TABLE OF CONTENTS
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August 2017 Volume 24, Issue 8 |
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HIV IMMUNITY AND ERADICATION, A HERRENHAUSEN SYMPOSIUM November 2-3, 2017 | Hanover, Germany REGISTER NOW! | | |
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News and Views | Top |
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Articles | Top |
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PAR-TERRA directs homologous sex chromosome pairing pp620 - 631 Hsueh-Ping Chu, John E Froberg, Barry Kesner, Hyun Jung Oh, Fei Ji et al. doi:10.1038/nsmb.3432 New analyses reveal that TERRA transcripts arising from the subtelomeric pseudoautosomal (PAR) region of sex chromosomes nucleate pairing of X alleles in mouse ES cells.
See also: News and Views by Krivega & Dean |
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Asparagine endopeptidase cleaves α-synuclein and mediates pathologic activities in Parkinson's disease pp632 - 642 Zhentao Zhang, Seong Su Kang, Xia Liu, Eun Hee Ahn, Zhaohui Zhang et al. doi:10.1038/nsmb.3433 Asparagine endopeptidase (AEP) cleaves human α-synuclein at Asn103, yielding a fragment with higher aggregation propensity than that of the full-length protein. Truncated α-synuclein is also more neurotoxic and leads to dopaminergic neuronal loss and motor impairments in mice. |
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Regulator-dependent mechanisms of C3b processing by factor I allow differentiation of immune responses pp643 - 651 Xiaoguang Xue, Jin Wu, Daniel Ricklin, Federico Forneris, Patrizia Di Crescenzio et al. doi:10.1038/nsmb.3427 The structure of C3b in complex with factor I and a shortened version of factor H, along with functional analyses, leads to a mechanistic model for how regulators determine sequential cleavage events on C3b. |
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Mechanochemical evolution of the giant muscle protein titin as inferred from resurrected proteins pp652 - 657 Aitor Manteca, Jorg Schonfelder, Alvaro Alonso-Caballero, Marie J Fertin, Nerea Barruetabeña et al. doi:10.1038/nsmb.3426 Single-molecule spectroscopy analyses of titin fragments from modern animals and reconstructed from the last common ancestors to mammals, sauropsids and tetrapods shed light on the evolution of the mechanical properties of muscle titin from the Paleozoic to our days. |
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Multi-domain utilization by TUT4 and TUT7 in control of let-7 biogenesis pp658 - 665 Christopher R Faehnle, Jack Walleshauser and Leemor Joshua-Tor doi:10.1038/nsmb.3428 Structural analysis of the uridyl transferases TUT4 and TUT7 reveals the use of two functional modules in the switch from monouridylation of pre-let-7, which promotes let-7 expression, to oligouridylation of pre-let-7, which marks it for degradation. |
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A two-helix motif positions the lysophosphatidic acid acyltransferase active site for catalysis within the membrane bilayer pp666 - 671 Rosanna M Robertson, Jiangwei Yao, Stefan Gajewski, Gyanendra Kumar, Erik W Martin et al. doi:10.1038/nsmb.3436 The crystal structure of Thermotoga maritima lysophosphatidic acid acyltransferase reveals a two-helix motif that positions the active site for catalysis within the membrane bilayer. |
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Musashi 1 regulates the timing and extent of meiotic mRNA translational activation by promoting the use of specific CPEs pp672 - 681 Laure Weill, Eulàlia Belloc, Chiara Lara Castellazzi and Raúl Méndez doi:10.1038/nsmb.3434 New data reveal how Musashi binding to Xenopus oocyte mRNAs promotes changes in RNA secondary structure that modulate CPEB1 binding and influence polyadenylation and translational efficiency.
See also: News and Views by Lasko |
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