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Visit our open access funding page or contact openaccess@nature.com to learn more about APC funding. | | | | | | Latest Review | View all Reviews | | | | | Fate and freedom in developing neocortical circuits OPEN | | | Denis Jabaudon | | | Proper functioning of the neocortex – the center of higher-order brain functions – depends on the correct assembly of neocortical neural circuits during development. Here the author discusses how cell-intrinsic developmental programs and activity-dependent signals together shape the formation of neocortical circuits. | | | 03 July 2017 | doi: 10.1038/ncomms16042 | | | | | | | | | | Latest Articles | View all Articles | | | | | Eco-evolutionary dynamics in a contemporary human population OPEN | | | Fanie Pelletier, Gabriel Pigeon, Patrick Bergeron, Francine M. Mayer, Mireille Boisvert, Denis Réale and Emmanuel Milot | | | Evolution can occur rapidly enough to influence population growth, though this possibility tends to be discounted for human populations. Here, the authors analyse genealogical records and show that evolution of women’s age at first reproduction contributed significantly to the growth of the île aux Coudres population. | | | 04 July 2017 | doi: 10.1038/ncomms15947 | | |
| Deeply divergent archaic mitochondrial genome provides lower time boundary for African gene flow into Neanderthals OPEN | | | Cosimo Posth, Christoph Wißing, Keiko Kitagawa, Luca Pagani, Laura van Holstein, Fernando Racimo, Kurt Wehrberger, Nicholas J. Conard, Claus Joachim Kind, Hervé Bocherens and Johannes Krause | | | Ancient DNA keeps expanding our understanding of complex genetic relationships between Pleistocene hominins. Here, Posth and colleagues analyse the mitochondrial genome of an archaic human that diverged from other Neanderthals ∼270,000 years ago, providing the minimum age for an African introgression into Neanderthals. | | | 04 July 2017 | doi: 10.1038/ncomms16046 | | |
| AMPA-receptor specific biogenesis complexes control synaptic transmission and intellectual ability OPEN | | | Aline Brechet, Rebecca Buchert, Jochen Schwenk, Sami Boudkkazi, Gerd Zolles, Karine Siquier-Pernet, Irene Schaber, Wolfgang Bildl, Abdelkrim Saadi, Christine Bole-Feysot, Patrick Nitschke, Andre Reis, Heinrich Sticht, Nouriya Al-Sanna’a, Arndt Rolfs, Akos Kulik, Uwe Schulte, Laurence Colleaux, Rami Abou Jamra and Bernd Fakler et al. | | | The biogenesis of AMPA-type glutamate receptor (AMPAR) complexes is only partially understood. Here the authors identify transient assemblies of GluA1-4 proteins and proteins FRRS1l/CPT1c that drive formation of mature AMPAR complexes in the ER. Mutations in FRRS1l are associated with intellectual disability and epilepsy in three families. | | | 04 July 2017 | doi: 10.1038/ncomms15910 | | |
| The m6A pathway facilitates sex determination in Drosophila OPEN | | | Lijuan Kan, Anya V. Grozhik, Jeffrey Vedanayagam, Deepak P. Patil, Nan Pang, Kok-Seong Lim, Yi-Chun Huang, Brian Joseph, Ching-Jung Lin, Vladimir Despic, Jian Guo, Dong Yan, Shu Kondo, Wu-Min Deng, Peter C. Dedon, Samie R. Jaffrey and Eric C. Lai | | | N 6-methyladenosine (m6A) is a conserved RNA modification that has recently emerged as an important regulator of messenger RNA processing and activity. Here, the authors provide evidence that m6A pathway facilitates female-specific splicing of Sxl, regulating sex determination in Drosophila. | | | 04 July 2017 | doi: 10.1038/ncomms15737 | | |
