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TABLE OF CONTENTS |
August 2017 Volume 35, Issue 8 |
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| Editorial News Bioentrepreneur Opinion and Comment Feature News and Views Research Careers and Recruitment
| | Advertisement | | | | Technical Note: Simplify Production of Complex Proteins & Biologics
Producing high quality, functional proteins in a rapid and cost-effective manner can be challenging when dealing with complex or difficult-to-express proteins, particularly if cGMP-compliance is needed. Find out how implementing the right expression platform can transform your efforts.
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Nature Outlook: Animal Health Animal and human health are closely linked. This Outlook examines how climate change is pushing diseases into formerly 'safe' regions of the world, the challenges in treating parasites, the efforts to vaccinate gorillas against Ebola and how a holistic approach to disease could further the well-being of animals. Access the Outlook free online Produced with support from Bayer Animal Health GmbH | | | |
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Editorial | Top |
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Time for the data to speak p689 doi:10.1038/nbt.3938 Retraction of a study claiming gene editing via an Argonaute enzyme illustrates the importance of post-publication peer review in the age of 24/7 media.
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News | Top |
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First approval in sight for Novartis' CAR-T therapy after panel vote pp691 - 693 Cormac Sheridan doi:10.1038/nbt0817-691
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LifeArc splashes out, fuelled by Keytruda p693 doi:10.1038/nbt0817-693
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Loxo TRK inhibitor data wows oncologists pp694 - 695 Elie Dolgin doi:10.1038/nbt0817-694
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First new drug approval for AML in 15 years pp696 - 698 Cormac Sheridan doi:10.1038/nbt0817-696
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Innovation drive seizes Indian biotech p698 Killugudi Jayaraman doi:10.1038/nbt0817-698
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First multi-gene NGS diagnostic kit approved p699 Mark Ratner doi:10.1038/nbt0817-699
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Plant breeders test drive first open-source seed bank p700 Lucas Laursen doi:10.1038/nbt0817-700
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Google, Novartis back Medicxi's ambitions p701 Melanie Senior doi:10.1038/nbt0817-701
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Around the world in a month p702 doi:10.1038/nbt0817-702
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Data Page |
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Drug pipeline 2Q17 p703 Laura DeFrancesco doi:10.1038/nbt.3941
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News Feature |
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Engineering the animal out of animal products pp704 - 707 Amber Dance doi:10.1038/nbt.3933 Amber Dance reports on a new wave of domestication[mdash]turning cells, rather than animals, into food.
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Bringing Edman Back to Life
Shimadzu's protein sequencers provide reliable, sensitive N-terminal sequencing to researchers through automated Edman degradation. Software enables compliance with FDA 21 CFR Part 11 guidelines, while easy-to-use data analysis functions simplify operation, data processing and reporting.
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Bioentrepreneur | Top |
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Data page |
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Research biotech patenting 2016 pp708 - 709 Brady Huggett and Kathryn Paisner doi:10.1038/nbt.3829
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Opinion and Comment | Top |
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Correspondence |
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Policy implications for post-Brexit biotech pp710 - 711 John Annaloro and Tim K Mackey doi:10.1038/nbt.3930
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What the roll out of EU data legislation means for you pp712 - 713 Rajam Neethu doi:10.1038/nbt.3928
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Ethical lessons from a tale of two genetically modified insects pp713 - 716 Carolyn P Neuhaus and Arthur L Caplan doi:10.1038/nbt.3927
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Rules of the road for insect gene drive research and testing pp716 - 718 Zach Adelman, Omar Akbari, John Bauer, Ethan Bier, Cinnamon Bloss et al. doi:10.1038/nbt.3926
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Feature | Top |
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Patents |
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Recent patents in synthetic biology p719 doi:10.1038/nbt.3946
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News and Views | Top |
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Research | Top |
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Perspective |
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Minimum information about a single amplified genome (MISAG) and a metagenome-assembled genome (MIMAG) of bacteria and archaea pp 725 – 731 Robert M Bowers, Nikos C Kyrpides, Ramunas Stepanauskas, Miranda Harmon-Smith, Devin Doud et al. doi:10.1038/nbt.3893 Standards for sequencing the microbial 'uncultivated majority', namely bacterial and archaeal single-cell genome sequences, and genome sequences from metagenomic datasets, are proposed.
