Beatriz Albuixech-Crespo, Lucía Fanlo, Ylenia D’Agostino, Andre Gohr, Enrique Navas-Perez, Ana Riesgo, Claudia Cuomo, Giovanna Benvenuto, Lionel A. Christiaen, Elisa Martí, Salvatore D’Aniello, Antonietta Spagnuolo, Filomena Ristoratore, Maria Ina Arnone et al. | | | Epithelial-mesenchymal interplays are essential to many ontogenetic processes in vertebrates. Here Burguera et al. show diverse embryonic morphogenetic processes regulated by Epithelial Splicing Regulatory Protein (Esrp) in different deuterostome species. | | 27 November 2017 | doi: 10.1038/s41467-017-01961-y | | Evolutionary developmental biology Transcriptomics | Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism OPEN | | Benoit Bilanges, Samira Alliouachene, Wayne Pearce, Daniele Morelli, Gyorgy Szabadkai, Yuen-Li Chung, Gaëtan Chicanne, Colin Valet, Julia M. Hill, Peter J. Voshol, Lucy Collinson, Christopher Peddie, Khaled Ali, Essam Ghazaly, Vinothini Rajeeve, Georgios Trichas, Shankar Srinivas, Claire Chaussade, Rachel S. Salamon, Jonathan M. Backer et al. | | | Vps34 is a lipid kinase conserved from yeast to humans and involved in in intracellular vesicular trafficking and autophagy. Here Bilanges et al. show that inhibition of this kinase in mice improves glucose tolerance and diet-induced steatosis by modulating mitochondrial respiration and metabolism. | | 27 November 2017 | doi: 10.1038/s41467-017-01969-4 | | Energy metabolism Type 2 diabetes | Rods progressively escape saturation to drive visual responses in daylight conditions OPEN | | Alexandra Tikidji-Hamburyan, Katja Reinhard, Riccardo Storchi, Johannes Dietter, Hartwig Seitter, Katherine E. Davis, Saad Idrees, Marion Mutter, Lauren Walmsley, Robert A. Bedford, Marius Ueffing, Petri Ala-Laurila, Timothy M. Brown, Robert J. Lucas & Thomas A. Münch | | | Rod photoreceptors are thought to be saturated under bright light. Here, the authors describe the physiological parameters that mediate response saturation of rod photoreceptors in mouse retina, and show that rods can drive visual responses in photopic conditions. | | 27 November 2017 | doi: 10.1038/s41467-017-01816-6 | | Network models Neurodegenerative diseases Neurophysiology Retina | A rapidly-reversible absorptive and emissive vapochromic Pt(II) pincer-based chemical sensor OPEN | | M. J. Bryant, J. M. Skelton, L. E. Hatcher, C. Stubbs, E. Madrid, A. R. Pallipurath, L. H. Thomas, C. H. Woodall, J. Christensen, S. Fuertes, T. P. Robinson, C. M. Beavers, S. J. Teat, M. R. Warren, F. Pradaux-Caggiano, A. Walsh, F. Marken, D. R. Carbery, S. C. Parker, N. B. McKeown et al. | | | Solid state Pt(II)-pincer complexes exhibiting vapochromic responses show promise for chemical sensing applications, but their slow responses typically limit their utility. Here, Raithby and colleagues design a Pt(II)-pincer complex with a subsecond, highly-selective vapochromic response to water and methanol. | | 27 November 2017 | doi: 10.1038/s41467-017-01941-2 | | Coordination chemistry Electronic materials Inorganic chemistry Sensors | Analyses of gut microbiota and plasma bile acids enable stratification of patients for antidiabetic treatment OPEN | | Yanyun Gu, Xiaokai Wang, Junhua Li, Yifei Zhang, Huanzi Zhong, Ruixin Liu, Dongya Zhang, Qiang Feng, Xiaoyan Xie, Jie Hong, Huahui Ren, Wei Liu, Jing Ma, Qing Su, Hongmei Zhang, Jialin Yang, Xiaoling Wang, Xinjie Zhao, Weiqiong Gu, Yufang Bi et al. | | | The authors examine the effects of antidiabetic medication on the gut microbiome and bile acid composition and show that these data can be used to stratify treatment regimens for type 2 diabetes. | | 27 November 2017 | doi: 10.1038/s41467-017-01682-2 | | Diabetes Metagenomics