| Structural insights into the mechanism of the membrane integral N-acyltransferase step in bacterial lipoprotein synthesis OPEN | | | Maciej Wiktor, Dietmar Weichert, Nicole Howe, Chia-Ying Huang, Vincent Olieric, Coilín Boland, Jonathan Bailey, Lutz Vogeley, Phillip J. Stansfeld, Nienke Buddelmeijer, Meitian Wang and Martin Caffrey | | | Lipoproteins are essential components of bacterial membranes. Here the authors present the crystal structures of Pseudomonas aeruginosa and Escherichia coli apolipoprotein N-acyltransferase, which catalyses the final step in the lipoprotein synthesis pathway, and give insights into its mechanism. | | | 04 July 2017 | doi: 10.1038/ncomms15952 | | |
| Correlated rotational switching in two-dimensional self-assembled molecular rotor arrays OPEN | | | Natalie A. Wasio, Diana P. Slough, Zachary C. Smith, Christopher J. Ivimey, Samuel W. Thomas III, Yu-Shan Lin and E. Charles H. Sykes | | | Single molecular machines are capable of a variety of functions, but methods to couple motion between them are still lacking. Here, Wasio et al. report the emergent behaviour of spontaneously formed two-dimensional crystals, which display correlated switching of their sub-molecular rotor units. | | | 04 July 2017 | doi: 10.1038/ncomms16057 | | |
| The evolution of host-symbiont dependence OPEN | | | Roberta M. Fisher, Lee M. Henry, Charlie K. Cornwallis, E. Toby Kiers and Stuart A. West | | | Hosts vary in how dependent they are on their beneficial symbionts. Here, Fisher and colleagues analyse the results of symbiont-removal experiments from 106 symbioses in a phylogenetic context and show that host dependence is associated with symbiont transmission mode, function, and genome size. | | | 04 July 2017 | doi: 10.1038/ncomms15973 | | |
| Cytoplasmic E2f4 forms organizing centres for initiation of centriole amplification during multiciliogenesis OPEN | | | Munemasa Mori, Renin Hazan, Paul S. Danielian, John E. Mahoney, Huijun Li, Jining Lu, Emily S. Miller, Xueliang Zhu, Jacqueline A. Lees and Wellington V. Cardoso | | | Multiciliogenesis requires activation of transcriptional and protein assembly programs; however, the mechanisms that initiate the formation of these multiprotein complexes are unclear. Here the authors show that after inducing centriole biogenesis genes, the transcription factor E2f4 is required in the cytoplasm for assembly and nucleation of deuterosomes. | | | 04 July 2017 | doi: 10.1038/ncomms15857 | | |
| Crystal structure of E. coli apolipoprotein N-acyl transferase OPEN | | | Guangyuan Lu, Yingzhi Xu, Kai Zhang, Yong Xiong, He Li, Lei Cui, Xianping Wang, Jizhong Lou, Yujia Zhai, Fei Sun and Xuejun C. Zhang | | | Apolipoprotein N-acyl transferase (Lnt) catalyses the final step in the protein lipidation pathway of Gram-negative bacteria. Here, the authors present the crystal structure of E. coli Lnt, which consists of a transmembrane domain and a nitrilase domain localised at the periplasmic side of the membrane. | | | 04 July 2017 | doi: 10.1038/ncomms15948 | | |
| Cobamide-mediated enzymatic reductive dehalogenation via long-range electron transfer OPEN | | | Cindy Kunze, Martin Bommer, Wilfred R. Hagen, Marie Uksa, Holger Dobbek, Torsten Schubert and Gabriele Diekert | | | Cobalamin-containing reductive dehalogenases from organohalide-respiring bacteria play a key role in the degradation of halogenated organic compounds. Here the authors proposed a catalytic mechanism for dehalogenation that relies on a long-range electron transfer from the cobalt in the centre of the enzyme’s cofactor to the substrate. | | | 03 July 2017 | doi: 10.1038/ncomms15858 | | |
| Transplantation of enteric nervous system stem cells rescues nitric oxide synthase deficient mouse colon OPEN | | | Conor J. McCann, Julie E. Cooper, Dipa Natarajan, Benjamin Jevans, Laura E. Burnett, Alan J. Burns and Nikhil Thapar | | | Isolated human and mouse enteric nervous system stem cells (ENSCs) are capable of integrating and promoting innervation of the mouse colon. Here the authors show that transplantation of mouse ENSCs into a mouse model of human enteric neuropathy restores colon motility. | | | 03 July 2017 | doi: 10.1038/ncomms15937 | | |
