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All new submissions, if accepted, will be published open access and an article processing charge (APC) will apply. For more information visit the website. Visit our open access funding page or contact openaccess@nature.com to learn more about APC funding. | | | | Latest Articles | View all Articles | | | Charge carrier localised in zero-dimensional (CH3NH3)3Bi2I9 clusters OPEN | | Chengsheng Ni, Gordon Hedley, Julia Payne, Vladimir Svrcek, Calum McDonald, Lethy Krishnan Jagadamma, Paul Edwards, Robert Martin, Gunisha Jain, Darragh Carolan, Davide Mariotti, Paul Maguire, Ifor Samuel & John Irvine | | | Understanding the confinement and transport of excitons in low dimensional systems will aid the development of next generation photovoltaics. Via photophysical studies Ni et al. observe 'quantum cutting' in 0D metal-organic hybrid materials based on methylammonium bismuth halide (CH3NH3)3Bi2I9. | | 01 August 2017 | doi: 10.1038/s41467-017-00261-9 | | Nanophotonics and plasmonics Optical materials and structures | Structures and transport dynamics of a Campylobacter jejuni multidrug efflux pump OPEN | | Chih-Chia Su, Linxiang Yin, Nitin Kumar, Lei Dai, Abhijith Radhakrishnan, Jani Reddy Bolla, Hsiang-Ting Lei, Tsung-Han Chou, Jared A. Delmar, Kanagalaghatta R. Rajashankar, Qijing Zhang, Yeon-Kyun Shin & Edward W. Yu | | | Multidrug efflux pumps significantly contribute for bacteria resistance to antibiotics. Here the authors present the structure of Campylobacter jejuni CmeB pump combined with functional FRET assays to propose a transport mechanism where each CmeB protomers is functionally independent from the trimer. | | 01 August 2017 | doi: 10.1038/s41467-017-00217-z | | Single-molecule biophysics Transporters X-ray crystallography | Therapeutic efficacy of a respiratory syncytial virus fusion inhibitor OPEN | | Dirk Roymans, Sarhad S Alnajjar, Michael B Battles, Panchan Sitthicharoenchai, Polina Furmanova-Hollenstein, Peter Rigaux, Joke Van den Berg, Leen Kwanten, Marcia Van Ginderen, Nick Verheyen, Luc Vranckx, Steffen Jaensch, Eric Arnoult, Richard Voorzaat, Jack M. Gallup, Alejandro Larios-Mora, Marjolein Crabbe, Dymphy Huntjens, Pierre Raboisson, Johannes P. Langedijk et al. | | | Respiratory syncytial virus causes lung infections in children, immunocompromised adults, and in the elderly. Here the authors show that a chemical inhibitor to a viral fusion protein is effective in reducing viral titre and ameliorating infection in rodents and neonatal lambs. | | 01 August 2017 | doi: 10.1038/s41467-017-00170-x | | Antivirals Pharmacokinetics Respiratory tract diseases | The ancestral flower of angiosperms and its early diversification OPEN | | Hervé Sauquet, Maria von Balthazar, Susana Magallón, James A. Doyle, Peter K. Endress, Emily J. Bailes, Erica Barroso de Morais, Kester Bull-Hereñu, Laetitia Carrive, Marion Chartier, Guillaume Chomicki, Mario Coiro, Raphaël Cornette, Juliana H. L. El Ottra, Cyril Epicoco, Charles S. P. Foster, Florian Jabbour, Agathe Haevermans, Thomas Haevermans, Rebeca Hernández et al. | | | The fossil record of flowers is limited, necessitating other approaches to understanding floral evolution. Here, Sauquet and colleagues reconstruct the characteristics and diversification of ancient angiosperm flowers by combining models of flower evolution with an extensive database of extant floral traits. | | 01 August 2017 | doi: 10.1038/ncomms16047 | | Phylogenetics Plant evolution | Oropharyngeal mucosal transmission of Zika virus in rhesus macaques OPEN | | Christina M. Newman, Dawn M. Dudley, Matthew T. Aliota, Andrea M. Weiler, Gabrielle L. Barry, Mariel S. Mohns, Meghan E. Breitbach, Laurel M. Stewart, Connor R. Buechler, Michael E. Graham, Jennifer Post, Nancy Schultz-Darken, Eric Peterson, Wendy Newton, Emma L. Mohr, Saverio Capuano, David H. O’Connor & Thomas C. Friedrich | | | Zika virus (ZIKV) is present in body fluids, including saliva, but transmission risk through mucosal contact is not well known. Here, the