| | | | | Table of ContentsNews & Views Review Articles | Volume 36, Number 14 | News & Views | New studies show how the activity of a multitasking DNA repair nuclease is precisely regulated at DNA interstrand crosslinks. Orlando D Schärer Published online 28.06.2017 | | Two recent studies reveal the structural basis for ribosome hibernation, a process by which bacteria form inactive ribosome dimers to survive environmental stress. Ruben L Gonzalez, Jr Published online 03.07.2017 | Review | This part of our Metabolism review series highlights both the physiological roles of adipose tissue and the pathological consequences of its dysfunction. Alexandros Vegiopoulos, Maria Rohm, and Stephan Herzig Published online 16.06.2017 | Articles | Early autophagic markers are recruited to endoplasmic reticulum‐plasma membrane (ER‐PM) contact sites established by tethering factors extended synaptotagmins, allowing for local phosphatidylinositol‐3‐phosphate synthesis and autophagosome biogenesis. Anna Chiara Nascimbeni, Francesca Giordano, Nicolas Dupont, Daniel Grasso, Maria I Vaccaro, Patrice Codogno, and Etienne Morel Published online 26.05.2017 | | Patient‐derived and separation‐of‐function mutations distinguish nucleotide excision repair and interstrand crosslink repair roles of a key structure‐specific endonuclease. Daisy Klein Douwel, Wouter S Hoogenboom, Rick ACM Boonen, and Puck Knipscheer | | Unhooking of interstrand crosslinks on DNA structures mimicking arrested replication fork requires incision nuclease collaboration with replication protein A. Ummi B Abdullah, Joanna F McGouran, Sanja Brolih, Denis Ptchelkine, Afaf H El‐Sagheer, Tom Brown, and Peter J McHugh | | The structure of two ribosomes held together by hibernation promotion factor reveals how bacteria form inactive 100S disomes to limit translation when entering stationary phase. Bertrand Beckert, Maha Abdelshahid, Heinrich Schäfer, Wieland Steinchen, Stefan Arenz, Otto Berninghausen, Roland Beckmann, Gert Bange, Kürşad Turgay, and Daniel N Wilson Published online 03.05.2017 | | By combining cryoEM and NMR, this study illustrates how bacterial ribosomes are stored in an inactive dimeric 100S (disome) state during stress responses. Iskander Khusainov, Quentin Vicens, Rustam Ayupov, Konstantin Usachev, Alexander Myasnikov, Angelita Simonetti, Shamil Validov, Bruno Kieffer, Gulnara Yusupova, Marat Yusupov, and Yaser Hashem Published online 23.06.2017 | | The discovery of a conserved phosphorylation site in Argonaute 2, a key effector of miRNA‐dependent gene regulation, reveals a new level of active control in the RNA silencing machinery. Miguel Quévillon Huberdeau, Daniela M Zeitler, Judith Hauptmann, Astrid Bruckmann, Lucile Fressigné, Johannes Danner, Sandra Piquet, Nicholas Strieder, Julia C Engelmann, Guillaume Jannot, Rainer Deutzmann, Martin J Simard, and Gunter Meister Published online 23.06.2017 | | Calcium channel‐dependent induction of the calcium sensor secretagogin regulates insulin secretion not merely via the SNARE machinery, but also through the interacting deubiquitinase USP9X preventing ER stress and β‐cell loss. Katarzyna Malenczyk, Fatima Girach, Edit Szodorai, Petter Storm, Åsa Segerstolpe, Giuseppe Tortoriello, Robert Schnell, Jan Mulder, Roman A Romanov, Erzsébet Borók, Fabiana Piscitelli, Vincenzo Di Marzo, Gábor Szabó, Rickard Sandberg, Stefan Kubicek, Gert Lubec, Tomas Hökfelt, Ludwig Wagner, Leif Groop, and Tibor Harkany Published online 21.06.2017 | | Local deletion of OPA1 in differentiated muscle evokes mitochondrial dysfunction and ER stress but concomitantly induces FGF21 and favorable metabolism in aged mice. Renata Oliveira Pereira, Satya M Tadinada, Frederick M Zasadny, Karen Jesus Oliveira, Karla Maria Pereira Pires, Angela Olvera, Jennifer Jeffers, Rhonda Souvenir, Rose Mcglauflin, Alec Seei, Trevor Funari, Hiromi Sesaki, Matthew J Potthoff, Christopher M Adams, Ethan J Anderson, and E Dale Abel Published online 12.06.2017 | | Interaction of preimplantation embryo and uterine epithelium facilitates synthesis of lysophosphatidic acid, which triggers HB‐EGF and SOX‐2 signal required for implantation in the uterus. Shizu Aikawa, Kuniyuki Kano, Asuka Inoue, Jiao Wang, Daisuke Saigusa, Takeshi Nagamatsu, Yasushi Hirota, Tomoyuki Fujii, Soken Tsuchiya, Yoshitaka Taketomi, Yukihiko Sugimoto, Makoto Murakami, Makoto Arita, Makoto Kurano, Hitoshi Ikeda, Yutaka Yatomi, Jerold Chun, and Junken Aoki | | The minimal duration of a DNA damage‐induced G2 phase arrest is controlled by pan‐nuclear ATM activity on chromatin, and not by the presence of ATM activity at DNA damage foci. Himjyot Jaiswal, Jan Benada, Erik Müllers, Karen Akopyan, Kamila Burdova, Tobias Koolmeister, Thomas Helleday, René H Medema, Libor Macurek, and Arne Lindqvist Published online 12.06.2017 | | | |
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