| A transcriptomics data-driven gene space accurately predicts liver cytopathology and drug-induced liver injury OPEN | | | Pekka Kohonen, Juuso A. Parkkinen, Egon L. Willighagen, Rebecca Ceder, Krister Wennerberg, Samuel Kaski and Roland C. Grafström | | | Predicting the hepatotoxic effects of new drugs is still a challenge. Using toxicogenomics data, the authors here define a predictive toxicogenomic space (PTGS), the component gene space capturing dose-dependent cytotoxicity, and demonstrate that it can be used to accurately predict drug-induced liver pathology, including human drug-induced liver injury from in vitro data. | | | 03 July 2017 | doi: 10.1038/ncomms15932 | | |
| Compensatory metabolic networks in pancreatic cancers upon perturbation of glutamine metabolism OPEN | | | Douglas E. Biancur, Joao A. Paulo, Beata Małachowska, Maria Quiles Del Rey, Cristovão M. Sousa, Xiaoxu Wang, Albert S. W. Sohn, Gerald C. Chu, Steven P. Gygi, J. Wade Harper, Wojciech Fendler, Joseph D. Mancias and Alec C. Kimmelman | | | Glutaminase inhibition (GLSi) has promising activity against certain cancers. Here, the authors show that GLSi has no effect on multiple mouse models of pancreatic cancer and characterize the metabolic pathways activated in response to GLSi whose concomitant inhibition may have therapeutic utility. | | | 03 July 2017 | doi: 10.1038/ncomms15965 | | |
| A point-of-care microfluidic biochip for quantification of CD64 expression from whole blood for sepsis stratification OPEN | | | U. Hassan, T. Ghonge, B. Reddy Jr., M. Patel, M. Rappleye, I. Taneja, A. Tanna, R. Healey, N. Manusry, Z. Price, T. Jensen, J. Berger, A. Hasnain, E. Flaugher, S. Liu, B. Davis, J. Kumar, K. White and R. Bashir | | | Sepsis is a potentially life–threatening complication of infection and diagnosis depends on rapid assessment of leukocyte count and CD64 expression. Here the authors present a microfluidic chip that can quantify these parameters from minimal amounts of whole blood with no manual processing. | | | 03 July 2017 | doi: 10.1038/ncomms15949 | | |
| Scanning tunnelling spectroscopy of superconductivity on surfaces of LiTi2O4(111) thin films OPEN | | | Yoshinori Okada, Yasunobu Ando, Ryota Shimizu, Emi Minamitani, Susumu Shiraki, Satoshi Watanabe and Taro Hitosugi | | | Atomic and electronic reconstructions at surfaces/interfaces bring about various emergent phenomena. Here, Okada et al. report an unexpected superconducting gap and a long coherence length on the surface of LiTi2O4 (111) thin films. | | | 03 July 2017 | doi: 10.1038/ncomms15975 | | |
| The A-B transition in superfluid helium-3 under confinement in a thin slab geometry OPEN | | | N. Zhelev, T. S. Abhilash, E. N. Smith, R. G. Bennett, X. Rojas, L. Levitin, J. Saunders and J. M. Parpia | | | Superfluid helium-3 provides a clean testing ground for the understanding of quantum phases and their transitions. Here the authors show that when helium is confined in a nanofluidic cavity supercooling across the first-order A–B transition is suppressed, indicating an intrinsic nucleation mechanism. | | | 03 July 2017 | doi: 10.1038/ncomms15963 | | |
| Microwave-free nuclear magnetic resonance at molecular scales OPEN | | | James D. A. Wood, Jean-Philippe Tetienne, David A. Broadway, Liam T. Hall, David A. Simpson, Alastair Stacey and Lloyd C. L. Hollenberg | | | Nitrogen vacancy centres can be used for nanoscale nuclear magnetic resonance detection but this typically involves strong microwave control pulses, making practical realizations difficult. Here the authors demonstrate a microwave-free spectroscopic protocol that can detect spins in external samples. | | | 03 July 2017 | doi: 10.1038/ncomms15950 | | |
