| | | | | | | Latest Articles | View all Articles | | | Annotating pathogenic non-coding variants in genic regions OPEN | | Sahar Gelfman, Quanli Wang, K. Melodi McSweeney, Zhong Ren, Francesca La Carpia, Matt Halvorsen, Kelly Schoch, Fanni Ratzon, Erin L. Heinzen, Michael J. Boland, Slavé Petrovski & David B. Goldstein | | | While non-coding synonymous and intronic variants are often not under strong selective constraint, they can be pathogenic through affecting splicing or transcription. Here, the authors develop a score that uses sequence context alterations to predict pathogenicity of synonymous and non-coding genetic variants, and provide a web server of pre-computed scores. | | 09 August 2017 | doi: 10.1038/s41467-017-00141-2 | | Genome informatics Personalized medicine Sequence annotation | Activated NK cells cause placental dysfunction and miscarriages in fetal alloimmune thrombocytopenia OPEN | | Issaka Yougbaré, Wei-She Tai, Darko Zdravic, Brigitta Elaine Oswald, Sean Lang, Guangheng Zhu, Howard Leong-Poi, Dawei Qu, Lisa Yu, Caroline Dunk, Jianhong Zhang, John G. Sled, Stephen J. Lye, Jelena Brkić, Chun Peng, Petter Höglund, B. Anne Croy, S. Lee Adamson, Xiao-Yan Wen, Duncan J. Stewart et al. | | | Fetal/neonatal alloimmune thrombocytopenia (FNAIT) is a gestational disease caused by maternal immune responses against fetal platelets. Using a FNAIT mouse model and human trophoblast cell lines, here the authors show that uterine natural killer cell-mediated trophoblast apoptosis contributes to FNAIT pathogenesis. | | 09 August 2017 | doi: 10.1038/s41467-017-00269-1 | | Cell death and immune response Embryology Innate immunity NK cells | The non-coding RNA landscape of human hematopoiesis and leukemia OPEN | | Adrian Schwarzer, Stephan Emmrich, Franziska Schmidt, Dominik Beck, Michelle Ng, Christina Reimer, Felix Ferdinand Adams, Sarah Grasedieck, Damian Witte, Sebastian Käbler, Jason W. H. Wong, Anushi Shah, Yizhou Huang, Razan Jammal, Aliaksandra Maroz, Mojca Jongen-Lavrencic, Axel Schambach, Florian Kuchenbauer, John E. Pimanda, Dirk Reinhardt et al. | | | While micro-RNAs are known regulators of haematopoiesis and leukemogenesis, the role of long non-coding RNAs is less clear. Here the authors provide a non-coding RNA expression landscape of the human hematopoietic system, highlighting their role in the formation and maintenance of the human blood hierarchy. | | 09 August 2017 | doi: 10.1038/s41467-017-00212-4 | | Acute myeloid leukaemia Long non-coding RNAs | A Plasmodium yoelii HECT-like E3 ubiquitin ligase regulates parasite growth and virulence OPEN | | Sethu C. Nair, Ruixue Xu, Sittiporn Pattaradilokrat, Jian Wu, Yanwei Qi, Martine Zilversmit, Sundar Ganesan, Vijayaraj Nagarajan, Richard T. Eastman, Marlene S. Orandle, John C. Tan, Timothy G. Myers, Shengfa Liu, Carole A. Long, Jian Li & Xin-zhuan Su | | | Many strains of Plasmodium differ in virulence, but factors that control these distinctions are not known. Here the authors comparatively map virulence loci using the offspring from a P. yoelii YM and N67 genetic cross, and identify a putative HECT E3 ubiquitin ligase that may explain the variance. | | 09 August 2017 | doi: 10.1038/s41467-017-00267-3 | | Malaria Parasite genetics | Origin of charge transfer and enhanced electron–phonon coupling in single unit-cell FeSe films on SrTiO3 OPEN | | Huimin Zhang, Ding Zhang, Xiaowei Lu, Chong Liu, Guanyu Zhou, Xucun Ma, Lili Wang, Peng Jiang, Qi-Kun Xue & Xinhe Bao | | | The origin of interface charge transfer and electron-phonon coupling in single unit-cell FeSe on SrTiO3 remains elusive. Here, Zhang et al. report strengthened Ti-O bond and band bending at the FeSe/SrTiO3 interface, which leads to several important