Nature Chemistry Contents August 2017 Volume 9 Number 8 pp 725 - 830

If you are unable to see the message below, click here to view.

Advertisement npj Clean Water: open for submissions  An open access, online-only journal, dedicated to publishing high-quality papers that describe the significant and cutting-edge research that continues to ensure the supply of clean water to populations. Explore the benefits of submitting your next manuscript. TABLE OF CONTENTS August 2017 Volume 9, Issue 8 Thesis News and Views Correction Review Articles Retractions Addendum In Your Element Advertisement   Nature Reviews Materials is an online-only, materials science journal that provides an accurate and balanced discussion on a chosen topic, together with an authoritative voice from experienced researchers. Spanning physics, chemistry, biology and engineering, the journal publishes a broad range of Reviews and Comments from world-leading scientists. EXPLORE THE JOURNAL NOW Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement Nature Catalysis is a new online-only journal that will publish work on all areas of catalysis. The journal will provide coverage of the science and business of catalysis research, creating a unique journal for scientists, engineers, and researchers in industry. Nature Catalysis is launching in January 2018 and is now open for submissions.  SUBMIT YOUR RESEARCH TODAY   Advertisement Nature Reviews Chemistry is an online-only journal that provides both an introduction to chemists embarking on a new topic of investigation and thought-provoking, in-depth sections for the expert. The journal also publishes regular columns which focus on the teaching of chemistry and on the translation of research into business opportunities. EXPLORE THE JOURNAL NOW   Thesis Top 101 libations   pp725 - 726 Bruce C. Gibb doi:10.1038/nchem.2832 Bruce C. Gibb takes a look at the complex cocktail of chemical compounds that make up gin. News and Views Top Cytosolic delivery: Just passing through   pp727 - 728 Macarena Sanchez-Navarro, Meritxell Teixidó and Ernest Giralt doi:10.1038/nchem.2837 Intracellular protein delivery has been a major challenge in the field of cell biology for decades. Engineering such delivery is a key step in the development of protein- and antibody-based therapeutics. Now, two different approaches that enable the delivery of antibodies and antibody fragments into the cytosol have been developed. See also: Article by Akishiba et al. | Article by Herce et al. Photosynthesis: Nature's power switching station   pp728 - 730 Peter J. Walla doi:10.1038/nchem.2838 The flow of energy in Earth's primary light harvesters — photosynthetic pigment–protein complexes — needs to be heavily regulated, as the sun's energy supply can vary over many orders of magnitude. Observing hundreds of individual light-harvesting complexes has now provided important insights into the machinery that regulates this process. See also: Article by Kondo et al. Correction Correction   p730 doi:10.1038/nchem.2827 Chemistry JOBS of the week Two (Full-) Professors for Physical Chemistry (Pay Grade: W3) University of Bayreuth Assistant Professor (Tenure Track) of Inorganic Chemistry ETH Zurich - The Swiss Federal Institute of Technology in Zurich Institute Research Investigator - Medicinal Chemistry MD Anderson Cancer Center Faculty Position of Chemistry Southern University of Science and Technology (SUSTech) Postdoctoral Scholars: Nucleic Acid Chemistry and Synthetic Biology Okinawa Institute of Science and Technology (OIST) More Science jobs from Chemistry EVENT ICCCP 2018 8th International Conference on Chemistry and Chemical Process (ICCCP 2018) 23.02.18 Nha Trang, Vietnam More science events from Review Top The versatility of boron in biological target engagement   pp731 - 742 Diego B. Diaz and Andrei K. Yudin doi:10.1038/nchem.2814 Recent years have witnessed a surge of interest in targeted covalent inhibition of disease-associated proteins. Among the electrophiles used to interact with nucleophilic residues in protein structures, boron is unique for its chameleonic ability to display a range of coordination modes upon interaction with protein targets. Advertisement npj Materials Degradation is a new open access journal that is now open for submissions. The journal publishes the finest content describing basic and applied research discoveries in the area of corrosion (degradation) and protection of materials.  