| Revising the hygroscopicity of inorganic sea salt particles OPEN | | | P. Zieger, O. Väisänen, J. C. Corbin, D. G. Partridge, S. Bastelberger, M. Mousavi-Fard, B. Rosati, M. Gysel, U. K. Krieger, C. Leck, A. Nenes, I. Riipinen, A. Virtanen and M. E. Salter | | | Sea spray, one of the largest natural aerosol sources, plays an important role in the Earth’s radiative budget. Here the authors show that the ability of sea salt particles to take up water is smaller than for pure salt, with implications for the parameterization of the direct aerosol radiative effect. | | | 03 July 2017 | doi: 10.1038/ncomms15883 | | |
| Universal features of amorphous plasticity OPEN | | | Zoe Budrikis, David Fernandez Castellanos, Stefan Sandfeld, Michael Zaiser and Stefano Zapperi | | | The universality class for plastic yield in amorphous materials remains controversial. Here authors present a tensorial mesoscale model that captures both complex shear patterns and avalanche scaling behaviour, which differs from mean-field models and suggests a distinct type of critical phenomenon. | | | 03 July 2017 | doi: 10.1038/ncomms15928 | | |
| Cryo-EM structure of haemoglobin at 3.2 Å determined with the Volta phase plate OPEN | | | Maryam Khoshouei, Mazdak Radjainia, Wolfgang Baumeister and Radostin Danev | | | Single particle cryo-EM is commonly used for the structure determination of large complexes. Here, the authors present the 3.2 Å resolution cryo-EM structure of human haemoglobin, which has a molecular weight of 64 kDa. | | | 30 June 2017 | doi: 10.1038/ncomms16099 | | |
| Magnetic turbulence in a table-top laser-plasma relevant to astrophysical scenarios OPEN | | | Gourab Chatterjee, Kevin M. Schoeffler, Prashant Kumar Singh, Amitava Adak, Amit D. Lad, Sudip Sengupta, Predhiman Kaw, Luis O. Silva, Amita Das and G. Ravindra Kumar | | | Understanding the role of magnetic turbulence in the atmosphere is difficult as direct access is limited, but latest laser technology can enable such studies in the lab. Here the authors probe the evolution of such turbulence in laser-generated plasma with its implications to astrophysical environments. | | | 30 June 2017 | doi: 10.1038/ncomms15970 | | |
| Polar rotor scattering as atomic-level origin of low mobility and thermal conductivity of perovskite CH3NH3PbI3 OPEN | | | Bing Li, Yukinobu Kawakita, Yucheng Liu, Mingchao Wang, Masato Matsuura, Kaoru Shibata, Seiko Ohira-Kawamura, Takeshi Yamada, Shangchao Lin, Kenji Nakajima and Shengzhong (Frank) Liu | | | Clarifying the atomistic behaviour of materials will lead to a deeper fundamental understanding and the rational design of future materials. Using time-of-flight quasi-elastic and inelastic neutron scattering measurements Li et al. study the atomic motions of metal-halide perovskite CH3NH3PbI3. | | | 30 June 2017 | doi: 10.1038/ncomms16086 | | |
| Ultrafast water sensing and thermal imaging by a metal-organic framework with switchable luminescence OPEN | | | Ling Chen, Jia-Wen Ye, Hai-Ping Wang, Mei Pan, Shao-Yun Yin, Zhang-Wen Wei, Lu-Yin Zhang, Kai Wu, Ya-Nan Fan and Cheng-Yong Su | | | Fast and sensitive detection of water molecules in organic solvents and gases remains an important challenge. Here, Pan and co-workers design a metal-organic framework capable of ultrafast and reversible water sensing by photoluminescence switching via an excited state intramolecular proton transfer mechanism. | | | 30 June 2017 | doi: 10.1038/ncomms15985 | | |
