Thursday, July 6, 2017

Leukemia - Table of Contents alert Volume 31 Issue 7

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Leukemia: Collection on Acute Myeloid Leukemia

AML is an area of focus for Leukemia and this collection brings together a number of recent key articles published in the journal. 

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Funded by a grant from Astex Pharmaceuticals, Inc.
(a member of the Otsuka group)


Volume 31, Issue 7 (July 2017)

In this issue
Original Articles
Letters To The Editor

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Celebrating 30 years of Leukemia — 1987 to 2017

Thank you to the editors, board members, contributors, reviewers and readers, past and present for their invaluable contributions, and for bringing the journal to this milestone.

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Immunoglobulin gene sequence analysis in chronic lymphocytic leukemia: updated ERIC recommendations OPEN

R Rosenquist, P Ghia, A Hadzidimitriou, L-A Sutton, A Agathangelidis, P Baliakas, N Darzentas, V Giudicelli, M-P Lefranc, A W Langerak, C Belessi, F Davi and K Stamatopoulos ERIC, the European Research Initiative on CLL

Leukemia 2017 31: 1477-1481; advance online publication, April 25, 2017; 10.1038/leu.2017.125

Full Text



Measurable residual disease testing in acute myeloid leukaemia

C S Hourigan, R P Gale, N J Gormley, G J Ossenkoppele and R B Walter

Leukemia 2017 31: 1482-1490; advance online publication, April 7, 2017; 10.1038/leu.2017.113

Abstract | Full Text

Original Articles



Genomic and transcriptional landscape of P2RY8-CRLF2-positive childhood acute lymphoblastic leukemia OPEN

C Vesely, C Frech, C Eckert, G Cario, A Mecklenbräuker, U zur Stadt, K Nebral, F Kraler, S Fischer, A Attarbaschi, M Schuster, C Bock, H Cavé, A von Stackelberg, M Schrappe, M A Horstmann, G Mann, O A Haas and R Panzer-Grümayer

Leukemia 2017 31: 1491-1501; advance online publication, November 30, 2016; 10.1038/leu.2016.365

Abstract | Full Text


Differential signaling networks of Bcr–Abl p210 and p190 kinases in leukemia cells defined by functional proteomics OPEN

S Reckel, R Hamelin, S Georgeon, F Armand, Q Jolliet, D Chiappe, M Moniatte and O Hantschel

Leukemia 2017 31: 1502-1512; advance online publication, January 23, 2017; 10.1038/leu.2017.36

Abstract | Full Text

Differential signaling through p190 and p210 BCR-ABL fusion proteins revealed by interactome and phosphoproteome analysis

J A Cutler, R Tahir, S K Sreenivasamurthy, C Mitchell, S Renuse, R S Nirujogi, A H Patil, M Heydarian, X Wong, X Wu, T-C Huang, M-S Kim, K L Reddy and A Pandey

Leukemia 2017 31: 1513-1524; advance online publication, February 17, 2017; 10.1038/leu.2017.61

Abstract | Full Text

Treatment-free remission following frontline nilotinib in patients with chronic myeloid leukemia in chronic phase: results from the ENESTfreedom study OPEN

A Hochhaus, T Masszi, F J Giles, J P Radich, D M Ross, M T Gómez Casares, A Hellmann, J Stentoft, E Conneally, V García-Gutiérrez, N Gattermann, W Wiktor-Jedrzejczak, P D le Coutre, B Martino, S Saussele, H D Menssen, W Deng, N Krunic, V Bedoucha and G Saglio

Leukemia 2017 31: 1525-1531; advance online publication, February 20, 2017; 10.1038/leu.2017.63

Abstract | Full Text

Cobll1 is linked to drug resistance and blastic transformation in chronic myeloid leukemia

S H Han, S-H Kim, H-J Kim, Y Lee, S-Y Choi, G Park, D-H Kim, A Lee, J Kim, J-M Choi, Y Kim, K Myung, H Kim and D-W Kim

Leukemia 2017 31: 1532-1539; advance online publication, February 24, 2017; 10.1038/leu.2017.72

