The EMBO Journal Table of Contents for 03 July 2017; Vol. 36, No. 13

03 July 2017 | Volume 36, Number 13 Submit Table of Contents News & Views Review Articles Volume 36, Number 13 News & Views OH MYeloid! Immune cells wreaking havoc on brain homeostasis New mouse models show that dementia‐associated TREM2 mutation can cause microglial dysfunction and precipitate changes in cerebral blood flow and metabolism. Liana Bonanno and Tony Wyss‐Coray Published online 16.06.2017 c‐MYC mRNA tail tale about glutamine control of transcription Glutamine‐dependent adenosine promotes c‐MYC mRNA translation via its 3′‐UTR, linking metabolism to Pol II pause‐release. Chi V Dang Published online 15.05.2017 Suppressing mTORC1 on the lysosome A recent study shows that under conditions of growth factor deprivation, the phosphoinositide kinase PI3K‐C2β inhibits via local PtdIns(3,4)P2 production mTOR complex 1 directly on lysosomes. Camilla Raiborg, Kay O Schink, and Harald Stenmark Published online 16.06.2017 Review Molecular definitions of autophagy and related processes Autophagy‐related responses are described in an increasing number of distinct biological contexts. This review discusses the use of appropriate terms for autophagic processes with the aim to provide recommendations and avoid confusion in the field of autophagy research. Lorenzo Galluzzi, Eric H Baehrecke, Andrea Ballabio, Patricia Boya, José Manuel Bravo‐San Pedro, Francesco Cecconi, Augustine M Choi, Charleen T Chu, Patrice Codogno, Maria Isabel Colombo, Ana Maria Cuervo, Jayanta Debnath, Vojo Deretic, Ivan Dikic, Eeva‐Liisa Eskelinen, Gian Maria Fimia, Simone Fulda, David A Gewirtz, Douglas R Green, Malene Hansen, J Wade Harper, Marja Jäättelä, Terje Johansen, Gabor Juhasz, Alec C Kimmelman, Claudine Kraft, Nicholas T Ktistakis, Sharad Kumar, Beth Levine, Carlos Lopez‐Otin, Frank Madeo, Sascha Martens, Jennifer Martinez, Alicia Melendez, Noboru Mizushima, Christian Münz, Leon O Murphy, Josef M Penninger, Mauro Piacentini, Fulvio Reggiori, David C Rubinsztein, Kevin M Ryan, Laura Santambrogio, Luca Scorrano, Anna Katharina Simon, Hans‐Uwe Si mon, Anne Simonsen, Nektarios Tavernarakis, Sharon A Tooze, Tamotsu Yoshimori, Junying Yuan, Zhenyu Yue, Qing Zhong, and Guido Kroemer Published online 08.06.2017 Articles The FTD‐like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism A knock‐in mouse model of the frontotemporal dementia disease‐associated TREM2 mutation, p.T66M, shows a loss‐of‐function phenotype with age‐dependent reduction in microglial activity and systemic metabolic alterations throughout the brain. Gernot Kleinberger, Matthias Brendel, Eva Mracsko, Benedikt Wefers, Linda Groeneweg, Xianyuan Xiang, Carola Focke, Maximilian Deußing, Marc Suárez‐Calvet, Fargol Mazaheri, Samira Parhizkar, Nadine Pettkus, Wolfgang Wurst, Regina Feederle, Peter Bartenstein, Thomas Mueggler, Thomas Arzberger, Irene Knuesel, Axel Rominger, and Christian Haass Published online 30.05.2017 The MYC mRNA 3′‐UTR couples RNA polymerase II function to glutamine and ribonucleotide levels Glutamine and its metabolite adenosine control translation of MYC via the 3′‐UTR, linking RNA polymerase II (RNAPII) function to nucleotide availability. Bypassing this control induces stalling of RNAPII and R‐loop formation. Francesca R Dejure, Nadine Royla, Steffi Herold, Jacqueline Kalb, Susanne Walz, Carsten P Ade, Guido Mastrobuoni, Jens T Vanselow, Andreas Schlosser, Elmar Wolf, Stefan Kempa, and Martin Eilers Published