| Giant linear strain gradient with extremely low elastic energy in a perovskite nanostructure array OPEN | | | Y. L. Tang, Y. L. Zhu, Y. Liu, Y. J. Wang and X. L. Ma | | | Inherent elastic strains are useful to tune the physical properties of functional materials but it is difficult to build. Here, Tang et al. report a fabrication of inhomogeneous strains with a linear gradient as giant as 106 per meter in a BiFeO3 nanostructure array grown on a LaAlO3 substrate. | | | 30 June 2017 | doi: 10.1038/ncomms15994 | | |
| Single-molecule quantum dot as a Kondo simulator OPEN | | | R. Hiraoka, E. Minamitani, R. Arafune, N. Tsukahara, S. Watanabe, M. Kawai and N. Takagi | | | Tuning the structure in the atomic scale enables manipulation of the quantum state in a molecular based system. Here, Hiraoka et al. tune the Kondo coupling between molecular spins and the Au electrode by controlling the position of Fe2+ ions in the molecular cage with a tip. | | | 30 June 2017 | doi: 10.1038/ncomms16012 | | |
| GroEL actively stimulates folding of the endogenous substrate protein PepQ OPEN | | | Jeremy Weaver, Mengqiu Jiang, Andrew Roth, Jason Puchalla, Junjie Zhang and Hays S. Rye | | | In the prevailing model for assisted protein folding, chaperonins act passively by preventing protein aggregation. Here, the authors use single-molecule fluorescence measurements and cryo-electron microscopy and show that the E. coli GroELS chaperonin system also has an active role in folding the endogenous bacterial protein PepQ. | | | 30 June 2017 | doi: 10.1038/ncomms15934 | | |
| Alternative splicing promotes tumour aggressiveness and drug resistance in African American prostate cancer OPEN | | | Bi-Dar Wang, Kristin Ceniccola, SuJin Hwang, Ramez Andrawis, Anelia Horvath, Jennifer A. Freedman, Jacqueline Olender, Stefan Knapp, Travers Ching, Lana Garmire, Vyomesh Patel, Mariano A. Garcia-Blanco, Steven R. Patierno and Norman H. Lee | | | In prostate cancer tumour aggressiveness can be related to race. Here, the authors identify an alternative RNA splice variant of PIK3CD as a potential mechanism to explain racial disparities in the incidence and aggressiveness of prostate cancer between African American and European American men. | | | 30 June 2017 | doi: 10.1038/ncomms15921 | | |
| Damage tolerance of nuclear graphite at elevated temperatures OPEN | | | Dong Liu, Bernd Gludovatz, Harold S. Barnard, Martin Kuball and Robert O. Ritchie | | | Nuclear-grade graphite is an important high-temperature structural material for fission reactors. Here, the authors perform simultaneous X-ray tomography and mechanical testing on a nuclear-grade graphite, finding simultaneous improvement of strength and toughness at elevated temperatures which they attribute primarily to reduction of residual tensile stresses in the as-made material. | | | 30 June 2017 | doi: 10.1038/ncomms15942 | | |
| Imaging the real space structure of the spin fluctuations in an iron-based superconductor OPEN | | | Shun Chi, Ramakrishna Aluru, Stephanie Grothe, A. Kreisel, Udai Raj Singh, Brian M. Andersen, W. N. Hardy, Ruixing Liang, D. A. Bonn, S. A. Burke and Peter Wahl | | | The knowledge of how spin fluctuations affect high-Tc superconductivity comes exclusively from neutron scattering. Here, Chi et al. establish characteristic excitation features of the spin fluctuations in real space from the scanning tunnelling spectra in an iron-based superconductor. | | | 29 June 2017 | doi: 10.1038/ncomms15996 | | |
| Understanding dynamic friction through spontaneously evolving laboratory earthquakes OPEN | | | V. Rubino, A. J. Rosakis and N. Lapusta | | | The role of friction is key to understanding how faults may rupture and generate earthquakes. Here, the authors capture the local evolution of dynamic friction in laboratory experiments via a new approach using a high-speed imaging technique, which may be used to understand the frictional resistance of faults. | | | 29 June 2017 | doi: 10.1038/ncomms15991 | | |