processes. | | 09 August 2017 | doi: 10.1038/s41467-017-00281-5 | | Electronic properties and materials Superconducting properties and materials Surfaces, interfaces and thin films | Plasmonic silver nanoshells for drug and metabolite detection OPEN | | Lin Huang, Jingjing Wan, Xiang Wei, Yu Liu, Jingyi Huang, Xuming Sun, Ru Zhang, Deepanjali D. Gurav, Vadanasundari Vedarethinam, Yan Li, Ruoping Chen & Kun Qian | | | Preparation of samples for diagnosis can affect the detection of biomarkers and metabolites. Here, the authors use a silver nanoparticle plasmonics approach for the detection of biomarkers in patients as well as investigate the distribution of drugs in serum and cerebral spinal fluid. | | 09 August 2017 | doi: 10.1038/s41467-017-00220-4 | | Diagnostic markers Mass spectrometry Metabolomics Nanoparticles | Agonist-induced dimer dissociation as a macromolecular step in G protein-coupled receptor signaling OPEN | | Julian Petersen, Shane C. Wright, David Rodríguez, Pierre Matricon, Noa Lahav, Aviv Vromen, Assaf Friedler, Johan Strömqvist, Stefan Wennmalm, Jens Carlsson & Gunnar Schulte | | | Frizzled 6 (FZD6) is a G protein-coupled receptor (GPCR) involved in several cellular processes. Here, the authors use live cell imaging and spectroscopy to show that FZD6 forms dimers, whose association is regulated by WNT proteins and that dimer dissociation is crucial for FZD6 signaling. | | 09 August 2017 | doi: 10.1038/s41467-017-00253-9 | | Cellular imaging G protein-coupled receptors Hormone receptors Membrane structure and assembly | Discovery and ramifications of incidental Magnéli phase generation and release from industrial coal-burning OPEN | | Yi Yang, Bo Chen, James Hower, Michael Schindler, Christopher Winkler, Jessica Brandt, Richard Giulio, Jianping Ge, Min Liu, Yuhao Fu, Lijun Zhang, Yuru Chen, Shashank Priya & Michael F. Hochella | | | Solid-state emissions from coal burning remain an environmental concern. Here, the authors have found that TiO2 minerals present in coal are converted into titanium suboxides during burning, and initial biotoxicity screening suggests that further testing is needed to look into human lung consequences. | | 08 August 2017 | doi: 10.1038/s41467-017-00276-2 | | Atmospheric chemistry Carbon cycle Environmental impact Geochemistry | Fragmentation in spin ice from magnetic charge injection OPEN | | E. Lefrançois, V. Cathelin, E. Lhotel, J. Robert, P. Lejay, C. V. Colin, B. Canals, F. Damay, J. Ollivier, B. Fåk, L. C. Chapon, R. Ballou & V. Simonet | | | Exploring unconventional magnetism facilities both fundamental understanding of materials and their real applications. Here the authors demonstrate that a magnetic monopole crystal is stabilized by a staggered magnetic field in the pyrochlore iridate Ho2Ir2O7, leading to a fragmented magnetization. | | 08 August 2017 | doi: 10.1038/s41467-017-00277-1 | | Magnetic properties and materials | Therapeutic radiation for childhood cancer drives structural aberrations of NF2 in meningiomas OPEN | | Sameer Agnihotri, Suganth Suppiah, Peter D. Tonge, Shahrzad Jalali, Arnavaz Danesh, Jeffery P. Bruce, Yasin Mamatjan, George Klironomos, Lior Gonen, Karolyn Au, Sheila Mansouri, Sharin Karimi, Felix Sahm, Andreas Deimling, Michael D. Taylor, Normand J. Laperriere, Trevor J. Pugh, Kenneth D. Aldape & Gelareh Zadeh | | | Radiation-induced meningiomas are often more aggressive than sporadic ones. In this study, the authors perform an exome, methylation and RNA-seq analysis of 31 cases of radiation-induced meningioma and show NF2 rearrangement, an observation previously unreported in the sporadic tumors. | | 04 August 2017 | doi: 10.1038/s41467-017-00174-7 | | Cancer Genetics | Long-range transport of airborne