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As of January 2016, the journal only publishes open access content, and legacy subscription content published in Nature Communications prior to 2016 has been made freely accessible. For more information visit our website.
Visit our open access funding page or contact openaccess@nature.com to learn more about APC funding. | | | | | | Latest Articles | View all Articles | | | | | Long-term microdystrophin gene therapy is effective in a canine model of Duchenne muscular dystrophy OPEN | | | Caroline Le Guiner, Laurent Servais, Marie Montus, Thibaut Larcher, Bodvaël Fraysse, Sophie Moullec, Marine Allais, Virginie François, Maeva Dutilleul, Alberto Malerba, Taeyoung Koo, Jean-Laurent Thibaut, Béatrice Matot, Marie Devaux, Johanne Le Duff, Jack-Yves Deschamps, Inès Barthelemy, Stéphane Blot, Isabelle Testault, Karim Wahbi et al. | | | Duchenne muscular dystrophy is a progressive degenerative disease of muscles caused by mutations in the dystrophin gene. Here the authors use AAV vectors to deliver microdystrophin to dogs with muscular dystrophy, and show restoration of dystrophin expression and reduction of symptoms up to 26 months of age. | | | 25 July 2017 | doi: 10.1038/ncomms16105 | | |
| A peptide-based viral inactivator inhibits Zika virus infection in pregnant mice and fetuses OPEN | | | Yufeng Yu, Yong-Qiang Deng, Peng Zou, Qian Wang, Yanyan Dai, Fei Yu, Lanying Du, Na-Na Zhang, Min Tian, Jia-Nan Hao, Yu Meng, Yuan Li, Xiaohui Zhou, Jasper Fuk-Woo Chan, Kwok-Yung Yuen, Cheng-Feng Qin, Shibo Jiang and Lu Lu | | | Zika virus (ZIKV) has spread rapidly in recent years and there is a need for antiviral treatments. Here, the authors develop an antiviral peptide, based on the stem region of ZIKV envelope protein, and show that it is safe in pregnant mice and inhibits ZIKV infection in pregnant mice and fetuses. | | | 25 July 2017 | doi: 10.1038/ncomms15672 | | |
| Inverted battery design as ion generator for interfacing with biosystems OPEN | | | Chengwei Wang, Kun (Kelvin) Fu, Jiaqi Dai, Steven D. Lacey, Yonggang Yao, Glenn Pastel, Lisha Xu, Jianhua Zhang and Liangbing Hu | | | At the molecular level, biological activities involve the transport of ions in a system. Here the authors demonstrate an ‘electron battery’ by inverting the configuration of a traditional Li-ion battery to generate an ionic current to interact with a biosystem for potential biomedical applications. | | | 24 July 2017 | doi: 10.1038/ncomms15609 | | |
| BRG1-SWI/SNF-dependent regulation of the Wt1 transcriptional landscape mediates epicardial activity during heart development and disease OPEN | | | Joaquim Miguel Vieira, Sara Howard, Cristina Villa del Campo, Sveva Bollini, Karina N. Dubé, Megan Masters, Damien N. Barnette, Mala Rohling, Xin Sun, Laura E. Hankins, Daria Gavriouchkina, Ruth Williams, Daniel Metzger, Pierre Chambon, Tatjana Sauka-Spengler, Benjamin Davies and Paul R. Riley | | | Priming of the adult mouse heart with Tβ4 activates dormant epicardium-derived cells to aid repair of injured myocardium. Here, Vieira et al. explain this process and show that Tβ4 binds a chromatin remodeller BRG1 and activates Wt1, the key regulator of epicardial epithelial-to-mesenchymal transformation, by altering the epigenetic landscape of the Wt1 locus. | | | 24 July 2017 | doi: 10.1038/ncomms16034 | | |
| Selective production of arenes via direct lignin upgrading over a niobium-based catalyst OPEN | | | Yi Shao, Qineng Xia, Lin Dong, Xiaohui Liu, Xue Han, Stewart F. Parker, Yongqiang Cheng, Luke L. Daemen, Anibal J. Ramirez-Cuesta, Sihai Yang and Yanqin Wang | | | Lignin is cheap and abundant, and potentially a major source of aromatic compounds. Here the authors show selective production of arenes via hydrodeoxygenation of lignin over Ru/Nb2O5, and mechanistically show the strong influence of the Nb2O5 support on phenolic bond dissociation energies. | | | 24 July 2017 | doi: 10.1038/ncomms16104 | | |