| Myosin 7 and its adaptors link cadherins to actin OPEN | | | I-Mei Yu, Vicente J. Planelles-Herrero, Yannick Sourigues, Dihia Moussaoui, Helena Sirkia, Carlos Kikuti, David Stroebel, Margaret A. Titus and Anne Houdusse | | | Cadherin is essential for mechanotransduction and myosin-adaptor-harmonin complexes anchor it to actin. Here the authors present the structures of myosin 7 MF2 domains bound to the harmonin PDZ3c domain and give insights into myosin-adaptor-harmonin complex assembly. | | | 29 June 2017 | doi: 10.1038/ncomms15864 | | |
| Sodium vanadium titanium phosphate electrode for symmetric sodium-ion batteries with high power and long lifespan OPEN | | | Dongxue Wang, Xiaofei Bie, Qiang Fu, Ditty Dixon, Natalia Bramnik, Yong-Sheng Hu, Francois Fauth, Yingjin Wei, Helmut Ehrenberg, Gang Chen and Fei Du | | | Discovering suitable electrodes is a challenge for the development of sodium-ion batteries. Here the authors demonstrate a high-performance symmetric battery based on Na2VTi(PO4)3, highlighting its potential application in a smart grid. | | | 29 June 2017 | doi: 10.1038/ncomms15888 | | |
| Jahn-Teller distortion driven magnetic polarons in magnetite OPEN | | | H. Y. Huang, Z. Y. Chen, R. -P. Wang, F. M. F. de Groot, W. B. Wu, J. Okamoto, A. Chainani, A. Singh, Z. -Y. Li, J. -S. Zhou, H. -T. Jeng, G. Y. Guo, Je-Geun Park, L. H. Tjeng, C. T. Chen and D. J. Huang | | | The Verwey transition of magnetite is complex due to the coexistence of strong correlations and electron-phonon coupling. Here, the authors use resonant inelastic X-ray scattering to show evidence for magnetic polarons in magnetite and provide insight into the nature of the transition. | | | 29 June 2017 | doi: 10.1038/ncomms15929 | | |
| Clustering of arc volcanoes caused by temperature perturbations in the back-arc mantle OPEN | | | Changyeol Lee and Ikuko Wada | | | Volcanoes may cluster along volcanic arcs, but controls on cluster locations are still unclear. Here, using numerical models, the authors show that clustering along arcs is the result of inflow of hotter mantle material, and subdued inflow of colder material creating a 3D mantle flow pattern. | | | 29 June 2017 | doi: 10.1038/ncomms15753 | | |
| Ten-eleven translocation 2 interacts with forkhead box O3 and regulates adult neurogenesis OPEN | | | Xuekun Li, Bing Yao, Li Chen, Yunhee Kang, Yujing Li, Ying Cheng, Liping Li, Li Lin, Zhiqin Wang, Mengli Wang, Feng Pan, Qing Dai, Wei Zhang, Hao Wu, Qiang Shu, Zhaohui Qin, Chuan He, Mingjiang Xu and Peng Jin | | | Epigenetic modifications, such as DNA methylation, play an important role in adult neurogenesis. Here the authors show that Tet2, which converts 5mC to 5hmC, interacts with the transcription factor Foxo3a and regulates critical genes related to the proliferation and differentiation of adult neural stem cells. | | | 29 June 2017 | doi: 10.1038/ncomms15903 | | |
| Common mechanism of thermodynamic and mechanical origin for ageing and crystallization of glasses OPEN | | | Taiki Yanagishima, John Russo and Hajime Tanaka | | | Glass is characterized by stochastic and slow structural relaxation dynamics, whose details remain elusive due to its complicated kinetic processes. Here, the authors show that avalanche-like dynamics in both ageing and devitrifying glasses are governed by thermodynamic initiation and a transient loss in mechanical stability. | | | 29 June 2017 | doi: 10.1038/ncomms15954 | | |
