Tuesday, July 25, 2017

Nature Chemistry Contents August 2017 Volume 9 Number 8 pp 725 - 830

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August 2017 Volume 9, Issue 8

News and Views
In Your Element
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101 libations   pp725 - 726
Bruce C. Gibb
Bruce C. Gibb takes a look at the complex cocktail of chemical compounds that make up gin.

News and Views


Cytosolic delivery: Just passing through   pp727 - 728
Macarena Sanchez-Navarro, Meritxell Teixidó and Ernest Giralt
Intracellular protein delivery has been a major challenge in the field of cell biology for decades. Engineering such delivery is a key step in the development of protein- and antibody-based therapeutics. Now, two different approaches that enable the delivery of antibodies and antibody fragments into the cytosol have been developed.

See also: Article by Akishiba et al. | Article by Herce et al.

Photosynthesis: Nature's power switching station   pp728 - 730
Peter J. Walla
The flow of energy in Earth's primary light harvesters — photosynthetic pigment–protein complexes — needs to be heavily regulated, as the sun's energy supply can vary over many orders of magnitude. Observing hundreds of individual light-harvesting complexes has now provided important insights into the machinery that regulates this process.

See also: Article by Kondo et al.


Correction   p730

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The versatility of boron in biological target engagement   pp731 - 742
Diego B. Diaz and Andrei K. Yudin

Recent years have witnessed a surge of interest in targeted covalent inhibition of disease-associated proteins. Among the electrophiles used to interact with nucleophilic residues in protein structures, boron is unique for its chameleonic ability to display a range of coordination modes upon interaction with protein targets.

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Main-chain metallopolymers at the static–dynamic boundary based on nickelocene   pp743 - 750
Rebecca A. Musgrave, Andrew D. Russell, Dominic W. Hayward, George R. Whittell, Paul G. Lawrence et al.

Main-chain polymetallocenes are typically static in nature due to strong metal–ligand bonding. Now, it has been shown that such polymers based on nickelocene are dynamic due to weaker nickel–cyclopentadienyl interactions, and at low concentration or at elevated temperature, depolymerization to the moderately strained monomer occurs.
Chemical compounds

Cytosolic antibody delivery by lipid-sensitive endosomolytic peptide   pp751 - 761
Misao Akishiba, Toshihide Takeuchi, Yoshimasa Kawaguchi, Kentarou Sakamoto, Hao-Hsin Yu et al.

The trapping of antibodies in endosomes often limits their use for intracellular targeting. Now, a single amino acid substitution on a spider-venom peptide has been shown to attenuate the cell membrane lytic activity and enables the selective rupturing of endosomal membranes. The peptide can be used to facilitate the escape of antibodies from endosomes into the cytosol.

See also: News and Views by Sanchez-Navarro et al.

Cell-permeable nanobodies for targeted immunolabelling and antigen manipulation in living cells   pp762 - 771
Henry D. Herce, Dominik Schumacher, Anselm F. L. Schneider, Anne K. Ludwig, Florian A. Mann et al.

Delivery of antibodies into living cells enables the labelling and manipulation of intracellular antigens; however, transporting antibodies into the cytosol in a functional state is difficult. Now, a modular strategy for creating cell-permeable nanobodies capable of targeting intracellular antigens has been developed. The cell-permeable nanobodies are formed by site-specific attachment of cyclic arginine-rich cell-penetrating peptides to camelid-derived single-chain antibody fragments.

See also: News and Views by Sanchez-Navarro et al.

Single-molecule spectroscopy of LHCSR1 protein dynamics identifies two distinct states responsible for multi-timescale photosynthetic photoprotection   pp772 - 778
Toru Kondo, Alberta Pinnola, Wei Jia Chen, Luca Dall'Osto, Roberto Bassi et al.

Photoprotection is crucial for the fitness of organisms that carry out oxygenic photosynthesis. LHCSR, a photosynthetic light-harvesting complex, has been implicated in photoprotection in green algae and moss. Now, single-molecule studies of LHCSR have revealed that multi-timescale protein dynamics underlie photoprotective dissipation of excess energy.

See also: News and Views by Walla

Parameterization of phosphine ligands demonstrates enhancement of nickel catalysis via remote steric effects   pp779 - 784
Kevin Wu and Abigail G. Doyle

Ligand development underlies many advances in Pd-catalysed cross coupling but has seen limited application in the growing field of Ni catalysis. Now, a phosphine framework is shown to enable Ni-catalysed Suzuki coupling of acetals. Parameterization studies provide structural insight into ligand success and a quantitative model to facilitate further ligand design.
Chemical compounds

Scalable and uniform 1D nanoparticles by synchronous polymerization, crystallization and self-assembly   pp785 - 792
Charlotte E. Boott, Jessica Gwyther, Robert L. Harniman, Dominic W. Hayward and Ian Manners

A scalable, one-pot, solution-based protocol for the controlled synthesis of uniform non-spherical block copolymer micelles is a desirable but challenging target. Now, a polymerization-induced crystallization-driven self-assembly process has been developed that offers facile access to 1D and platelet micelle morphologies and to near monodisperse cylinders of controlled length.