Microbiome Translational research | Nano-enabled pancreas cancer immunotherapy using immunogenic cell death and reversing immunosuppression OPEN | | Jianqin Lu, Xiangsheng Liu, Yu-Pei Liao, Felix Salazar, Bingbing Sun, Wen Jiang, Chong Hyun Chang, Jinhong Jiang, Xiang Wang, Anna M. Wu, Huan Meng & Andre E. Nel | | | Pancreatic cancer remains difficult to treat mainly due to the drug delivery challenges posed by a strong stromal component. Here the authors develop nanocarriers that improve drug delivery efficiency and engage the host immune system against the tumor resulting in reduction of tumor growth and metastasis. | | 27 November 2017 | doi: 10.1038/s41467-017-01651-9 | | Cancer immunotherapy Cell death and immune response Drug delivery Nanoparticles | Transcribed ultraconserved region 339 promotes carcinogenesis by modulating tumor suppressor microRNAs OPEN | | Ivan Vannini, Petra M. Wise, Kishore B. Challagundla, Meropi Plousiou, Mirco Raffini, Erika Bandini, Francesca Fanini, Giorgia Paliaga, Melissa Crawford, Manuela Ferracin, Cristina Ivan, Linda Fabris, Ramana V. Davuluri, Zhiyi Guo, Maria Angelica Cortez, Xinna Zhang, Lu Chen, Shuxing Zhang, Cecilia Fernandez-Cymering, Leng Han et al. | | | T-UCRs encode long non-coding RNAs implicated in human carcinogenesis, but the underlying mechanisms are poorly understood. Here, the authors identify uc.339 as an oncogene in lung cancer that is upregulated through the loss of TP53 and promotes Cyclin E activation by entrapping regulatory miRNAs. | | 27 November 2017 | doi: 10.1038/s41467-017-01562-9 | | Long non-coding RNAs Mechanisms of disease Non-small-cell lung cancer | STIM1 promotes migration, phagosomal maturation and antigen cross-presentation in dendritic cells OPEN | | Paula Nunes-Hasler, Sophia Maschalidi, Carla Lippens, Cyril Castelbou, Samuel Bouvet, Daniele Guido, Flavien Bermont, Esen Y. Bassoy, Nicolas Page, Doron Merkler, Stéphanie Hugues, Denis Martinvalet, Bénédicte Manoury & Nicolas Demaurex | | | STIM proteins sense Ca2+ depletion in the ER and activate store-operated Ca2+-entry (SOCE) in response, a process associated with dendritic cell functions. Here the authors show STIM1 is the major isoform controlling SOCE in mouse dendritic cells and provide a mechanism for its requirement in antigen cross-presentation. | | 24 November 2017 | doi: 10.1038/s41467-017-01600-6 | | Antigen-presenting cells Calcium signalling | DNA double-strand break repair pathway regulates PD-L1 expression in cancer cells OPEN | | Hiro Sato, Atsuko Niimi, Takaaki Yasuhara, Tiara Bunga Mayang Permata, Yoshihiko Hagiwara, Mayu Isono, Endang Nuryadi, Ryota Sekine, Takahiro Oike, Sangeeta Kakoti, Yuya Yoshimoto, Kathryn D. Held, Yoshiyuki Suzuki, Koji Kono, Kiyoshi Miyagawa, Takashi Nakano & Atsushi Shibata | | | PD-L1 is upregulated in many cancers due to exogenous cellular stress. Here the authors show that PD-L1 is upregulated in response to DNA double strand breaks via STAT and IRF1 signalling. | | 24 November 2017 | doi: 10.1038/s41467-017-01883-9 | | Cancer therapy Cell signalling | Origami silicon optoelectronics for hemispherical electronic eye systems OPEN | | Kan Zhang, Yei Hwan Jung, Solomon Mikael, Jung-Hun Seo, Munho Kim, Hongyi Mi, Han Zhou, Zhenyang Xia, Weidong Zhou, Shaoqin Gong & Zhenqiang Ma | | | Hemispherical format has been adopted in camera systems to better mimic human eyes, yet the current designs rely on complicated fabrications. Here, Zhang et al. show an origami-inspired approach that enables planar silicon-based photodetector arrays to reshape into concave or convex geometries. | | 24 November 2017 | doi: 10.1038/s41467-017-01926-1 | | Electrical and electronic