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Review |
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Characterization of noncoding regulatory DNA in the human genome pp732 - 746 Ran Elkon and Reuven Agami doi:10.1038/nbt.3863 Genome-wide mapping of regulatory elements will improve our understanding of how genetic variation in the noncoding genome affects disease phenotypes.
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Articles |
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A wellness study of 108 individuals using personal, dense, dynamic data clouds pp747 - 756 Nathan D Price, Andrew T Magis, John C Earls, Gustavo Glusman, Roie Levy et al. doi:10.1038/nbt.3870 Longitudinal clinical and multi-omics data from 108 healthy individuals are analyzed to identify putative biomarkers and diagnostics of early disease states.
See also: News and Views by Butte
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Nanoscale imaging of clinical specimens using pathology-optimized expansion microscopy pp757 - 764 Yongxin Zhao, Octavian Bucur, Humayun Irshad, Fei Chen, Astrid Weins et al. doi:10.1038/nbt.3892 Expansion microscopy, a technique for super-resolution imaging, is extended to clinical human tissue samples that are formalin fixed, paraffin embedded, stained and/or fresh frozen.
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HLA-E-expressing pluripotent stem cells escape allogeneic responses and lysis by NK cells pp765 - 772 German G Gornalusse, Roli K Hirata, Sarah E Funk, Laura Riolobos, Vanda S Lopes et al. doi:10.1038/nbt.3860 Expression of the minimally polymorphic HLA-E molecule prevents NK-cell-mediated rejection of cells lacking expression of HLA-A, B and C.
See also: News and Views by Kim & Adams
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Long time-lapse nanoscopy with spontaneously blinking membrane probes pp773 - 780 Hideo Takakura, Yongdeng Zhang, Roman S Erdmann, Alexander D Thompson, Yu Lin et al. doi:10.1038/nbt.3876 Super-resolution imaging of the dynamics of organelle structures in live cells is facilitated by blinking, far-red dyes.
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Inference and quantification of peptidoforms in large sample cohorts by SWATH-MS pp781 - 788 George Rosenberger, Yansheng Liu, Hannes L Rost, Christina Ludwig, Alfonso Buil et al. doi:10.1038/nbt.3908 Detection of post-translational modifications by mass spectrometry is enhanced with an analytic method for data-independent acquisition proteomics.
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Letters |
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Engineered Cpf1 variants with altered PAM specificities pp789 - 792 Linyi Gao, David B T Cox, Winston X Yan, John C Manteiga, Martin W Schneider et al. doi:10.1038/nbt.3900 The targeting range of the CRISPR endonuclease Cpf1 is increased three-fold by molecular engineering.
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Rapid cloning of genes in hexaploid wheat using cultivar-specific long-range chromosome assembly pp793 - 796 Anupriya Kaur Thind, Thomas Wicker, Hana Simkova, Dario Fossati, Odile Moullet et al. doi:10.1038/nbt.3877 Rapid cloning of genes from any crop plant species (or cultivar) whose chromosomes can be flow sorted is enabled by a combination of short-read sequencing and proximity ligation.
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Retraction |
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Retraction: DNA-guided genome editing using the Natronobacterium gregoryi Argonaute p797 Feng Gao, Xiao Z Shen, Feng Jiang, Yongqiang Wu and Chunyu Han doi:10.1038/nbt0817-797a
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Errata |
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Erratum: Nature Biotechnology's academic spinouts of 2016 p797 Aaron Bouchie, Laura DeFrancesco, Cormac Sheridan and Sarah Webb doi:10.1038/nbt0817-797b
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Erratum: Making individualized drugs a reality p797 Huub Schellekens, Mohammed Aldosari, Herre Talsma and Enrico Mastrobattista doi:10.1038/nbt0817-797c
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Erratum: Genome-wide target specificities of CRISPR RNA-guided programmable deaminases p797 Daesik Kim, Kayeong Lim, Sang-Tae Kim, Sun-heui Yoon, Kyoungmi Kim et al. doi:10.1038/nbt0817-797d
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Careers and Recruitment | Top |
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Second-quarter biotech job picture p798 Michael Francisco doi:10.1038/nbt.3937
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People |
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People p800 doi:10.1038/nbt.3945
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HIV IMMUNITY AND ERADICATION, A HERRENHAUSEN SYMPOSIUM
November 2-3, 2017 | Hanover, Germany
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