Nature Reviews Neuroscience contents September 2017 Volume 18 Number 9 pp 511-567

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TABLE OF CONTENTS
September 2017 Volume 18 Number 9
2016 2-year Impact Factor 28.880 Journal Metrics 2-year Median 23	In this issue Research Highlights Reviews Perspectives Also this month  Featured article: Prefrontal–hippocampal interactions in episodic memory Howard Eichenbaum
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RESEARCH HIGHLIGHTS Top Ageing: Setting the speed p511 | doi:10.1038/nrn.2017.109 Hypothalamic neural stem cells may be important regulators of the speed at which ageing proceeds in mice. PDF Motor systems: Mice get manual p512 | doi:10.1038/nrn.2017.108 Species-dependent regulation of plexin A1 signalling may underlie the elimination and retention of cortico–motor neuronal contacts in developing mice and in developing primates, respectively. PDF Sleep and memory: Spindles take charge p512 | doi:10.1038/nrn.2017.98 This study provides evidence for a role for the thalamus in the synchronization of brain rhythms that drive memory consolidation during sleep. PDF Behavioural neuroscience: King of the castle p513 | doi:10.1038/nrn.2017.102 The likelihood of winning a bout of competitive behaviour is increased by past wins, and the neural circuitry underlying this crucial determinant of social rank in a group of mice is identified as a projection from the mediodorsal thalamus to the dorsomedial prefrontal cortex. PDF Psychiatric disorders: Splitting depression apart p514 | doi:10.1038/nrn.2017.99 Two major components of depression-like behaviour in mice — social avoidance and helplessness — are mediated by distinct circuits that include parvalbumin-expressing neurons in the ventral pallidum. PDF IN BRIEF Gut-brain communication: Permitting pain | Neuronal networks: Individual arrangements | Neurodegenerative disease: A programmed killer | Psychiatric disorders: Acute actions PDF Nature Reviews Neuroscience JOBS of the week Postdoctoral fellow position in Neuroscience Klinikum der Universität München - Ludwig-Maximilians-University Postdoctoral fellow / associate positions in neuroscience State University of New York Chair, Department of Neuroscience UConn Health Assistant / Associate Professor University of Utah Postdoctoral Fellow / Anatomy & Neurobiology The University of Tennessee Health Science Center More Science jobs from Nature Reviews Neuroscience EVENT 3rd Annual Neuroscience R&D Technologies Conference 28.09.17 London, UK More science events from
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REVIEWS		Top
Animal models of α-synucleinopathy for Parkinson disease drug development James B. Koprich, Lorraine V. Kalia & Jonathan M. Brotchie p515 | doi:10.1038/nrn.2017.75 The aggregation of α-synuclein in neurons is characteristic of Parkinson disease. Koprich, Kalia and Brotchie provide a critical overview of preclinical, mammalian models of α-synucleinopathy and their merits and limitations in drug development for Parkinson disease, and suggest a combination of different models for optimal proof-of-principle investigation of novel therapeutics. Abstract | Full Text | PDF
Neuronal cell-type classification: challenges, opportunities and the path forward Hongkui Zeng & Joshua R. Sanes p530 | doi:10.1038/nrn.2017.85 Attempts to group the cells of the nervous system into classes or types face technical and conceptual barriers. Zeng and Sanes consider the current approaches to classification and propose a strategy and set of principles to guide future classification efforts. Abstract | Full Text | PDF
Prefrontal–hippocampal interactions in episodic memory Howard Eichenbaum p547 | doi:10.1038/nrn.2017.74 The prefrontal cortex and the hippocampus have distinct and complementary roles in episodic memory, and their interactions are also crucial for memory. Eichenbaum describes the pathways and mechanisms mediating these interactions and suggests a model of how these regions communicate to retrieve cued memories. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION A new look at domain specificity: insights from social neuroscience Robert P. Spunt & Ralph Adolphs p559 | doi:10.1038/nrn.2017.76 The idea that specialized cognitive processes or brain regions are devoted to particular cognitive functions — known as domain specificity — remains an area of substantial debate. Adolphs and Spunt outline the challenges in defining and assessing domain specificity and use social neuroscience findings to suggest a new approach. Abstract | Full Text | PDF
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