online 13.04.2017 A Pseudomonas aeruginosa TIR effector mediates immune evasion by targeting UBAP1 and TLR adaptors PumA from a multi‐drug resistant bacterial strain subverts the host innate immune system through interference with NF‐κB activation by both Toll‐like receptors and inflammatory cytokine receptors. Paul RC Imbert, Arthur Louche, Jean‐Baptiste Luizet, Teddy Grandjean, Sarah Bigot, Thomas E Wood, Stéphanie Gagné, Amandine Blanco, Lydia Wunderley, Laurent Terradot, Philip Woodman, Steve Garvis, Alain Filloux, Benoit Guery, and Suzana P Salcedo Published online 08.05.2017 In vitro expansion of mouse primordial germ cell‐like cells recapitulates an epigenetic blank slate cAMP signaling agonists stimulate in vitro proliferation of murine primordial germ cell like cells, accompanied by loss of DNA methylation patterns. Hiroshi Ohta, Kazuki Kurimoto, Ikuhiro Okamoto, Tomonori Nakamura, Yukihiro Yabuta, Hidetaka Miyauchi, Takuya Yamamoto, Yukiko Okuno, Masatoshi Hagiwara, Kenjiro Shirane, Hiroyuki Sasaki, and Mitinori Saitou Published online 30.05.2017 DNA‐binding determinants and cellular thresholds for human telomerase repeat addition processivity Telomerase mutants with reduced processivity may still maintain telomeres, and at higher expression levels can even cause telomere over‐elongation in human cells. Robert Alexander Wu, Jane Tam, and Kathleen Collins Published online 11.05.2017 Intrinsic regulation of enteroendocrine fate by Numb Symmetric distribution of Numb during intestinal stem cell division as well as de novo synthesis in the differentiating daughter cell are required for enteroendocrine cell specification and homeostasis in the Drosophila intestine. Jérémy Sallé, Louis Gervais, Benjamin Boumard, Marine Stefanutti, Katarzyna Siudeja, and Allison J Bardin Published online 22.05.2017 AMPKα1‐LDH pathway regulates muscle stem cell self‐renewal by controlling metabolic homeostasis The master regulator of cellular energy homeostasis, AMPKα1, regulates muscle regeneration by acting on lactate dehydrogenase (LDH) activity and thus the oxidative phosphorylation versus aerobic glycolysis switch that controls differentiation/self‐renewal of muscle stem cells. Marine Theret, Linda Gsaier, Bethany Schaffer, Gaëtan Juban, Sabrina Ben Larbi, Michèle Weiss‐Gayet, Laurent Bultot, Caterina Collodet, Marc Foretz, Dominique Desplanches, Pascual Sanz, Zizhao Zang, Lin Yang, Guillaume Vial, Benoit Viollet, Kei Sakamoto, Anne Brunet, Bénédicte Chazaud, and Rémi Mounier Published online 17.05.2017 Phosphorylation of Pkp1 by RIPK4 regulates epidermal differentiation and skin tumorigenesis Desmosomal junction protein plakophilin 1 is a RIPK4 kinase substrate in skin cell progenitors, whose phosphorylation is critical for epidermal development and carcinogenesis. Philbert Lee, Shangwen Jiang, Yuanyuan Li, Jiping Yue, Xuewen Gou, Shao‐Yu Chen, Yingming Zhao, Markus Schober, Minjia Tan, and Xiaoyang Wu Published online 15.05.2017 PAR‐1 promotes microtubule breakdown during dendrite pruning in Drosophila Severing of unspecific neurites during neuronal morphogenesis is facilitated by PAR‐1‐mediated Tau phosphorylation, which increases microtubule dynamics prior to disassembly. Svende Herzmann, Rafael Krumkamp, Sandra Rode, Carina Kintrup, and Sebastian Rumpf Published online 29.05.2017   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 973 University Avenue * Los Gatos, CA 95032 * U.S.A. Copyright © 2017 by the European Molecular Biology Organisation.