The EMBO Journal Table of Contents for 15 August 2017; Vol. 36, No. 16

15 August 2017 | Volume 36, Number 16 Submit Table of Contents Commentary News & Views Articles Resource Volume 36, Number 16 Commentary Expanding our scientific horizons: utilization of unique model organisms in biological research Animals have evolved diverse strategies to survive in harsh environments, fend off diseases, hunt and incapacitate their prey. Expanding the range of established animal models in research to understand their unique adaptations could yield enormous benefits for understanding and treating human diseases. Angela K Peter, Claudia Crocini, and Leslie A Leinwand Published online 10.07.2017 News & Views New Q(ues) to keep blood vessels growing Two studies show the importance of glutamine as a TCA cycle carbon source in endothelial cells, promoting cell proliferation, biomass synthesis and vessel sprouting. Jorge Andrade and Michael Potente Published online 04.08.2017 A chief source of cancer and repair in stomachs Lgr5‐expressing gastric chief cells are recruited to become stem cells that can regenerate damaged tissue but also initiate precancerous lesions. Megan D Radyk and Jason C Mills Published online 30.06.2017 Articles Glutamine fuels proliferation but not migration of endothelial cells Glutamine supplies the majority of carbons in the tricyclic acid (TCA) cycle of endothelial cells (ECs) and is required for cataplerosis and as a nitrogen source in order to sustain EC proliferation. Boa Kim, Jia Li, Cholsoon Jang, and Zoltan Arany Published online 28.06.2017 Role of glutamine and interlinked asparagine metabolism in vessel formation Vessel sprouting during angiogenesis is highly dependent on endothelial cell glutamine metabolism, which serves multiple metabolic functions but is especially interlinked with asparagine synthesis. Hongling Huang, Saar Vandekeere, Joanna Kalucka, Laura Bierhansl, Annalisa Zecchin, Ulrike Brüning, Asjad Visnagri, Nadira Yuldasheva, Jermaine Goveia, Bert Cruys, Katleen Brepoels, Sabine Wyns, Stephen Rayport, Bart Ghesquière, Stefan Vinckier, Luc Schoonjans, Richard Cubbon, Mieke Dewerchin, Guy Eelen, and Peter Carmeliet Published online 28.06.2017 SIRT1 regulates macrophage self‐renewal The life span regulator SIRT1 controls a transcriptional network for macrophage cell cycle progression and stress responses, implying macrophage self‐renewal as a potential parameter of aging. Francesco Imperatore, Julien Maurizio, Stephanie Vargas Aguilar, Clara J Busch, Jérémy Favret, Elisabeth Kowenz‐Leutz, Wilfried Cathou, Rebecca Gentek, Pierre Perrin, Achim Leutz, Carole Berruyer, and Michael H Sieweke Published online 12.07.2017 Tumor matrix stiffness promotes metastatic cancer cell interaction with the endothelium Quantitative mass spectrometry identifies CCN1 as the basis for matrix stiffness effects on tumor progression via mediating adhesion to endothelial cells and thereby cancer cell intravasation into the vasculature. Steven E Reid, Emily J Kay, Lisa J Neilson, Anne‐Theres Henze, Jens Serneels, Ewan J McGhee, Sandeep Dhayade, Colin Nixon, John BG Mackey, Alice Santi, Karthic Swaminathan, Dimitris Athineos, Vasileios Papalazarou, Francesca Patella, Álvaro Román‐Fernández, Yasmin ElMaghloob, Juan Ramon Hernandez‐Fernaud, Ralf H Adams, Shehab Ismail, David M Bryant, Manuel Salmeron‐Sanchez, Laura M Machesky, Leo M Carlin, Karen Blyth, Massimiliano Mazzone, and Sara Zanivan Published online 10.07.2017 Integrin αvβ3 enhances the suppressive effect of interferon‐γ on hematopoietic stem cells Integrin β3 defines functional hematopoietic stem cells (HSCs) and synergises with inflammatory IFNγ via STAT1 serine phosphorylation to suppress HSC engraftment in vivo. Terumasa Umemoto, Yu Matsuzaki, Yoshiko Shiratsuchi, Michihiro Hashimoto, Takayuki Yoshimoto, Ayako Nakamura‐Ishizu, Brian Petrich, Masayuki Yamato, and Toshio Suda Published online 03.07.2017 Type I interferon is required for T helper (Th) 2 induction by dendritic cells Type I interferon (IFN‐I) mediates dendritic cell (cDC) activation in a type 2 inflammatory response to parasitic worm infection or the allergen house dust mite, supporting T‐helper 2 (Th2) cell induction. Lauren M Webb, Rachel J Lundie, Jessica G Borger, Sheila L Brown, Lisa M Connor, Adam NR Cartwright, Annette M Dougall, Ruud HP Wilbers, Peter C Cook, Lucy H Jackson‐Jones, Alexander T Phythian‐Adams, Cecilia Johansson, Daniel M Davis, Benjamin G Dewals, Franca Ronchese, and Andrew S MacDonald Published online 17.07.2017 The AAA+ ATPase TRIP13 remodels HORMA domains through N‐terminal engagement and unfolding Crosslinking mass spectrometry and crystallography reveal how TRIP13 and the adaptor p31comet recognize MAD2 and release its “safety belt” during mitotic checkpoint silencing. Qiaozhen Ye, Dong Hyun Kim, Ihsan Dereli, Scott C Rosenberg, Goetz Hagemann, Franz Herzog, Attila Tóth, Don W Cleveland, and Kevin D Corbett Published online 28.06.2017 PPR polyadenylation factor defines mitochondrial mRNA identity and stability in trypanosomes By controlling a switch between adenylation and uridylation of mitochondrial mRNAs, RNA‐binding protein KPAF3 illustrates how the nature of mRNA 3′ ends can serve as a checkpoint for RNA editing. Liye Zhang, Francois M Sement, Takuma Suematsu, Tian Yu, Stefano Monti, Lan Huang, Ruslan Aphasizhev, and Inna Aphasizheva Published online 06.07.2017 Resource Protease cleavage site fingerprinting by label‐free in‐gel degradomics reveals pH‐dependent specificity switch of legumain Direct In‐gel Profiling of Protease Specificity (DIPPS) under a large variety of experimental conditions offers a quick and reliable starting point for protease functional characterization and substrate design. Robert Vidmar, Matej Vizovišek, Dušan Turk, Boris Turk, and Marko Fonović Published online 21.07.2017   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 973 University Avenue * Los Gatos, CA 95032 * U.S.A. Copyright © 2017 by the European Molecular Biology Organisation.