The EMBO Journal Table of Contents for 01 August 2017; Vol. 36, No. 15

01 August 2017 | Volume 36, Number 15 Submit Table of Contents Commentary News & Views Review Articles Volume 36, Number 15 Commentary Mitochondrial genome inheritance and replacement in the human germline Mitochondrial replacement therapy aims to prevent the transmission of mitochondrial‐linked diseases by exchanging maternal mitochondria with healthy ones. To improve its safety and efficiency, it is vital to understand how and which mitochondrial genomes of the oocyte are tagged for replication in the growing embryo. Don P Wolf, Tomonari Hayama, and Shoukhrat Mitalipov Published online 05.07.2017 News & Views The lipid‐binding side of Notch ligands Notch ligand‐receptor interactions are promoted by ligand binding to membrane lipids, suggesting a new mode of Notch signaling regulation. Ben‐Zion Shilo and David Sprinzak Published online 14.07.2017 A new twist to Sin3 complexes in pluripotent cells The discovery of a stem cell‐specific Sin3a‐HDAC subunit required for self‐renewal suggests that chromatin modifying complexes may exist in a variety of cell type‐dependent forms. Raphaël Pantier, Nicholas P Mullin, and Ian Chambers Published online 28.06.2017 Review Focus: Metabolism: Endothelial cell metabolism in health and disease: impact of hypoxia The metabolic and hypoxic signaling pathways acting in vascular endothelial cells, and impacting on conditions such as cancer and atherosclerosis, are the focus of this part of our Metabolism review series. Brian W Wong, Elke Marsch, Lucas Treps, Myriam Baes, and Peter Carmeliet Published online 21.06.2017 Articles Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands Structural variability in the C2 domain of Notch ligands determines membrane binding and regulates Notch activation, a role that is lost in disease‐associated Jagged1 variants. Richard J Suckling, Boguslawa Korona, Pat Whiteman, Chandramouli Chillakuri, Laurie Holt, Penny A Handford, and Susan M Lea Published online 01.06.2017 Fam60a defines a variant Sin3a‐Hdac complex in embryonic stem cells required for self‐renewal Quantitative proteomics identifies an ES cell‐specific form of a chromatin repressor complex, which shapes the particular chromatin state required for proliferation and self‐renewal of these cells. Gundula Streubel, Darren J Fitzpatrick, Giorgio Oliviero, Andrea Scelfo, Bruce Moran, Sudipto Das, Nayla Munawar, Ariane Watson, Kieran Wynne, Gian Luca Negri, Eugene T Dillon, SriGanesh Jammula, Karsten Hokamp, Darran P O'Connor, Diego Pasini, Gerard Cagney, and Adrian P Bracken Published online 29.05.2017 Glycosylation of KEAP1 links nutrient sensing to redox stress signaling Restraint of the NRF2 antioxidant response in unstressed cells requires O‐GlcNAcylation of the cullin ligase adaptor KEAP1, and can be released by glucose deprivation. Po‐Han Chen, Timothy J Smith, Jianli Wu, Priscila F Siesser, Brittany J Bisnett, Farhan Khan, Maxwell Hogue, Erik Soderblom, Flora Tang, Jeffrey R Marks, Michael B Major, Benjamin M Swarts, Michael Boyce, and Jen‐Tsan Chi Published online 29.06.2017 Structural basis of divergent cyclin‐dependent kinase activation by Spy1/RINGO proteins Co‐crystallization reveals how a cancer‐associated non‐cyclin activator induces an active Cdk2 conformation refractory to canonical cell cycle‐related regulatory mechanisms. Denise A McGrath, Bre‐Anne Fifield, Aimee H Marceau, Sarvind Tripathi, Lisa A Porter, and Seth M Rubin Published online 30.06.2017 Multivalent binding of PWWP2A to H2A.Z regulates mitosis and neural crest differentiation A novel histone variant‐specific interactor localizes to H2A.Z‐containing nucleosomes at start sites of highly transcribed genes, affecting gene expression profiles, cell division and organ development. Sebastian Pünzeler, Stephanie Link, Gabriele Wagner, Eva C Keilhauer, Nina Kronbeck, Ramona MM Spitzer, Susanne Leidescher, Yolanda Markaki, Edith Mentele, Catherine Regnard, Katrin Schneider, Daisuke Takahashi, Masayuki Kusakabe, Chiara Vardabasso, Lisa M Zink, Tobias Straub, Emily Bernstein, Masahiko Harata, Heinrich Leonhardt, Matthias Mann, Ralph AW Rupp, and Sandra B Hake Published online 23.06.2017 p21 maintains senescent cell viability under persistent DNA damage response by restraining JNK and caspase signaling Deletion of p21 in senescent cells leads to increased DNA damage response and NF‐κB/JNK/caspase‐mediated cell death in vitro as well as alleviated liver fibrosis in vivo. Reut Yosef, Noam Pilpel, Nurit Papismadov, Hilah Gal, Yossi Ovadya, Ezra Vadai, Stav Miller, Ziv Porat, Shifra Ben‐Dor, and Valery Krizhanovsky Published online 12.06.2017 The endoplasmic reticulum HSP40 co‐chaperone ERdj3/DNAJB11 assembles and functions as a tetramer CryoEM reveals that co‐chaperone ERdj3 displays an unusual tetramer organization, which is required for efficient substrate binding and for maintaining secretory proteostasis during ER stress. Kai‐Chun Chen, Song Qu, Saikat Chowdhury, Isabelle C Noxon, Joseph D Schonhoft, Lars Plate, Evan T Powers, Jeffery W Kelly, Gabriel C Lander, and R Luke Wiseman Published online 27.06.2017   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 973 University Avenue * Los Gatos, CA 95032 * U.S.A. Copyright © 2017 by the European Molecular Biology Organisation.