Nature Cell Biology contents: August 2017 Volume 19 Number 8, pp 875 - 1003

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Advertisement Cancer Evolution Collection This collection highlights the most recent research and review articles published on this topic.   Access this collection free online for six months   Produced with support from EMD Serono  TABLE OF CONTENTS August 2017 Volume 19, Issue 8 Editorial Review News and Views Articles Letters Corrigenda Advertisement   The CryoCube® F740 series of ULT Freezers combines advancements that maximize sample security and temperature uniformity with improved efficiency and quiet operation. Key features include an automatic vacuum release port and optional advanced interface for data and event logging and access control. Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement Open for Submissions npj Precision Oncology is a new open access, online-only, peer-reviewed journal committed to publishing cutting-edge scientific research in all aspects of precision oncology from basic science to translational applications, to clinical medicine. The journal is part of the Nature Partner Journals series and published in partnership with The Hormel Institute, University of Minnesota. Explore the benefits of submitting your manuscript.   Advertisement HIV IMMUNITY AND ERADICATION, A HERRENHAUSEN SYMPOSIUM November 2-3, 2017 | Hanover, Germany REGISTER NOW!   Editorial Top Journal metrics: what's in a number?   p875 doi:10.1038/ncb3589 Metrics of research assessment should be applied with judgment and clarity to avoid undermining scientific efforts. Review Top Organelle biogenesis in the endoplasmic reticulum   pp876 - 882 Amit S. Joshi, Hong Zhang and William A. Prinz doi:10.1038/ncb3579 In this Review, Prinz and co-authors discuss the role of the endoplasmic reticulum (ER) in the de novo generation of peroxisomes, lipid droplets and omegasomes, and how this requires subdomains with specific protein and lipid compositions. News and Views Top CTCF fences make good neighbours   pp883 - 885 Ivan Krivega and Ann Dean doi:10.1038/ncb3584 CCCTC-binding factor (CTCF) sites are enriched at the boundaries of topologically associated domains (TADs), but their function within TADs is unclear. Removal of sub-TAD CTCF sites adjacent to the α-globin enhancers is now shown to result in inappropriate activation of neighbouring genes. Intra-TAD enhancer insulation might be broadly important for tissue specificity of enhancers. See also: Article by Hanssen et al. Origin and regulation of a lung repair kit   pp885 - 886 Jichao Chen doi:10.1038/ncb3585 The lung undergoes a striking repair process in response to severe injuries such as influenza infection. A study now demonstrates that associated stem/progenitor cells are heterogeneous in nature and comprise subpopulations dominated by hypoxia/Notch or Wnt signalling. Modulation of this heterogeneity in favour of functional repair may have therapeutic value. See also: Article by Xi et al. The skinny on obesity and cancer   pp887 - 888 Jaclyn Sceneay and Sandra S. McAllister doi:10.1038/ncb3583 Obesity now rivals smoking as one of the leading preventable causes of cancer. Obesity-associated neutrophilia is now shown to enhance breast cancer metastasis and to be reversible through dietary modification and weight loss. See also: Article by Quail et al. A key HDAC6 dependency of ARID1A-mutated ovarian cancer   pp889 - 890 Lucia Altucci doi:10.1038/ncb3588 Mutations in AT rich interactive domain 1A (ARID1A) are common in ovarian cancers. A study now shows that HDAC6 activity is required for survival of ovarian cancer cells bearing ARID1A mutations. HDAC6 inhibition selectively promotes apoptosis of ARID1A-inactivated cells, supporting the use of HDAC6 inhibition in the treatment of clear cell ovarian cancer. See also: Article by Bitler et al. Cell Biology JOBS of the week Post Doc in Cell Signaling / Cancer Biology Rutgers Cancer Institute of New Jersey Postdoc in Cell Biology and Innate Immunity The Laboratory for Molecular Infection Medicine Sweden, MIMS, Department of Molecular Biology Postdoctoral Fellowship in Epithelial Stem Cell Biology Laboratory University of Michigan Healthcare System Postdoctoral Fellow-cancer cell biology UCSF Assistant Professor of Stem Cell and Regenerative Biology - Harvard University Harvard University More Science jobs from Cell Biology EVENT International Congress of Cell Biology 2018 27.01.18 Hyderabad, India More science events from Advertisement An open access journal dedicated to highlighting the most important scientific advances in Parkinson's disease research, spanning the motor and non-motor disorders of Parkinson's disease. Part of the Nature Partner Journals series, npj Parkinson's Disease is published in partnership with the Parkinson's Disease Foundation.  