authors show that oropharyngeal mucosal infection of macaques with a high ZIKV dose results in viremia, but that transmission risk from saliva of infected animals is low. | | 01 August 2017 | doi: 10.1038/s41467-017-00246-8 | | Viral infection Viral transmission | RORα controls hepatic lipid homeostasis via negative regulation of PPARγ transcriptional network OPEN | | Kyeongkyu Kim, Kyungjin Boo, Young Suk Yu, Se Kyu Oh, Hyunkyung Kim, Yoon Jeon, Jinhyuk Bhin, Daehee Hwang, Keun Il Kim, Jun-Su Lee, Seung-Soon Im, Seul Gi Yoon, Il Yong Kim, Je Kyung Seong, Ho Lee, Sungsoon Fang & Sung Hee Baek | | | Hepatic steatosis development may result from dysregulation of lipid metabolism, which is finely tuned by several transcription factors including the PPAR family. Here Kim et al. show that the nuclear receptor RORα inhibits PPARγ-mediated transcriptional activity by interacting with HDAC3 and competing for the promoters of lipogenic genes. | | 31 July 2017 | doi: 10.1038/s41467-017-00215-1 | | Metabolic syndrome Non-alcoholic fatty liver disease Nuclear receptors | Major agricultural changes required to mitigate phosphorus losses under climate change OPEN | | M. C. Ockenden, M. J. Hollaway, K. J. Beven, A. L. Collins, R. Evans, P. D. Falloon, K. J. Forber, K. M. Hiscock, R. Kahana, C. J. A. Macleod, W. Tych, M. L. Villamizar, C. Wearing, P. J. A. Withers, J. G. Zhou, P. A. Barker, S. Burke, J. E. Freer, P. J. Johnes, M. A. Snell et al. | | | The impact of climate change on phosphorus (P) loss from land to water is unclear. Here, the authors use P flux data, climate simulations and P transfer models to show that only large scale agricultural change will limit the effect of climate change on average winter P loads in three catchments across the UK. | | 31 July 2017 | doi: 10.1038/s41467-017-00232-0 | | Climate-change adaptation Element cycles Environmental health Hydrology | Ubiquitination of stalled ribosome triggers ribosome-associated quality control OPEN | | Yoshitaka Matsuo, Ken Ikeuchi, Yasushi Saeki, Shintaro Iwasaki, Christian Schmidt, Tsuyoshi Udagawa, Fumiya Sato, Hikaru Tsuchiya, Thomas Becker, Keiji Tanaka, Nicholas T. Ingolia, Roland Beckmann & Toshifumi Inada | | | Several protein quality control mechanisms are in place to trigger the rapid degradation of aberrant polypeptides and mRNAs. Here the authors describe a mechanism of ribosome-mediated quality control that involves the ubiquitination of ribosomal proteins by the E3 ubiquitin ligase Hel2/RQT1. | | 31 July 2017 | doi: 10.1038/s41467-017-00188-1 | | Protein quality control Ribosome Ubiquitylation | Two mouse models reveal an actionable PARP1 dependence in aggressive chronic lymphocytic leukemia OPEN | | Gero Knittel, Tim Rehkämper, Darya Korovkina, Paul Liedgens, Christian Fritz, Alessandro Torgovnick, Yussor Al-Baldawi, Mona Al-Maarri, Yupeng Cun, Oleg Fedorchenko, Arina Riabinska, Filippo Beleggia, Phuong-Hien Nguyen, F. Thomas Wunderlich, Monika Ortmann, Manuel Montesinos-Rongen, Eugen Tausch, Stephan Stilgenbauer, Lukas P. Frenzel, Marco Herling et al. | | | ATM and TP53 mutations are associated with poor prognosis in chronic lymphocytic leukaemia (CLL). Here the authors generate mouse models of Tp53- and Atm-defective CLL mimicking the high-risk form of human disease and show that Atm-deficient CLL is sensitive to PARP1 inhibition. | | 28 July 2017 | doi: 10.1038/s41467-017-00210-6 | | Chronic lymphocytic leukaemia Genetic engineering Targeted therapies | Afferent specific role of NMDA receptors for the circuit integration of hippocampal neurogliaform cells OPEN | | R. Chittajallu, J. C. Wester, M. T. Craig, E. Barksdale, X. Q. Yuan, G. Akgül, C. Fang, D. Collins, S. Hunt, K. A. Pelkey & C. J. McBain | | | Proper brain function depends on the correct assembly of excitatory and inhibitory neurons into neural circuits. Here the authors show that during early postnatal development in mice, NMDAR signaling via activity of long-range synaptic inputs onto neurogliaform cells is required for their appropriate integration