Nature Reviews Molecular Cell Biology contents August 2017 Volume 18 Number 8 pp 467-527

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TABLE OF CONTENTS
August 2017 Volume 18 Number 8
2016 2-year Impact Factor 46.602 Journal Metrics 2-year Median 28.5	In this issue Research Highlights Progress Reviews Perspectives Also this month Article series: DNA damage Post-translational modifications  Featured article: Vascular heterogeneity and specialization in development and disease Michael Potente & Taija Mäkinen
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RESEARCH HIGHLIGHTS Top Stem cells: Colonic organoids for drug testing and colorectal disease modelling p467 | doi:10.1038/nrm.2017.70 Two studies report the generation of human colonic organoids, which could be useful for disease modelling and drug testing. PDF Chromosome biology: Structuring interphase chromatin p468 | doi:10.1038/nrm.2017.65 The oligomerization of scaffold attachment factor A through its binding to chromatin-associated RNAs regulates the structure of interphase chromosomes. PDF Circadian rhythms: Replication keeps the clock ticking p468 | doi:10.1038/nrm.2017.69 DNA replication regulates nucleosome dynamics at the promoter of a negative element of the circadian clock, thereby providing regulatory feedback into circadian rhythms. PDF Cancer biology: Therapy-induced transcription is cryptically widespread p469 | doi:10.1038/nrm.2017.64 Inhibitors of DNA methyltransferases and of histone deacetylases induce transcription from cryptic transposable elements, which results in 5[prime]-truncated and mis-spliced proteins that may increase cancer immunogenicity. PDF JOURNAL CLUB Ribosome cycle emerges from DNA replication p470 | doi:10.1038/nrm.2017.59 A modification of Meselson and Stahl's density gradient centrifugation method and a rare Texan yeast helped show that eukaryotic ribosomes dissociate and reform during translation. PDF Unfolded protein response: Reacting to membrane stress p471 | doi:10.1038/nrm.2017.74 Changes in endoplasmic reticulum membrane composition induce the oligomerization of Ire1 and activate the unfolded protein response. PDF Molecular Cell Biology JOBS of the week Postdoctoral Scientist Research Openings Cedars-Sinai Assistant / Associate Professor University of Southern California Associate Principal Scientist - Cell Engineering Merck & Co. Post-Doctoral Fellow in Gut Microbiota and Colon Cancer University of Toronto Junior Principal Investigator (Unit Leader) IFOM the FIRC Institute of Molecualr Oncology More Science jobs from Molecular Cell Biology EVENT SMART 2017 - Scientific Methods in Academic Research and Teaching 08.09.17 Timi?oara, Romania More science events from
PROGRESS		Top
Physiological functions of programmed DNA breaks in signal-induced transcription Janusz Puc, Aneel K. Aggarwal & Michael G. Rosenfeld p471 | doi:10.1038/nrm.2017.43 Recent evidence indicates that controlled generation of DNA breaks, accompanied by activation of DNA damage repair pathways, can regulate transcription through promoter and enhancer activation and the relief of DNA torsional stress. Abstract | Full Text | PDF
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REVIEWS		Top
Vascular heterogeneity and specialization in development and disease Michael Potente & Taija Mäkinen p477 | doi:10.1038/nrm.2017.36 Blood and lymphatic vessels have essential roles in physiology and disease. The endothelial cells that line these vessels specialize to fulfil the needs of the tissue that they pervade. Recent studies in animal models have provided insights into the mechanisms underlying vessel type- and organ-specific specialization, which is crucial for the understanding of several diseases. Abstract | Full Text | PDF
Article series: DNA damage Non-homologous DNA end joining and alternative pathways to double-strand break repair Howard H. Y. Chang, Nicholas R. Pannunzio, Noritaka Adachi & Michael R. Lieber p495 | doi:10.1038/nrm.2017.48 In mammalian cells, DNA double-strand breaks (DSBs) are repaired predominantly by the non-homologous end joining (NHEJ) pathway, which includes subpathways that can repair different DNA-end configurations. Furthermore, the repair of some DNA-end configurations can be shunted to the auxiliary pathways of alternative end joining (a-EJ) or single-strand annealing (SSA). Abstract | Full Text | PDF | Supplementary information
Mechanisms of DNA replication termination James M. Dewar & Johannes C. Walter p507 | doi:10.1038/nrm.2017.42 The termination of DNA replication involves convergence of replication forks, the completion of DNA synthesis, replisome disassembly and the decatenation of daughter DNA molecules. Recent discoveries illustrate how replisome disassembly in eukaryotes is controlled by E3 ubiquitin ligases and how this activity is regulated to avoid genome instability. Abstract | Full Text | PDF
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PERSPECTIVES		Top
TIMELINE Article series: Post-translational modifications The winding path of protein methylation research: milestones and new frontiers Jernej Murn & Yang Shi p517 | doi:10.1038/nrm.2017.35 Protein methylation was discovered over 50 years ago, but only with the advent of genomic and proteomic technologies could its mechanisms and cellular functions be studied in detail. Shi and Murn discuss the seminal discoveries in protein methylation research and highlight future directions for this field. Abstract | Full Text | PDF
Corrigendum: Transcriptional and epigenetic control of brown and beige adipose cell fate and function Takeshi Inagaki, Juro Sakai & Shingo Kajimura p527 | doi:10.1038/nrm.2017.72 Full Text | PDF
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