Nature Reviews Genetics Contents October 2017 Volume 18 Number 10 pp 577-636

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TABLE OF CONTENTS
October 2017 Volume 18 Number 10		Advertisement
2016 2-year Impact Factor 40.282 Journal Metrics 2-year Median 28.5	In this issue Research Highlights Reviews   Also this month  Featured article: Settling the score: variant prioritization and Mendelian disease Karen Eilbeck, Aaron Quinlan & Mark Yandell	Springer Nature offers a free open access funding support service to enable authors to discover and apply for article processing charge funding available to them. Visit our website for further advice on the funding options available, and guidance in approaching funders and institutions, or email openaccess@nature.com for more information.
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RESEARCH HIGHLIGHTS   Top Model organisms: New tools, new insights — probing social behaviour in ants p577 | doi:10.1038/nrg.2017.70 PDF Pathogen genetics: Evolutionary dynamics driving drug resistance p578 | doi:10.1038/nrg.2017.68 PDF Chromosome biology: Different turfs for cohesin and condensin p578 | doi:10.1038/nrg.2017.71 PDF Genetic engineering: Pigs without PERVs p579 | doi:10.1038/nrg.2017.73 PDF Gene therapy: Human genome editing in heart disease p580 | doi:10.1038/nrg.2017.69 PDF   Genetics JOBS of the week Postdoctoral Position- Developmental Genetics, Cardiovascular Biology and Stroke: University of Calgary University of Calgary Faculty Position in Cellular Genetics Wellcome Trust Sanger Institute Director - Clinical Genomic Care Sidra Medical and Research Centre Postdoctoral Fellowships in Biomedical Science (Cancer Research) Columbia University Medical Center Assistant Professor of Oncology McArdle Laboratory for Cancer Research, University of Wisconsin-Madison School of Medicine and Public Health More Science jobs from Genetics EVENT EMBO | EMBL Symposium: Systems Genetics: From Genotypes to Molecular Phenotypes to Complex Traits 24.10.18 UK More science events from
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REVIEWS		Top
Evolutionary biology through the lens of budding yeast comparative genomics Souhir Marsit, Jean-Baptiste Leducq, Éléonore Durand, Axelle Marchant, Marie Filteau & Christian R. Landry p581 | doi:10.1038/nrg.2017.49 Saccharomyces cerevisiae has become an important model organism in the field of evolutionary genomics. Comparative genomic analysis of laboratory, wild and domesticated yeast populations is generating insights into how new species form and how populations adapt to their environments. Abstract | Full Text | PDF
Settling the score: variant prioritization and Mendelian disease Karen Eilbeck, Aaron Quinlan & Mark Yandell p599 | doi:10.1038/nrg.2017.52 For clinical cases of Mendelian disease that lack a genetic diagnosis, genome and exome sequencing are increasingly used for seeking the genetic cause. This Review discusses the strategies and computational tools for prioritizing the many genetic variants identified in each genome into those that are most likely to be causal for disease. The authors discuss how diverse types of biochemical, evolutionary, pedigree and clinical-phenotype information are used, and they highlight common pitfalls to be aware of for responsible variant prioritization. Abstract | Full Text | PDF
Synthetic lethality and cancer Nigel J. O'Neil, Melanie L. Bailey & Philip Hieter p613 | doi:10.1038/nrg.2017.47 The authors review the concept of synthetic lethality — when the perturbation of one of two genes alone is viable, but the perturbation of both genes simultaneously results in the loss of viability — from model organisms to human cancers, and discuss how genetic interactions can be exploited for the identification of new drug targets in cancer. Abstract | Full Text | PDF
Dissecting evolution and disease using comparative vertebrate genomics Jennifer R. S. Meadows & Kerstin Lindblad-Toh p624 | doi:10.1038/nrg.2017.51 The last 25 years has seen a revolution in sequencing, with more than 100 vertebrate genome sequences now available. In this Review, Meadows and Lindblad-Toh discuss how the genomics of non-human organisms can provide insights into vertebrate biology and conservation, and how they can contribute to the understanding of human health and disease. Abstract | Full Text | PDF
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