Nature Reviews Immunology Contents August 2017 Volume 17 Number 8 pp 461-528

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TABLE OF CONTENTS
August 2017 Volume 17 Number 8		Advertisement
2016 2-year Impact Factor 39.932 Journal Metrics 2-year Median 29	In this issue Comment Research Highlights Focus on: Early life immunology Also this month  Focus on: Early life immunology	An open access, online-only, multidisciplinary research journal dedicated to publishing the most important scientific advances in the life sciences, physical sciences, and engineering fields that are facilitated by spaceflight and analogue platforms. Explore the benefits of submitting your next research article.
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A community map of cancer immunity Immunotherapy is influenced by a complex set of tumour, host and environmental factors. Such factors combine to characterise the immunological status — or cancer-immune set point — of an individual. Collaborate with peers to update, evolve and improve the cancer-immune set point framework
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Comment: The theory of disappearing microbiota and the epidemics of chronic diseases Martin J. Blaser p461 | doi:10.1038/nri.2017.77 Abstract | Full Text | PDF
RESEARCH HIGHLIGHTS Top Early life immunology: Fetal DCs — born to be mild p465 | doi:10.1038/nri.2017.79 Fetal dendritic cells suppress pro-inflammatory T cell activity. PDF JOURNAL CLUB NK cell allorecognition p466 | doi:10.1038/nri.2017.23 Ashley Moffett describes a 1995 paper by Colonna and Samaridis that provided the stiumulus to understanding the link between NK cells and pre-eclampsia. PDF Haematopoiesis: Osteopontin skews lymphoid-myeloid balance p466 | doi:10.1038/nri.2017.80 Intracellular and secreted isoforms of osteopontin differentially regulate myeloid progenitors and differentiated lymphoid cells, respectively, through pro- and anti-apoptotic effects. PDF Type 2 immunity: Hero turns villain in fatty liver p466 | doi:10.1038/nri.2017.81 Obesity associated non-alcoholic fatty liver disease is associated with pro-fibrotic type 2 immune responses PDF Tumour vaccines: Personal training by vaccination p468 | doi:10.1038/nri.2017.88 Two groups have shown that personalized, neoantigen-based tumour vaccines elicit effective T cell responses in patients with advanced melanoma, leading to favourable clinical outcomes. Combination with checkpoint blockade can be of additional benefit. PDF IN BRIEF Asthma and allergy: Vitamin D primes neonatal immune system | Microbiota: Baby bugs can't stop the thugs... | Innate immunity: Alarmins rewire innate immunity in newborns PDF Nature Reviews Immunology JOBS of the week PhD Student in Immunology Saarland University Chairs for Department of Biochemistry and Molecular Biology and Department of Immunology at Peking University The Peking University Health Science Center Postdoctoral position in mucosal immunology Sainte-Justine Hospital Research Center Postdoc in Precision Immunology Assay Development Icahn School of Medicine at Mount Sinai Post-doctoral Research Scholar - Immunology University of California San Diego (UCSD) More Science jobs from Nature Reviews Immunology EVENT Immunology 2018 (CPD accredited) 05.07.18 Vienna, Austria More science events from
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npj Vaccines is an online-only, open access, multidisciplinary journal dedicated to publishing cutting-edge research and development on human and veterinary vaccines. npj Vaccines is now open for submissions. Explore the benefits of submitting your next manuscript to the journal.
Focus on: Early life immunology REVIEWS Top The unique immunological and microbial aspects of pregnancy Gil Mor, Paulomi Aldo & Ayesha B. Alvero p469 | doi:10.1038/nri.2017.64 Although healthy pregnancies were traditionally considered to require an anti-inflammatory state, emerging evidence suggests that inflammation is important for a healthy pregnancy. Here, the authors discuss how the immune response varies throughout the main stages of pregnancy, and they consider how bacterial and viral infections can affect immune responses at the maternal-fetal interface. Abstract | Full Text | PDF Immunological implications of pregnancy-induced microchimerism Jeremy M. Kinder, Ina A. Stelzer, Petra C. Arck & Sing Sing Way p483 | doi:10.1038/nri.2017.38 This Review discusses how genetically discordant microchimeric cells transferred between a mother and her offspring during pregnancy have important implications for definitions of immunological identity and tolerance. Abstract | Full Text | PDF | Supplementary information Unique aspects of the perinatal immune system Xiaoming Zhang, Dania Zhivaki & Richard Lo-Man p495 | doi:10.1038/nri.2017.54 Why are newborns more vulnerable to infection? Here, the authors explain that it is not the immaturity of the immune system per se, but the unique regulation of immune responses in early life that limits immunity to infection yet allows safe development in utero and the accommodation of microbial colonization at birth. Abstract | Full Text | PDF How nutrition and the maternal microbiota shape the neonatal immune system Andrew J. Macpherson, Mercedes Gomez de Aguero & Stephanie C. Ganal-Vonarburg p508 | doi:10.1038/nri.2017.58 This Review discusses the importance of the maternal microbiota in shaping the development of the fetus, with a focus on the developing immune system. Abstract | Full Text | PDF Early life factors that affect allergy development Lisa A. Reynolds & B. Brett Finlay p518 | doi:10.1038/nri.2017.39 Accumulating evidence suggests that environmental experiences during childhood can result in the development of allergies that persist into adulthood. In this Review, the authors present the evidence for specific early life exposures that may tip the balance between tolerance and allergic sensitization. Abstract | Full Text | PDF
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