TABLE OF CONTENTS
| | | | Volume 31, Issue 7 (July 2017) | | In this issue Editorial Review Original Articles Letters To The Editor Corrigenda
Also new AOP | | | | | Advertisement | | | | | Editorial | Top | | Immunoglobulin gene sequence analysis in chronic lymphocytic leukemia: updated ERIC recommendations OPENR Rosenquist, P Ghia, A Hadzidimitriou, L-A Sutton, A Agathangelidis, P Baliakas, N Darzentas, V Giudicelli, M-P Lefranc, A W Langerak, C Belessi, F Davi and K Stamatopoulos ERIC, the European Research Initiative on CLL Leukemia 2017 31: 1477-1481; advance online publication, April 25, 2017; 10.1038/leu.2017.125 Full Text | | Review | Top | | Measurable residual disease testing in acute myeloid leukaemiaC S Hourigan, R P Gale, N J Gormley, G J Ossenkoppele and R B Walter Leukemia 2017 31: 1482-1490; advance online publication, April 7, 2017; 10.1038/leu.2017.113 Abstract | Full Text | | Original Articles | Top | | ACUTE LYMPHOBLASTIC LEUKEMIA | Genomic and transcriptional landscape of P2RY8-CRLF2-positive childhood acute lymphoblastic leukemia OPENC Vesely, C Frech, C Eckert, G Cario, A Mecklenbräuker, U zur Stadt, K Nebral, F Kraler, S Fischer, A Attarbaschi, M Schuster, C Bock, H Cavé, A von Stackelberg, M Schrappe, M A Horstmann, G Mann, O A Haas and R Panzer-Grümayer Leukemia 2017 31: 1491-1501; advance online publication, November 30, 2016; 10.1038/leu.2016.365 Abstract | Full Text | | | | CHRONIC MYELOGENOUS LEUKEMIA | Differential signaling networks of Bcr–Abl p210 and p190 kinases in leukemia cells defined by functional proteomics OPENS Reckel, R Hamelin, S Georgeon, F Armand, Q Jolliet, D Chiappe, M Moniatte and O Hantschel Leukemia 2017 31: 1502-1512; advance online publication, January 23, 2017; 10.1038/leu.2017.36 Abstract | Full Text | | | | Differential signaling through p190 and p210 BCR-ABL fusion proteins revealed by interactome and phosphoproteome analysisJ A Cutler, R Tahir, S K Sreenivasamurthy, C Mitchell, S Renuse, R S Nirujogi, A H Patil, M Heydarian, X Wong, X Wu, T-C Huang, M-S Kim, K L Reddy and A Pandey Leukemia 2017 31: 1513-1524; advance online publication, February 17, 2017; 10.1038/leu.2017.61 Abstract | Full Text | | | | Treatment-free remission following frontline nilotinib in patients with chronic myeloid leukemia in chronic phase: results from the ENESTfreedom study OPENA Hochhaus, T Masszi, F J Giles, J P Radich, D M Ross, M T Gómez Casares, A Hellmann, J Stentoft, E Conneally, V García-Gutiérrez, N Gattermann, W Wiktor-Jedrzejczak, P D le Coutre, B Martino, S Saussele, H D Menssen, W Deng, N Krunic, V Bedoucha and G Saglio Leukemia 2017 31: 1525-1531; advance online publication, February 20, 2017; 10.1038/leu.2017.63 Abstract | Full Text | | | | Cobll1 is linked to drug resistance and blastic transformation in chronic myeloid leukemiaS H Han, S-H Kim, H-J Kim, Y Lee, S-Y Choi, G Park, D-H Kim, A Lee, J Kim, J-M Choi, Y Kim, K Myung, H Kim and D-W Kim Leukemia 2017 31: 1532-1539; advance online publication, February 24, 2017; 10.1038/leu.2017.72 Abstract | Full Text | | | | Increased megakaryocytic proliferation, pro-platelet deposition and expression of fibrosis-associated factors in children with chronic myeloid leukaemia with bone marrow fibrosisK Hussein, A Stucki-Koch, G Göhring, H Kreipe and M Suttorp