Nature Cell Biology contents: September 2017 Volume 19 Number 9, pp 1005 - 1129

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Advertisement Do You Treat Your Cells the Same Way Every Time? Explore how GCCP can simplify generation of highly reproducible results in cell culture experiments with comparable parameters, independent of the person performing the experiments. https://www.eppendorf.com/reproducibility TABLE OF CONTENTS September 2017 Volume 19, Issue 9 Editorial News and Views Articles   Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement Free Naturejobs Career Expo London - registration is now open  The 11th annual Naturejobs Career Expo will be held in London on October 4, 2017. Join us for your chance to network with leading global employers, receive one-to-one CV checking, attend free talks and workshops, learn how to enhance your employability and lots more.  Register FREE today!    Advertisement Nature Index China 2017 China continues to increase its global share of research papers, but publication numbers are just one indicator that a country's science is thriving. Read the full supplement free for six months   Advertisement npj Precision Oncology is a new open access, online-only, peer-reviewed journal committed to publishing cutting-edge scientific research in all aspects of precision oncology from basic science to translational applications, to clinical medicine. The journal is part of the Nature Partner Journals series and published in partnership with The Hormel Institute, University of Minnesota.   Explore the benefits of submitting your manuscript   Editorial Top Principles of refereeing   p1005 doi:10.1038/ncb3606 Peer review is a key element of scientific publishing. Here we discuss what constitutes the ideal referee report.   News and Views Top Enhancing brown fat with NFIA   pp1006 - 1007 Suzanne N. Shapira and Patrick Seale doi:10.1038/ncb3591 Brown adipose tissue is a key metabolic organ that oxidizes fatty acids and glucose to generate heat. Through epigenomic analyses of multiple adipose depots, the transcription factor nuclear factor I-A (NFIA) is now shown to drive the brown fat genetic program through binding to lineage-specific cis-regulatory elements. See also: Article by Hiraike et al. DNA sensing in senescence   pp1008 - 1009 Marina Ruiz de Galarreta and Amaia Lujambio doi:10.1038/ncb3603 Cellular senescence, a cell-autonomous growth arrest program, also executes pleiotropic non-cell-autonomous activities through the senescence-associated secretory phenotype (SASP). The innate cGAS–STING DNA-sensing pathway is now shown to regulate senescence by recognizing cytosolic DNA and inducing SASP factors, uncovering an unexpected link between these two previously unrelated pathways. See also: Article by Glück et al. Lab-grown mini-brains upgraded   pp1010 - 1012 Lin Yang and Huck-Hui Ng doi:10.1038/ncb3601 Three-dimensional brain organoid models have come into the spotlight as in vitro tools to recapitulate complex features of the brain. Four recent papers now leverage current technologies to generate new flavours of brain organoids and address aspects of brain biology which, to date, have been challenging to explore. See also: Research by Lancaster et al. | Article by Quadrato et al. | Article by Bagley et al. | Article by Birey et al. A fruitful liaison of ZSCAN10 and ROS on the road to rejuvenation   pp1012 - 1013 Clea Bárcena & Carlos López-Otín doi:10.1038/ncb3602 Induced pluripotent stem cells derived from aged donors (A-iPSCs) usually show genomic instability that affects their utility and raises concerns about their safety. Now, a study highlights the importance of ZSCAN10-dependent recovery of glutathione–ROS homeostasis in counteracting the genomic defects in A-iPSCs. See also: Article by Skamagki et al. A caspase-independent way to kill cancer cells   pp1014 - 1015 Brent E. Fitzwalter and Andrew Thorburn doi:10.1038/ncb3604 Cancer treatments often focus on killing tumour cells through apoptosis, which is thought to typically require mitochondrial outer membrane permeabilization (MOMP) and subsequent caspase activation. A study now shows that MOMP can trigger TNF-dependent, but caspase-independent cell death, suggesting a different approach to improve cancer therapy. See also: Article by Giampazolias et al. Nature Cell Biology JOBS of the week Postdoctoral Fellow in Bioengineering, Hematopoietic Stem Cell Biology, Cancer Biology, and Blood Disorders Brigham & Women's Hospital - Harvard Medical School - Broad Institute of MIT and Harvard Assistant Professor in Developmental or Cell Biology Princeton University, Department of Molecular Biology Postdoctoral Position in Mammalian Stem Cell Biology New York University School of Medicine Assistant Professor of Immunology in the Department of Stem Cell and Regenerative Biology, Harvard University Harvard University Faculty Position - Yale University Department of Cell Biology Yale University School of Medicine More Science jobs from Nature Cell Biology EVENT International Congress of Cell Biology 