engineering Electronic devices Materials for optics Optoelectronic devices and components | Microbial volatile communication in human organotypic lung models OPEN | | Layla J. Barkal, Clare L. Procknow, Yasmín R. Álvarez-García, Mengyao Niu, José A. Jiménez-Torres, Rebecca A. Brockman-Schneider, James E. Gern, Loren C. Denlinger, Ashleigh B. Theberge, Nancy P. Keller, Erwin Berthier & David J. Beebe | | | There is a need for improved in vitro models of host-microbe interactions in the lung. Here, Barkal et al. present a microscale organotypic model of the human bronchiole for studying pulmonary infection, including volatile compound communication between microbial populations and host cells. | | 24 November 2017 | doi: 10.1038/s41467-017-01985-4 | | Antimicrobial responses Chemokines Microbial communities Tissue engineering | Exosomal cargo including microRNA regulates sensory neuron to macrophage communication after nerve trauma OPEN | | Raffaele Simeoli, Karli Montague, Hefin R. Jones, Laura Castaldi, David Chambers, Jayne H. Kelleher, Valentina Vacca, Thomas Pitcher, John Grist, Hadil Al-Ahdal, Liang-Fong Wong, Mauro Perretti, Johnathan Lai, Peter Mouritzen, Paul Heppenstall & Marzia Malcangio | | | Exosomes are known to contain microRNAs (miRs). Here the authors show that dorsal root ganglion neurons release exosomes containing miR-21-5p, which contributes to inflammatory cell recruitment following peripheral nerve injury. | | 24 November 2017 | doi: 10.1038/s41467-017-01841-5 | | Chronic pain miRNAs | Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling OPEN | | Inma M. Berenjeno, Roberto Piñeiro, Sandra D. Castillo, Wayne Pearce, Nicholas McGranahan, Sally M. Dewhurst, Valerie Meniel, Nicolai J. Birkbak, Evelyn Lau, Laurent Sansregret, Daniele Morelli, Nnennaya Kanu, Shankar Srinivas, Mariona Graupera, Victoria E. R. Parker, Karen G. Montgomery, Larissa S. Moniz, Cheryl L. Scudamore, Wayne A. Phillips, Robert K. Semple et al. | | | Activated PI3K causes cancer, but the role of active PI3K mutations in early stages of malignancy are unclear. Here, the authors show in a mouse model that active PI3K induces centrosome amplification via AKT, ROCK, CDK2/Cyclin E and nucleophosmin, and increased tolerance of genome doubling. | | 24 November 2017 | doi: 10.1038/s41467-017-02002-4 | | Cancer Growth factor signalling Oncogenes | Regulatory T cells control toxicity in a humanized model of IL-2 therapy OPEN | | Yan Li, Helene Strick-Marchand, Ai Ing Lim, Jiazi Ren, Guillemette Masse-Ranson, Dan Li, Gregory Jouvion, Lars Rogge, Sophie Lucas, Bin Li & James P. Di Santo | | | High dose IL-2 is a viable treatment option for cancer immune therapy, but the underlying mechanism for the accompanying undesirable morbidity is unclear. Here the authors show, using human immune system mouse models, that regulatory T cells and their functions on effector T cells are essential modulators of the related pathogenesis. | | 24 November 2017 | doi: 10.1038/s41467-017-01570-9 | | Immunosuppression Interleukins Regulatory T cells Translational immunology | Microneedle-array patches loaded with dual mineralized protein/peptide particles for type 2 diabetes therapy OPEN | | Wei Chen, Rui Tian, Can Xu, Bryant C. Yung, Guohao Wang, Yijing Liu, Qianqian Ni, Fuwu Zhang, Zijian Zhou, Jingjing Wang, Gang Niu, Ying Ma, Liwu Fu & Xiaoyuan Chen | | | Diabetes treatments often rely on frequent and scheduled drug administration, which reduces patient compliance and increases treatment cost. Here, the authors develop a microneedle-array patch that separately loads drug-releasing module and glucose-sensing element for on-demand, long-term diabetes therapy. | | 