Leukemia 2017 31: 1540-1546; advance online publication, February 27, 2017; 10.1038/leu.2017.73 Abstract | Full Text | | | | CHRONIC LYMPHOCYTIC LEUKEMIA | EGR2 mutations define a new clinically aggressive subgroup of chronic lymphocytic leukemiaE Young, D Noerenberg, L Mansouri, V Ljungström, M Frick, L-A Sutton, S J Blakemore, J Galan-Sousa, K Plevova, P Baliakas, D Rossi, R Clifford, D Roos-Weil, V Navrkalova, B Dörken, C A Schmitt, K E Smedby, G Juliusson, B Giacopelli, J S Blachly, C Belessi, P Panagiotidis, N Chiorazzi, F Davi, A W Langerak, D Oscier, A Schuh, G Gaidano, P Ghia, W Xu, L Fan, O A Bernard, F Nguyen-Khac, L Rassenti, J Li, T J Kipps, K Stamatopoulos, S Pospisilova, T Zenz, C C Oakes, J C Strefford, R Rosenquist and F Damm Leukemia 2017 31: 1547-1554; advance online publication, November 28, 2016; 10.1038/leu.2016.359 Abstract | Full Text | | | | Restrictions in the T-cell repertoire of chronic lymphocytic leukemia: high-throughput immunoprofiling supports selection by shared antigenic elementsA Vardi, E Vlachonikola, M Karypidou, E Stalika, V Bikos, K Gemenetzi, C Maramis, A Siorenta, A Anagnostopoulos, S Pospisilova, N Maglaveras, I Chouvarda, K Stamatopoulos and A Hadzidimitriou Leukemia 2017 31: 1555-1561; advance online publication, November 25, 2016; 10.1038/leu.2016.362 Abstract | Full Text | | | | MULTIPLE MYELOMA, GAMMOPATHIES | Interphase fluorescence in situ hybridization in untreated AL amyloidosis has an independent prognostic impact by abnormality type and treatment categoryE Muchtar, A Dispenzieri, S K Kumar, R P Ketterling, D Dingli, M Q Lacy, F K Buadi, S R Hayman, P Kapoor, N Leung, R Chakraborty, W Gonsalves, R Warsame, T V Kourelis, S Russell, J A Lust, Y Lin, R S Go, S Zeldenrust, R A Kyle, S V Rajkumar and M A Gertz Leukemia 2017 31: 1562-1569; advance online publication, December 1, 2016; 10.1038/leu.2016.369 Abstract | Full Text | | | | The AP-1 transcription factor JunB is essential for multiple myeloma cell proliferation and drug resistance in the bone marrow microenvironmentF Fan, M H Bashari, E Morelli, G Tonon, S Malvestiti, S Vallet, M Jarahian, A Seckinger, D Hose, L Bakiri, C Sun, Y Hu, C R Ball, H Glimm, M Sattler, H Goldschmidt, E F Wagner, P Tassone, D Jaeger and K Podar Leukemia 2017 31: 1570-1581; advance online publication, November 28, 2016; 10.1038/leu.2016.358 Abstract | Full Text | | | | STEM CELL TRANSPLANTATION | Extended time-lapse in vivo imaging of tibia bone marrow to visualize dynamic hematopoietic stem cell engraftmentS Kim, L Lin, G A J Brown, K Hosaka and E W Scott Leukemia 2017 31: 1582-1592; advance online publication, November 28, 2016; 10.1038/leu.2016.354 Abstract | Full Text | | | | MOLECULAR TARGETS FOR THERAPY | Histone deacetylase inhibitors interrupt HSP90•RASGRP1 and HSP90•CRAF interactions to upregulate BIM and circumvent drug resistance in lymphoma cellsH Ding, K L Peterson, C Correia, B Koh, P A Schneider, G S Nowakowski and S H Kaufmann Leukemia 2017 31: 1593-1602; advance online publication, November 28, 2016; 10.1038/leu.2016.357 Abstract | Full Text | | | | IMMUNOTHERAPY | Casein kinase 2 controls the survival of normal thymic and leukemic γδ T cells via promotion of AKT signaling OPENS T Ribeiro, M Tesio, J C Ribot, E Macintyre, J T Barata and B Silva-Santos