Abstract | Full Text

Increased megakaryocytic proliferation, pro-platelet deposition and expression of fibrosis-associated factors in children with chronic myeloid leukaemia with bone marrow fibrosis

K Hussein, A Stucki-Koch, G Göhring, H Kreipe and M Suttorp

Leukemia 2017 31: 1540-1546; advance online publication, February 27, 2017; 10.1038/leu.2017.73

Abstract | Full Text


EGR2 mutations define a new clinically aggressive subgroup of chronic lymphocytic leukemia

E Young, D Noerenberg, L Mansouri, V Ljungström, M Frick, L-A Sutton, S J Blakemore, J Galan-Sousa, K Plevova, P Baliakas, D Rossi, R Clifford, D Roos-Weil, V Navrkalova, B Dörken, C A Schmitt, K E Smedby, G Juliusson, B Giacopelli, J S Blachly, C Belessi, P Panagiotidis, N Chiorazzi, F Davi, A W Langerak, D Oscier, A Schuh, G Gaidano, P Ghia, W Xu, L Fan, O A Bernard, F Nguyen-Khac, L Rassenti, J Li, T J Kipps, K Stamatopoulos, S Pospisilova, T Zenz, C C Oakes, J C Strefford, R Rosenquist and F Damm

Leukemia 2017 31: 1547-1554; advance online publication, November 28, 2016; 10.1038/leu.2016.359

Abstract | Full Text

Restrictions in the T-cell repertoire of chronic lymphocytic leukemia: high-throughput immunoprofiling supports selection by shared antigenic elements

A Vardi, E Vlachonikola, M Karypidou, E Stalika, V Bikos, K Gemenetzi, C Maramis, A Siorenta, A Anagnostopoulos, S Pospisilova, N Maglaveras, I Chouvarda, K Stamatopoulos and A Hadzidimitriou

Leukemia 2017 31: 1555-1561; advance online publication, November 25, 2016; 10.1038/leu.2016.362

Abstract | Full Text


Interphase fluorescence in situ hybridization in untreated AL amyloidosis has an independent prognostic impact by abnormality type and treatment category

E Muchtar, A Dispenzieri, S K Kumar, R P Ketterling, D Dingli, M Q Lacy, F K Buadi, S R Hayman, P Kapoor, N Leung, R Chakraborty, W Gonsalves, R Warsame, T V Kourelis, S Russell, J A Lust, Y Lin, R S Go, S Zeldenrust, R A Kyle, S V Rajkumar and M A Gertz

Leukemia 2017 31: 1562-1569; advance online publication, December 1, 2016; 10.1038/leu.2016.369

Abstract | Full Text

The AP-1 transcription factor JunB is essential for multiple myeloma cell proliferation and drug resistance in the bone marrow microenvironment

F Fan, M H Bashari, E Morelli, G Tonon, S Malvestiti, S Vallet, M Jarahian, A Seckinger, D Hose, L Bakiri, C Sun, Y Hu, C R Ball, H Glimm, M Sattler, H Goldschmidt, E F Wagner, P Tassone, D Jaeger and K Podar

Leukemia 2017 31: 1570-1581; advance online publication, November 28, 2016; 10.1038/leu.2016.358

Abstract | Full Text


Extended time-lapse in vivo imaging of tibia bone marrow to visualize dynamic hematopoietic stem cell engraftment

S Kim, L Lin, G A J Brown, K Hosaka and E W Scott

Leukemia 2017 31: 1582-1592; advance online publication, November 28, 2016; 10.1038/leu.2016.354

Abstract | Full Text


Histone deacetylase inhibitors interrupt HSP90•RASGRP1 and HSP90•CRAF interactions to upregulate BIM and circumvent drug resistance in lymphoma cells

H Ding, K L Peterson, C Correia, B Koh, P A Schneider, G S Nowakowski and S H Kaufmann

Leukemia 2017 31: 1593-1602; advance online publication, November 28, 2016; 10.1038/leu.2016.357

Abstract | Full Text


Casein kinase 2 controls the survival of normal thymic and leukemic γδ T cells via promotion of AKT signaling OPEN