| High performance platinum single atom electrocatalyst for oxygen reduction reaction OPEN | | | Jing Liu, Menggai Jiao, Lanlu Lu, Heather M. Barkholtz, Yuping Li, Ying Wang, Luhua Jiang, Zhijian Wu, Di-jia Liu, Lin Zhuang, Chao Ma, Jie Zeng, Bingsen Zhang, Dangsheng Su, Ping Song, Wei Xing, Weilin Xu, Ying Wang, Zheng Jiang and Gongquan Sun et al. | | | High-performance electrocatalysts for the oxygen reduction reaction (ORR) typically use platinum (Pt), however its high cost is a hindrance to commercial scale up. Here, the authors report a cost-effective, efficient and durable Pt single-atom electrocatalyst for ORR with a Pt utilization of 0.13 gPt kW−1 in a fuel cell. | | | 24 July 2017 | doi: 10.1038/ncomms15938 | | |
| Distribution of high-dimensional entanglement via an intra-city free-space link OPEN | | | Fabian Steinlechner, Sebastian Ecker, Matthias Fink, Bo Liu, Jessica Bavaresco, Marcus Huber, Thomas Scheidl and Rupert Ursin | | | Increasing the dimensionality of entangled states improves robustness and capacity of secure quantum communications, but it requires suitably modified setups. Here the authors report the distribution of high-dimensional polarization and energy-time entangled photons via a 1.2 km-long free-space link. | | | 24 July 2017 | doi: 10.1038/ncomms15971 | | |
| Coherent superpositions of three states for phosphorous donors in silicon prepared using THz radiation OPEN | | | S. Chick, N. Stavrias, K. Saeedi, B. Redlich, P. T. Greenland, G. Matmon, M. Naftaly, C. R. Pidgeon, G. Aeppli and B. N. Murdin | | | Control of the interaction between atoms and their neighbours is important to quantum information processing and has been studied using two states. Here the authors demonstrate a more flexible control using a three-state superposition of donors in silicon using THz quantum beat spectroscopy. | | | 24 July 2017 | doi: 10.1038/ncomms16038 | | |
| Actomyosin drives cancer cell nuclear dysmorphia and threatens genome stability OPEN | | | Tohru Takaki, Marco Montagner, Murielle P. Serres, Maël Le Berre, Matt Russell, Lucy Collinson, Karoly Szuhai, Michael Howell, Simon J. Boulton, Erik Sahai and Mark Petronczki | | | Recent findings suggest that forces acting on the cell nucleus can cause DNA damage, but the mechanisms are unclear. Here Takaki et al. report that actomyosin is a determinant of nuclear shape and that unrestrained contractility elicits nuclear envelope rupture and genome instability in cancer cells. | | | 24 July 2017 | doi: 10.1038/ncomms16013 | | |
| Natural variation of macrophage activation as disease-relevant phenotype predictive of inflammation and cancer survival OPEN | | | Konrad Buscher, Erik Ehinger, Pritha Gupta, Akula Bala Pramod, Dennis Wolf, George Tweet, Calvin Pan, Charles D. Mills, Aldons J. Lusis and Klaus Ley | | | The inter-individual variation of the immune system broadly impacts pathophysiology. Here, the authors use the hybrid mouse diversity panel as a surrogate for human natural immune variation and derive a macrophages gene signature robustly correlating with susceptibility to macrophage-related disorders in humans. | | | 24 July 2017 | doi: 10.1038/ncomms16041 | | |
| Nrp2 is sufficient to instruct circuit formation of mitral-cells to mediate odour-induced attractive social responses OPEN | | | Kasumi Inokuchi, Fumiaki Imamura, Haruki Takeuchi, Ryang Kim, Hiroyuki Okuno, Hirofumi Nishizumi, Haruhiko Bito, Takefumi Kikusui and Hitoshi Sakano | | | Neuropilin 2 (Nrp2) is expressed by a subset of mitral cells in the postero-ventral olfactory bulb in mice. Here the authors show that Nrp2 is sufficient to instruct mitral cell targeting to the anterior part of medial amygdala that modulates olfactory-driven attractive social behaviour. | | | 21 July 2017 | doi: 10.1038/ncomms15977 | | |