Leukemia 2017 31: 1603-1610; advance online publication, November 30, 2016; 10.1038/leu.2016.363 Abstract | Full Text | | | | A TLR7 agonist enhances the antitumor efficacy of obinutuzumab in murine lymphoma models via NK cells and CD4 T cells OPENE J Cheadle, G Lipowska-Bhalla, S J Dovedi, E Fagnano, C Klein, J Honeychurch and T M Illidge Leukemia 2017 31: 1611-1621; advance online publication, November 28, 2017; 10.1038/leu.2016.352 Abstract | Full Text | | Letters To The Editor | Top | | Epigenetic loss of the RNA decapping enzyme NUDT16 mediates C-MYC activation in T-cell acute lymphoblastic leukemia OPENC Anadón, G van Tetering, H J Ferreira, C Moutinho, A Martínez-Cardús, A Villanueva, M Soler, H Heyn, S Moran, M Castro de Moura, F Setien, A Vidal, E Genescà, J M Ribera, J F Nomdedeu, S Guil and M Esteller Leukemia 2017 31: 1622-1625; advance online publication, March 27, 2017; 10.1038/leu.2017.99 Full Text | | | | Gain in the short arm of chromosome 2 (2p+) induces gene overexpression and drug resistance in chronic lymphocytic leukemia: analysis of the central role of XPO1A Cosson, E Chapiro, N Bougacha, J Lambert, L Herbi, H-A Cung, C Algrin, B Keren, F Damm, C Gabillaud, M-N Brunelle-Navas, F Davi, H Merle-Béral, M Le Garff-Tavernier, D Roos-Weil, S Choquet, M Uzunov, V Morel, V Leblond, K Maloum, S Lepretre, P Feugier, C Lesty, J Lejeune, L Sutton, Y Landesman, S A Susin and F Nguyen-Khac Leukemia 2017 31: 1625-1629; advance online publication, March 27, 2017; 10.1038/leu.2017.100 Full Text | | | | Recurrent MYB rearrangement in blastic plasmacytoid dendritic cell neoplasmK Suzuki, Y Suzuki, A Hama, H Muramatsu, M Nakatochi, M Gunji, D Ichikawa, M Hamada, R Taniguchi, S Kataoka, N Murakami, D Kojima, Y Sekiya, E Nishikawa, N Kawashima, A Narita, N Nishio, Y Nakazawa, H Iwafuchi, K-i Watanabe, Y Takahashi, M Ito, S Kojima, S Kato and Y Okuno Leukemia 2017 31: 1629-1633; advance online publication, March 27, 2017; 10.1038/leu.2017.101 Full Text | | | | PD-L1 is commonly expressed and transcriptionally regulated by STAT3 and MYC in ALK-negative anaplastic large-cell lymphomaV Atsaves, N Tsesmetzis, D Chioureas, L Kis, V Leventaki, E Drakos, T Panaretakis, D Grander, L J Medeiros, K H Young and G Z Rassidakis Leukemia 2017 31: 1633-1637; advance online publication, March 27, 2017; 10.1038/leu.2017.103 Full Text | | | | Donor cell leukemia: evidence for multiple preleukemic clones and parallel long term clonal evolution in donor and recipientS Herold, M Kuhn, M v Bonin, T Stange, U Platzbecker, J Radke, T Lange, K Sockel, K Gutsche, J Schetelig, C Röllig, C Schuster, I Roeder, A Dahl, B Mohr, H Serve, C Brandts, G Ehninger, M Bornhäuser and C Thiede Leukemia 2017 31: 1637-1640; advance online publication, March 28, 2017; 10.1038/leu.2017.104 Full Text | | | | Acute myeloid leukemia in the elderly is characterized by a distinct genetic and epigenetic landscapeP Silva, M Neumann, M P Schroeder, S Vosberg, C Schlee, K Isaakidis, J Ortiz-Tanchez, L R Fransecky, T Hartung, S Türkmen, A Graf, S Krebs, H Blum, C Müller-Tidow, C Thiede, G Ehninger, H Serve, J Hecht, W E Berdel, P A Greif, C Röllig and C D Baldus Leukemia 2017 31: 1640-1644; advance online publication, April 3, 2017; 10.1038/leu.2017.109 Full Text | | | | PLCG2 C2 domain mutations co-occur