Thursday, July 27, 2017

Nature Reviews Immunology Contents August 2017 Volume 17 Number 8 pp 461-528

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Nature Reviews Immunology

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In this issue
Research Highlights
Focus on: Early life immunology

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 Focus on:
Early life immunology

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A community map of cancer immunity

Immunotherapy is influenced by a complex set of tumour, host and environmental factors. Such factors combine to characterise the immunological status — or cancer-immune set point — of an individual.

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Comment: The theory of disappearing microbiota and the epidemics of chronic diseases
Martin J. Blaser
p461 | doi:10.1038/nri.2017.77
Abstract | Full Text | PDF


Early life immunology: Fetal DCs — born to be mild
p465 | doi:10.1038/nri.2017.79
Fetal dendritic cells suppress pro-inflammatory T cell activity.


NK cell allorecognition

p466 | doi:10.1038/nri.2017.23
Ashley Moffett describes a 1995 paper by Colonna and Samaridis that provided the stiumulus to understanding the link between NK cells and pre-eclampsia.


Haematopoiesis: Osteopontin skews lymphoid-myeloid balance
p466 | doi:10.1038/nri.2017.80
Intracellular and secreted isoforms of osteopontin differentially regulate myeloid progenitors and differentiated lymphoid cells, respectively, through pro- and anti-apoptotic effects.


Type 2 immunity: Hero turns villain in fatty liver
p466 | doi:10.1038/nri.2017.81
Obesity associated non-alcoholic fatty liver disease is associated with pro-fibrotic type 2 immune responses


Tumour vaccines: Personal training by vaccination
p468 | doi:10.1038/nri.2017.88
Two groups have shown that personalized, neoantigen-based tumour vaccines elicit effective T cell responses in patients with advanced melanoma, leading to favourable clinical outcomes. Combination with checkpoint blockade can be of additional benefit.



Asthma and allergy: Vitamin D primes neonatal immune system | Microbiota: Baby bugs can't stop the thugs... | Innate immunity: Alarmins rewire innate immunity in newborns

Nature Reviews Immunology
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  Focus on: Early life immunology
The unique immunological and microbial aspects of pregnancy
Gil Mor, Paulomi Aldo & Ayesha B. Alvero
p469 | doi:10.1038/nri.2017.64
Although healthy pregnancies were traditionally considered to require an anti-inflammatory state, emerging evidence suggests that inflammation is important for a healthy pregnancy. Here, the authors discuss how the immune response varies throughout the main stages of pregnancy, and they consider how bacterial and viral infections can affect immune responses at the maternal-fetal interface.
Abstract | Full Text | PDF

Immunological implications of pregnancy-induced microchimerism
Jeremy M. Kinder, Ina A. Stelzer, Petra C. Arck & Sing Sing Way
p483 | doi:10.1038/nri.2017.38
This Review discusses how genetically discordant microchimeric cells transferred between a mother and her offspring during pregnancy have important implications for definitions of immunological identity and tolerance.
Abstract | Full Text | PDF | Supplementary information

Unique aspects of the perinatal immune system
Xiaoming Zhang, Dania Zhivaki & Richard Lo-Man
p495 | doi:10.1038/nri.2017.54
Why are newborns more vulnerable to infection? Here, the authors explain that it is not the immaturity of the immune system per se, but the unique regulation of immune responses in early life that limits immunity to infection yet allows safe development in utero and the accommodation of microbial colonization at birth.
Abstract | Full Text | PDF

How nutrition and the maternal microbiota shape the neonatal immune system
Andrew J. Macpherson, Mercedes Gomez de Aguero & Stephanie C. Ganal-Vonarburg
p508 | doi:10.1038/nri.2017.58
This Review discusses the importance of the maternal microbiota in shaping the development of the fetus, with a focus on the developing immune system.
Abstract | Full Text | PDF

Early life factors that affect allergy development
Lisa A. Reynolds & B. Brett Finlay
p518 | doi:10.1038/nri.2017.39
Accumulating evidence suggests that environmental experiences during childhood can result in the development of allergies that persist into adulthood. In this Review, the authors present the evidence for specific early life exposures that may tip the balance between tolerance and allergic sensitization.
Abstract | Full Text | PDF

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