24 November 2017 | doi: 10.1038/s41467-017-01764-1 | | Drug delivery Molecular medicine | NSD1- and NSD2-damaging mutations define a subset of laryngeal tumors with favorable prognosis OPEN | | Suraj Peri, Evgeny Izumchenko, Adrian D. Schubert, Michael J. Slifker, Karen Ruth, Ilya G. Serebriiskii, Theresa Guo, Barbara A. Burtness, Ranee Mehra, Eric A. Ross, David Sidransky & Erica A. Golemis | | | The authors use an integrative clustering approach to identify two laryngeal cancer clusters with distinct prognosis and show that mutations damaging the NSD1 and NSD2 methyltransferases segregate to the cluster with favorable prognosis, and independently predict longer survival in patients with laryngeal, but not other head and neck cancers. | | 24 November 2017 | doi: 10.1038/s41467-017-01877-7 | | Data mining Head and neck cancer Prognostic markers | Quenching protein dynamics interferes with HIV capsid maturation OPEN | | Mingzhang Wang, Caitlin M. Quinn, Juan R. Perilla, Huilan Zhang, Randall Shirra Jr., Guangjin Hou, In-Ja Byeon, Christopher L. Suiter, Sherimay Ablan, Emiko Urano, Theodore J. Nitz, Christopher Aiken, Eric O. Freed, Peijun Zhang, Klaus Schulten, Angela M. Gronenborn & Tatyana Polenova | | | The process of HIV particle maturation involves complex molecular transitions. Here the authors combine NMR spectroscopy, cryo-EM, and molecular dynamics simulations to provide insight into the conformational equilibria in CA-SP1 assemblies relevant to HIV-1 maturation intermediates formation. | | 24 November 2017 | doi: 10.1038/s41467-017-01856-y | | Computational biophysics Solid-state NMR Virology | Single-cell absolute contact probability detection reveals chromosomes are organized by multiple low-frequency yet specific interactions OPEN | | Diego I. Cattoni, Andrés M. Cardozo Gizzi, Mariya Georgieva, Marco Di Stefano, Alessandro Valeri, Delphine Chamousset, Christophe Houbron, Stephanie Déjardin, Jean-Bernard Fiche, Inma González, Jia-Ming Chang, Thomas Sexton, Marc A. Marti-Renom, Frédéric Bantignies, Giacomo Cavalli & Marcelo Nollmann | | | Eukaryotic genomes are partitioned into self-interacting modules or topologically associated domains (TADs) that exist at the kilo-megabase scale. Here Cattoni et al. combine super-resolution microscopy with DNA-labeling methods to quantify absolute frequencies of interactions within TADs. | | 24 November 2017 | doi: 10.1038/s41467-017-01962-x | | Computational biology and bioinformatics Epigenomics Nanoscale biophysics Super-resolution microscopy | Interplay between Notch1 and Notch3 promotes EMT and tumor initiation in squamous cell carcinoma OPEN | | Mitsuteru Natsuizaka, Kelly A. Whelan, Shingo Kagawa, Koji Tanaka, Veronique Giroux, Prasanna M. Chandramouleeswaran, Apple Long, Varun Sahu, Douglas S. Darling, Jianwen Que, Yizeng Yang, Jonathan P. Katz, E. Paul Wileyto, Devraj Basu, Yoshiaki Kita, Shoji Natsugoe, Seiji Naganuma, Andres J. Klein-Szanto, J. Alan Diehl, Adam J. Bass et al. | | | Notch receptors can exert different roles in cancer. In this manuscript, the authors reveal that Notch1 activation and EMT promote tumor initiation and cancer cell heterogeneity in squamous cell carcinoma, while the repression of Notch3 by ZEB1 limits Notch1-induced differentiation, permitting Notch1-mediated EMT. | | 24 November 2017 | doi: 10.1038/s41467-017-01500-9 | | Cancer Oesophageal cancer Oncogenes | HIF drives lipid deposition and cancer in ccRCC via repression of fatty acid metabolism OPEN | | Weinan Du, Luchang Zhang, Adina Brett-Morris, Brittany Aguila, Janos Kerner, Charles L. Hoppel, Michelle Puchowicz, Dolors Serra, Laura Herrero, Brian I. Rini, Steven Campbell & Scott M. Welford | | | Clear cell renal cancers (ccRCC) display elevated intracellular lipid storage. Here the authors show that such lipid accumulation is due to the repression of carnitine palmitoyltransferase 1A (CPT1A) enzyme that impairs fatty acid (FA) transport into the mitochondrion resulting in reduced FA beta oxidation. | | 24 November 2017 | doi: 10.1038/s41467-017-01965-8 | | Cancer metabolism Renal cell carcinoma | GABAA receptor dependent synaptic inhibition rapidly tunes KCC2 activity via the Cl−-sensitive WNK1 kinase OPEN | | Martin Heubl, Jinwei Zhang, Jessica C. Pressey, Sana Al Awabdh, Marianne Renner, Ferran Gomez-Castro, Imane Moutkine, Emmanuel Eugène, Marion Russeau, Kristopher T. Kahle, Jean Christophe Poncer & Sabine Lévi | | | GABAergic transmission regulates the K+-Cl− co-transporter KCC2. Here the authors demonstrate that inhibitory transmission, via GABAA receptor and WNK signaling, regulates KCC2 expression in the membrane of hippocampal neurons. | | 24 November 2017 | doi: 10.1038/s41467-017-01749-0 | | Neurophysiology Neurotransmitters Transporters in the nervous system | A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells OPEN | | Chris J. C. Johnston, Danielle J. Smyth, Ravindra B. Kodali, Madeleine P. J. White, Yvonne Harcus, Kara J. Filbey, James P. Hewitson, Cynthia S. Hinck, Alasdair Ivens, Andrea M. Kemter, Anna O. Kildemoes, Thierry Le Bihan, Dinesh C. Soares, Stephen M. Anderton, Thomas Brenn, Stephen J. Wigmore, Hannah V. Woodcock, Rachel C. Chambers, Andrew P. Hinck, Henry J. McSorley et al. | | | Heligmosomoides polygyrus can activate mammalian TGF-β signalling pathways, but how it does so is not known. Here the authors identify and isolate a H. polygyrus TFG-β mimic that can bind both mammalian TGF-β receptor subunits, activate Smad signalling and generate inducible regulatory T cells. | | 23 November 2017 | doi: 10.1038/s41467-017-01886-6 | | Immune evasion Parasitic infection Regulatory T cells Transforming growth factor beta | Structure of Rap1b bound to talin reveals a pathway for triggering integrin activation OPEN | | Liang Zhu, Jun Yang, Thomas Bromberger, Ashley Holly, Fan Lu, Huan Liu, Kevin Sun, Sarah Klapproth, Jamila Hirbawi, Tatiana V. Byzova, Edward F. Plow, Markus Moser & Jun Qin | | | The transmembrane receptor integrin is activated by talin, but so far it has remained elusive how talin is recruited to the plasma membrane. Here, the authors identify the Rap1-mediated membrane-targeting mechanism for talin, present the Rap1b/talin-F0 structure and show that talin is a direct Rap1b effector. | | 23 November 2017 | doi: 10.1038/s41467-017-01822-8 | | Integrins Solution-state NMR | Ultrafast non-radiative dynamics of atomically thin MoSe2 OPEN | | Ming-Fu Lin, Vidya Kochat, Aravind Krishnamoorthy, Lindsay Bassman, Clemens Weninger, Qiang Zheng, Xiang Zhang, Amey Apte, Chandra Sekhar Tiwary, Xiaozhe Shen, Renkai Li, Rajiv Kalia, Pulickel Ajayan, Aiichiro Nakano, Priya Vashishta, Fuyuki Shimojo, Xijie Wang, David M. Fritz & Uwe Bergmann | | | Knowledge of the energy transfer pathways in transition metal dichalcogenides is essential to design efficient optoelectronic devices. Here, the authors use megaelectronvolt ultrafast electron diffraction to unveil the sub-picosecond lattice dynamics in MoSe2 following photoexcitation of charge carriers | | 23 November 2017 | doi: 10.1038/s41467-017-01844-2 | | Molecular dynamics Two-dimensional materials | Host STING-dependent MDSC mobilization drives extrinsic radiation resistance OPEN | | Hua Liang, Liufu Deng, Yuzhu Hou, Xiangjiao Meng, Xiaona Huang, Enyu Rao, Wenxin Zheng, Helena Mauceri, Matthias Mack, Meng Xu, Yang-Xin Fu & Ralph R. Weichselbaum | | | Tumors often develop resistance to radiotherapy. Here the authors show that irradiation leads to a CCR2-dependent infiltration by myeloid derived suppressor cells that promote radio-resistance through inhibition of adaptive immune responses and that the use of CCR2 antibodies in mice reduces such resistance. | | 23 November 2017 | doi: 10.1038/s41467-017-01566-5 | | Cancer microenvironment Immunosuppression | Whole blood stabilization for the microfluidic isolation and molecular characterization of circulating tumor cells OPEN | | Keith H. K. Wong, Shannon N. Tessier, David T. Miyamoto, Kathleen L. Miller, Lauren D. Bookstaver, Thomas R. Carey, Cleo J. Stannard, Vishal Thapar, Eric C. Tai, Kevin D. Vo, Erin S. Emmons, Haley M. Pleskow, Rebecca D. Sandlin, Lecia V. Sequist, David T. Ting, Daniel A. Haber, Shyamala Maheswaran, Shannon L. Stott & Mehmet Toner | | | The current FDA-approved whole blood stabilization method for circulating tumor cell (CTC) isolation suffers from RNA degradation. Here the authors combine hypothermic preservation and antiplatelet strategies to stabilize whole blood up to 72 h without compromising CTC yield and RNA integrity. | | 23 November 2017 | doi: 10.1038/s41467-017-01705-y | | Cancer screening Diagnostic markers Laboratory techniques and procedures | Mutational and putative neoantigen load predict clinical benefit of adoptive T cell therapy in melanoma OPEN | | Martin Lauss, Marco Donia, Katja Harbst, Rikke Andersen, Shamik Mitra, Frida Rosengren, Maryem Salim, Johan Vallon-Christersson, Therese Törngren, Anders Kvist, Markus Ringnér, Inge Marie Svane & Göran Jönsson | | | Adoptive T cell therapy (ACT) has yielded high response rates in melanoma, however 50–60% of patients experience no clinical benefit. Here, the authors identify predictive biomarkers, high non-synonymous mutation and high expressed neoantigen load, that associate with clinical benefit in ACT melanoma patients. | | 23 November 2017 | doi: 10.1038/s41467-017-01460-0 | | Melanoma Tumour immunology | Scallop genome reveals molecular adaptations to semi-sessile life and neurotoxins OPEN | | Yuli Li, Xiaoqing Sun, Xiaoli Hu, Xiaogang Xun, Jinbo Zhang, Ximing Guo, Wenqian Jiao, Lingling Zhang, Weizhi Liu, Jing Wang, Ji Li, Yan Sun, Yan Miao, Xiaokang Zhang, Taoran Cheng, Guoliang Xu, Xiaoteng Fu, Yangfan Wang, Xinran Yu, Xiaoting Huang et al. | | | Bivalve molluscs have evolved various characteristics to adapt to benthic filter-feeding. Here, Li et al investigate the genome, transcriptomes and proteomes of scallop Chlamys farreri, revealing evidences of molecular adaptations to semi-sessile life and neurotoxins. | | 23 November 2017 | doi: 10.1038/s41467-017-01927-0 | | Genome Molecular evolution Next-generation sequencing | Glucocorticoid-induced phosphorylation by CDK9 modulates the coactivator functions of transcriptional cofactor GRIP1 in macrophages OPEN | | David A. Rollins, Joubert B. Kharlyngdoh, Maddalena Coppo, Bowranigan Tharmalingam, Sanda Mimouna, Ziyi Guo, Maria A. Sacta, Miles A. Pufall, Robert P. Fisher, Xiaoyu Hu, Yurii Chinenov & Inez Rogatsky | | | Glucocorticoid reduces inflammation by both inducing anti-inflammatory genes and suppressing pro-inflammatory genes, but how these two functions are dictated is unclear. Here the authors show that phosphorylated glucocorticoid receptor-interacting protein 1 (GRIP1) serves as a coactivator for this response in macrophage. | | 23 November 2017 | doi: 10.1038/s41467-017-01569-2 | | Immunosuppression Inflammation Monocytes and macrophages Transcription | MYC regulates ductal-neuroendocrine lineage plasticity in pancreatic ductal adenocarcinoma associated with poor