microbes over the global tropical and subtropical ocean OPEN | | Eva Mayol, Jesús M. Arrieta, Maria A. Jiménez, Adrián Martínez-Asensio, Neus Garcias-Bonet, Jordi Dachs, Belén González-Gaya, Sarah-J. Royer, Verónica M. Benítez-Barrios, Eugenio Fraile-Nuez & Carlos M. Duarte | | | The extent to which the ocean acts as a sink and source of airborne particles to the atmosphere is unresolved. Here, the authors report high microbial loads over the tropical Atlantic, Pacific and Indian oceans and propose islands as stepping stones for the transoceanic transport of terrestrial microbes.. | | 04 August 2017 | doi: 10.1038/s41467-017-00110-9 | | Air microbiology Biodiversity Marine biology Marine microbiology Microbial ecology | HIPP neurons in the dentate gyrus mediate the cholinergic modulation of background context memory salience OPEN | | Syed Ahsan Raza, Anne Albrecht, Gürsel Çalışkan, Bettina Müller, Yunus Emre Demiray, Susann Ludewig, Susanne Meis, Nicolai Faber, Roland Hartig, Burkhart Schraven, Volkmar Lessmann, Herbert Schwegler & Oliver Stork | | | Intra-hippocampal circuits are essential for associating a background context with behaviorally salient stimuli and involve cholinergic modulation at SST+ interneurons. Here the authors show that the salience of the background context memory is modulated through muscarinic activation of NPY+ hilar perforant path associated interneurons and NPY signaling in the dentate gyrus. | | 04 August 2017 | doi: 10.1038/s41467-017-00205-3 | | Fear conditioning Hippocampus Neural circuits Post-traumatic stress disorder | Molecular characterization of breast cancer CTCs associated with brain metastasis OPEN | | Debasish Boral, Monika Vishnoi, Haowen N. Liu, Wei Yin, Marc L. Sprouse, Antonio Scamardo, David S. Hong, Tuan Z. Tan, Jean P. Thiery, Jenny C. Chang & Dario Marchetti | | | Characterization of CTCs derived from breast cancer patients with brain metastasis (BCBM) may allow for early diagnosis of brain metastasis and/or help for treatment choice and its efficacy. In this study, the authors identify a unique signature, based on patient-derived CTCs transcriptomes, for BCBM- CTCs that is different from primary tumors. | | 04 August 2017 | doi: 10.1038/s41467-017-00196-1 | | Breast cancer Metastasis | Modulation of the tick gut milieu by a secreted tick protein favors Borrelia burgdorferi colonization OPEN | | Sukanya Narasimhan, Tim J. Schuijt, Nabil M. Abraham, Nallakkandi Rajeevan, Jeroen Coumou, Morven Graham, Andrew Robson, Ming-Jie Wu, Sirlei Daffre, Joppe W. Hovius & Erol Fikrig | | | Borrelia burgdorferi, the causative agent of Lyme disease, is transmitted by the tick Ixodes scapularis. Here, the authors show that a tick secreted protein (PIXR) modulates the tick gut microbiota and facilitates B. burgdorferi colonization. | | 04 August 2017 | doi: 10.1038/s41467-017-00208-0 | | Antimicrobial responses Microbiome Pathogens Zoology | 53-attosecond X-ray pulses reach the carbon K-edge OPEN | | Jie Li, Xiaoming Ren, Yanchun Yin, Kun Zhao, Andrew Chew, Yan Cheng, Eric Cunningham, Yang Wang, Shuyuan Hu, Yi Wu, Michael Chini & Zenghu Chang | | | Isolated attosecond pulses are produced using high harmonic generation and sources of these pulses often suffer from low photon flux in soft X-ray regime. Here the authors demonstrate efficient generation and characterization of 53 as pulses with photon energy near the water window. | | 04 August 2017 | doi: 10.1038/s41467-017-00321-0 | | High-harmonic generation X-rays | CLICs-dependent chloride efflux is an essential and proximal upstream event for NLRP3 inflammasome activation OPEN | | Tiantian Tang, Xueting Lang, Congfei Xu, Xiaqiong Wang, Tao Gong, Yanqing Yang, Jun Cui, Li Bai, Jun Wang, Wei