2018 27.01.18 Hyderabad, India More science events from Advertisement Nature Outline: Critical limb ischaemia  Blocked arteries slow or limit the blood flow to the legs, causing pain. Bad cases of this critical limb ischaemia can end up with amputation or even be life threatening. Regenerative therapies might be able to change this. Access free online>> Produced with support from  Translational Research Informatics Center (TRI)   Articles Top Lactate dehydrogenase activity drives hair follicle stem cell activation   pp1017 - 1026 Aimee Flores, John Schell, Abigail S. Krall, David Jelinek, Matilde Miranda et al. doi:10.1038/ncb3575 Flores et al. show that hair follicle stem cells rely on the production of lactate via the LDHA enzyme to become activated. Inducing Ldha through Mpc1 inhibition or Myc activation successfully reactivates the hair cycle in quiescent follicles. See also: Article by Schell et al. Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism   pp1027 - 1036 John C. Schell, Dona R. Wisidagama, Claire Bensard, Helong Zhao, Peng Wei et al. doi:10.1038/ncb3593 Schell et al. demonstrate that inactivation of the mitochondrial pyruvate carrier in mouse and fly intestinal stem cells (ISCs) locks the cell into a glycolytic metabolic program and promotes the expansion of the stem cell compartment. See also: Article by Flores et al. ZSCAN10 expression corrects the genomic instability of iPSCs from aged donors   pp1037 - 1048 Maria Skamagki, Cristina Correia, Percy Yeung, Timour Baslan, Samuel Beck et al. doi:10.1038/ncb3598 Skamagki et al. show that pluripotency factor ZSCAN10 is poorly expressed in iPSCs derived from aged donors, and its addition during reprogramming restores the DNA damage response and genomic stability through normalization of ROS–glutathione levels. See also: News and Views by Bárcena & López-Otín An apical MRCK-driven morphogenetic pathway controls epithelial polarity   pp1049 - 1060 Ceniz Zihni, Evi Vlassaks, Stephen Terry, Jeremy Carlton, Thomas King Chor Leung et al. doi:10.1038/ncb3592 Zihni et al. discover a role for Cdc42–MRCK signalling in establishing contractility at the apical pole, which in turn controls epithelial polarity in mammalian cells and Drosophila photoreceptors.   Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence   pp1061 - 1070 Selene Glück, Baptiste Guey, Muhammet Fatih Gulen, Katharina Wolter, Tae-Won Kang et al. doi:10.1038/ncb3586 Glück et al. find that the DNA-sensing component cyclic GMP-AMP synthase (cGAS) recognizes cytosolic chromatin fragments produced in senescent cells leading to STING-mediated production of SASPs, which promotes paracrine senescence. See also: News and Views by de Galarreta & Lujambio SMC complexes differentially compact mitotic chromosomes according to genomic context   pp1071 - 1080 Stephanie Andrea Schalbetter, Anton Goloborodko, Geoffrey Fudenberg, Jon-Matthew Belton, Catrina Miles et al. doi:10.1038/ncb3594 Schalbetter et al. show by Hi-C and modelling that mitotic chromosome compaction in budding yeast occurs by cis-looping of chromatin, and reveal distinct roles for cohesin and condensin depending on chromatin context.   NFIA co-localizes with PPARγ and transcriptionally controls the brown fat gene program   pp1081 - 1092 Yuta Hiraike, Hironori Waki, Jing Yu, Masahiro Nakamura, Kana Miyake et al. doi:10.1038/ncb3590 Hiraike et al. identify nuclear factor I-A (NFIA) as a transcriptional regulator of brown fat. NFIA activates cell-type-specific enhancers prior to differentiation and facilitates PPARγ binding to regulate the brown fat gene program. See also: News and Views by Shapira & Seale Early loss of Crebbp confers malignant stem cell properties on lymphoid progenitors   pp1093 - 1104 Sarah J. Horton, George Giotopoulos, Haiyang Yun, Shabana Vohra, Olivia Sheppard et al. doi:10.1038/ncb3597 Horton et al. show that early Crebbp loss in haematopoietic progenitors results in a defective p53-mediated DNA damage response, leading to the accumulation of epigenetic and genetic alterations, which promote the onset of lymphoid malignancies.   A regulated PNUTS mRNA to lncRNA splice switch mediates EMT and tumour progression   pp1105 - 1115 Simon Grelet, Laura A. Link, Breege Howley, Clémence Obellianne, Viswanathan Palanisamy et al. doi:10.1038/ncb3595 Grelet et al. find that hnRNP E1 release from PNUTS pre-RNA in response to TGFβ generates a lncRNA that acts as competitive sponge for miR-205, promoting epithelial-mesenchymal transition in cancer.   Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiency   pp1116 - 1129 Evangelos Giampazolias, Barbara Zunino, Sandeep Dhayade, Florian Bock, Catherine Cloix et al. doi:10.1038/ncb3596 Tait and colleagues show that caspase-independent cell death induced by mitochondrial permeabilization stimulates NF-κB activity through downregulation of inhibitor of apoptosis, and enhances anti-tumour effects. See also: News and Views by Fitzwalter & Thorburn Top Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

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