Nature Biotechnology Contents: Volume 35 pp 993 - 1112

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Advertisement Cisbio is committed to helping you achieve great advancements in your drug discovery research. Cisbio's IP One - Gq assays detect the accumulation of inositol monophosphate, a stable downstream metabolite of IP3 induced by activation of a phospholipase C (PLC) cascade. Our guides are designed to help you master your assay and receive great results. TABLE OF CONTENTS November 2017 Volume 35, Issue 11 In This Issue Editorial News Correction Opinion and Comment Features News and Views Research Careers and Recruitment Advertisement   Profile DNA, RNA, protein, and phospho-protein targets up to 800-plex from a single sample. With curated content for specific research areas, including Immuno-Oncology, Solid Tumor, and Heme Profiling, get more data from less sample.  Learn more about 3D Biology™ Technology Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement Discover a new path to your success via Human Data Science. IMS Health and Quintiles are now IQVIA™— created to advance your pursuits of human science by unleashing the power of data science and human ingenuity. We are here to help you find solutions to drive healthcare forward. Join the journey today.   Advertisement BIOPHARMA DEALMAKERS Company Profiles and Partnering Opportunities   Advertisement Nature Index: Melbourne Interactive Map 2017  The Nature Index Melbourne interactive map enables you to explore the scientific job opportunities, collaborations and partnerships at the centre of Australia's life science and healthcare epicentre. Use the interactive map to benchmark the global reach of the Melbourne's key institutions and to view key connections at the heart of Melbourne's success.  Access the free Interactive Map   Advertisement nature.com webcasts Nature Research Custom presents a webcast on: The emerging role of cryo-EM in pharmaceutical development Date: Tuesday, October 17, 2017 This webcast has been produced on behalf of the sponsor who retains sole responsibility for content  Register for FREE Sponsored by:  Thermo Fisher Scientific   In This Issue Top In this issue   ppvii - vii Kathy Aschheim, Michael Francisco and Andrew Marshall doi:10.1038/nbt.4019 Editorial Top Humans 2.0   p993 doi:10.1038/nbt.4018 Of the germline engineering approaches, mitochondrial replacement, rather than gene editing, is poised to have the greatest impact on our lives. News Top With Alnylam's amyloidosis success, RNAi approval hopes soar   pp995 - 997 Cormac Sheridan doi:10.1038/nbt1117-995 RET-oncogene-targeting drugs draw notice   p996 doi:10.1038/nbt1117-996 First AAV gene therapy poised for landmark approval   pp998 - 999 Eric Smalley doi:10.1038/nbt1117-998 Duchenne drug clings on for FDA nod   p999 doi:10.1038/nbt1117-999 Age-related macular degeneration foils drugmakers   pp1000 - 1001 Elie Dolgin doi:10.1038/nbt1117-1000 Allergan's Mohawk evergreening patent deal draws criticism, but ultimately may flop   p1002 Eva von Schaper doi:10.1038/nbt1117-1002 Spanish group defeats Shkreli in Chagas voucher race   p1003 Lisa Melton doi:10.1038/nbt1117-1003 Podcast First rounders: Stelios Papadopoulos   p1004 doi:10.1038/nbt.3995 Around the world in a month   p1004 doi:10.1038/nbt1117-1004 Correction Top Corrections   p1004 doi:10.1038/nbt1117-1004c Faster, Simpler Biological LC-MS/MS Analysis Shimadzu's Clinical Laboratory Automation Module, a fully integrated sample pretreatment module for LC-MS/MS, automatically performs all of the processes necessary for analyzing blood and other biological samples, providing more precise results by reducing human error and improving laboratory safety and efficiency. Learn more. News Top Data Page 3Q17—Funding and partnership into overdrive   p1005 Laura DeFrancesco doi:10.1038/nbt.4012 News Features Better beings?   pp1006 - 1011 Amber Dance doi:10.1038/nbt.3998 As the technology to create genetically modified babies moves closer to practice, what questions should we ask before such procedures are contemplated? Amber Dance investigates. When replacement becomes reversion   pp1012 - 1015 Steve Connor doi:10.1038/nbt.3996 Mitochondrial replacement therapy is being touted as a means of combating maternally inherited disease. But concerns are growing about mitochondrial reversion compromising cures. Steve Connor investigates. Reproducing with DNA   pp1016 - 1020 Malorye Allison Branca doi:10.1038/nbt.4002 Finding partners through DNA profiles has yet to catch on, but the commercial sector for preconception and prenatal testing is booming. Malorye Allison Branca reports. Characterize the epitope landscape of your entire antibody library at the earliest stages of discovery to make smart decisions: Maximize epitope diversity Identify unique epitopes Build your IP portfolio Learn about the rapid assessment of an antibody library's epitopic diversity by reading this application note. Download the Application Note >>       Opinion and Comment Top Correspondence Public views on gene editing and its uses   pp1021 - 1023 George Gaskell, Imre Bard, Agnes Allansdottir, Rui Vieira da Cunha, Peter Eduard et al. doi:10.1038/nbt.3958 Query the merits of embryo editing