Monday, July 17, 2017

Nature Reviews Genetics Contents August 2017 Volume 18 Number 8 pp 453-512

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Nature Reviews Genetics

A new open access journal dedicated to publishing the most important scientific advances in all aspects of genomics and its application in the practice of medicine.

Part of the Nature Partner Journals series, the journal is published in partnership with the Center of Excellence in Genomic Medicine Research. 

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August 2017 Volume 18 Number 8
Nature Reviews Genetics cover
2016 2-year Impact Factor 40.282 Journal Metrics 2-year Median 28.5
In this issue
Research Highlights

Also this month
Article series:
Applications of next-generation sequencing
 Featured article:
Dynamic chromatin technologies: from individual molecules to epigenomic regulation in cells
Olivier Cuvier & Beat Fierz

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November 2-3, 2017 | Hanover, Germany


Non-coding RNA: A protective role for TERRA at telomeres
p453 | doi:10.1038/nrg.2017.58

Disease genetics: Repeat expansion disorders — going through a phase
p454 | doi:10.1038/nrg.2017.54

Gene expression: Microglia — environment defines identity
p454 | doi:10.1038/nrg.2017.55

Cancer epigenetics: Therapy-induced transcription is cryptically widespread
p455 | doi:10.1038/nrg.2017.53

Technique: Sizing up tumours with Tuba-seq
p456 | doi:10.1038/nrg.2017.50

Cancer genetics: A 3D view of genome rearrangements
p456 | doi:10.1038/nrg.2017.56

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Article series: Epigenetics
Dynamic chromatin technologies: from individual molecules to epigenomic regulation in cells
Olivier Cuvier & Beat Fierz
p457 | doi:10.1038/nrg.2017.28
A full understanding of chromatin in diverse cellular processes requires the consideration of its dynamics, but most standard chromatin assays provide only a static snapshot. This Review describes various emerging methods for probing chromatin dynamics across a wide range of temporal and spatial scales, and discusses the resulting biological insights.
Abstract | Full Text | PDF

Article series: Applications of next-generation sequencing
Reference standards for next-generation sequencing
Simon A. Hardwick, Ira W. Deveson & Tim R. Mercer
p473 | doi:10.1038/nrg.2017.44
Technical errors can hamper the interpretation of next-generation sequencing (NGS) data, which poses a major challenge for the clinical application of this technology. This Review discusses how reference standards circumvent this issue by calibrating NGS measurements and evaluating diagnostic performance of NGS-based genetic tests.
Abstract | Full Text | PDF

Article series: Applications of next-generation sequencing
Human Y-chromosome variation in the genome-sequencing era
Mark A. Jobling & Chris Tyler-Smith
p485 | doi:10.1038/nrg.2017.36
Genetic variation of the human Y chromosome plays a key part in studies of human evolution, population history, genealogy, forensics and male medical genetics. This Review outlines how next-generation sequencing has contributed to recent progress in these fields.
Abstract | Full Text | PDF

The origin of Metazoa: a unicellular perspective
Arnau Sebé-Pedrós, Bernard M. Degnan & Iñaki Ruiz-Trillo
p498 | doi:10.1038/nrg.2017.21
Multicellular organisms rely on a complex interplay between diverse cell types, but how multicellularity evolved from unicellular ancestors has long been a debated research question. In this Review, the authors describe how comparative and functional genomics have provided valuable insights into the transition between unicellularity and multicellularity, including how various molecular networks have been adopted for multicellular life.
Abstract | Full Text | PDF

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