Jiang & Rongbin Zhou | | | The NLRP3 inflammasome is key to the regulation of innate immunity against pathogens or stress, but the underlying signaling regulation is still unclear. Here the authors show that chloride intracellular channels (CLIC) interface between mitochondria stress and inflammasome activation to modulate inflammatory responses. | | 04 August 2017 | doi: 10.1038/s41467-017-00227-x | | Inflammasome Monocytes and macrophages NOD-like receptors Signal transduction | Retrograde BDNF to TrkB signaling promotes synapse elimination in the developing cerebellum OPEN | | Myeongjeong Choo, Taisuke Miyazaki, Maya Yamazaki, Meiko Kawamura, Takanobu Nakazawa, Jianling Zhang, Asami Tanimura, Naofumi Uesaka, Masahiko Watanabe, Kenji Sakimura & Masanobu Kano | | | During development, synapses are selectively strengthened or eliminated by activity-dependent competition. Here, the authors show that BDNF-TrkB retrograde signaling is a “punishment” signal that leads to elimination of climbing fiber-onto-Purkinje cell synapses in the developing cerebellum. | | 04 August 2017 | doi: 10.1038/s41467-017-00260-w | | Neural circuits Neurotrophic factors Synaptic development | Broadband achromatic optical metasurface devices OPEN | | Shuming Wang, Pin Chieh Wu, Vin-Cent Su, Yi-Chieh Lai, Cheng Hung Chu, Jia-Wern Chen, Shen-Hung Lu, Ji Chen, Beibei Xu, Chieh-Hsiung Kuan, Tao Li, Shining Zhu & Din Ping Tsai | | | Metasurfaces suffer from large chromatic aberration due to the high phase dispersion of their building blocks, limiting their applications. Here, Wang et al. design achromatic metasurface devices which eliminate the chromatic aberration over a continuous region from 1200 to 1680 nm in a reflection schleme. | | 04 August 2017 | doi: 10.1038/s41467-017-00166-7 | | Metamaterials Nanophotonics and plasmonics Sub-wavelength optics | Rationalizing the light-induced phase separation of mixed halide organic–inorganic perovskites OPEN | | Sergiu Draguta, Onise Sharia, Seog Joon Yoon, Michael C. Brennan, Yurii V. Morozov, Joseph M. Manser, Prashant V. Kamat, William F. Schneider & Masaru Kuno | | | Mixed halide hybrid perovskites possess tunable band gaps, however, under illumination they undergo phase separation. Using spectroscopic measurements and theoretical modelling, Draguta and Sharia et al. quantitatively rationalize the microscopic processes that occur during phase separation. | | 04 August 2017 | doi: 10.1038/s41467-017-00284-2 | | Energy Solar cells | Pan-urologic cancer genomic subtypes that transcend tissue of origin OPEN | | Fengju Chen, Yiqun Zhang, Dominick Bossé, Aly-Khan A. Lalani, A. Ari Hakimi, James J. Hsieh, Toni K. Choueiri, Don L. Gibbons, Michael Ittmann & Chad J. Creighton | | | Urological cancers have disparate tissues and cells of origin but share many molecular features. Here, the authors use multidimensional and comprehensive molecular characterization to classify urological cancers into nine major genomic subtypes, highlighting potential therapeutic targets. | | 04 August 2017 | doi: 10.1038/s41467-017-00289-x | | Cancer genomics Urological cancer | Unraveling a tumor type-specific regulatory core underlying E2F1-mediated epithelial-mesenchymal transition to predict receptor protein signatures OPEN | | Faiz M. Khan, Stephan Marquardt, Shailendra K. Gupta, Susanne Knoll, Ulf Schmitz, Alf Spitschak, David Engelmann, Julio Vera, Olaf Wolkenhauer & Brigitte M. Pützer | | | Deregulation of E2F family transcription factors is associated with cancer progression and metastasis. Here, the authors construct a map of the regulatory network around the E2F family, and using gene expression profiles, identify tumour type-specific regulatory cores and receptor expression signatures