S T Ribeiro, M Tesio, J C Ribot, E Macintyre, J T Barata and B Silva-Santos

Leukemia 2017 31: 1603-1610; advance online publication, November 30, 2016; 10.1038/leu.2016.363

Abstract | Full Text

A TLR7 agonist enhances the antitumor efficacy of obinutuzumab in murine lymphoma models via NK cells and CD4 T cells OPEN

E J Cheadle, G Lipowska-Bhalla, S J Dovedi, E Fagnano, C Klein, J Honeychurch and T M Illidge

Leukemia 2017 31: 1611-1621; advance online publication, November 28, 2017; 10.1038/leu.2016.352

Abstract | Full Text

Letters To The Editor


Epigenetic loss of the RNA decapping enzyme NUDT16 mediates C-MYC activation in T-cell acute lymphoblastic leukemia OPEN

C Anadón, G van Tetering, H J Ferreira, C Moutinho, A Martínez-Cardús, A Villanueva, M Soler, H Heyn, S Moran, M Castro de Moura, F Setien, A Vidal, E Genescà, J M Ribera, J F Nomdedeu, S Guil and M Esteller

Leukemia 2017 31: 1622-1625; advance online publication, March 27, 2017; 10.1038/leu.2017.99

Full Text

Gain in the short arm of chromosome 2 (2p+) induces gene overexpression and drug resistance in chronic lymphocytic leukemia: analysis of the central role of XPO1

A Cosson, E Chapiro, N Bougacha, J Lambert, L Herbi, H-A Cung, C Algrin, B Keren, F Damm, C Gabillaud, M-N Brunelle-Navas, F Davi, H Merle-Béral, M Le Garff-Tavernier, D Roos-Weil, S Choquet, M Uzunov, V Morel, V Leblond, K Maloum, S Lepretre, P Feugier, C Lesty, J Lejeune, L Sutton, Y Landesman, S A Susin and F Nguyen-Khac

Leukemia 2017 31: 1625-1629; advance online publication, March 27, 2017; 10.1038/leu.2017.100

Full Text

Recurrent MYB rearrangement in blastic plasmacytoid dendritic cell neoplasm

K Suzuki, Y Suzuki, A Hama, H Muramatsu, M Nakatochi, M Gunji, D Ichikawa, M Hamada, R Taniguchi, S Kataoka, N Murakami, D Kojima, Y Sekiya, E Nishikawa, N Kawashima, A Narita, N Nishio, Y Nakazawa, H Iwafuchi, K-i Watanabe, Y Takahashi, M Ito, S Kojima, S Kato and Y Okuno

Leukemia 2017 31: 1629-1633; advance online publication, March 27, 2017; 10.1038/leu.2017.101

Full Text

PD-L1 is commonly expressed and transcriptionally regulated by STAT3 and MYC in ALK-negative anaplastic large-cell lymphoma

V Atsaves, N Tsesmetzis, D Chioureas, L Kis, V Leventaki, E Drakos, T Panaretakis, D Grander, L J Medeiros, K H Young and G Z Rassidakis

Leukemia 2017 31: 1633-1637; advance online publication, March 27, 2017; 10.1038/leu.2017.103

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Donor cell leukemia: evidence for multiple preleukemic clones and parallel long term clonal evolution in donor and recipient

S Herold, M Kuhn, M v Bonin, T Stange, U Platzbecker, J Radke, T Lange, K Sockel, K Gutsche, J Schetelig, C Röllig, C Schuster, I Roeder, A Dahl, B Mohr, H Serve, C Brandts, G Ehninger, M Bornhäuser and C Thiede

Leukemia 2017 31: 1637-1640; advance online publication, March 28, 2017; 10.1038/leu.2017.104

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Acute myeloid leukemia in the elderly is characterized by a distinct genetic and epigenetic landscape

P Silva, M Neumann, M P Schroeder, S Vosberg, C Schlee, K Isaakidis, J Ortiz-Tanchez, L R Fransecky, T Hartung, S Türkmen, A Graf, S Krebs, H Blum, C Müller-Tidow, C Thiede, G Ehninger, H Serve, J Hecht, W E Berdel, P A Greif, C Röllig and C D Baldus