| Virus-host relationships of marine single-celled eukaryotes resolved from metatranscriptomics OPEN | | | Mohammad Moniruzzaman, Louie L. Wurch, Harriet Alexander, Sonya T. Dyhrman, Christopher J. Gobler and Steven W. Wilhelm | | | Viruses are partners in ecosystem ecology, yet their study has been primarily limited to laboratory models virus-host or derived from metagenomics. Here, Moniruzzaman et al. use metatranscriptomics to resolve interactions between giant viruses and single-celled eukaryotic hosts. | | | 28 June 2017 | doi: 10.1038/ncomms16054 | | |
| Polyaromatic molecular peanuts OPEN | | | Kohei Yazaki, Munetaka Akita, Soumyakanta Prusty, Dillip Kumar Chand, Takashi Kikuchi, Hiroyasu Sato and Michito Yoshizawa | | | The complex, multicomponent structures often found in nature are difficult to mimic synthetically. Here, the authors assemble a molecular analogue of a peanut through coordinative and π-stacking interactions, in which a polyaromatic double capsule ‘pod’ held together by metal ions encapsulates fullerene ‘beans’. | | | 28 June 2017 | doi: 10.1038/ncomms15914 | | |
| Neutral and charged inter-valley biexcitons in monolayer MoSe2 OPEN | | | Kai Hao, Judith F. Specht, Philipp Nagler, Lixiang Xu, Kha Tran, Akshay Singh, Chandriker Kavir Dass, Christian Schüller, Tobias Korn, Marten Richter, Andreas Knorr, Xiaoqin Li and Galan Moody | | | Atomically thin transition metal dichalcogenides host excitons and trions, however higher-order states, although possible, are difficult to identify experimentally. Here, the authors perform polarization-resolved coherent spectroscopy to unveil the signature of neutral and charged inter-valley biexcitons in monolayer MoSe2. | | | 28 June 2017 | doi: 10.1038/ncomms15552 | | |
| Exsolution trends and co-segregation aspects of self-grown catalyst nanoparticles in perovskites OPEN | | | Ohhun Kwon, Sivaprakash Sengodan, Kyeounghak Kim, Gihyeon Kim, Hu Young Jeong, Jeeyoung Shin, Young-Wan Ju, Jeong Woo Han and Guntae Kim | | | Exsolution of transition metals from perovskites provides an effective route to useful catalysts, but the underlying factors governing exsolution remain poorly understood. Here, the authors find trends in exsolution in layered perovskites, showing that co-segregation of B-site dopant and oxygen vacancies plays a central role. | | | 28 June 2017 | doi: 10.1038/ncomms15967 | | |
| E3 Ubiquitin ligase ZNRF4 negatively regulates NOD2 signalling and induces tolerance to MDP OPEN | | | Pradeep Bist, Wan Shoo Cheong, Aylwin Ng, Neha Dikshit, Bae-Hoon Kim, Niyas Kudukkil Pulloor, Hanif Javanmard Khameneh, Matija Hedl, Avinash R. Shenoy, Vanniarajan Balamuralidhar, Najib Bin Abdul Malik, Michelle Hong, Albert Neutzner, Keh-Chuang Chin, Koichi S. Kobayashi, Antonio Bertoletti, Alessandra Mortellaro, Clara Abraham, John D. MacMicking, Ramnik J. Xavier et al. | | | Prolonged NOD2 ligand engagement induces tolerance and attenuated NOD2 signalling, but the molecular mechanisms leading to this tolerance induction are unclear. Here the authors show that the degradation of a NOD2 adaptor, RIP2, by the E3 ligase ZNRF4 is essential for the down-regulation of NOD2 signalling. | | | 28 June 2017 | doi: 10.1038/ncomms15865 | | |
| Light controlled 3D micromotors powered by bacteria OPEN | | | Gaszton Vizsnyiczai, Giacomo Frangipane, Claudio Maggi, Filippo Saglimbeni, Silvio Bianchi and Roberto Di Leonardo | | | Bacteria are able to propel themselves and thus drive systems out of equilibrium. Here the authors aim to control this motion and exploit it in microengineered motors which are powered by genetically modified bacteria and driven by light. | | | 28 June 2017 | doi: 10.1038/ncomms15974 | | |