associated with epithelial-mesenchymal transition in bladder and breast cancer. | | 04 August 2017 | doi: 10.1038/s41467-017-00268-2 | | Cellular signalling networks Computational models Tumour biomarkers | Electromagnetic reprogrammable coding-metasurface holograms OPEN | | Lianlin Li, Tie Jun Cui, Wei Ji, Shuo Liu, Jun Ding, Xiang Wan, Yun Bo Li, Menghua Jiang, Cheng-Wei Qiu & Shuang Zhang | | | Realizing metasurfaces with reconfigurability, high efficiency, and control over phase and amplitude is a challenge. Here, Li et al. introduce a reprogrammable hologram based on a 1-bit coding metasurface, where the state of each unit cell of the coding metasurface can be switched electrically. | | 04 August 2017 | doi: 10.1038/s41467-017-00164-9 | | Electrical and electronic engineering Metamaterials Microwave photonics | Solution nuclear magnetic resonance spectroscopy on a nanostructured diamond chip OPEN | | P. Kehayias, A. Jarmola, N. Mosavian, I. Fescenko, F. M. Benito, A. Laraoui, J. Smits, L. Bougas, D. Budker, A. Neumann, S. R. J. Brueck & V. M. Acosta | | | Nitrogen vacancy (NV) centres in diamond can be used for NMR spectroscopy, but increased sensitivity is needed to avoid long measurement times. Kehayias et al. present a nanostructured diamond grating with a high density of NV centres, enabling NMR spectroscopy of picoliter-volume solutions. | | 04 August 2017 | doi: 10.1038/s41467-017-00266-4 | | Optical properties of diamond Solution-state NMR | | | | | | | | Latest CORRIGENDA | | | | Corrigendum: Allelic variation contributes to bacterial host specificity OPEN | | Min Yue, Xiangan Han, Leon De Masi, Chunhong Zhu, Xun Ma, Junjie Zhang, Renwei Wu, Robert Schmieder, Radhey S. Kaushik, George P. Fraser, Shaohua Zhao, Patrick F. McDermott, François-Xavier Weill, Jacques G. Mainil, Cesar Arze, W. Florian Fricke, Robert A. Edwards, Dustin Brisson, Nancy R. Zhang, Shelley C. Rankin et al. | | 08 August 2017 | doi: 10.1038/ncomms15229 | | Bacterial genetics Bacterial physiology Genetic variation | Corrigendum: Phosphate steering by Flap Endonuclease 1 promotes 5′-flap specificity and incision to prevent genome instability OPEN | | Susan E. Tsutakawa, Mark J. Thompson, Andrew S. Arvai, Alexander J. Neil, Steven J. Shaw, Sana I. Algasaier, Jane C. Kim, L. David Finger, Emma Jardine, Victoria J. B. Gotham, Altaf H. Sarker, Mai Z. Her, Fahad Rashid, Samir M. Hamdan, Sergei M. Mirkin, Jane A. Grasby & John A. Tainer | | 07 August 2017 | doi: 10.1038/ncomms16145 | | DNA Enzyme mechanisms Genomic instability X-ray crystallography | Corrigendum: A simple and versatile design concept for fluorophore derivatives with intramolecular photostabilization OPEN | | Jasper H. M. van der Velde, Jens Oelerich, Jingyi Huang, Jochem H. Smit, Atieh Aminian Jazi, Silvia Galiani, Kirill Kolmakov, Giorgos Gouridis, Christian Eggeling, Andreas Herrmann, Gerard Roelfes & Thorben Cordes | | 04 August 2017 | doi: 10.1038/ncomms16144 | | Biophysical chemistry Organic chemistry | | | | | Latest ERRATA | | | | Erratum: YAP determines the cell fate of injured mouse hepatocytes in vivo OPEN | | Norio Miyamura, Shoji Hata, Tohru Itoh, Minoru Tanaka, Miki Nishio, Michiko Itoh, Yoshihiro Ogawa, Shuji Terai, Isao Sakaida, Akira Suzuki, Atsushi Miyajima & Hiroshi Nishina | | 07 August 2017 | doi: 10.1038/ncomms16146 | | Stress signalling | | | | | Advertisement | | Nature Briefing Stay informed with the best science news from Nature and beyond. Curated by our global news team and delivered direct to your inbox every weekday, free of charge. Click to learn more | | | | | | Advertisement | | | | | | | | | | | Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. 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