with BTK and PLCG2 resistance mutations in chronic lymphocytic leukemia undergoing ibrutinib treatmentD Jones, J A Woyach, W Zhao, S Caruthers, H Tu, J Coleman, J C Byrd, A J Johnson and G Lozanski Leukemia 2017 31: 1645-1647; advance online publication, April 3, 2017; 10.1038/leu.2017.110 Full Text | | | | NEK2 induces osteoclast differentiation and bone destruction via heparanase in multiple myeloma OPENM Hao, R Franqui-Machin, H Xu, J Shaughnessy, Jr, B Barlogie, D Roodman, D E Quelle, S Janz, M H Tomasson, R D Sanderson, L Qiu, I Frech, G Tricot and F Zhan Leukemia 2017 31: 1648-1650; advance online publication, April 12, 2017; 10.1038/leu.2017.115 Full Text | | | | Tunneling nanotubes facilitate autophagosome transfer in the leukemic niche OPENB de Rooij, R Polak, F Stalpers, R Pieters and M L den Boer Leukemia 2017 31: 1651-1654; advance online publication, April 12, 2017; 10.1038/leu.2017.117 Full Text | | | | Donor type, in addition to transplantation in chronic phase and myeloablative conditioning, influence transplant survival for patients with advanced chronic myeloid leukemia in the era of tyrosine kinase inhibitorsP Kongtim, K Adekola, D R Milton, R Ramlal, A Jimenez, J Chen, G Rondon, S Ahmed, P Kebriaei, O Betul, C M Hosing, U Popat, I Khouri, E Jabbour, J E Cortes, H M Kantarjian, R E Champlin and S O Ciurea Leukemia 2017 31: 1654-1657; advance online publication, April 12, 2017; 10.1038/leu.2017.118 Full Text | | Corrigenda | Top | | Highly effective combination of LSD1 (KDM1A) antagonist and pan-histone deacetylase inhibitor against human AML cellsW Fiskus, S Sharma, B Shah, B P Portier, S G T Devaraj, K Liu, S P Iyer, D Bearss and K N Bhalla Leukemia 2017 31: 1658; advance online publication, March 21, 2017; 10.1038/leu.2017.77 Full Text | | | | A clinical trial for patients with acute myeloid leukemia or myelodysplastic syndromes not eligible for standard clinical trialsG Montalban-Bravo, X Huang, K Naqvi, E Jabbour, G Borthakur, C D DiNardo, N Pemmaraju, J Cortes, S Verstovsek, T Kadia, N Daver, W Wierda, Y Alvarado, M Konopleva, F Ravandi, Z Estrov, N Jain, A Alfonso, M Brandt, T Sneed, H C Chen, H Yang, C Bueso-Ramos, S Pierce, E Estey, Z Bohannan, H M Kantarjian and G Garcia-Manero Leukemia 2017 31: 1659; advance online publication, March 24, 2017; 10.1038/leu.2017.85 Full Text | | | | Epistasis between TIFAB and miR-146a: neighboring genes in del(5q) myelodysplastic syndromeM E Varney, K Choi, L Bolanos, S Christie, J Fang, H L Grimes, J P Maciejewski, J-I Inoue and D T Starczynowski Leukemia 2017 31: 1659; advance online publication, April 7, 2017; 10.1038/leu.2017.95 Full Text | | | | Cobll1 is linked to drug resistance and blastic transformation in chronic myeloid leukemiaS H Han, S-H Kim, H-J Kim, Y Lee, S-Y Choi, G Park, D-H Kim, A Lee, J Kim, J-M Choi, Y Kim, K Myung, H Kim and D-W Kim Leukemia 2017 31: 1659; advance online publication, April 11, 2017; 10.1038/leu.2017.107 Full Text | | | | Equivalence of BCSH and WHO diagnostic criteria for ETC N Harrison, M F McMullin, A R Green and A J Mead Leukemia 2017 31: 1660; advance online publication, May 5, 2017; 10.1038/leu.2017.119 Full Text | | | | | | | | | | | Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. 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