for reproductive research now   pp1023 - 1025 Insoo Hyun and Catherine Osborn doi:10.1038/nbt.4000 MMseqs2 enables sensitive protein sequence searching for the analysis of massive data sets   pp1026 - 1028 Martin Steinegger and Johannes Soding doi:10.1038/nbt.3988 Features Top Revisiting the Warnock rule   pp1029 - 1042 J Benjamin Hurlbut, Insoo Hyun, Aaron D Levine, Robin Lovell-Badge, Jeantine E Lunshof et al. doi:10.1038/nbt.4015 Is it time to reassess the 14-day rule for human embryo research? Patents Recent patents related to germline modification   p1043 doi:10.1038/nbt.4013 News and Views Top Coiled coils unspring protein origami   pp1044 - 1045 Greg L Hura and John A Tainer doi:10.1038/nbt.4003 Self-assembling sequences of protein coiled coils create polyhedral nanostructures for advanced applications in biomedicine, chemistry and materials science. See also: Research by Ljubetic et al. Engineered bacteria self-organize to sense pressure   pp1045 - 1047 Neydis Moreno Morales and Megan N McClean doi:10.1038/nbt.3992 Bacteria are engineered with pattern-generating circuits to produce self-organized materials that can function as pressure sensors. See also: Research by Cao et al. The ecological landscape of microbiome science   pp1047 - 1049 Daryl M Gohl doi:10.1038/nbt.3983 Two reports examine the sources of variation in methods for analyzing microbial communities. See also: Research by Costea et al. | Research by Sinha et al. Research Highlights   p1049 doi:10.1038/nbt.3999 Biotechnology JOBS of the week Assistant Professor (Tenure Track) of Food Biotechnology ETH Zurich - The Swiss Federal Institute of Technology in Zurich Faculty Position in Plant Biotechnology MIT Postdoc / Bioinformatician (m / f) Heidelberg University Geneticist for Scientific User Support (part-time) INFRAFRONTIER GmbH Postdoctoral Researcher position (research associate) in Systems Biomedicine (m / f) University of Luxembourg More Science jobs from Biotechnology EVENT 4th International Conference on Bioengineering and Biotechnology (ICBB'18) August 19, 2018 Madrid, Spain More science events from Research Top Perspective Ethical principles for the use of human cellular biotechnologies   pp1050 - 1058 Paul Root Wolpe, Karen S Rommelfanger and the Drafting and Reviewing Delegates of the BEINGS Working Groups:  doi:10.1038/nbt.4007 A group of interdisciplinary delegates drawn from the top biotech-producing countries of the world offers a consensus statement outlining a set of principles important to consider in the ethical conversation about human cellular biotechnological research moving forward. Review Assisted reproductive technologies to prevent human mitochondrial disease transmission   pp1059 - 1068 Andy Greenfield, Peter Braude, Frances Flinter, Robin Lovell-Badge, Caroline Ogilvie et al. doi:10.1038/nbt.3997 Replacement of pathogenic mitochondrial DNA in human embryos is poised for clinical application. Analysis Towards standards for human fecal sample processing in metagenomic studies   pp1069 - 1076 Paul I Costea, Georg Zeller, Shinichi Sunagawa, Eric Pelletier, Adriana Alberti et al. doi:10.1038/nbt.3960 Testing 21 different fecal DNA extraction protocols in multiple laboratories results in a standardized protocol with the potential to improve comparability across human gut microbiome studies. See also: News and Views by Gohl Assessment of variation in microbial community amplicon sequencing by the Microbiome Quality Control (MBQC) project consortium   pp1077 - 1086 Rashmi Sinha, Galeb Abu-Ali, Emily Vogtmann, Anthony A Fodor, Boyu Ren et al. doi:10.1038/nbt.3981 The Microbiome Quality Control project consortium reports outcomes of a baseline study (MBQC) that will guide future improvements in reproducibility of microbiome analyses. See also: News and Views by Gohl Articles Programmable assembly of pressure sensors using pattern-forming bacteria   pp1087 - 1093 Yangxiaolu Cao, Yaying Feng, Marc D Ryser, Kui Zhu, Gregory Herschlag et al. doi:10.1038/nbt.3978 Engineered bacteria self-assemble to generate structures that act as pressure sensors. See also: News and Views by Morales & McClean Design of coiled-coil protein-origami cages that self-assemble in vitro and in vivo    pp1094 - 1101 Ajasja Ljubetic, Fabio Lapenta, Helena Gradisar, Igor Drobnak, Jana Aupic et al. doi:10.1038/nbt.3994 Protein origami using coiled-coil building blocks produces self-assembling polyhedral cages for diverse applications. See also: News and Views by Hura & Tainer Molecular afterglow imaging with bright, biodegradable polymer nanoparticles   pp1102 - 1110 Qingqing Miao, Chen Xie, Xu Zhen, Yan Lyu, Hongwei Duan et al. doi:10.1038/nbt.3987 Ultra-high signal-to-background in vivo imaging is enabled by biocompatible semiconducting polymer nanoparticles. Careers and Recruitment Top Third-quarter biotech job picture   p1111 Michael Francisco doi:10.1038/nbt.4008 People People   p1112 doi:10.1038/nbt.4014 Advertisement FANTOM5 Collection Bringing together FANTOM5 research articles, analyses and resource papers that have been published by Nature Research.  Access the Collection online   Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

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