| MARK4 regulates NLRP3 positioning and inflammasome activation through a microtubule-dependent mechanism OPEN | | | Xuan Li, Sarah Thome, Xiaodan Ma, Mamta Amrute-Nayak, Alison Finigan, Lauren Kitt, Leanne Masters, John R. James, Yuguang Shi, Guoyu Meng and Ziad Mallat | | | Microtubules regulate activation of the NLRP3 inflammasome, but the underlying molecular mechanism is unclear. Here the authors show that MARK4 binds NLRP3 and shuttles it to the microtubule-organizing centre to promote optimal inflammasome activation. | | | 28 June 2017 | doi: 10.1038/ncomms15986 | | |
| Neurovascular EGFL7 regulates adult neurogenesis in the subventricular zone and thereby affects olfactory perception OPEN | | | Frank Bicker, Verica Vasic, Guilherme Horta, Felipe Ortega, Hendrik Nolte, Atria Kavyanifar, Stefanie Keller, Nevenka Dudvarski Stankovic, Patrick N. Harter, Rui Benedito, Beat Lutz, Tobias Bäuerle, Jens Hartwig, Jan Baumgart, Marcus Krüger, Konstantin Radyushkin, Lavinia Alberi, Benedikt Berninger and Mirko H. H. Schmidt | | | The vascular stem cell niche regulates the proliferation and differentiation of neural stem cells (NSCs) in the adult subventricular zone. Here the authors identify EGFL7 as a neurovascular regulator of NSCs in vivo; EGFL7-knockout mice show reduced neurogenesis, and exhibit impaired olfactory perception and behaviour. | | | 28 June 2017 | doi: 10.1038/ncomms15922 | | |
| Negative regulation of EGFR signalling by the human folliculin tumour suppressor protein OPEN | | | Laura A. Laviolette, Julien Mermoud, Isabel A. Calvo, Nicholas Olson, Myriam Boukhali, Ortrud K. Steinlein, Elisabeth Roider, Elke C. Sattler, Dachuan Huang, Bin Tean Teh, Mo Motamedi, Wilhelm Haas and Othon Iliopoulos | | | Folliculin is a known tumour suppressor but the molecular mechanisms behind this function are unclear. Here the authors show that Folliculin regulates EGFR signalling by modulating its Rab7a-dependent trafficking. | | | 28 June 2017 | doi: 10.1038/ncomms15866 | | |
| Critical mingling and universal correlations in model binary active liquids OPEN | | | Nicolas Bain and Denis Bartolo | | | Self-driven particles can drive the system out of equilibrium without the help of external forces. Here Bain et al. develop a model for two groups of motile bodies targeting opposite directions and show that the system exhibits critical behaviour as a function of particle density. | | | 28 June 2017 | doi: 10.1038/ncomms15969 | | |
| Ensemble-averaged Rabi oscillations in a ferromagnetic CoFeB film OPEN | | | Amir Capua, Charles Rettner, See-Hun Yang, Timothy Phung and Stuart S. P. Parkin | | | External driving of Rabi oscillations is a first step in the coherent manipulation of spin systems. Here the authors use ultrafast optical pulses to produce classical Rabi oscillations in ferromagnetic CoFeB, enabling the exploration of coherent phenomena in dense ferromagnetic ensembles. | | | 28 June 2017 | doi: 10.1038/ncomms16004 | | | | | | | | | | | | | Latest Corrigenda | | | | | | Corrigendum: Leukocyte integrin Mac-1 regulates thrombosis via interaction with platelet GPIbα OPEN | | | Yunmei Wang, Huiyun Gao, Can Shi, Paul W. Erhardt, Alexander Pavlovsky, Dmitry A. Soloviev, Kamila Bledzka, Valentin Ustinov, Liang Zhu, Jun Qin, Adam D. Munday, Jose Lopez, Edward Plow and Daniel I. Simon | | | 04 July 2017 | doi: 10.1038/ncomms16124 | | |
| | | | | Corrigendum: The genetic landscape of benign thyroid nodules revealed by whole exome and transcriptome sequencing OPEN | | | Lei Ye, Xiaoyi Zhou, Fengjiao Huang, Weixi Wang, Yicheng Qi, Heng Xu, Yang Shu, Liyun Shen, Xiaochun Fei, Jing Xie, Min Cao, Yulin Zhou, Wei Zhu, Shu Wang, Guang Ning and Weiqing Wang | | | 04 July 2017 | doi: 10.1038/ncomms16129 | | |
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