Thursday, July 13, 2017

Gene Therapy - Table of Contents alert Volume 24 Issue 7

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Gene Therapy

TECHNICAL NOTE: Why is AAV one of the most promising viral gene transfer vectors? 

AAV vectors provide promising gene delivery vehicles in large scale preclinical productions for target identification/validation studies, or used in large animal models and clinical trials of human gene therapy.

The technical note explores:
  • Achieving preclinical efficacy
  • Basic systems for growing cells in culture
  • Use of bioreactors
Read technical note


Volume 24, Issue 7 (July 2017)

In this issue
Original Articles

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Presented by: Ospedale San Raffaele | Nature

The conference will feature sessions on regeneration in animal models, functional and dysfunctional regeneration in mammals, and new therapeutic approaches to regeneration.

November 16-18, 2017 | Milan, Italy



Current application of CRISPR/Cas9 gene-editing technique to eradication of HIV/AIDS

Z Huang, A Tomitaka, A Raymond and M Nair

Gene Ther 2017 24: 377-384; advance online publication, June 1, 2017; 10.1038/gt.2017.35

Abstract | Full Text

Herpesvirus microRNAs for use in gene therapy immune-evasion strategies

S T F Bots and R C Hoeben

Gene Ther 2017 24: 385-391; advance online publication, May 9, 2017; 10.1038/gt.2017.37

Abstract | Full Text

Original Articles


INSR gene polymorphisms correlate with sensitivity to platinum-based chemotherapy and prognosis in patients with epithelial ovarian cancer

J-L Hu, X-L Hu, Q Han, A-Y Guo, C-J Wang, Y-Y Wen and S-D Cang

Gene Ther 2017 24: 392-398; advance online publication, April 24, 2017; 10.1038/gt.2017.26

Abstract | Full Text

SOST silencing promotes proliferation and invasion and reduces apoptosis of retinoblastoma cells by activating Wnt/β-catenin signaling pathway

T Wu, L-N Wang, D-R Tang and F-Y Sun

Gene Ther 2017 24: 399-407; advance online publication, June 15, 2017; 10.1038/gt.2017.31

Abstract | Full Text

Coinjection of IL2 DNA enhances E7-specific antitumor immunity elicited by intravaginal therapeutic HPV DNA vaccination with electroporation

Y Sun, S Peng, A Yang, E Farmer, T-C Wu and C-F Hung

Gene Ther 2017 24: 408-415; advance online publication, May 11, 2017; 10.1038/gt.2017.38

Abstract | Full Text

Effect of IL-1β, TNF-α and IGF-1 on trans-endothelial passage of synthetic vectors through an in vitro vascular endothelial barrier of striated muscle

J P Gomez, C Gonçalves, C Pichon and P Midoux

Gene Ther 2017 24: 416-424; advance online publication, May 15, 2017; 10.1038/gt.2017.40

Abstract | Full Text

CD34+ cells from dental pulp stem cells with a ZFN-mediated and homology-driven repair-mediated locus-specific knock-in of an artificial β-globin gene

S Chattong, O Ruangwattanasuk, W Yindeedej, A Setpakdee and K Manotham

Gene Ther 2017 24: 425-432; advance online publication, May 22, 2017; 10.1038/gt.2017.42

Abstract | Full Text

Synergistic effects of deleting multiple nonessential elements in nonreplicative HSV-1 BAC genomic vectors play a critical role in their viability

M Ventosa, A Ortiz-Temprano, H Khalique and F Lim

Gene Ther 2017 24: 433-440; advance online publication, May 29, 2017; 10.1038/gt.2017.43

Abstract | Full Text

A new open access journal dedicated to publishing the most important scientific advances in all aspects of genomics and its application in the practice of medicine.

Part of the Nature Partner Journals series, the journal is published in partnership with the Center of Excellence in Genomic Medicine Research. 

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