| Activity dependent feedback inhibition may maintain head direction signals in mouse presubiculum OPEN | | | Jean Simonnet, Mérie Nassar, Federico Stella, Ivan Cohen, Bertrand Mathon, Charlotte N. Boccara, Richard Miles and Desdemona Fricker | | | Head direction is encoded by cells in the presubiculum, but the role of local circuitry in head direction encoding remains unknown. Here the authors demonstrate how a specific inhibitory neuron type, the Martinotti cell, together with excitatory pyramidal cells supports head direction signals. | | | 20 July 2017 | doi: 10.1038/ncomms16032 | | |
| Biological iron-sulfur storage in a thioferrate-protein nanoparticle OPEN | | | Brian J. Vaccaro, Sonya M. Clarkson, James F. Holden, Dong-Woo Lee, Chang-Hao Wu, Farris L. Poole II, Julien J. H. Cotelesage, Mark J. Hackett, Sahel Mohebbi, Jingchuan Sun, Huilin Li, Michael K. Johnson, Graham N. George and Michael W. W. Adams | | | The biosynthesis of iron-sulfur clusters in anaerobic organisms has not been extensively investigated. Here, the authors identify and characterize a multi-subunit protein that stores iron and sulfur in thioferrate for the assembly of the clusters in Pyrococcus furiosus. | | | 20 July 2017 | doi: 10.1038/ncomms16110 | | |
| Strain-induced skeletal rearrangement of a polycyclic aromatic hydrocarbon on a copper surface OPEN | | | Akitoshi Shiotari, Takahiro Nakae, Kota Iwata, Shigeki Mori, Tetsuo Okujima, Hidemitsu Uno, Hiroshi Sakaguchi and Yoshiaki Sugimoto | | | Mechanical strains can induce chemical transformations otherwise inaccessible by conventional stimuli. Here, the authors show the unusual strain-induced transformation of a polycyclic aromatic hydrocarbon on a metal surface by means of atomic force microscopy. | | | 20 July 2017 | doi: 10.1038/ncomms16089 | | |
| A shape-shifting redox foldase contributes to Proteus mirabilis copper resistance OPEN | | | Emily J. Furlong, Alvin W. Lo, Fabian Kurth, Lakshmanane Premkumar, Makrina Totsika, Maud E. S. Achard, Maria A. Halili, Begoña Heras, Andrew E. Whitten, Hassanul G. Choudhury, Mark A. Schembri and Jennifer L. Martin | | | Bacterial disulfide isomerases shuffle incorrect disulfide bonds. Here, the authors structurally characterize the disulfide isomerase ScsC from Proteus mirabilis and identify a functionally important shape-shifting motif that allows ScsC to adopt a diverse range of conformations and enable swarming in the presence of copper stress. | | | 19 July 2017 | doi: 10.1038/ncomms16065 | | |
| Highly variable recurrence of tsunamis in the 7,400 years before the 2004 Indian Ocean tsunami OPEN | | | Charles M. Rubin, Benjamin P. Horton, Kerry Sieh, Jessica E. Pilarczyk, Patrick Daly, Nazli Ismail and Andrew C. Parnell | | | Tsunamis can be an extremely hazardous event, but understanding their occurrence through past records remains challenging. Here, the authors document tsunami occurrence from a 7,400 year old record of tsunami deposits in a cave in Indonesia, helping us to reconstruct the frequency of earthquakes in the region. | | | 19 July 2017 | doi: 10.1038/ncomms16019 | | |
| Crustal rheology controls on the Tibetan plateau formation during India-Asia convergence OPEN | | | Lin Chen, Fabio A. Capitanio, Lijun Liu and Taras V. Gerya | | | Tibetan plateau deformation is variable, but what controls those variations is still poorly understood. Here, the authors use 3D numerical models to show that the variations observed in lithosphere deformation are controlled by heterogeneities in the strength of the Asian continental crust. | | | 19 July 2017 | doi: 10.1038/ncomms15992 | | |
| Highly-conducting molecular circuits based on antiaromaticity OPEN | | | Shintaro Fujii, Santiago Marqués-González, Ji-Young Shin, Hiroshi Shinokubo, Takuya Masuda, Tomoaki Nishino, Narendra P. Arasu, Héctor Vázquez and Manabu Kiguchi | | | Antiaromatic molecules are predicted to have unusual charge transport properties, but are notoriously unstable and reactive. Here, the authors successfully fabricate an antiaromatic molecular circuit, based on a macrocyclic complex, displaying much higher conductance than its aromatic counterpart. | | | 19 July 2017 | doi: 10.1038/ncomms15984 | | |
