The EMBO Journal Table of Contents for 16 October 2017; Vol. 36, No. 20

16 October 2017 | Volume 36, Number 20 Submit Table of Contents News & Views Review Articles Volume 36, Number 20 News & Views Liquidizing FUS via prion‐like domain phosphorylation Phosphorylation of the Amyotrophic Lateral Sclerosis‐linked protein FUS inhibits its pathological aggregation and toxicity, suggesting a potential therapeutic strategy for FUS proteinopathies. James Shorter Published online 28.09.2017 New functions in translation termination uncovered for NMD factor UPF3B The discovery of direct ribosome binding and translation termination control by UPF3B calls for a reassessment of current models for mammalian nonsense‐mediated RNA decay Oliver Mühlemann and Evangelos D Karousis Published online 21.09.2017 Review Dysregulated molecular pathways in amyotrophic lateral sclerosis–frontotemporal dementia spectrum disorder A review of the key cellular pathways affected in ALS and FTD neurodegenerative diseases highlights the complexity of the underlying pathogenic mechanisms and the potential for identifying future therapeutic targets. Fen‐Biao Gao, Sandra Almeida and Rodrigo Lopez‐Gonzalez Published online 15.09.2017 Articles Phosphorylation of the FUS low‐complexity domain disrupts phase separation, aggregation, and toxicity Post‐translational modification emerges as a cellular mechanism for controlling physiological assembly of the ALS and FTD neurodegenerative disease‐linked RNA‐binding protein FUS. Zachary Monahan, Veronica H Ryan, Abigail M Janke, Kathleen A Burke, Shannon N Rhoads, Gül H Zerze, Robert O'Meally, Gregory L Dignon, Alexander E Conicella, Wenwei Zheng, Robert B Best, Robert N Cole, Jeetain Mittal, Frank Shewmaker and Nicolas L Fawzi Published online 08.08.2017 Dual function of UPF3B in early and late translation termination In vitro reconstitution assays reveal that UPF3B plays a direct role in translation termination and sheds light on the mechanism of nonsense‐mediated mRNA decay in mammals. Gabriele Neu‐Yilik, Etienne Raimondeau, Boris Eliseev, Lahari Yeramala, Beate Amthor, Aurélien Deniaud, Karine Huard, Kathrin Kerschgens, Matthias W Hentze, Christiane Schaffitzel and Andreas E Kulozik Published online 12.09.2017 Epigenetic regulation of left–right asymmetry by DNA methylation Laterality organizer formation during zebrafish development is controlled by DNA methyltransferases that promote progenitor specification and cell migration. Lu Wang, Zhibin Liu, Hao Lin, Dongyuan Ma, Qinghua Tao and Feng Liu Published online 07.09.2017 Snapin promotes HIV‐1 transmission from dendritic cells by dampening TLR8 signaling A proteomic and siRNA screen identifies signalling components required for HIV‐1 evasion of the host innate immune response in dendritic cells. Elham Khatamzas, Madeleine Maria Hipp, Daniel Gaughan, Tica Pichulik, Alasdair Leslie, Ricardo A Fernandes, Daniele Muraro, Sarah Booth, Kieran Zausmer, Mei‐Yi Sun, Benedikt Kessler, Sarah Rowland‐Jones, Vincenzo Cerundolo and Alison Simmons Published online 18.09.2017 Qualitative differences in T‐cell activation by dendritic cell‐derived extracellular vesicle subtypes Dendritic cell (DC)‐derived extracellular vesicle (EV) subtypes show functional heterogeneity depending on the DC maturation stage, thus highlighting the importance of characterizing all EV subtypes for their function. Mercedes Tkach, Joanna Kowal, Andres E Zucchetti, Lotte Enserink, Mabel Jouve, Danielle Lankar, Michael Saitakis, Lorena Martin‐Jaular and Clotilde Théry Published online 18.09.2017 Ret receptor tyrosine kinase sustains proliferation and tissue maturation in intestinal epithelia Ret maintains fly intestinal stem cells and mouse postnatal gut development. Daniel Perea, Jordi Guiu, Bruno Hudry, Chrysoula Konstantinidou, Alexandra Milona, Dafni Hadjieconomou, Thomas Carroll, Nina Hoyer, Dipa Natarajan, Jukka Kallijärvi, James A Walker, Peter Soba, Nikhil Thapar, Alan J Burns, Kim B Jensen and Irene Miguel‐Aliaga Published online 12.09.2017 Casein kinase 1‐epsilon or 1‐delta required for Wnt‐mediated intestinal stem cell maintenance Casein kinase isoforms CKIδ and CKIε facilitate Wnt‐mediated intestinal homeostasis and stem cell survival. Yael Morgenstern, Upasana Das Adhikari, Muneef Ayyash, Ela Elyada, Beáta Tóth, Andreas Moor, Shalev Itzkovitz and Yinon Ben‐Neriah Published online 28.09.2017 Structural basis for antibacterial peptide self‐immunity by the bacterial ABC transporter McjD Transient opening of the antibacterial peptide transporter McjD prevents the influx of its toxic substrate MccJ25 and distinguishes it from other multi‐drug transporters. Kiran Bountra, Gregor Hagelueken, Hassanul G Choudhury, Valentina Corradi, Kamel El Omari, Armin Wagner, Indran Mathavan, Séverine Zirah, Weixiao Yuan Wahlgren, D Peter Tieleman, Olav Schiemann, Sylvie Rebuffat and Konstantinos Beis Published online 01.09.2017 Structure of a VirD4 coupling protein bound to a VirB type IV secretion machinery Biochemical analysis and negative‐stain electron microscopy reveal the localisation of the VirD4 ATPase within the inner membrane complex of the Escherichia coli type IV secretion system. Adam Redzej, Marta Ukleja, Sarah Connery, Martina Trokter, Catarina Felisberto‐Rodrigues, Adam Cryar, Konstantinos Thalassinos, Richard D Hayward, Elena V Orlova and Gabriel Waksman Published online 18.09.2017   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 973 University Avenue * Los Gatos, CA 95032 * U.S.A. Copyright © 2017 by the European Molecular Biology Organisation.