Sign up for article e-alerts >>    Articles Top Main-chain metallopolymers at the static–dynamic boundary based on nickelocene   pp743 - 750 Rebecca A. Musgrave, Andrew D. Russell, Dominic W. Hayward, George R. Whittell, Paul G. Lawrence et al. doi:10.1038/nchem.2743 Main-chain polymetallocenes are typically static in nature due to strong metal–ligand bonding. Now, it has been shown that such polymers based on nickelocene are dynamic due to weaker nickel–cyclopentadienyl interactions, and at low concentration or at elevated temperature, depolymerization to the moderately strained monomer occurs. Chemical compounds Cytosolic antibody delivery by lipid-sensitive endosomolytic peptide   pp751 - 761 Misao Akishiba, Toshihide Takeuchi, Yoshimasa Kawaguchi, Kentarou Sakamoto, Hao-Hsin Yu et al. doi:10.1038/nchem.2779 The trapping of antibodies in endosomes often limits their use for intracellular targeting. Now, a single amino acid substitution on a spider-venom peptide has been shown to attenuate the cell membrane lytic activity and enables the selective rupturing of endosomal membranes. The peptide can be used to facilitate the escape of antibodies from endosomes into the cytosol. See also: News and Views by Sanchez-Navarro et al. Cell-permeable nanobodies for targeted immunolabelling and antigen manipulation in living cells   pp762 - 771 Henry D. Herce, Dominik Schumacher, Anselm F. L. Schneider, Anne K. Ludwig, Florian A. Mann et al. doi:10.1038/nchem.2811 Delivery of antibodies into living cells enables the labelling and manipulation of intracellular antigens; however, transporting antibodies into the cytosol in a functional state is difficult. Now, a modular strategy for creating cell-permeable nanobodies capable of targeting intracellular antigens has been developed. The cell-permeable nanobodies are formed by site-specific attachment of cyclic arginine-rich cell-penetrating peptides to camelid-derived single-chain antibody fragments. See also: News and Views by Sanchez-Navarro et al. Single-molecule spectroscopy of LHCSR1 protein dynamics identifies two distinct states responsible for multi-timescale photosynthetic photoprotection   pp772 - 778 Toru Kondo, Alberta Pinnola, Wei Jia Chen, Luca Dall'Osto, Roberto Bassi et al. doi:10.1038/nchem.2818 Photoprotection is crucial for the fitness of organisms that carry out oxygenic photosynthesis. LHCSR, a photosynthetic light-harvesting complex, has been implicated in photoprotection in green algae and moss. Now, single-molecule studies of LHCSR have revealed that multi-timescale protein dynamics underlie photoprotective dissipation of excess energy. See also: News and Views by Walla Parameterization of phosphine ligands demonstrates enhancement of nickel catalysis via remote steric effects   pp779 - 784 Kevin Wu and Abigail G. Doyle doi:10.1038/nchem.2741 Ligand development underlies many advances in Pd-catalysed cross coupling but has seen limited application in the growing field of Ni catalysis. Now, a phosphine framework is shown to enable Ni-catalysed Suzuki coupling of acetals. Parameterization studies provide structural insight into ligand success and a quantitative model to facilitate further ligand design. Chemical compounds Scalable and uniform 1D nanoparticles by synchronous polymerization, crystallization and self-assembly   pp785 - 792 Charlotte E. Boott, Jessica Gwyther, Robert L. Harniman, Dominic W. Hayward and Ian Manners doi:10.1038/nchem.2721 A scalable, one-pot, solution-based protocol for the controlled synthesis of uniform non-spherical block copolymer micelles is a desirable but challenging target. Now, a polymerization-induced crystallization-driven self-assembly process has been developed that offers facile access to 1D and platelet micelle morphologies and to near monodisperse cylinders of controlled length. Unified biomimetic assembly of voacalgine A and bipleiophylline via divergent oxidative couplings   pp793 - 798 David Lachkar, Natacha Denizot, Guillaume Bernadat, Kadiria Ahamada, Mehdi A. Beniddir et al. doi:10.1038/nchem.2735 The biomimetic syntheses of bipleiophylline, one of the most complex monoterpene indole alkaloids, and voacalgine A, its biosynthetic precursor, have been achieved from pleiocarpamine starting material. The development of a divergent oxidative coupling for the formation of the benzofuro[2,3-b]indolenine and isochromano[3,4-b]indolenine moieties was key to this accomplishment. Chemical compounds Design of multi-phase dynamic chemical networks   pp799 - 804 Chenrui Chen, Junjun Tan, Ming-Chien Hsieh, Ting Pan, Jay T. Goodwin et al. doi:10.1038/nchem.2737 Di- and tripeptide building blocks in which the C-terminus has been converted into an aldehyde are shown to form dynamic chemical networks through imine condensation followed by the formation of cyclic N,N-acetals. The networks