Unified biomimetic assembly of voacalgine A and bipleiophylline via divergent oxidative couplings   pp793 - 798
David Lachkar, Natacha Denizot, Guillaume Bernadat, Kadiria Ahamada, Mehdi A. Beniddir et al.

The biomimetic syntheses of bipleiophylline, one of the most complex monoterpene indole alkaloids, and voacalgine A, its biosynthetic precursor, have been achieved from pleiocarpamine starting material. The development of a divergent oxidative coupling for the formation of the benzofuro[2,3-b]indolenine and isochromano[3,4-b]indolenine moieties was key to this accomplishment.
Chemical compounds

Design of multi-phase dynamic chemical networks   pp799 - 804
Chenrui Chen, Junjun Tan, Ming-Chien Hsieh, Ting Pan, Jay T. Goodwin et al.

Di- and tripeptide building blocks in which the C-terminus has been converted into an aldehyde are shown to form dynamic chemical networks through imine condensation followed by the formation of cyclic N,N-acetals. The networks exhibit multi-phase growth of prion-like assemblies that template the formation of chain-length-specific peptide-like oligomers.
Chemical compounds
See also: Article by Omosun et al.

Catalytic diversity in self-propagating peptide assemblies   pp805 - 809
Tolulope O. Omosun, Ming-Chien Hsieh, W. Seth Childers, Dibyendu Das, Anil K. Mehta et al.

Simple peptides are shown to assemble into well-defined amyloid phases with paracrystalline surfaces that can catalyse reactions in an enantioselective manner. Modifying individual amino acids in the building blocks enables the structure of the assembled aggregates, and the reactions that they can catalyse, to be controlled predictably.
Chemical compounds
See also: Article by Chen et al.

MoS2 monolayer catalyst doped with isolated Co atoms for the hydrodeoxygenation reaction   pp810 - 816
Guoliang Liu, Alex W. Robertson, Molly Meng-Jung Li, Winson C. H. Kuo, Matthew T. Darby et al.

Converting oxygen-rich biomass into fuels requires the removal of oxygen groups through hydrodeoxygenation. MoS2 monolayer sheets decorated with isolated Co atoms bound to sulfur vacancies in the basal plane have now been synthesized that exhibit superior catalytic activity, selectivity and stability for the hydrodeoxygenation of 4-methylphenol to toluene when compared to conventionally prepared materials.

Macromolecular metamorphosis via stimulus-induced transformations of polymer architecture   pp817 - 823
Hao Sun, Christopher P. Kabb, Yuqiong Dai, Megan R. Hill, Ion Ghiviriga et al.

Many properties of polymers are dictated by topology. However, the topology of a macromolecule is typically a static feature after synthesis. Now, an approach to dynamic and transformable macromolecular architecture has been developed. When triggered by an external stimulus, macromolecular topology can be triggered to transform via thermodynamic control.

A device that operates within a self-assembled 3D DNA crystal   pp824 - 827
Yudong Hao, Martin Kristiansen, Ruojie Sha, Jens J. Birktoft, Carina Hernandez et al.

Although DNA nanotechnology has found many applications in developing functional structures, there has never been an independent device contained within a 3D crystal. Now, a self-assembled three-state device that can change the colour of its crystal by diffusion of DNA-ligated dyes has been reported, representing the potential to develop programmable nanomechanical devices.

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Addendum: Activating lattice oxygen redox reactions in metal oxides to catalyse oxygen evolution   p828
Alexis Grimaud, Oscar Diaz-Morales, Binghong Han, Wesley T. Hong, Yueh-Lin Lee et al.



Retraction: Charge transfer to solvent identified using dark channel fluorescence-yield L-edge spectroscopy   p828
Emad F. Aziz, M. Hannelore Rittmann-Frank, Kathrin M. Lange, Sebastien Bonhommeau and Majed Chergui

Retraction: Transferring electrons to water   p828
Anders Nilsson

In Your Element


Meitnerium in tribute   p830
Adrian Dingle
Adrian Dingle tells the story of how the name of element 109 represents the lasting recognition that one of the greatest nuclear physicists was in danger of never receiving.

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