Open for submissions >>    Articles Top Bone marrow adipocytes promote the regeneration of stem cells and haematopoiesis by secreting SCF   pp891 - 903 Bo O. Zhou, Hua Yu, Rui Yue, Zhiyu Zhao, Jonathan J. Rios et al. doi:10.1038/ncb3570 Zhou et al. demonstrate that bone marrow adipocytes, but not intraperitoneal adipocytes, express high levels of stem cell factor (SCF), which is essential for the regeneration of haematopoietic stem cells and haematopoiesis after irradiation. Local lung hypoxia determines epithelial fate decisions during alveolar regeneration   pp904 - 914 Ying Xi, Thomas Kim, Alexis N. Brumwell, Ian H. Driver, Ying Wei et al. doi:10.1038/ncb3580 Xi et al. show that after influenza infection, hypoxia drives Notch signalling to expand Krt5+ basal-like cells in the lung. On HIF1α loss, epithelial progenitors directly differentiate into alveolar type II cells and promote functional regeneration. See also: News and Views by Chen Dll4 and Notch signalling couples sprouting angiogenesis and artery formation   pp915 - 927 Mara E. Pitulescu, Inga Schmidt, Benedetto Daniele Giaimo, Tobiah Antoine, Frank Berkenfeld et al. doi:10.1038/ncb3555 Pitulescu et al. and Hasan et al. show that Dll4–Notch signalling in endothelial tip cells regulates angiogenesis through control of artery formation, linking sprouting angiogenesis and artery formation. See also: Article by Hasan et al. Endothelial Notch signalling limits angiogenesis via control of artery formation   pp928 - 940 Sana S. Hasan, Roman Tsaryk, Martin Lange, Laura Wisniewski, John C. Moore et al. doi:10.1038/ncb3574 Pitulescu et al. and Hasan et al. show that Dll4–Notch signalling in endothelial tip cells regulates angiogenesis through control of artery formation, linking sprouting angiogenesis and artery formation. See also: Article by Pitulescu et al. Budding yeast Wee1 distinguishes spindle pole bodies to guide their pattern of age-dependent segregation   pp941 - 951 Jette Lengefeld, Manuel Hotz, Meaghen Rollins, Kristin Baetz and Yves Barral doi:10.1038/ncb3576 Lengefeld et al. reveal how yeast cells distinguish between newly synthesized and pre-existing spindle pole bodies to enable their asymmetric segregation, through a mechanism involving Swe1, Kin3 and NuA4. Tissue-specific CTCF–cohesin-mediated chromatin architecture delimits enhancer interactions and function in vivo   pp952 - 961 Lars L. P. Hanssen, Mira T. Kassouf, A. Marieke  Oudelaar, Daniel Biggs, Chris Preece et al. doi:10.1038/ncb3573 Hanssen et al. show that CTCF–cohesin binding sites at the α-globin gene cluster function as boundaries to restrict the interaction of enhancers with the flanking chromatin, thus preventing abnormal gene expression. See also: News and Views by Krivega & Dean ARID1A-mutated ovarian cancers depend on HDAC6 activity   pp962 - 973 Benjamin G. Bitler, Shuai Wu, Pyoung Hwa Park, Yang Hai, Katherine M. Aird et al. doi:10.1038/ncb3582 Bitler et al. show that HDAC6 activity is essential for the survival of ovarian cancer cells carrying loss-of-function ARID1A mutation, thus representing a promising therapeutic target. See also: News and Views by Altucci Obesity alters the lung myeloid cell landscape to enhance breast cancer metastasis through IL5 and GM-CSF   pp974 - 987 Daniela F. Quail, Oakley C. Olson, Priya Bhardwaj, Logan A. Walsh, Leila Akkari et al. doi:10.1038/ncb3578 Joyce and colleagues report that obesity promotes lung neutrophilia in mice, which in the presence of a primary breast tumour fosters metastasis to the lung in a manner dependent on GM-CSF and IL5. See also: News and Views by Sceneay & McAllister Advertisement Call for Papers - Virology  Nature Microbiology is now accepting submissions in Virology research. Have something in the pipeline?  Submit your manuscript!   Letters Top Cortical forces and CDC-42 control clustering of PAR proteins for Caenorhabditis elegans embryonic polarization   pp988 - 995 Shyi-Chyi Wang, Tricia Yu Feng Low, Yukako Nishimura, Laurent Gole, Weimiao Yu et al. doi:10.1038/ncb3577 Studying polarity establishment in C. elegans zygotes, Wang et al. find, by imaging GFP-tagged proteins, that clusters of the PAR-3 polarity protein assemble in response to membrane tension created by actomyosin contractility. Regulation of Hippo pathway transcription factor TEAD by p38 MAPK-induced cytoplasmic translocation   pp996 - 1002 Kimberly C. Lin, Toshiro Moroishi, Zhipeng Meng, Han-Sol Jeong, Steven W. Plouffe et al. doi:10.1038/ncb3581 Lin et al. find that stress-induced p38 MAPK activation leads to cytoplasmic relocation of the Hippo pathway nuclear transcription factor TEAD. TEAD relocation causes inhibition of YAP activity and suppresses YAP-driven cancer cell growth. Corrigenda Top Corrigendum: Pramel7 mediates ground-state pluripotency through proteasomal–epigenetic combined pathways   p1003 Urs Graf, Elisa A. Casanova, Sarah Wyck, Damian Dalcher, Marco Gatti et al. doi:10.1038/ncb3572 Corrigendum: Pulsatile cell-autonomous contractility drives compaction in the mouse embryo   p1003 Jean-Leon Maître, Ritsuya Niwayama, Hervé Turlier, Francois Nedelec and Takashi Hiiragi doi:10.1038/ncb3587 Top Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

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