exhibit multi-phase growth of prion-like assemblies that template the formation of chain-length-specific peptide-like oligomers. Chemical compounds See also: Article by Omosun et al. Catalytic diversity in self-propagating peptide assemblies   pp805 - 809 Tolulope O. Omosun, Ming-Chien Hsieh, W. Seth Childers, Dibyendu Das, Anil K. Mehta et al. doi:10.1038/nchem.2738 Simple peptides are shown to assemble into well-defined amyloid phases with paracrystalline surfaces that can catalyse reactions in an enantioselective manner. Modifying individual amino acids in the building blocks enables the structure of the assembled aggregates, and the reactions that they can catalyse, to be controlled predictably. Chemical compounds See also: Article by Chen et al. MoS2 monolayer catalyst doped with isolated Co atoms for the hydrodeoxygenation reaction   pp810 - 816 Guoliang Liu, Alex W. Robertson, Molly Meng-Jung Li, Winson C. H. Kuo, Matthew T. Darby et al. doi:10.1038/nchem.2740 Converting oxygen-rich biomass into fuels requires the removal of oxygen groups through hydrodeoxygenation. MoS2 monolayer sheets decorated with isolated Co atoms bound to sulfur vacancies in the basal plane have now been synthesized that exhibit superior catalytic activity, selectivity and stability for the hydrodeoxygenation of 4-methylphenol to toluene when compared to conventionally prepared materials. Macromolecular metamorphosis via stimulus-induced transformations of polymer architecture   pp817 - 823 Hao Sun, Christopher P. Kabb, Yuqiong Dai, Megan R. Hill, Ion Ghiviriga et al. doi:10.1038/nchem.2730 Many properties of polymers are dictated by topology. However, the topology of a macromolecule is typically a static feature after synthesis. Now, an approach to dynamic and transformable macromolecular architecture has been developed. When triggered by an external stimulus, macromolecular topology can be triggered to transform via thermodynamic control. A device that operates within a self-assembled 3D DNA crystal   pp824 - 827 Yudong Hao, Martin Kristiansen, Ruojie Sha, Jens J. Birktoft, Carina Hernandez et al. doi:10.1038/nchem.2745 Although DNA nanotechnology has found many applications in developing functional structures, there has never been an independent device contained within a 3D crystal. Now, a self-assembled three-state device that can change the colour of its crystal by diffusion of DNA-ligated dyes has been reported, representing the potential to develop programmable nanomechanical devices. Advertisement An open access, online-only, multidisciplinary research journal dedicated to publishing the most important scientific advances in the life sciences, physical sciences, and engineering fields that are facilitated by spaceflight and analogue platforms.  Explore the benefits of submitting your next research article >>    Addendum Top Addendum: Activating lattice oxygen redox reactions in metal oxides to catalyse oxygen evolution   p828 Alexis Grimaud, Oscar Diaz-Morales, Binghong Han, Wesley T. Hong, Yueh-Lin Lee et al. doi:10.1038/nchem.2819 Retractions Top Retraction: Charge transfer to solvent identified using dark channel fluorescence-yield L-edge spectroscopy   p828 Emad F. Aziz, M. Hannelore Rittmann-Frank, Kathrin M. Lange, Sebastien Bonhommeau and Majed Chergui doi:10.1038/nchem.2830 Retraction: Transferring electrons to water   p828 Anders Nilsson doi:10.1038/nchem.2831 In Your Element Top Meitnerium in tribute   p830 Adrian Dingle doi:10.1038/nchem.2833 Adrian Dingle tells the story of how the name of element 109 represents the lasting recognition that one of the greatest nuclear physicists was in danger of never receiving. Top Advertisement Nature Briefing Stay informed with the best science news from Nature and beyond. Curated by our global news team and delivered direct to your inbox every weekday, free of charge. Click to learn more   Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/myaccount (You will need to log in to be recognised as a nature.com registrant) For further technical assistance, please contact our registration department For print subscription enquiries, please contact our subscription department For other enquiries, please contact our customer feedback department Springer Nature | One New York Plaza, Suite 4500 | New York | NY 10004-1562 | USA Springer Nature's worldwide offices: London - Paris - Munich - New Delhi - Tokyo - Melbourne San Diego - San Francisco - Washington - New York - Boston Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at The Campus, 4 Crinan Street, London, N1 9XW. © 2017 Macmillan Publishers Limited, part of Springer Nature. All Rights Reserved.