Nature Reviews Neuroscience contents October 2017 Volume 18 Number 10 pp 569 - 640

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TABLE OF CONTENTS
October 2017 Volume 18 Number 10
2016 2-year Impact Factor 28.880 Journal Metrics 2-year Median 23	In this issue Research Highlights Reviews   Also this month  Featured article: The impact of cytoskeletal organization on the local regulation of neuronal transport Jeffrey J. Nirschl, Amy E. Ghiretti & Erika L. F. Holzbaur
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RESEARCH HIGHLIGHTS   Top Decision making: Making hasty decisions p569 | doi:10.1038/nrn.2017.116 The activity of neurons in the basal ganglia contributes to the weighting of speed versus accuracy, rather than to deliberation, in a motor decision-making task. PDF Reward: Restraint from risky reward p570 | doi:10.1038/nrn.2017.114 In mice, a set of projections from the medial prefrontal cortex to the nucleus accumbens suppress reward seeking under risky conditions. PDF Non-coding RNA: Regulatory circles p570 | doi:10.1038/nrn.2017.118 In mice, the circular RNA Cdr1as regulates microRNA expression in the brain and sensorimotor gating. PDF Learning and memory: Memories take the sub-way p571 | doi:10.1038/nrn.2017.117 Two pathways from CA1 to the entorhinal cortex — a direct pathway and an indirect pathway, that projects via the hippocampal subiculum — are shown to play dissociable roles in memory formation and retrieval, respectively. PDF Reward: Eating goes down a treat p572 | doi:10.1038/nrn.2017.115 A study in mice identified neurons in the central amygdala that express the serotonin 2A receptor and positively reinforce the consumption of food. PDF   IN BRIEF Neurodegenerative disease: Towards transplant therapy | Visual processing: Face off | Techniques: Having a field day | Neurodevelopmental disorders: A transcription-targeting target PDF Nature Reviews Neuroscience JOBS of the week Post-Doctoral Positions in Obesity & Diabetes Research Monash University - Biomedicine Discovery Institute Assistant Professor / Postdoctoral Fellow University of Tsukuba Brain Science Researcher KIST (Korea Institute of Sience and Technology) Development and application of single cell sequencing procedures. Gigas - Universit� de Liege Professor in Neuroscience Universit�t Basel More Science jobs from Nature Reviews Neuroscience EVENT 13th International Neuroscience and Biological Psychiatry ISBS Regional (S. America) Conference "NEUROSCIENCE OF STRESS" 01.12.17 Rio de Janeiro, Brazil More science events from
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REVIEWS		Top
The use of brain organoids to investigate neural development and disease Elizabeth Di Lullo & Arnold R. Kriegstein p573 | doi:10.1038/nrn.2017.107 By capturing and manipulating the self-organizing capacity of pluripotent stem cells, researchers have established protocols for the production of in vitro brain-like 'organoids'. Di Lullo and Kriegstein evaluate approaches to organoid generation and consider their potential as models of brain development and disease. Abstract | Full Text | PDF
The impact of cytoskeletal organization on the local regulation of neuronal transport Jeffrey J. Nirschl, Amy E. Ghiretti & Erika L. F. Holzbaur p585 | doi:10.1038/nrn.2017.100 Neuronal trafficking has to meet the requirements of various intracellular compartments. In this Review, Nirschl, Ghiretti and Holzbaur examine how the transport machinery, including the cytoskeleton and molecular motors, is locally regulated to allow neuronal compartment-specific transport. Abstract | Full Text | PDF
Electrodiffusion phenomena in neuroscience: a neglected companion Leonid P. Savtchenko, Mu Ming Poo & Dmitri A. Rusakov p598 | doi:10.1038/nrn.2017.101 Neuroscience is going nanoscopic, but can it still rely on classical electrophysiology? In this Review, Savtchenko, Poo and Rusakov argue that accurate interpretation of physiological observations on the nanoscale must account for electrodiffusion phenomena arising from local perturbations of ionic concentrations. Abstract | Full Text | PDF
Polyglutamine spinocerebellar ataxias — from genes to potential treatments Henry L. Paulson, Vikram G. Shakkottai, H. Brent Clark & Harry T. Orr p613 | doi:10.1038/nrn.2017.92 Several of the spinocerebellar ataxias (SCAs) result from expansion of polyglutamine (polyQ)-encoding regions in different genes. Here, Orr and colleagues examine the clinical features of the the polyQ SCAs, and suggest that understanding the molecular and physiological mechanisms underlying polyQ SCAs can inform therapeutic strategies for these and other polyQ disorders. Abstract | Full Text | PDF
Noncoding RNAs in neurodegeneration Evgenia Salta & Bart De Strooper p627 | doi:10.1038/nrn.2017.90 Non-coding RNAs (ncRNAs) have been implicated in the pathophysiology of various neurodegenerative diseases. In this Review, Salta and De Strooper discuss the mechanisms by which ncRNAs may be linked to neurodegeneration and touch on the use of ncRNA-based biomarkers and therapies for these conditions. Abstract | Full Text | PDF | Supplementary information
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