outcome and chemoresistance OPEN | | Amy S. Farrell, Meghan Morrison Joly, Brittany L. Allen-Petersen, Patrick J. Worth, Christian Lanciault, David Sauer, Jason Link, Carl Pelz, Laura M. Heiser, Jennifer P. Morton, Nathiya Muthalagu, Megan T. Hoffman, Sara L. Manning, Erica D. Pratt, Nicholas D. Kendsersky, Nkolika Egbukichi, Taylor S. Amery, Mary C. Thoma, Zina P. Jenny, Andrew D. Rhim et al. | | | Neuroendocrine differentiation of epithelial tumor cells can contribute to cancer cell resistance and survival. Here, the authors show that dysregulated c-Myc promotes neuroendocrine differentiation in pancreatic ductal adenocarcinoma, leading to poor survival and chemoresistance. | | 23 November 2017 | doi: 10.1038/s41467-017-01967-6 | | Pancreatic cancer Tumour heterogeneity | Stress-responsive FKBP51 regulates AKT2-AS160 signaling and metabolic function OPEN | | Georgia Balsevich, Alexander S. Häusl, Carola W. Meyer, Stoyo Karamihalev, Xixi Feng, Max L. Pöhlmann, Carine Dournes, Andres Uribe-Marino, Sara Santarelli, Christiana Labermaier, Kathrin Hafner, Tianqi Mao, Michaela Breitsamer, Marily Theodoropoulou, Christian Namendorf, Manfred Uhr, Marcelo Paez-Pereda, Gerhard Winter, Felix Hausch, Alon Chen et al. | | | Stress is recognized as risk factor for the development of type 2 diabetes. Here Balsevich et al. show that the stress responsive co-chaperone FKBP5 regulates glucose metabolism in mice by modulating AS160 phosphorylation, glucose transporter expression and muscle glucose uptake. | | 23 November 2017 | doi: 10.1038/s41467-017-01783-y | | Obesity Stress and resilience Type 2 diabetes | Complex three-dimensional self-assembly in proxies for atmospheric aerosols OPEN | | C. Pfrang, K. Rastogi, E. R. Cabrera-Martinez, A. M. Seddon, C. Dicko, A. Labrador, T. S. Plivelic, N. Cowieson & A. M. Squires | | | Nearly all atmospheric aerosols contain surface-active organic compounds; however, the nature of how they arrange remains poorly understood. Here, the authors show that fatty acids in atmospheric aerosol proxies self-assemble into highly ordered, viscous 3D nanostructures that undergo changes upon exposure to humidity and ozone. | | 23 November 2017 | doi: 10.1038/s41467-017-01918-1 | | Atmospheric chemistry Characterization and analytical techniques Molecular self-assembly | T cell-targeting nanoparticles focus delivery of immunotherapy to improve antitumor immunity OPEN | | Daniela Schmid, Chun Gwon Park, Christina A. Hartl, Nikita Subedi, Adam N. Cartwright, Regina Bou Puerto, Yiran Zheng, James Maiarana, Gordon J. Freeman, Kai W. Wucherpfennig, Darrell J. Irvine & Michael S. Goldberg | | | Targeted delivery of immunomodulatory compounds to defined subsets of endogenous immune cells may improve the efficacy of combination immunotherapies. Here, the authors use PD-1-targeting nanoparticles containing a TGFβ inhibitor or a TLR7/8 agonist to deliver these payloads to T cells or via T cells to the tumor microenvironment, respectively, leading to anti-tumor efficacy in vivo. | | 23 November 2017 | doi: 10.1038/s41467-017-01830-8 | | Cancer immunotherapy Nanoparticles | Genome-wide identification and differential analysis of translational initiation OPEN | | Peng Zhang, Dandan He, Yi Xu, Jiakai Hou, Bih-Fang Pan, Yunfei Wang, Tao Liu, Christel M. Davis, Erik A. Ehli, Lin Tan, Feng Zhou, Jian Hu, Yonghao Yu, Xi Chen, Tuan M. Nguyen, Jeffrey M. Rosen, David H. Hawke, Zhe Ji & Yiwen Chen | | | Translation initiation sequencing (TI-seq) has revealed unexpected diversity in protein isoforms. Here, Zhang et al. present Ribo-TISH, a computational toolkit that can detect and compare TIs across conditions and improve open reading frame