| Accumulating the hydride state in the catalytic cycle of [FeFe]-hydrogenases OPEN | | | Martin Winkler, Moritz Senger, Jifu Duan, Julian Esselborn, Florian Wittkamp, Eckhard Hofmann, Ulf-Peter Apfel, Sven Timo Stripp and Thomas Happe | | | Of the four intermediates in the catalytic cycle of [FeFe]-hydrogenases, the hydride state still has eluded characterization. Here, the authors shift the reaction equilibrium for three hydrogenases and enrich the hydride-bound species, characterizing them using a real-time IR spectroscopic technique. | | | 19 July 2017 | doi: 10.1038/ncomms16115 | | |
| Stability of iron-bearing carbonates in the deep Earth’s interior OPEN | | | Valerio Cerantola, Elena Bykova, Ilya Kupenko, Marco Merlini, Leyla Ismailova, Catherine McCammon, Maxim Bykov, Alexandr I. Chumakov, Sylvain Petitgirard, Innokenty Kantor, Volodymyr Svitlyk, Jeroen Jacobs, Michael Hanfland, Mohamed Mezouar, Clemens Prescher, Rudolf Rüffer, Vitali B. Prakapenka and Leonid Dubrovinsky | | | Carbonates are shown to exist in the lower mantle as seen in diamond inclusions, but thermodynamic constraints are poorly understood. Here, the authors synthesise two new iron carbonate compounds and find that self-oxidation-reduction reactions can preserve carbonates in the mantle. | | | 19 July 2017 | doi: 10.1038/ncomms15960 | | |
| Silk micrococoons for protein stabilisation and molecular encapsulation OPEN | | | Ulyana Shimanovich, Francesco S. Ruggeri, Erwin De Genst, Jozef Adamcik, Teresa P. Barros, David Porter, Thomas Müller, Raffaele Mezzenga, Christopher M. Dobson, Fritz Vollrath, Chris Holland and Tuomas P. J. Knowles | | | Silk fibres currently used in biotechnology are chemically reconstituted silk fibroins (RSF), which are more stable than native silk fibroin (NSF) but possess different biophysical properties. Here, the authors use microfluidic droplets to encapsulate and store NSF, preserving their native structure. | | | 19 July 2017 | doi: 10.1038/ncomms15902 | | |
| Universality and chaoticity in ultracold K+KRb chemical reactions OPEN | | | J. F. E. Croft, C. Makrides, M. Li, A. Petrov, B. K. Kendrick, N. Balakrishnan and S. Kotochigova | | | Studying chemical reactions near zero temperature in detail is challenging both in theory and practice. Here the authors report an explicit quantum mechanical study of the benchmark ultracold reaction between a K atom and a KRb molecule, important for future controlled chemistry experiments. | | | 19 July 2017 | doi: 10.1038/ncomms15897 | | |
| TRPV1 regulates excitatory innervation of OLM neurons in the hippocampus OPEN | | | Joaquin I. Hurtado-Zavala, Binu Ramachandran, Saheeb Ahmed, Rashi Halder, Christiane Bolleyer, Ankit Awasthi, Markus A. Stahlberg, Robin J. Wagener, Kristin Anderson, Ryan M. Drenan, Henry A. Lester, Julie M. Miwa, Jochen F. Staiger, Andre Fischer and Camin Dean | | | The role of TRPV1 in the CNS is not fully understood. Here the authors show that TRPV1 is expressed specifically in somatostatin-positive OLM interneurons of the hippocampus, where it promotes excitatory innervation of these cells. | | | 19 July 2017 | doi: 10.1038/ncomms15878 | | |
| Multifunctional nanoparticles as a tissue adhesive and an injectable marker for image-guided procedures OPEN | | | Kwangsoo Shin, Jin Woo Choi, Giho Ko, Seungmin Baik, Dokyoon Kim, Ok Kyu Park, Kyoungbun Lee, Hye Rim Cho, Sang Ihn Han, Soo Hong Lee, Dong Jun Lee, Nohyun Lee, Hyo-Cheol Kim and Taeghwan Hyeon | | | The use of tissue adhesives for the closure of wounds is of growing interest for surgery and trauma management. Here, the authors develop an adhesive that is biocompatible, enables tissue adhesion and also permits real-time imaging due to the presence of contrast agents for multiple modalities. | | | 19 July 2017 | doi: 10.1038/ncomms15807 | | | | | | | | | | |
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