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Bringing Edman Back to Life
Shimadzu's protein sequencers provide reliable, sensitive N-terminal sequencing to researchers through automated Edman degradation. Software enables compliance with FDA 21 CFR Part 11 guidelines, while easy-to-use data analysis functions simplify operation, data processing and reporting.
Learn more. | | | | | | | | Maternal H3K27me3 controls DNA methylation-independent imprinting Analysis of parental allele-specific chromatin accessibility genome-wide in mouse zygotes and morula embryos, and investigation of the epigenetic mechanisms underlying these allelic sites, identifying maternal H3K27me3 as a DNA methylation-independent mechanism for genomic imprinting. Azusa Inoue, Lan Jiang, Falong Lu et al. | In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target In vivo CRISPR screening reveals that loss of Ptpn2 increases the response of tumour cells to immunotherapy and increases IFNγ signalling, suggesting that PTPN2 inhibition may potentiate the effect of immunotherapies that invoke an IFNγ response. Robert T. Manguso, Hans W. Pope, Margaret D. Zimmer et al. | | Global forest loss disproportionately erodes biodiversity in intact landscapes Deforestation increases the odds of a species being threatened by extinction, and this effect is disproportionately strong in relatively intact landscapes, suggesting that efforts are needed to protect intact forest landscapes and prevent a new wave of extinctions. Matthew G. Betts, Christopher Wolf, William J. Ripple et al. | Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway Therapy-resistant cancer cell states identified across diverse contexts are selectively vulnerable to ferroptotic cell death induced by inhibition of lipid peroxidase pathways converging on GPX4. Vasanthi S. Viswanathan, Matthew J. Ryan, Harshil D. Dhruv et al. | Cysteine protease cathepsin B mediates radiation-induced bystander effects The cysteine protease CPR-4, a cathepsin B homologue, is identified as a radiation-induced bystander effect (RIBE) factor in nematodes in response to ultraviolet or ionizing radiation, and causes inhibition of cell death and increased embryonic lethality. Yu Peng, Man Zhang, Lingjun Zheng et al. | A novel mechanism for mechanosensory-based rheotaxis in larval zebrafish In the absence of visual information, larval zebrafish (Danio rerio) use their mechanosensory lateral line to perform rheotaxis by using flow velocity gradients as navigational cues. Pablo Oteiza, Iris Odstrcil, George Lauder et al. | Unique roles for histone H3K9me states in RNAi and heritable silencing of transcription Heterochromatin formation involves histone H3 methylation, with H3K9me2 defining a distinct heterochromatin state that is transcriptionally permissive and can couple with RNAi, and the transition to non-permissive H3K9me3 required for the epigenetic heritability of heterochromatin. Gloria Jih, Nahid Iglesias, Mark A. Currie et al. | Crystal structures of agonist-bound human cannabinoid receptor CB1 Crystal structures of the human cannabinoid receptor 1 (CB1) bound to the agonists AM11542 and AM841 reveal notable structural rearrangements upon receptor activation, and this flexibility may be a common feature among other G-protein-coupled receptors. Tian Hua, Kiran Vemuri, Spyros P. Nikas et al. | Significant and variable linear polarization during the prompt optical flash of GRB 160625B The prompt optical flash produced by the γ-ray burst GRB 160625B is highly linearly polarized, suggesting that it is produced by fast-cooling synchrotron radiation in a large-scale magnetic field. E. Troja, V. M. Lipunov, C. G. Mundell et al. | Neuromorphic computing with nanoscale spintronic oscillators Spoken-digit recognition using a nanoscale spintronic oscillator that mimics the behaviour of neurons demonstrates the potential of such oscillators for realizing large-scale neural networks in future hardware. Jacob Torrejon, Mathieu Riou, Flavio Abreu Araujo et al. | Spontaneous breaking of rotational symmetry in copper oxide superconductors The electronic nematic phase in copper oxide superconductors is found over a broad range of temperature and doping but is not aligned with the crystal axes. J. Wu, A. T. Bollinger, X. He et al. | Synergy of synthesis, computation and NMR reveals correct baulamycin structures Experimental and computed nuclear magnetic resonance data and an iterative synthetic strategy have revealed the correct structures of the baulamycins, potentially important antimicrobial compounds, allowing them to be chemically synthesized. Jingjing Wu, Paula Lorenzo, Siying Zhong et al. | Synaptic organization of visual space in primary visual cortex Mapping the organization of excitatory inputs onto the dendritic spines of individual mouse visual cortex neurons reveals how inputs representing features from the extended visual scene are organized and establishes a computational unit suited to amplify contours and elongated edges. M. Florencia Iacaruso, Ioana T. Gasler, Sonja B. Hofer | The lysosomal potassium channel TMEM175 adopts a novel tetrameric architecture The lysosomal potassium channel TMEM175 has a tetrameric structure unlike that of the canonical potassium channels, with an hourglass-shaped pore in which isoleucine residues have a key role in channel selectivity. Changkeun Lee, Jiangtao Guo, Weizhong Zeng et al. | | | | |
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