into the hippocampal circuitry. | | 28 July 2017 | doi: 10.1038/s41467-017-00218-y | | Neural circuits Neuronal physiology Synaptic plasticity | Carbon stocks and changes of dead organic matter in China's forests OPEN | | Jianxiao Zhu, Huifeng Hu, Shengli Tao, Xiulian Chi, Peng Li, Lai Jiang, Chengjun Ji, Jiangling Zhu, Zhiyao Tang, Yude Pan, Richard A. Birdsey, Xinhua He & Jingyun Fang | | | Reliable estimates of the total forest carbon (C) pool are lacking due to insufficient information on dead organic matter (DOM). Here, the authors estimate that the current DOM C stock in China is 925 ± 54 Tg and that it grew by 6.7 ± 2.2 Tg C/yr over the past two decades primarily due to increasing forest area | | 28 July 2017 | doi: 10.1038/s41467-017-00207-1 | | Carbon cycle Climate-change ecology Forest ecology | Slow conformational exchange and overall rocking motion in ubiquitin protein crystals OPEN | | Vilius Kurauskas, Sergei A. Izmailov, Olga N. Rogacheva, Audrey Hessel, Isabel Ayala, Joyce Woodhouse, Anastasya Shilova, Yi Xue, Tairan Yuwen, Nicolas Coquelle, Jacques-Philippe Colletier, Nikolai R. Skrynnikov & Paul Schanda | | | X-ray crystallography is the main method for protein structure determination. Here the authors combine solid-state NMR measurements and molecular dynamics simulations and show that crystal packing alters the thermodynamics and kinetics of local conformational exchange as well as overall rocking motion of protein molecules in the crystal lattice. | | 27 July 2017 | doi: 10.1038/s41467-017-00165-8 | | Computational biophysics Molecular modelling Solid-state NMR X-ray crystallography | Regulation of Drosophila hematopoietic sites by Activin-β from active sensory neurons OPEN | | Kalpana Makhijani, Brandy Alexander, Deepti Rao, Sophia Petraki, Leire Herboso, Katelyn Kukar, Itrat Batool, Stephanie Wachner, Katrina S. Gold, Corinna Wong, Michael B. O’Connor & Katja Brückner | | | Hematopoietic sites in the Drosophila larva require the local peripheral nervous system for blood cells (hemocytes) to survive and proliferate, but how this is mediated is unclear. Here, the authors identify Activin-β from sensory neurons as signalling to hemocytes, affecting proliferation and adhesion. | | 27 July 2017 | doi: 10.1038/ncomms15990 | | Drosophila Growth factor signalling Peripheral nervous system | Bayesian association scan reveals loci associated with human lifespan and linked biomarkers OPEN | | Aaron F. McDaid, Peter K. Joshi, Eleonora Porcu, Andrea Komljenovic, Hao Li, Vincenzo Sorrentino, Maria Litovchenko, Roel P. J. Bevers, Sina Rüeger, Alexandre Reymond, Murielle Bochud, Bart Deplancke, Robert W. Williams, Marc Robinson-Rechavi, Fred Paccaud, Valentin Rousson, Johan Auwerx, James F. Wilson & Zoltán Kutalik | | | Along with various environmental factors, a complex genetic architecture influences human lifespan. Here, McDaid and colleagues reveal novel loci associated with human lifespan and linked biomarkers by Bayesian association scan. | | 27 July 2017 | doi: 10.1038/ncomms15842 | | Data integration Genome-wide association studies Statistical methods | ATP-dependent modulation of MgtE in Mg2+ homeostasis OPEN | | Atsuhiro Tomita, Mingfeng Zhang, Fei Jin, Wenhui Zhuang, Hironori Takeda, Tatsuro Maruyama, Masanori Osawa, Ken-ichi Hashimoto, Hisashi Kawasaki, Koichi Ito, Naoshi Dohmae, Ryuichiro Ishitani, Ichio Shimada, Zhiqiang Yan, Motoyuki Hattori & Osamu Nureki | | | MgtE is an Mg2+ transporter involved in Mg2+ homeostasis. Here, the authors report that ATP regulates the Mg+2-dependent gating of MgtE and use X-ray crystallography combined with functional studies to propose the molecular mechanisms involved in this process. | | 27 July 2017 | doi: 10.1038/s41467-017-00082-w | | Ion channels Membrane proteins X-ray crystallography | High-energy mid-infrared sub-cycle pulse synthesis from a parametric amplifier OPEN | | Houkun Liang, Peter Krogen, Zhou Wang, Hyunwook Park, Tobias Kroh, Kevin Zawilski, Peter Schunemann, Jeffrey Moses, Louis F. DiMauro, Franz X. Kärtner & Kyung-Han Hong | | | Stable sub-cycle pulses in the mid-infrared region allow damage-free investigation of electron dynamics in solids. Here, the authors develop a suitable source to this end which is based on an optical parametric amplifier. | | 26 July 2017 | doi: 10.1038/s41467-017-00193-4 | | High-harmonic generation Nonlinear optics Ultrafast lasers | Non-aqueous selective synthesis of orthosilicic acid and its oligomers OPEN | | Masayasu Igarashi, Tomohiro Matsumoto, Fujio Yagihashi, Hiroshi Yamashita, Takashi Ohhara, Takayasu Hanashima, Akiko Nakao, Taketo Moyoshi, Kazuhiko Sato & Shigeru Shimada | | | Orthosilicic acid is essential to many natural and synthetic materials but notoriously difficult to isolate, limiting its use in materials synthesis. Here, the authors successfully synthesize and stabilize orthosilicic acid and its oligomers, making available a new family of building blocks for silicon oxide-based materials. | | 26 July 2017 | doi: 10.1038/s41467-017-00168-5 | | Inorganic chemistry Materials chemistry Chemical synthesis | The liver-enriched lnc-LFAR1 promotes liver fibrosis by activating TGFβ and Notch pathways OPEN | | Kun Zhang, Xiaohui Han, Zhen Zhang, Lina Zheng, Zhimei Hu, Qingbin Yao, Hongmei Cui, Guiming Shu, Maojie Si, Chan Li, Zhemin Shi, Ting Chen, Yawei Han, Yanan Chang, Zhi Yao, Tao Han & Wei Hong | | | Activated hepatic stellate cells are the principal contributors to liver fibrosis by secreting a variety of pro-fibrogenic cytokines . Here Zhang et al. demonstrate that a liver-enriched lncRNA, lnc-LFAR1, promotes liver fibrosis and HSC activation by activating TGFβ and Notch signaling. | | 26 July 2017 | doi: 10.1038/s41467-017-00204-4 | | Extracellular signalling molecules Liver fibrosis Long non-coding RNAs Mechanisms of disease | AIM1 is an actin-binding protein that suppresses cell migration and micrometastatic dissemination OPEN | | Michael C. Haffner, David M. Esopi, Alcides Chaux, Meltem Gürel, Susmita Ghosh, Ajay M. Vaghasia, Harrison Tsai, Kunhwa Kim, Nicole Castagna, Hong Lam, Jessica Hicks, Nicolas Wyhs, Debika Biswal Shinohara, Paula J. Hurley, Brian W. Simons, Edward M. Schaeffer, Tamara L. Lotan, William B. Isaacs, George J. Netto, Angelo M. De Marzo et al. | | | Invasion of malignant cells involves changes in cytoskeleton dynamics. Here the authors identify absent in melanoma 1 as an actin binding protein and show that it regulates cytoskeletal remodeling and cell migration in prostate epithelial cells, acting as a metastatic suppressor in cancer cells. | | 26 July 2017 | doi: 10.1038/s41467-017-00084-8 | | Cell migration Prostate cancer | | | | | | | | Latest ERRATA | | | | Erratum: Uniform electroactive fibre-like micelle nanowires for organic electronics OPEN | | Xiaoyu Li, Piotr J. Wolanin, Liam R. MacFarlane, Robert L. Harniman, Jieshu Qian, Oliver E. C. Gould, Thomas G. Dane, John Rudin, Martin J. Cryan, Thomas Schmaltz, Holger Frauenrath, Mitchell A. Winnik, Charl F. J. Faul & Ian Manners | | 27 July 2017 | doi: 10.1038/ncomms16142 | | Conjugated polymers Self-assembly | | | | | Latest CORRIGENDA | | | | Corrigendum: Large-scale production of megakaryocytes from human pluripotent stem cells by chemically defined forward programming OPEN | | Thomas Moreau, Amanda L. Evans, Louella Vasquez, Marloes R. Tijssen, Ying Yan, Matthew W. Trotter, Daniel Howard, Maria Colzani, Meera Arumugam, Wing Han Wu, Amanda Dalby, Riina Lampela, Guenaelle Bouet, Catherine M. Hobbs, Dean C. Pask, Holly Payne, Tatyana Ponomaryov, Alexander Brill, Nicole Soranzo, Willem H. Ouwehand et al. | | 28 July 2017 | doi: 10.1038/ncomms15076 | | | | | | Advertisement | | Nature Reviews Materials is an online-only, materials science journal that provides an accurate and balanced discussion on a chosen topic, together with an authoritative voice from experienced researchers. Spanning physics, chemistry, biology and engineering, the journal publishes a broad range of Reviews and Comments from world-leading scientists.
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