prediction from different types of ribosome profiling data. | | 23 November 2017 | doi: 10.1038/s41467-017-01981-8 | | Computational biology and bioinformatics Functional genomics Long non-coding RNAs Translation | Initiation of HIV neutralizing B cell lineages with sequential envelope immunizations OPEN | | Wilton B. Williams, Jinsong Zhang, Chuancang Jiang, Nathan I. Nicely, Daniela Fera, Kan Luo, M. Anthony Moody, Hua-Xin Liao, S. Munir Alam, Thomas B. Kepler, Akshaya Ramesh, Kevin Wiehe, James A. Holland, Todd Bradley, Nathan Vandergrift, Kevin O. Saunders, Robert Parks, Andrew Foulger, Shi-Mao Xia, Mattia Bonsignori et al. | | | An efficient HIV-1 vaccine will likely depend on eliciting broadly neutralizing antibodies (bnAb). Here the authors analyze the B cell repertoire in macaques and knock-in mice in response to sequential immunization with Env variants that induce a bnAb targeting the CD4-binding site of Env in a HIV-1 infected individual. | | 23 November 2017 | doi: 10.1038/s41467-017-01336-3 | | B-cell receptor HIV infections Peripheral tolerance Protein vaccines | Quantifying protein densities on cell membranes using super-resolution optical fluctuation imaging OPEN | | Tomáš Lukeš, Daniela Glatzová, Zuzana Kvíčalová, Florian Levet, Aleš Benda, Sebastian Letschert, Markus Sauer, Tomáš Brdička, Theo Lasser & Marek Cebecauer | | | The ability to quantify the organization of cell membrane molecules is limited by the density of labeling and experimental conditions. Here, the authors use super-resolution optical fluctuation (SOFI) for molecular density and clustering analyses, and investigate nanoscale distribution of CD4 glycoprotein. | | 23 November 2017 | doi: 10.1038/s41467-017-01857-x | | Fluorescence imaging Imaging the immune system Super-resolution microscopy | | | | | Nature Communications EVENT | | Vita Scientia 2018 03.01.18 "Vilnius, Lithuania Vilnius, Lithuania" | | | | | | | | | | | Latest Errata | | | | Erratum: The anaphase promoting complex impacts repair choice by protecting ubiquitin signalling at DNA damage sites OPEN | | Kyungsoo Ha, Chengxian Ma, Han Lin, Lichun Tang, Zhusheng Lian, Fang Zhao, Ju-Mei Li, Bei Zhen, Huadong Pei, Suxia Han, Marcos Malumbres, Jianping Jin, Huan Chen, Yongxiang Zhao, Qing Zhu & Pumin Zhang | | 29 November 2017 | doi: 10.1038/ncomms16156 | | DNA damage response Double-strand DNA breaks | | | | | Latest Corrigenda | | | | Corrigendum: Insufficient antibody validation challenges oestrogen receptor beta research OPEN | | Sandra Andersson, Mårten Sundberg, Nusa Pristovsek, Ahmed Ibrahim, Philip Jonsson, Borbala Katona, Carl-Magnus Clausson, Agata Zieba, Margareta Ramström, Ola Söderberg, Cecilia Williams & Anna Asplund | | 29 November 2017 | doi: 10.1038/ncomms16164 | | Breast cancer Immunohistochemistry Tumour biomarkers | Corrigendum: Potent single-domain antibodies that arrest respiratory syncytial virus fusion protein in its prefusion state OPEN | | Iebe Rossey, Morgan S. A. Gilman, Stephanie C. Kabeche, Koen Sedeyn, Daniel Wrapp, Masaru Kanekiyo, Man Chen, Vicente Mas, Jan Spitaels, José A. Melero, Barney S. Graham, Bert Schepens, Jason S. McLellan & Xavier Saelens | | 29 November 2017 | doi: 10.1038/ncomms16165 | | Antibody fragment therapy Virus structures X-ray crystallography | | | | | Advertisement | | Is your organization planning a scientific event or conference for 2018? Looking for a way to increase the number of attendees? Advertise in the Natureevents Directory 2018. Available online and in print. Ad close deadline: 4 December, 2017. | | | | | | | | | | | | Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. 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