Nature Reviews Microbiology contents August 2017 Volume 15 Number 8 pp 449-510

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TABLE OF CONTENTS
August 2017 Volume 15 Number 8
2016 2-year Impact Factor 26.819 Journal Metrics 2-year Median 18	In this issue Research Highlights News and Analysis Reviews Perspectives Featured article Article series: Microbiome Vector-borne diseases  Featured article: Persistent bacterial infections and persister cells Robert A. Fisher, Bridget Gollan & Sophie Helaine
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RESEARCH HIGHLIGHTS Top Antimicrobials: Modified sugar compound can clear intestinal colonization by UPEC p449 | doi:10.1038/nrmicro.2017.77 This study found a new role for chaperone-usher pathway (CUP) pili in the colonization of the gut by uropathogenic Escherichia coli (UPEC) and identified a mannoside compound that could be used to prevent their binding to host cells. PDF Bacterial secretion: Shigella sonnei has the edge p450 | doi:10.1038/nrmicro.2017.74 This study shows that a type VI secretion system contributes to the competitiveness of Shigella sonnei. PDF Structural biology: Cascade keeps its targets in the loop p450 | doi:10.1038/nrmicro.2017.80 This study presents cryo-electron microscopy structures of the type I-E Cascade and provides insights into PAM-dependent R-loop formation, Cas3 recruitment and substrate handover. PDF Viral infection: Packing to leave p450 | doi:10.1038/nrmicro.2017.81 In this study, Patel, White et al. discover that the hepatitis B virus pre-genome RNA contains specific nucleotide motifs that mediate interactions with the viral capsid protein to drive nucleocapsid assembly. PDF IN BRIEF Microbiota: Leishmaniasis breaks the equilibrium | Viral evolution: Every flu evolves in the same way | Structural biology: Insights into bacterial microcompartments PDF Nature Reviews Microbiology JOBS of the week Postdoctoral position in Experimental Immunology Universität Basel Research Fellow Longwood Medical Area (Dana-Farber Cancer Institute) Postdoctoral Fellow in Interneuron Development National Institute of Child Health and Human Development (NICHD) Postdoctoral fellowship in Tissue Fibrosis University of California - San Francisco Multiple Opportunities in Molecular Neuroscience Loyola University Chicago - Stritch School of Medicine More Science jobs from Nature Reviews Microbiology EVENT Microbiology Society Annual Conference 2018 10.04.18 Birmingham, UK More science events from
NEWS AND ANALYSIS		Top
GENOME WATCH Adaptation... that's what you need? Chrispin Chaguza & Stephen D. Bentley p452 | doi:10.1038/nrmicro.2017.78This month's Genome Watch highlights how sequencing the genomes of multiple bacterial isolates from humans and animal infection models has revealed the presence of mutations that might represent adaptations for persistence in the host. This month's Genome Watch highlights how sequencing the genomes of multiple bacterial isolates from humans and animal infection models has revealed the presence of mutations that might represent adaptations for persistence in the host. PDF
REVIEWS		Top
Persistent bacterial infections and persister cells Robert A. Fisher, Bridget Gollan & Sophie Helaine p453 | doi:10.1038/nrmicro.2017.42 Many bacteria can infect and persist inside their hosts for long periods of time. In this Review, Fisher, Gollan and Helaine discuss recent developments in our understanding of bacterial persisters and their potential implications for the treatment of persistent infections. Abstract | Full Text | PDF
Article series: Microbiome Anticancer effects of the microbiome and its products Laurence Zitvogel, Romain Daillère, María Paula Roberti, Bertrand Routy & Guido Kroemer p465 | doi:10.1038/nrmicro.2017.44 The microbiota influences the development of cancer and the effect of cancer therapies. In this Review, the authors summarize the interactions between the microbiota, the immune system and tumours and how manipulation of the microbiota can be used therapeutically. Abstract | Full Text | PDF
Article series: Vector-borne diseases Variant surface antigens of Plasmodium falciparum and their roles in severe malaria Mats Wahlgren, Suchi Goel & Reetesh R. Akhouri p479 | doi:10.1038/nrmicro.2017.47 Plasmodium falciparum exports several variant antigens to the surface of erythrocytes. In this Review, Wahlgren, Goel and Akhouri discuss the three best characterized of these protein families, PfEMP1, RIFIN and STEVOR, and highlight their role in the development of severe malaria. Abstract | Full Text | PDF
Mechanisms of gene flow in archaea Alexander Wagner, Rachel J. Whitaker, David J. Krause, Jan-Hendrik Heilers, Marleen van Wolferen, Chris van der Does & Sonja-Verena Albers p492 | doi:10.1038/nrmicro.2017.41 Archaea are highly diverse microorganisms that inhabit various environments. This evolutionary flexibility and adaptability has been supported by abundant horizontal gene transfer. In this Review, Albers and colleagues discuss the mechanisms and consequences of archaeal DNA transfer. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION Pathways to zoonotic spillover Raina K. Plowright, Colin R. Parrish, Hamish McCallum, Peter J. Hudson, Albert I. Ko, Andrea L. Graham & James O. Lloyd-Smith p502 | doi:10.1038/nrmicro.2017.45 Zoonotic diseases present a substantial global health burden. In this Opinion article, Plowright et al. present an integrative conceptual and quantitative model that reveals that all zoonotic pathogens must overcome a hierarchical series of barriers to cause spillover infections in humans. Abstract | Full Text | PDF | Supplementary information
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