Leukemia 2017 31: 1640-1644; advance online publication, April 3, 2017; 10.1038/leu.2017.109

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PLCG2 C2 domain mutations co-occur with BTK and PLCG2 resistance mutations in chronic lymphocytic leukemia undergoing ibrutinib treatment

D Jones, J A Woyach, W Zhao, S Caruthers, H Tu, J Coleman, J C Byrd, A J Johnson and G Lozanski

Leukemia 2017 31: 1645-1647; advance online publication, April 3, 2017; 10.1038/leu.2017.110

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NEK2 induces osteoclast differentiation and bone destruction via heparanase in multiple myeloma OPEN

M Hao, R Franqui-Machin, H Xu, J Shaughnessy, Jr, B Barlogie, D Roodman, D E Quelle, S Janz, M H Tomasson, R D Sanderson, L Qiu, I Frech, G Tricot and F Zhan

Leukemia 2017 31: 1648-1650; advance online publication, April 12, 2017; 10.1038/leu.2017.115

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Tunneling nanotubes facilitate autophagosome transfer in the leukemic niche OPEN

B de Rooij, R Polak, F Stalpers, R Pieters and M L den Boer

Leukemia 2017 31: 1651-1654; advance online publication, April 12, 2017; 10.1038/leu.2017.117

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Donor type, in addition to transplantation in chronic phase and myeloablative conditioning, influence transplant survival for patients with advanced chronic myeloid leukemia in the era of tyrosine kinase inhibitors

P Kongtim, K Adekola, D R Milton, R Ramlal, A Jimenez, J Chen, G Rondon, S Ahmed, P Kebriaei, O Betul, C M Hosing, U Popat, I Khouri, E Jabbour, J E Cortes, H M Kantarjian, R E Champlin and S O Ciurea

Leukemia 2017 31: 1654-1657; advance online publication, April 12, 2017; 10.1038/leu.2017.118

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Highly effective combination of LSD1 (KDM1A) antagonist and pan-histone deacetylase inhibitor against human AML cells

W Fiskus, S Sharma, B Shah, B P Portier, S G T Devaraj, K Liu, S P Iyer, D Bearss and K N Bhalla

Leukemia 2017 31: 1658; advance online publication, March 21, 2017; 10.1038/leu.2017.77

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A clinical trial for patients with acute myeloid leukemia or myelodysplastic syndromes not eligible for standard clinical trials

G Montalban-Bravo, X Huang, K Naqvi, E Jabbour, G Borthakur, C D DiNardo, N Pemmaraju, J Cortes, S Verstovsek, T Kadia, N Daver, W Wierda, Y Alvarado, M Konopleva, F Ravandi, Z Estrov, N Jain, A Alfonso, M Brandt, T Sneed, H C Chen, H Yang, C Bueso-Ramos, S Pierce, E Estey, Z Bohannan, H M Kantarjian and G Garcia-Manero

Leukemia 2017 31: 1659; advance online publication, March 24, 2017; 10.1038/leu.2017.85

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Epistasis between TIFAB and miR-146a: neighboring genes in del(5q) myelodysplastic syndrome

M E Varney, K Choi, L Bolanos, S Christie, J Fang, H L Grimes, J P Maciejewski, J-I Inoue and D T Starczynowski

Leukemia 2017 31: 1659; advance online publication, April 7, 2017; 10.1038/leu.2017.95

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Cobll1 is linked to drug resistance and blastic transformation in chronic myeloid leukemia

S H Han, S-H Kim, H-J Kim, Y Lee, S-Y Choi, G Park, D-H Kim, A Lee, J Kim, J-M Choi, Y Kim, K Myung, H Kim and D-W Kim

Leukemia 2017 31: 1659; advance online publication, April 11, 2017; 10.1038/leu.2017.107

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Equivalence of BCSH and WHO diagnostic criteria for ET

C N Harrison, M F McMullin, A R Green and A J Mead

Leukemia 2017 31: 1660; advance online publication, May 5, 2017; 10.1038/leu.2017.119

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